With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.

Division of labour is a marked feature of multicellular organisms. Margulis proposed that the ancestors of metazoans had only one microtubule organizing center (MTOC), so they could not move and divide simultaneously. Selection for simultaneous movement and cell division had driven the division of labour between cells. However, no evidence or explanation for this assumption was provided. Why could the unicellular ancetors not have multiple MTOCs? The gain and loss of three possible strategies are discussed. It was found that the (...) advantage of one or two MTOC per cell is environment-dependent. Unicellular organisms with only one MTOC per cell are favored only in resource-limited environments without strong predatory pressure. If division of labour occurring in a bicellular organism just makes simultaneous movement and cell division possible, the possibility of its fixation by natural selection is very low because a somatic cell performing the function of an MTOC is obviously wasting resources. Evolutionary biologists should search for other selective forces for division of labour in cells. (shrink)

To cope with the water deficit resulting from saline environment, plant cells accumulate three kinds of osmotica: salts, small organic solutes and hydrophillic, glycine-rich proteins. Salts such as NaCl are cheap and available but has ion toxicity in high concentrations. Small organic solutes are assistant osmotica, their main function is to protect cytoplasmic enzymes from ionic toxicity and maintain the integrity of cellular membranes. Hydrophillic, glycine-rich proteins are the most effective osmotica, they have some characteristics to avoid crystallization even in (...) high concentration, but because they are expensive they are not as commonly used as salts or organic solutes. In addition there is the question of whether the genetic information for growth in saline environment is present in all kinds of plants, both halophytes and nonhalophytes. (shrink)

From the viewpoint of an evolutionary biologist, carcinogenesis should be looked upon as a protective mechanism against destruction of DNA. Because genes expressed in embryonic cells are covered and protected by heterochromatinization, they are the most appropriate ‘alternate genes’ compared to genes that are expressed already in somatic cells. When DNA-damage occurs, the embryonic genes can be activated. Some somatic cells exhibit some features of embryonic cells.

This study adapts a Medical English Language Anxiety Scale based on Horwitz’s Foreign Language Classroom Anxiety Scale and examines students’ anxiety in medical English vocabulary, listening and speaking, communication, literature reading, and academic paper writing. The biographical factors related to medical English language anxiety were also tested. The questionnaire sets including five dimensions were distributed to the students from a medical university in Sichuan, China, and were statistically analyzed by using SPSS 22.0 and AMOS 21.0. By employing the adapted MELAS, (...) it was found that 85.2% of the medical students surveyed suffered moderate and higher anxiety. Among all dimensions, students with listening and speaking anxiety recorded the highest, followed by literature reading anxiety, English academic writing anxiety, communication anxiety, and vocabulary learning anxiety. We also found that the anxiety of rural medical students in each dimension was higher than that of urban medical students. This study suggests that English teachers should be fully aware of their students’ language anxiety situation, design interesting class activities, and create a relaxed English learning atmosphere in classroom teaching to make students less nervous when learning medical English in class. (shrink)

Replication protein A (RPA) is the main eukaryotic single‐stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving ssDNA. RPA binds ssDNA with high affinity, thereby preventing the formation of secondary structures and protecting ssDNA from the action of nucleases, and directly interacts with other DNA processing proteins. Here, we discuss recent results supporting the idea that one function of RPA is to prevent annealing between short repeats that can lead to chromosome rearrangements by microhomology‐mediated end (...) joining or the formation of hairpin structures that are substrates for structure‐selective nucleases. We suggest that replication fork catastrophe caused by depletion of RPA could result from cleavage of secondary structures by nucleases, and that failure to cleave hairpin structures formed at DNA ends could lead to gene amplification. These studies highlight the important role RPA plays in maintaining genome integrity. (shrink)

