We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.

These notes discuss formalizing contexts as first class objects. The basic relationships are: ist(c,p) meaning that the proposition p is true in the context c, and value(c,p) designating the value of the term e in the context c Besides these, there are lifting formulas that relate the propositions and terms in subcontexts to possibly more general propositions and terms in the outer context. Subcontextx are often specialised with regard to time, place and terminology. Introducing contexts as formal objects will permit (...) axiomatizations in limited contexts to be expanded to transcend the original limitations. This seems necessary to provide AI programs using logic with certain capabilities that human fact representation and human reasoning possess. Fully implementing transcendence seems to require further extensions to mathematical logic, ie. beyond the nonmonotonic inference methods first invented in AI and now studied as a new domain of logic. (shrink)

Logical AI develops computer programs that represent what they know about the world primarily by logical formulas and decide what to do primarily by logical reasoning--including nonmonotonic logical reasoning. It is convenient to use logical sentences and terms whose meaning depends on context. The reasons for this are similar to what causes human language to use context dependent meanings. This note gives elements of some of the formalisms to which we have been led. Fuller treatments are in [McC93], [Guh91] and (...) [MB94] and the references cited in the Web page [Buv95]. The first main idea is to make contexts first class objects in the logic and use the formula ist(c,p) to assert that the proposition p is true in the context c. A second idea is to formalize how propositions true in one context transform when they are moved to different but related contexts. An ability to transcend the outermost context is needed to give computer programs the ability to reason about the totality of all they have thought about so far [McC96]. (shrink)

“...it seems that hardly anybody proposes to use different variables for propositions and for truth-values, or different variables for individuals and individual concepts.” (Carnap 1956, p. 113).

Used as the basis of the program at the Equinox Holistic Alternative School in Toronto, The Holistic Curriculum advocates for an integrative approach to teaching and learning with a focus on developing a deep connection between mind and body.

This wide-ranging, multidisciplinary collection of newly commissioned articles brings together distinguished voices in the field of Africana philosophy and African-American social and political thought. Provides a comprehensive critical survey of African-American philosophical thought. Collects wide-ranging, multidisciplinary, newly commissioned articles in one authoritative volume. Serves as a benchmark work of reference for courses in philosophy, social and political thought, cultural studies, and African-American studies.

A review with commentary on Mark A. Bedau and Emily C. Parke (eds): The Ethics of Protocells: Moral and Social Implications of Creating Life in the Laboratory (Basic Bioethics series) MIT Press, Cambridge,MA, 2009, 365 pp, ISBN 978-0-262-01262-1, ISBN 978-0-262-51269-5.

A review with commentary on the book, Understanding Beliefs, Nils J. Nilsson, MIT Press, 2014.

Roboethics is the recent offshoot of computer ethics that pays special attention to the alterations that need to be made to computer ethics when we give the computer mobility and a means to interact directly in the human environment. The closely related field of machine morality explores how ethical systems and behaviors may be programmed into social robotics applications. As robots move from the factory floor into our homes and work lives, they stand to change key aspects of the way (...) our lives are lived. In order to be successful, these machines must be programmed with the ability to navigate the human life world without committing ethical faux pas or moral outrage. Thus, the roboethicist is tasked not only with critiquing the attempts of robots engineers to achieve the integration of these machines into our life world, but also, and more importantly, with suggesting means of achieving better results than what is presently on offer. (shrink)

A student of Étienne Gilson and Joseph Owens, John P. Doyle taught medieval and Scholastic philosophy at Saint Louis University for forty years. Of continuing interest to Doyle has been the thought of Francisco Suárez, S.J. On this topic Doyle has published over a dozen articles and four English translations of portions of Suárez's key works. This volume celebrates the life and career of one of those rare kinds of scholars who has mastered an entire field of inquiry and (...) thought. (shrink)

The modern philosophers and freedom -- Autonomy -- Equality and freedom -- Rights and freedom -- The contradiction of liberalism -- Liberalism and utilitarianism -- Liberalism and some logical considerations -- A classical understanding of freedom -- Recapitulations--modern -- The premodern alternative.

This chapter contains sections titled: The Gods Problem The Evolution of Free Will Is Our Starting Point So Gods Evolved Gods Are Hidden Inside Us The Godless Must Walk the Earth Gods Must Be Made Manifest Religion Mediates Between Free Will and Gods Living in Harmony With Our Actual Gods.

