Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Presentation of self (via Goffman) is becoming increasingly popular as a means for explaining differences in meaning and activity of online participation. This article argues that self-presentation can be split into performances, which take place in synchronous “situations,” and artifacts, which take place in asynchronous “exhibitions.” Goffman’s dramaturgical approach (including the notions of front and back stage) focuses on situations. Social media, on the other hand, frequently employs exhibitions, such as lists of status updates and sets of photos, alongside situational (...) activities, such as chatting. A key difference in exhibitions is the virtual “curator” that manages and redistributes this digital content. This article introduces the exhibitional approach and the curator and suggests ways in which this approach can extend present work concerning online presentation of self. It introduces a theory of “lowest common denominator” culture employing the exhibitional approach. (shrink)

In recent times there have been increasing efforts at reinterpreting core CSR theories such as stakeholder theory with new perspectives as well as applying them to different contexts away from its Western masculinist connotations. This work seeks to add to these efforts by exploring the impacts that the African philosophical worldview of Afro-communitarianism has on small business stakeholder relationships. Specifically it discusses the kinds of relationships that owner/managers of small businesses, in adherence to Afro-communitarianism, maintain with their families, employees, local (...) communities and competitors- all key stakeholders. The contention is that such ethics demand more extensive ethical responsibilities from owner/managers of small businesses than owner/managers motivated by traditional stakeholder theory with its Western masculinist undertones. It is hoped that this effort will add significant perspectives to stakeholder theory as well as having implications for both small and large business practice. (shrink)

Research on moral distress has paid limited attention to nurses’ responses and actions. In a survey of nurses’ perceptions of moral distress and ethical climate, 292 nurses answered three open-ended questions about situations that they considered morally distressing. Participants identified a range of situations as morally distressing, including witnessing unnecessary suffering, being forced to provide care that compromised values, and negative judgments about patients. They linked these situations to contextual constraints such as workload and described responses, including feeling incompetent and (...) distancing themselves from patients. Participants described considerable effort to effect change, calling into question the utility of defining moral distress as an “inability to act due to institutional constraints” or a “failure to pursue a right course of action.” Various understandings of moral distress operated, and action was integral to their responses. The findings suggest further conceptual work on moral distress and effort to support system-level change. (shrink)

This paper constructs a theory according to which an intention is not a mental state but an action at a certain developmental stage. I model intention on organic life, and thus intention stands to action as tadpole stands to frog. I then argue for this theory by showing how it overcomes three problems: intending while merely preparing, not taking any steps, and the action is impossible. The problems vanish when we see that not all actions are mature. Just as some (...) frogs are immature frogs, some actions are immature actions. (shrink)

Personhood arguments for the moral permissibility of abortion -- Personhood arguments for the moral wrongness of abortion -- What if we cannot determine the concept of personhood? -- Women's rights and abortion -- The ethics of killing and abortion -- A virtue ethics approach to abortion -- Feminism and abortion -- Prenatal screening and human genetic ethical issues -- Law and abortion in the United States.

This article explores the 'second chance' myth that surrounds the role of adult education in society. This myth apparently offers all citizens an equal chance to access educational opportunities to improve their life chances. I argue that recent developments in educational policy-making are increasingly shaped by neoliberal discourses that adapt adult education principles, such as lifelong learning and emancipation, for its own economic and political logic. This has important implications for adult education, especially equality of opportunity and social inclusion.

This article explores the 'second chance' myth that surrounds the role of adult education in society. This myth apparently offers all citizens an equal chance to access educational opportunities to improve their life chances. I argue that recent developments in educational policy-making are increasingly shaped by neoliberal discourses that adapt adult education principles, such as lifelong learning and emancipation, for its own economic and political logic. This has important implications for adult education, especially equality of opportunity and social inclusion.

This paper describes how bilingual colleagues living in Hong Kong make small talk in instant messaging to achieve various business-oriented goals and construct multiple identities in the discursive process. Guided by James Paul Gee’s revised framework of discourse analysis, the analyses evidenced that, overall, colleagues use small talk in instant messages to maintain minimal ties with distant partners, fill in silence during computer work, affect informal decision-making at work, and to diffuse useful surrounding information into business talk. These instances interplay (...) with different affordances provided by the gadgets in the instant messenger interfaces. Such creative usage, together with the perceived nature of online interaction and instant messaging, results in multiple and turbulent identities circulating in the broader context of workplace discourse. The article concludes by arguing that computer-mediated communication has offered participants an emerging modus of interacting socially, beyond the physical and psychological constraints of time and space. (shrink)