In recent years, while extensive researches on various networks properties have been proposed and accomplished, little has been proposed and done on network robustness and node vulnerability assessment under cascades in directed large-scale online community networks. In essential, an online directed social network is a group-centered and information spread-dominated online platform which is very different from the traditional undirected social network. Some further research studies have indicated that the online social network has high robustness to random removals of nodes but (...) fails to the intentional attacks, particularly to those attacks based on node betweenness or node directed coefficient. To explore on the robustness of directed social network, in this article, we have proposed two novel node centralities of ITG and I M p v. These two new centrality models are designed to capture this cascading effect in directed online social networks. Furthermore, we also propose a new and highly efficient computing method based on iterations for I M p v. Then, with the abundant experiments on the synthetic signed network and real-life networks derived from directed online social media and directed human mobile phone calling network, it has been proved that our ITG and I M p v based on directed social network robustness and node vulnerability assessment method is more accurate, efficient, and faster than several traditional centrality methods such as degree and betweenness. And we also have proposed the solid reasoning and proof process of iteration times k in computation of I M p v. To the best knowledge of us, our research has drawn some new light on the leading edge of robustness on the directed social network. (shrink)

B a c k g r o u n d. Deng Xiaoping is considered the main architect of socialist reforms and the founder of China's modernization theory. He mastered and developed the socialist system, trying to adjust it to the national conditions of China. Deng Xiaoping believed that it was by following the course of "socialism with Chinese characteristics" that China would transform from a poor country into a highly developed one. The article provides a theoretical reconstruction of (...) the main content of Deng Xiaoping's concept of "socialism with Chinese characteristics." The main philosophical and socio-political aspects of the concept of building socialism with Chinese characteristics are presented in a systematic form in the context of the foundations of Chineseization of Marxism. M e t h o d s. In the article, a historical-logical approach was used to reveal the specified research topic, which allowed us to determine the socio-political prerequisites for the emergence of Chineseized Marxism. An interdisciplinary approach made it possible to carry out a theoretical analysis of social, economic, and political changes in modern China, which were caused by the proposed theory of Deng Xiaoping's "socialism with Chinese characteristics". Systemic, structural-functional, and constructivist methods, as well as methods of synthesis and generalization, were also applied. R e s u l t s. Because of the above, the purpose of this study was to carry out a theoretical reconstruction of Deng Xiaoping's theory of building "socialism with Chinese characteristics" and to find out how his ideas influenced the development of modern China after the completion of the "Great Leap Forward" and the "Cultural Revolution" of Mao Zedong. The key features of Deng Xiaoping's proposed theory of "socialism with Chinese characteristics" were established, including the idea of democratization of society and implementation of the legal basis of state functioning; the beginning of a new period of "reforms and openness"; determining the course for socialist modernization; following Marxism-Leninism and the ideas of Mao Zedong. C o n c l u s i o n s. In conclusion, it can be noted that the main feature of Deng Xiaoping's ideas was that they were inextricably linked with the national and cultural traditions of Chinese civilization, starting from Confucianism and the gradual synthesis with Marxist ideology. Evaluating the theory of Deng Xiaoping, it can be defined as a relatively complete scientific system that covers the fields of philosophy, political economy, and scientific socialism, it contains the doctrine of socialist ideology, and the doctrine of the essence and ways of socialist development, theories of the reform of socialist political and economic systems, the theory of building a socialist country. (shrink)

This essay reviews the philosophical roots and the development of the concept of creativity in the West and East. In particular, two conceptions of creativity that originated in the West--divinely inspired creativity and individual creativity--are discussed and compared to the two Eastern conceptions of creativity that are rooted in ancient Chinese philosophical thought--natural and individual creativity. Both Western and Eastern conceptions of individual creativity come from a theistic or cosmic tradition of either divinely inspired or natural creativity. However, a defining (...) feature of the Western concept of creativity--novelty--is not necessarily embraced by ancient Chinese concepts of creativity, but does exist in both modern Eastern conceptions. Reasons for cultural differences are explored and discussed. 2012 APA, all rights reserved). (shrink)

本书把最新反映邓小平哲学思想特色的论述分为:解放思想,实事求是,照辩证法办事,改革是解放和发展生产力的必由之路,面向世界,吸收人类文明成果等10部分加以编辑。.