Numbers and other mathematical objects are exceptional in having no locations in space or time or relations of cause and effect. This makes it difficult to account for the possibility of the knowledge of such objects, leading many philosophers to embrace nominalism, the doctrine that there are no such objects, and to embark on ambitious projects for interpreting mathematics so as to preserve the subject while eliminating its objects. This book cuts through a host of technicalities that have obscured previous (...) discussions of these projects, and presents clear, concise accounts of a dozen strategies for nominalistic interpretation of mathematics, thus equipping the reader to evaluate each and to compare different ones. The authors also offer critical discussion, rare in the literature, of the aims and claims of nominalistic interpretation, suggesting that it is significant in a very different way from that usually assumed. (shrink)

Darwinism, Democracy, and Race examines the development and defence of an argument that arose at the boundary between anthropology and evolutionary biology in twentieth-century America. In its fully articulated form, this argument simultaneously discredited scientific racism and defended free human agency in Darwinian terms. The volume is timely because it gives readers a key to assessing contemporary debates about the biology of race. By working across disciplinary lines, the book's focal figures--the anthropologist Franz Boas, the cultural anthropologist Alfred Kroeber, the (...) geneticist Theodosius Dobzhansky, and the physical anthropologist Sherwood Washburn--found increasingly persuasive ways of cutting between genetic determinist and social constructionist views of race by grounding Boas's racially egalitarian, culturally relativistic, and democratically pluralistic ethic in a distinctive version of the genetic theory of natural selection. Collaborators in making and defending this argument included Ashley Montagu, Stephen Jay Gould, and Richard Lewontin. Darwinism, Democracy, and Race will appeal to advanced undergraduates, graduate students, and academics interested in subjects including Philosophy, Critical Race Theory, Sociology of Race, History of Biology and Anthropology, and Rhetoric of Science. (shrink)

In this paper Sullins argues that in certain circumstances robots can be seen as real moral agents. A distinction is made between persons and moral agents such that, it is not necessary for a robot to have personhood in order to be a moral agent. I detail three requirements for a robot to be seen as a moral agent. The first is achieved when the robot is significantly autonomous from any programmers or operators of the machine. The second is when (...) one can analyze or explain the robot's behavior only by ascribing to it some predisposition or 'intention' to do good or harm. And finally, robot moral agency requires the robot to behave in a way that shows and understanding of responsibility to some other moral agent. Robots with all of these criteria will have moral rights as well as responsibilities regardless of their status as persons. (shrink)

By utilizing new information from both clinical and experimental (lesion, electrophysiological, and gene-activation) studies with animals, the anatomy underlying anterograde amnesia has been reformulated. The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part of an comprising the hippocampus, the fornix, the mamillary bodies, and the anterior thalamic nuclei. This view, which can be traced back to Delay and Brion (1969), differs from other recent models in (...) placing critical importance on the efferents from the hippocampus via the fornix to the diencephalon. These are necessary for the encoding and, hence, the effective subsequent recall of episodic memory. An additional feature of this hippocampalanterior thalamic and the perirhinal–medial dorsal thalamic systems are compromised, leading to severe deficits in both recall and recognition. (shrink)

While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental (...) mathematics on the one hand and computerized formal proofs on the other hand. Along the way, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed. (shrink)

A review and commentary on Killing By Remote Control: the Ethics of an Unmanned Military, edited by Bradley Jay Strawser (forward by Jeff McMahan), (Oxford University Press). -/- .

The debate over whether brain death is death has focused on whether individuals who have sustained total brain failure have satisfied the biological definition of death as “the irreversible loss of the integration of the organism as a whole.” In this paper, I argue that what it means for an organism to be integrated “as a whole” is undefined and vague in the views of those who attempt to define death as the irreversible loss of the integration of the organism (...) as a whole. I show how what it means for a living thing to be integrated as a whole depends on the sortal concept by which it is identified. Since interests, values, and ontological considerations besides strictly biological ones affect the concepts by which we individuate and identify living things, those non-biological considerations have a bearing on what it means for a particular kind of living thing to exist as a whole and thus what it means for one of us to die. Even if our bodies may remain organically integrated in some sense despite total brain failure, this fact should not lead us to reject brain death as death. Artificially sustained brain-dead human bodies are not human beings, but the remains of them. While such bodies may be alive in some sense, they are not human beings or human persons. They are not one of us. (shrink)

Highlighting previously neglected democratic strains in Machiavelli's major writings, McCormick excavates institutions through which the common people of ancient, medieval, and Renaissance republics constrained the power of wealthy citizens and public magistrates, and he imagines how such institutions might be revived today.

This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in ...

The most important distinctively American contribution to philosophy is the pragmatist tradition. In this short, lucid, and completely convincing exposition, Professor John P. Murphy begins by exploring the roots of this tradition as found in the work of Peirce, James, and Dewey, demonstrating its power and originality. Historians of philosophy will appreciate the insight Murphy brings to these figures, but the special value of this book lies in his discussion of how the pragmatist spirit has flowered in contemporary philosophy (...) in the work of Quine, Rorty, and Davidson.Throughout, Murphy emphasizes the logic and structure of the views held by these six philosophers and what it is they have in common that makes their work especially “pragmatist.” There is no better introduction to this historical tradition and perhaps no better way into the philosophies of the contemporaries whom Murphy discusses.Interest in pragmatist ideas is undergoing a revival at present, and this book shows us why. It will be of interest to both historians of philosophy and students of contemporary philosophy. (shrink)

Introduction A brief look at the competing present-day interpretations of Hume's philosophy will leave the uninitiated reader completely baffled. On the one hand , Hume is seen as a philosopher who attempted to analyse concepts with ...