It is acknowledged that parental engagement with children’s learning and education is of vital importance. But, there is a tendency to confuse engagement with learning with engagement with the school. While all types of parents’ involvement can have a positive effect, it is actually what parents do with their child at home that has the greatest impact. However, unless parental involvement in learning is embedded in whole-school processes it is unlikely to as effective as possible. This paper documents an action (...) research study that explores the inclusion of parents and home values in the construction of the teaching and learning environment. This was a small step towards positive parent-teacher collaboration, which allowed an exchange of knowledge, values and cultural background experiences. In acknowledging the ways in which the parents already engaged with their children’s learning, it began to enhance self-efficacy in their ability to directly affect this learning. This work has also provoked reflexive engagement of my influence and understanding of involving parents of children with additional and diverse learning needs. But, it also details the transformative journey that influenced my thinking about how we as a school could begin to develop whole-school processes to directly involve parents in policy development and school activities. (shrink)

The return of a classic book about games and play that illuminates the relationship between the well-played game and the well-lived life. In The Well-Played Game, games guru Bernard De Koven explores the interaction of play and games, offering players—as well as game designers, educators, and scholars—a guide to how games work. De Koven's classic treatise on how human beings play together, first published in 1978, investigates many issues newly resonant in the era of video and computer games, including social (...) gameplay and player modification. The digital game industry, now moving beyond its emphasis on graphic techniques to focus on player interaction, has much to learn from The Well-Played Game. De Koven explains that when players congratulate each other on a “well-played” game, they are expressing a unique and profound synthesis that combines the concepts of play (with its associations of playfulness and fun) and game (with its associations of rule-following). This, he tells us, yields a larger concept: the experience and expression of excellence. De Koven—affectionately and appreciatively hailed by Eric Zimmerman as “our shaman of play”—explores the experience of a well-played game, how we share it, and how we can experience it again; issues of cheating, fairness, keeping score, changing old games (why not change the rules in pursuit of new ways to play?), and making up new games; playing for keeps; and winning. His book belongs on the bookshelves of players who want to find a game in which they can play well, who are looking for others with whom they can play well, and who have discovered the relationship between the well-played game and the well-lived life. (shrink)

Examines indirect learning, suggestion, trance, psychodrama, relaxation, autogenics, bio-feedback, visualization, intuition, mind-control and meditation as approaches and techniques which can contribute to teaching and learning.

What is the meaning of Shiva dancing on a dwarf named Avidya? Why does Vishnu sleep upon an endless snake? To what did the Buddha awaken? What do we mean by soul? The practice of Yoga has become quite common and popular in the West; however, the stories of Yoga are still strange to Western ears. What do these ancient symbols mean, what are they trying to teach us, and how should we incorporate the knowledge skillfully into our Western lifestyle? (...) By looking at the myths of Yoga along with the stories that have influenced Western culture, we are presented with opportunities to select the best of both worlds, and create new maps to help guide us through the uncertainties of modern living. Stories are fun! Important stories guide us and educate us; they create mental models which work at an unconscious level to help us navigate through our modern society and govern our reactions to the ups-and-downs of life; they provide meaning and purpose for our life; and our stories entertain and entrance us. In this book, Bernie Clark looks at the spiritual stories found in the West that create a base map for our lives and then looks at the stories found in the East to see how they could improve our base maps. The stories offered are mix of light-hearted and enjoyable, and deep and profound. The importance of stories East and West are illustrated through the model proposed by the great 20th century mythologist, Joseph Campbell: myths, or stories, serve four great functions - the mystical, the cosmological, the sociological and the psychological function. The stories chosen illustrate these four functions of mythology and show how we can take these stories into ourselves to create a deeper experience of life. "You may find that, with a proper introduction, mythology will catch you." Joseph Campbell: The Power of Myth. (shrink)

Compares the myths of yoga to stories that have influenced Western culture and explores how these spiritual stories can work at an unconscious level to provide road maps for navigating through modern life.

In this paper, the historical alignment of nursing with divinity‐based perspectives and modern New Age nursing theories are explored. The nature of divinity in nursing is examined, together with the complexities and issues that arise in adopting a spiritual basis for care. The work of the key theorists in this area (Rogers, Newman, Parse, Watson, Dossey) is reconsidered and fundamental epistemological problems inherent in this approach reviewed. Specific concerns with the interpretation of holistic care, adoption of doxastic logic, faith‐based rationales, (...) influence of Caucasian Judeo‐Christian and New Age values, misappropriation of science, use of pseudoscience and development of divinity as social consumer product are discussed. Practical problems with using a spiritual basis in contemporary nursing practice are also explored and the alignment of divinity‐based nursing theories with the modern antiscience movement is examined. Overall, the re‐emergence of divinity‐based nursing and spiritual basis for care may be problematic, and would seem to counter the development of an inclusive profession. Additionally, the alignment of nursing with antiscience movements rejecting biomedicine has significant public health implications. This is argued as a regressive step for the advancement of the profession. (shrink)

In the 21st century, educators seem to have more capacity for thinking pluralistically about teaching than they did a few decades ago. It is now commonplace to talk about multiple intelligences, a variety of teaching and learning styles, different acceptable outcomes of education. If we take the lead from archetypal psychology, the Greek pantheon can provide us with language for talking about a wide range of distinct philosophies, value systems, energies, feeling states, habits of behavior and teaching styles as they (...) can be observed in the classroom. The gods are many, and if we follow the advice of the ancient Greeks we will be careful not to neglect any of them—and not get too carried away in worshiping any single one of them. (shrink)

This chapter contains sections titled: Archetype Great Zeus Glorious Hera Mother Demeter Bright‐eyed Athene Shining Apollo Artemis the Huntress Golden‐haired Aphrodite Winged Eros Ares theWarrior Crippled Hephaistos Aunty Hestia Dancing Dionysos Prometheus the Saviour Hermes the Salesman Conclusion References.