本书内容包括:走向“现代”:西方现代美学的历史起点和内在转捩、现代主义美学:非理性主体的表现和丑发展、现代主义美学:艺术的自足独立性和艺术走向抽象、主体性的衰落与美学形态的转变、后现代主义美学与后现代 性话语。.

本书把最新反映邓小平哲学思想特色的论述分为:解放思想,实事求是,照辩证法办事,改革是解放和发展生产力的必由之路,面向世界,吸收人类文明成果等10部分加以编辑。.

In order to establish his "school of principle" system of thought, which was founded on objective idealism, Zhu Xi proposed a theory of "investigating things and exhausting principles" [gewu qiongli]. This became the epistemological foundation for his system of thought. This epistemology formed an organic whole with his world view. On the one hand, his "theory-of-investigating-things" epistemology opened up pathways for his system of objective idealism; on the other hand, his "school-of-principle" system formed the theoretical foundation for his epistemology of (...) "investigating things" and gave this epistemology its obviously metaphysical characteristics. (shrink)

This is an invited commentary on "Physical Time within Human Time" (Gruber, Block, & Montemayor, 2022) and "Bridging the Neuroscience and Physics of Time" (Buonomano & Rovelli, 2021). I’m very sympathetic to aspects of each proposal. In this article, I offer some comments, starting with (Buonomano & Rovelli, 2021).

This essay argues that individual-oriented informed consent is inadequate to protect human research subjects in mainland China. The practice of family-oriented decision-making is better suited to guide moral research conduct. The family’s role in medical decision-making originates from the mutual benevolence that exists among family members, and is in accordance with family harmony, which is the aim of Confucian society. I argue that the practice of informed consent for medical research on human subjects ought to remain family-oriented in mainland China. (...) This essay explores the main features of this model of informed consent and demonstrates the proper authority of the family. The family’s participation in decision-making as a whole does not negate or deny the importance of the individual who is the subject of the choice, but rather acts more fully to protect research subjects. (shrink)

本书阐释了“命”论在王充的哲学体系中所起的作用,王充“气”论新议,王充“天地”论新议等内容。.

I offer an interpretation and a partial defense of Kit Fine's ‘Argument from Passage’, which is situated within his reconstruction of McTaggart's paradox. Fine argues that existing A-theoretic approaches to passage are no more dynamic, i.e. capture passage no better, than the B-theory. I argue that this comparative claim is correct. Our intuitive picture of passage, which inclines us towards A-theories, suggests more than coherent A-theories can deliver. In Finean terms, the picture requires not only Realism about tensed facts, but (...) also Neutrality, i.e. the tensed facts not being ‘oriented towards’ one privileged time. However unlike Fine, and unlike others who advance McTaggartian arguments, I take McTaggart's paradox to indicate neither the need for a more dynamic theory of passage nor that time does not pass. A more dynamic theory is not to be had: Fine's ‘non-standard realism’ amounts to no more than a conceptual gesture. But instead of concluding that time does not pass, we should conclude that theories of passage cannot deliver the dynamicity of our intuitive picture. For this reason, a B-theoretic account of passage that simply identifies passage with the succession of times is a serious contender. (shrink)

Elsewhere I have suggested that the B-theory includes a notion of passage, by virtue of including succession. Here, I provide further support for that claim by showing that uncontroversial elements of the B-theory straightforwardly ground a veridical sense of passage. First, I argue that the B-theory predicts that subjects of experience have a sense of passivity with respect to time that they do not have with respect to space, which they are right to have, even according to the B-theory. I (...) then ask what else might be involved in our experience of time as passing that is not yet vindicated by the B-theoretic conception. I examine a recent B-theoretic explanation of our ‘illusory’ sense of passage, by Robin Le Poidevin, and argue that it explains away too much: our perception of succession poses no more of a problem on the B-theory than it does on other theories of time. Finally, I respond to an objection by Oreste Fiocco that a causal account of our sense of passage cannot succeed, because it leaves out the ‘phenomenological novelty’ of each moment. (shrink)

