In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, macroscopic (...) and microscopic entities inhabit different “worlds”: the former is ruled by gravity and inertia, whereas the latter is governed by Brownian motion. One implication is that we should be extremely skeptical of models and analogies that seek to explain properties of microscopic entities by appealing to properties of macroscopic ones. Unfortunately, this is precisely what the appeal to engineering metaphors in molecular biology attempts to do. Molecular biologists routinely resort to such metaphors because they are familiar and intuitively intelligible. But if our machines were the size of molecules it would be impossible for them to function the way they do. It follows that we should avoid distorting biological reality by construing it in engineering terms. In this chapter I examine four key metaphors in molecular biology – “genetic program,” “cellular circuitry,” “molecular machine,” and “molecular motor” – and I argue that their deficiencies derive from their neglect of scale. I also try to explain why many biologists today appear to have forgotten the importance of scale that Haldane drew attention to in his essay. I suggest that the reason has to do with the influence of Schrödinger’s argument in 'What is Life?' regarding the stability of the gene. (shrink)

The question of whether chimpanzees, like humans, reason about unobservable mental states remains highly controversial. On one account, chimpanzees are seen as possessing a psychological system for social cognition that represents and reasons about behaviors alone. A competing account allows that the chimpanzee's social cognition system additionally construes the behaviors it represents in terms of mental states. Because the range of behaviors that each of the two systems can generate is not currently known, and because the latter system depends (...) upon the former, determining the presence of this latter system in chimpanzees is a far more difficult task than has been assumed. We call for recognition of this problem, and a shift from experimental paradigms that cannot resolve this question, to ones that might allow researchers to intelligently determine when it is necessary to postulate the presence of a system which reasons about both behavior and mental states. (shrink)

The machine conception of the organism (MCO) is one of the most pervasive notions in modern biology. However, it has not yet received much attention by philosophers of biology. The MCO has its origins in Cartesian natural philosophy, and it is based on the metaphorical redescription of the organism as a machine. In this paper I argue that although organisms and machines resemble each other in some basic respects, they are actually very different kinds of systems. I submit that the (...) most significant difference between organisms and machines is that the former are intrinsically purposive whereas the latter are extrinsically purposive. Using this distinction as a starting point, I discuss a wide range of dissimilarities between organisms and machines that collectively lay bare the inadequacy of the MCO as a general theory of living systems. To account for the MCO’s prevalence in biology, I distinguish between its theoretical, heuristic, and rhetorical functions. I explain why the MCO is valuable when it is employed heuristically but not theoretically, and finally I illustrate the serious problems that arise from the rhetorical appeal to the MCO. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Christian Naturalism: Christian Thinking for Living in This World Only by Karl E. PetersDaniel J. OttChristian Naturalism: Christian Thinking for Living in This World Only. Karl E. Peters. Boston: Wipf & Stock, 2022. xvi + 152 pp. $25.00 paperback; $22.00 eBook; $40.00 hardcover.The number of scholars who would call themselves Christian naturalists and the number of books that think through what it means to be both Christian and (...) naturalist are quite small. Karl E. Peters has been an outstanding figure in this small group for many years. He is a leader in the science and religion dialogue in the United States and has been thinking theologically for a long time about what it means to be a Christian in an age of science. For these reasons, I was eager to read Peters’s Christian Naturalism as it promised to be a concise and systematic summary of his thinking about Christian Naturalist theology. What I found was a book that may have its uses but is not always successful in both its approach and its argumentation.Peters states in the Introduction that the book is “intentionally written for a general audience” (xi), and he maintains an accessible style and vocabulary throughout. Often, the book has an autobiographical quality as Peters weaves in reflection on his own educational journey in both science and theology. Chapters 1 and 3 helpfully lay out a brief comparison of ancient cosmologies and a contemporary scientific cosmology. Chapter 3 is a good example of some of the interesting heuristics that Peters uses throughout as he tells the story of the beginnings of the universe and the emergence of life on Earth in a first-person narrative. The rest of the book proceeds in brief and accessible treatments of categories one would typically find in theology primers: God, Jesus, evil and sin, salvation, ethics, and after death. The remainder of this review will take up two of these categories: 1) evil, sin, and ethics and 2) after death. The former will serve as an example of the book’s relative weaknesses and the latter as an example of the book’s promise and usefulness.“Human Evil,” chapter 4, begins promisingly. Peters builds on an earlier introduction to the idea that we can associate “God” with the creative processes at work in the universe or with creativity itself. Here, Peters argues that being faithful to creativity becomes the norm for Christian faith and morality. “So, being moral means sustaining the well-being of already created dynamic systems and at the same time being open to creativity (God) and the emergence of new systems” (42). Perhaps these arguments would be better positioned at the [End Page 97] beginning of a chapter on morality and ethics rather than the chapter on evil and sin, though, especially since the corollary definition of sin doesn’t come for another twenty-four pages. There, Peters explains that “sin (the Christian term for human evil) is the attempt to limit the work of creativity (God) and to limit what is included in the family of life that arises from the work of creativity (God)” (66). These two definitions taken together offer one of the most theologically pregnant ideas in the book. Unfortunately, they are not pursued and applied in a systematic way throughout the remainder of this chapter and into chapters 7 and 8 on ethics and Christian practice. What we get, instead, is a collection of reflections on various ethical topics including: racism, xenophobia, sexism, and climate change.Perhaps if these sections were retitled “Karl’s Reflections on Wrestling with White, Male Privilege,” the reader would have the right expectation and their usefulness would reemerge. But as they stand they often lose the thread of their connections to his theological definitions and sometimes slip into problematic assumptions. The latter is exhibited when Peters employs the first-person again, this time in reference to certain social histories, as when “you and I” migrated from north Africa to the Caucasus Mountains (47), or when “you and I arrived in America from England in 1630” (58). The assumed “you” seems to be white, male people of anglo origin and therefore cuts... (shrink)