Philosophical Logic is a clear and concise critical survey of nonclassical logics of philosophical interest written by one of the world's leading authorities on the subject. After giving an overview of classical logic, John Burgess introduces five central branches of nonclassical logic, focusing on the sometimes problematic relationship between formal apparatus and intuitive motivation. Requiring minimal background and arranged to make the more technical material optional, the book offers a choice between an overview and in-depth study, and it balances (...) the philosophical and technical aspects of the subject.The book emphasizes the relationship between models and the traditional goal of logic, the evaluation of arguments, and critically examines apparatus and assumptions that often are taken for granted. Philosophical Logic provides an unusually thorough treatment of conditional logic, unifying probabilistic and model-theoretic approaches. It underscores the variety of approaches that have been taken to relevantistic and related logics, and it stresses the problem of connecting formal systems to the motivating ideas behind intuitionistic mathematics. Each chapter ends with a brief guide to further reading.Philosophical Logic addresses students new to logic, philosophers working in other areas, and specialists in logic, providing both a sophisticated introduction and a new synthesis. (shrink)

Critics of organ donation after circulatory death (DCD) argue that, even if donors are past the point of autoresuscitation, they have not satisfied the “irreversibility” requirement in the circulatory and respiratory criteria for determining death, since their circulation and respiration could be artificially restored. Thus, removing their vital organs violates the “dead-donor” rule. I defend DCD donation against this criticism. I argue that practical medical-ethical considerations, including respect for do-not-resuscitate orders, support interpreting “irreversibility” to mean permanent cessation of circulation and (...) respiration. Assuming a consciousness-related formulation of human death, I then argue that the loss of circulation and respiration is significant, because it leads to the permanent loss of consciousness and thus to the death of the human person. The DNR request by an organ donor should thus be interpreted to mean “do not restore to consciousness.” Finally, I respond to an objection that if “irreversibility” has a medical-ethical meaning, it would entail the absurd possibility that one of two individuals in the same physical state could be alive and the other dead—an implication that some think is inconsistent with understanding death as an objective biological state of the organism. I argue that advances in medical technology have created phenomena that challenge the assumption that human death can be understood in strictly biological terms. I argue that ethical and ontological considerations about our nature bear on the definition and determination of death and thus on the permissibility of DCD. (shrink)

(2013). Informed Consent, Big Data, and the Oxymoron of Research That Is Not Research. The American Journal of Bioethics: Vol. 13, No. 4, pp. 40-42. doi: 10.1080/15265161.2013.768864.

The great logician Gottlob Frege attempted to provide a purely logical foundation for mathematics. His system collapsed when Bertrand Russell discovered a contradiction in it. Thereafter, mathematicians and logicians, beginning with Russell himself, turned in other directions to look for a framework for modern abstract mathematics. Over the past couple of decades, however, logicians and philosophers have discovered that much more is salvageable from the rubble of Frege's system than had previously been assumed. A variety of repaired systems have been (...) proposed, each a consistent theory permitting the development of a significant portion of mathematics. This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in each. John Burgess considers every proposed fix, each with its distinctive philosophical advantages and drawbacks. These systems range from those barely able to reconstruct the rudiments of arithmetic to those that go well beyond the generally accepted axioms of set theory into the speculative realm of large cardinals. For the most part, Burgess finds that attempts to fix Frege do less than advertised to revive his system. This book will be the benchmark against which future analyses of the revival of Frege will be measured. (shrink)

The contents of this book were originally published in the September 1966 issue of Scientific American. A more appropriate-but perhaps less "catchy"—title would have been "Computers." The book is all about them and what they can—and cannot—do. Conspicuously missing is a chapter on the underlying mathematical theories of information, control, and computation. Nevertheless, there is a good deal of interesting material between the covers of this book. Of greatest concern to philosophers are the chapters on "Information" by John (...) class='Hi'>McCarthy, "Computer Logic and Memory" by David C. Evans, "The Uses of Computers in Science" by Anthony G. Oettinger, "The Uses of Computers in Education" by Patrick Suppes, and "Artificial Intelligence" by Marvin L. Minsky. The first of these consists of a brief history of computing machines, an outline of the general principles of digital computers, and an interesting discussion of some of the moral and social issues which such machines raise. Evans' article is a popular description of binary logics and logic devices. The present reviewer has used some of the material in this chapter as embellishments in an undergraduate course in logic. Oettinger's article describes the novel way in which computers may aid in the formation of scientific theories. The paper by Suppes ought to be required reading for members of the "Teaching machines undermine intellectual development" school of thought. Finally, a philosopher of mind might have a field day with some of the remarkable and outrageous notions in Minsky's article; what, for example, is the difference between "thinking" and "exhibiting intelligence"? In sum, this is a stimulating book about a technological development which, for good or ill, is going to affect all of us.—H. P. K. (shrink)