İnsanlardaki nefsin yatkınlık seviyesi ve mizacın denge oranı eşit düzeyde olmadığından onların Ayüstü âlemden ulaşan haber içerikli mesajları kabullerinde farklılıklar ortaya çıkar. Akıl yetisi yetkin, sezgisi kuvvetli, taklit kabiliyeti yüksek olan insanların diğerlerine kıyasla Ayüstü âlemden feyz edileni kabulü güçlüdür. Makalede metafizik tözlerden iletileni kabul eden ve bilinmeyen olaylara ilişkin haber veren insanlar hakkındaki bilgi üç aşamalı olarak verilmiştir: (a) Platon’un şâir, kâhin, âşık arasında yaptığı ayrımın Aristoteles ve Plutarkhos felsefesindeki yeri. (b) İslam öncesi dönemde şâir ile kâhinlerin konumu ve (...) müşrikler tarafından Hz. Muhammed’e hem şâirlik hem de kâhinlik atfedilmesi, Hz. Muhammed’in ayetlerde nebî olarak tanımlanması. (c) Fârâbî’yle İbn Sînâ’nın şâir, kâhin, âşık ve nebîye yükledikleri anlam. Bu çerçevede ‘Hem Fârâbî hem de İbn Sînâ’nın şâir-kâhin hakkındaki fikirlerinin felsefî temelleri ve nebî kavramıyla ilgili görüşlerinin dinî dayanağı nedir’ sorularına cevap aranmaya çalışılmıştır. Bu sorulara yanıt bulmaya gayret gösterilirken nübüvvetin şiir ve kehânetten üstünlüğü göz önünde bulundurularak nebînin şâir, kâhin ve âşıktan farklı olduğunu belirleme hedeflenmiştir. (shrink)

本书包括:法律与立法的二元观、普通法法治国的建构、普通法法治国的建构过程等内容。.

Does time seem to pass, even though it doesn’t, really? Many philosophers think the answer is ‘Yes’—at least when ‘time’s passing’ is understood in a particular way. They take time’s passing to be a process by which each time in turn acquires a special status, such as the status of being the only time that exists, or being the only time that is present. This chapter suggests that, on the contrary, all we perceive is temporal succession, one thing after another, (...) a notion to which modern physics is not inhospitable. The contents of perception are best described in terms of ‘before’ and ‘after’, rather than ‘past’, ‘present, and ‘future’. (shrink)

Usually, the B-theory of time is taken to involve the claim that time does not, in reality, pass; after all, on the B-theory, nothing really becomes present and then more and more past, times do not come into existence successively, and which facts obtain does not change. For this reason, many B-theorists have recently tried to explain away one or more aspect(s) of experience that they and their opponents take to constitute an experience of time as passing. In this paper, (...) I examine three prominent proposals of this kind and argue that, though intriguing, the proposals undermine, to some extent, the assumption that there is an element of experience that B-theorists need to take to be illusory. (shrink)