The phenomenon of conscience as articulated in Roman Catholic moral theology has at least three dimensions: a fundamental and universal call to moral goodness; the search for moral truth; and a commitment to act in a particular way. Recent moral theology has tended to focus on the latter two dimensions, but there has been a strong call from Thomas Ryan for attention to the first dimension of conscience, especially its constitution in ‘horizontal relationality’. In this article I respond to (...) Ryan's call, and demonstrate that the philosophy of Emmanuel Levinas can show how the experience of conscience is constituted in horizontal relationality, as well as that it supports an understanding of conscience as a universal call to responsibility. Correlatively, and perhaps more significantly, the introduction of Levinas’ philosophy into the discussion of conscience sheds light on a significant aspect of this call to moral responsibility. This highlights that the Roman Catholic understanding of conscience has ethical consequences for theology more broadly considered in terms of understanding why it is impossible to set aside considerations of responsibility in the search for truth. (shrink)

Because of the impact of church doctrine and many documents explaining the official confession of many denominations in Christianity, Trinity was mostly defined in terms of static and substantial categories. The undergirding research assumption is that the latter reflects, in most cases, more abstract and rather positivistic metaphysical speculation than representing the vividness of God’s compassionate being-with as explained and revealed in the narratives of the biblical account on God’s graceful intervention with the frailty of human life. The relational (...) dynamics between the Father, the Son and the Spirit should be revisited. In this respect, the Rublev icon on Trinity could help establish the circular and spiral thinking of divine perichoresis as modes of God’s unpredictable, but faithful, covenantal and redemptive encounter with human misery. Trinitarian thinking should be directed by hospice-categories rather than by personhood-categories representing ‘substance’. It is argued that the trinitarian interplay should be re-interpreted in terms of compassionate categories stemming from the passio Dei in theopaschitic theology. This approach should be supplemented by the bowel categories of ta splanchna in order to qualify the infiniscience of the JHWH-Godhead: the being of divine interventions in terms of verbing terminology. (shrink)

Is there an explanation of why the state of x's bearing the non-symmetric binary relation R to y is different from its differential opposite, the state of y's bearing R to x? One traditional view has it that the explanation is that non-symmetric relations hold of objects in an essentially directional way, ordering the relevant relata. We call this view ‘directionalism’. Kit Fine has suggested that this approach is subject to significant metaphysical difficulties, sufficient to motivate seeking an alternative analysis. (...) He considers two such alternative explanations, which he labels ‘positionalism’ and ‘anti-positionalism’. Of these he endorses the latter. We argue that anti-positionalism fails to provide a coherent explanation of the distinction between differential opposites, and that one should simply hold the minimalist position that there is no explanation for this metaphysical difference. (shrink)

Formal clinical trials of pig-to-human organ transplant—known as xenotransplantation—may begin this decade, with the first trials likely to consist of either adult renal transplants or pediatric cardiac transplant patients. Xenotransplantation as a systematic scientific study only reaches back to the latter half of the 20th century, with episodic xenotransplantation events occurring prior to that. As the science of xenotransplantation has progressed in the 20th and 21st centuries, the public's knowledge of the potential therapy has also increased. With this, there (...) have been shifting ethical stances toward xenotransplantation in key areas, such as religious and public viewpoints towards xenotransplantation, animal rights, and public health concerns. This review provides a historical–ethical account of xenotransplantation and details if or how viewpoints have shifted over time. (shrink)