"Make your own Bible. Select and collect all the words and sentences that in all your readings have been to you like the blast of a trumpet." -Ralph Waldo Emerson We have all come across a sentence in a book or a line of poetry that seems to jump off the page as if it has been patiently waiting for you to discover it in this precise instant. At times, the lyrics of a song or words spoken in a play (...) can feel as if God is speaking directly to you, guiding you on your quest for truth and authenticity in this weird and wonderful life. (shrink)

RÉSUMÉDes travaux récents par Joseph Raz, Niko Kolodny et Sergio Tenenbaum suggèrent qu'il n'existe aucune contrainte normative propre aux intentions. De telles contraintes seraient un mythe. Selon eux, il est possible d'articuler la rationalité des intentions sans postuler que l'intention est un état mental. Je soutiens que nous pouvons aussi comprendre la nature descriptive des intentions sans postuler que l'intention est un état mental. Tout comme l'idée selon laquelle il y aurait des contraintes normatives propres aux intentions, ce postulat est (...) aussi un mythe. L'intention est plutôt une action accompagnée de certaines sous-actions caractéristiques et jouant un rôle de coordination. (shrink)

What is the difference between an intended consequence and a foreseen unavoidable consequence? The answer, I argue, turns on the exercise of knowhow knowledge in the process that led to the consequence. I argue for this using a theory according to which acting intentionally is acting as a reason. I show how this gives us a more promising explanation of the difference than the dominant explanations, according to which acting intentionally is acting for a reason.

Natural Law, Science, and the Social Construction of Reality looks at changes in knowledge and the relationship to values from the modern era to today. Author Bernie Koenig examines Newton's influence on Locke and Kant, how Kant influenced Darwin and Freud, and the implications of their work for both anthropology and moral theory.

Russellian physicalism has the promise of answering all the typical challenges that non-physicalists have issued against standard versions of physicalism, while not giving up physicalism's commitment to the non-existence of fundamental mentality. However, it has been argued that Russellian physicalism must endorse the existence of physically unacceptable protomental properties in order to address these challenges, which would mean giving up on a core physicalist tenet of keeping the fundamental realm untainted by a special relationship to mentality. Against this, I argue (...) that a plausible version of Russellian physicalism can be constructed, which does not posit fundamental properties that are at all protomental in any problematic sense, yet which can explain the existence of subjective experience. This non-protomental Russellian physicalism, which is the only properly-physical version of Russellian physicalism, offers a satisfying solution to the mind-body problem -- including an answer to the conceivability argument -- without sacrificing any of its physicalist credentials. (shrink)

This book addresses the processes behind how we resolve moral issues and the factors that can impact that such as differing values and cultures.

Classical logic, beginning with the work of Aristotle, has developed into a powerful and rigorous mathematical theory with many applications in mathematics and ...

of (from British Columbia Philosophy Graduate Conference) This paper attempts to argue for an interpretation of Peter Strawson�s account of moral responsibility that successfully eliminates the threat of determinism. The goal is to capture the spirit of Strawson�s view and elucidate that spirit. I do this by emphasizing an aspect of Strawson�s account that others, like Paul Russell, may find insignificant, and then I demonstrate how this aspect is meant to quash the threat of determinism. Specifically, I claim that Strawson (...) wishes us to recognize that certain interpersonal relationships are explanatorily prior to the capacities necessary for morally responsible agency, and this explanatory relationship implies that (at least in our world) the capacities necessary for morally responsible agency could not include freedom from determinism. (shrink)

In their review, Ruba and Repacholi summarize the methods used to assess preverbal infants’ understanding of emotions, and analyze the existing evidence in light of classical and constructionist ac...

This talk was given Monday 13 May 2002 at Monash University in Melbourne, Australia, and previously to summer visitors at the IBM Watson Research Center in 2001. There are no section titles; the displayed material is what I wrote on the whiteboard as I spoke.

This article brings together research from the fields of chronic pain management and somatic practices to develop a novel framework of principles to support people living with persistent pain. These include movement-based approaches to awareness of the internal body (interoception), the external environment (exteroception) and movement in space (proprioception). These significantly work with the lived subjective experiences of people living with pain, to become aware of body signals and self-management of symptoms, explore fear and pleasure of movement, and understand how (...) social environments impact on pain. This analysis has potential to create new ways of supporting, understanding and articulating pain experiences, as well as shaping the future of somatic practices for chronic pain. (shrink)