Abstract Along with China’s stunning economic growth, marketing has become a multi-billion dollar business, afflicted by a plethora of marketing scandals. However, little attention has been paid, until now, to a more systematic approach to marketing ethics in China. This essay attempts to provide a broad and timely, but far from complete, view on marketing issues in China. It uses four ethical guidelines which capture the fundamental features particularly relevant to marketing activities: practicing honest communication; enhancing human capabilities; fostering creative (...) intercultural diversity; and promoting sustainable growth and eco-efficiency. These guidelines are then elucidated with 12 positive and negative cases of Chinese and non-Chinese companies. By combining guidelines with case studies, it is hoped that ethical challenges for marketing in China will be discerned in a more systematic and comprehensible fashion. The article concludes by indicating several perspectives for further research. Content Type Journal Article Category Original Paper Pages 1-20 DOI 10.1007/s13520-011-0014-0 Authors Georges Enderle, Mendoza College of Business, University of Notre Dame, Notre Dame, IN, USA Qibin Niu, School of Business Administration, China University of Petroleum, Changping, Beijing, People’s Republic of China Journal Asian Journal of Business Ethics Online ISSN 2210-6731 Print ISSN 2210-6723. (shrink)

A successful student has been defined as one who not only performs well in academics but is also happy. Hence, how to promote adolescents’ academic success and wellbeing is an important issue with which researchers have been concerned. A few studies have explored the relationship of filial piety to the academic achievement or life satisfaction of Chinese adolescents. However, in view of the close relationship between the two outcomes, the unique effects of filial piety on academic achievement and subjective wellbeing (...) and their underlying mechanisms need to be further clarified. Based on a sample of 677 students in Grade 6 (Mage = 12.24, SD = 0.36) and their parents in Beijing, China, this study examines how adolescents’ reciprocal filial piety (RFP) and authoritarian filial piety (AFP) are related to their academic achievement and subjective wellbeing. It also examines the mediating role of adolescents’ educational expectations in these relationships, and the moderating role of parents’ educational expectations in the relationships of adolescents’ filial piety to educational expectations and of adolescents’ educational expectations to academic achievement and subjective wellbeing. The results indicate that, when the two outcome factors are considered simultaneously, RFP is positively related to academic achievement and subjective wellbeing. In contrast, AFP is negatively related to academic achievement but not significantly related to subjective wellbeing. Moreover, adolescents’ educational expectations play a mediating role in the relationships of both RFP and AFP to academic achievement and subjective wellbeing. In addition, the positive effect of adolescents’ educational expectations on subjective wellbeing is stronger when mothers’ educational expectations are higher, supporting the moderating role of parents’ educational expectations. Our findings provide new insights into and implications for the moderated mediation mechanism underlying the links between filial piety and early adolescent development. (shrink)

In this paper, I try to make sense of the growing block view using Kit Fine’s three-fold classification of A-theoretic views of time. I begin by motivating the endeavor of making sense of the growing block view by examining John Earman’s project in ‘Reassessing the prospects for a growing block model of the universe’. Next, I review Fine’s reconstruction of McTaggart’s argument and its accompanying three-fold classification of A-theoretic views. I then consider three interpretations of Earman’s growing block model: the (...) hybrid growing block, the purely tensed growing block, and Michael Tooley’s growing block. I argue for three claims. First, Finean ‘standard’ versions of these views are less congenial to the growing blocker than ‘non-standard’ ones. Second, the hybrid view is problematic on either version. And third, ‘non-standard’ versions are not fully intelligible. I provide further support for the first and third of these claims and explain why I take them to support a minimal account of passage as succession, which undercuts some of the motivation for Earman’s project. Lastly, I answer three objections. (shrink)

Using a sample of 32 work teams (32 work team leaders and their 321 followers) in Chinese cultural context, this study investigated the relationships between leaders’ and their followers’ psychological capital and the multilevel multiple mediation effects of social exchange and emotional contagion. Structural equation model and hierarchical linear model were applied to analyze the survey data. The results revealed that leaders’ psychological capital had a positive influence on their followers’ psychological capital. Leader-member exchange was the cross-level mediator between leaders’ (...) psychological capital and their followers’. The cross-level mediating effect of leaders’ positive emotions perceived by followers was not significant. The results of this study extended the social exchange theory and enriched researches on leadership. The implication was discussed in details. (shrink)

Temporal ontology is the part of ontology involving the rival positions of presentism, eternalism, and the growing block theory. While this much is clear, it’s surprisingly difficult to elucidate the substance of the disagreement between presentists and eternalists. Certain events happened that are not happening now; what is it to disagree about whether these events exist? In spite of widespread suspicion concerning the status and methods of analytic metaphysics, skeptics’ doubts about this debate have not generally been heeded, neither by (...) metaphysicians, nor by philosophers of physics. This paper revisits the question in the light of prominent elucidation attempts from both camps. The upshot is that skeptics were right to be puzzled. The paper then explores a possible re-interpretation of positions in temporal ontology that links it to normative views about how we should live as temporal beings. (shrink)

This paper presents a new cosmological argument based on considerations about grounding. I argue that, by assuming three plausible principles about grounding, we can construct a cosmological argument for the existence of a unique ungrounded being that ultimately grounds everything else. At the end of the paper I consider two possible objections, and offer my replies to them.

The COVID-19 pandemic has forced higher education institutions to shift their teaching activities from traditional face-to-face to online learning. This brings a great challenge to the creativity training of vocational college students, who not only learn theoretical knowledge but also cultivate technical skills. Therefore, it is very important to explore the influencing factors of online learning on students’ creativity during the epidemic. By relying on the related literature review, an extensive model is developed by integrating the expectation confirmation model, technology (...) task fit model, and the technology acceptance model to illustrate key factors that influence creativity. Based on the proposed model, theory-based hypotheses are tested through structural equation modeling employing empirical data gathered through a survey questionnaire of 229 students from different vocational colleges in China. In addition, to extend the analysis results, this paper performs a comparative analysis based on gender. The findings demonstrate that perceived ease of use and perceived usefulness significantly influence knowledge sharing; knowledge sharing significantly affects creativity. However, there is no substantial relationship between perceived usefulness and attitude, and no relationship between attitude and knowledge sharing. Moreover, a multi-group comparison shows that there is a significant gender difference between perceived ease of use and attitude. Based on the findings, theoretical and practical implications are discussed. (shrink)

The level of psychological pain in patients with COVID-19 was investigated in this study by hypothesis testing, one-way ANOVA, multi factor ANOVA, and correlation analysis. The psychological pain thermometer and post-traumatic growth assessment scale were used as research tools. Many factors appear to influence the psychological state of COVID-19 patients including practical problems, communication problems, emotional problems, physical problems, and psychiatric/relative concerns. The severity of the disease, the surrounding environment, family health problems, life perceptions, interpersonal relationships, personal strength, mental changes, (...) new possibilities, and the total post-traumatic growth score are also affected. There is a significant negative correlation between psychological pain and post-traumatic growth. There are significant differences in the degree of psychological pain across the demographic data. Practical problems, communication problems, emotional problems, physical problems, and spiritual/religious concerns show significant effects on the degree of psychological pain. (shrink)

In his recent book ‘Experiencing time’, Simon Prosser discusses a wide variety of topics relating to temporal experience, in a way that is accessible both to those steeped in the philosophy of mind, and to those more familiar with the philosophy of time. He forcefully argues for the conclusion that the B-theorist of time can account for the temporal appearances. In this article, I offer a chapter by chapter response.

Some naturalists feel an affinity with some religions, or with a particular religion. They may have previously belonged to it, and/or been raised in it, and/or be close to people who belong to it, and/or simply feel attracted to its practices, texts and traditions. This raises the question of whether and to what extent a naturalist can lead the life of a religious believer. The sparse literature on this topic focuses on religious fictionalism. I also frame the debate in these (...) terms. I ask what religious fictionalism might amount to, reject some possible versions of it and endorse a different one. I then examine the existing proposals, by Robin Le Poidevin, Peter Lipton, Andrew Eshleman and Howard Wettstein, and show that even on my version of religious fictionalism, much of what has been described by these authors is still possible. (shrink)