That the world is awash with resentment poses a genuine question for educators. Here, we will suggest that resentment can be better harnessed for good if we stop focusing on people and tribes and, instead, focus on systems: those invisible norms that often produce locked-in structures of social interaction. A “systems lens” is vast, so fixes will have to be an iterative process of reflection, and revision toward a more just system. Nonetheless, resentment toward the status quo may be an (...) important element in keeping that otherwise tedious process going, with the caveat that resentment is only productive when it is combined with reason, and that, therefore, educators, rather than privileging participant reactive attitudes, ought, instead, to promote participant reactive reasoning, as the latter can be a genuine force for both personal and interpersonal growth, while the former might very well do the reverse. (shrink)

This essay offers a start on sorting out the relationships of argumentation and persuasion by identifying two systematic ways in which definitions of argumentation differ, namely, their descriptions of the ends and of the means involved in argumentative discourse. Against that backdrop, the traditional “conviction-persuasion” distinction is reassessed. The essay argues that the traditional distinction correctly recognizes the difference between the end of influencing attitudes and that of influencing behavior—but that it misanalyzes the means of achieving the latter (by (...) focusing on emotional arousal) and that it mistakenly contrasts “rational” and “emotional” means of influence. The larger conclusion is that understanding the relationships of the phenomena of argumentation and persuasion will require close attention to characterizations of communicative ends and means. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Over the last century, Alzheimer’s disease has proven a highly malleable concept. Initially an obscure diagnosis pertaining to rare cases of young onset dementia, by the latter half of the 20th cen...

The book roots corruption in the idea of a departure from conventional standards, and thus offers an account not only of its corrosiveness but also of its malleability and controversiality. In the course of a broadranging exploration, it examines various links between private and public corruption, connecting the latter with other social and political structures.

In democratic theory, “legitimacy” refers to the set of conditions that must be in place in order for the claims to authority of somebody to be deemed appropriate, and for their claims to compliance to be warranted. Though criteria of legitimacy have been elaborated in the context of democratic states, there is no reason for them not to be drawn up, with appropriate amendments, for other kinds of authority structures. This paper examines the claims to authority made over researchers by (...) international bodies governing research ethics, who exercise their authority by the research ethics guidelines they produce (including recent revisions to the Declaration of Helsinki and CIOMS Guidelines). We argue that discussions of such bodies and sets of guidelines often elide questions of justification and questions of legitimacy, and that the grounds that might allow us to mount a strong case for the latter are at present sorely underdeveloped. (shrink)

We introduce new leader humility scales capturing a theoretically rich conceptualization of leader-expressed humility aligned with traditional and ethically-grounded philosophies. These scales draw from recent inductive research (Oc et al., 2015) identifying nine dimensions of leader-expressed humility: (1) having an accurate view of self, (2) recognizing follower strengths and achievements, (3) modeling teachability and being correctable, (4) leading by example, (5) showing modesty, (6) working together for the collective good, (7) empathy and approachability, (8) showing mutual respect and fairness, and (...) (9) mentoring and coaching. The first three dimensions overlap with the most prominent conceptualization of leader-expressed humility in the literature (i.e., Owens et al., 2013). However, the latter six dimensions are unique and represent an expanded understanding of the humble behaviors of leaders, which have implications for leaders and their ethical behavior in organizations. We conducted three studies resulting in two versions of the leader-expressed humility measure: 1) a 27-item scale with the nine dimensions (i.e., the “Leader-Expressed Humility” [LEH] scale) and 2) a 9-item brief scale (i.e., the “Brief LEH” scale) comprised of one item from each of the nine dimensions. As an initial step, we generated a pool of items that reflected each dimension. Next, we validated the LEH and Brief LEH scales in Study 1 and cross-validated the Brief LEH scale in Study 2 with two samples of subordinates in Singapore. As a final step, in Study 3, we cross-validated the Brief LEH scale with a sample of subordinates in the United States. (shrink)

The Air Quality Index (AQI) shows the state of air pollution in a unique and more understandable way. This work aims to forecast the AQI in Algeciras (Spain) 8 hours in advance. The AQI is calculated indirectly through the predicted concentrations of five pollutants (O3, NO2, CO, SO2 and PM10) to achieve this goal. Artificial neural networks (ANNs), sequence-to-sequence long short-term memory networks (LSTMs) and a newly proposed method combing a rolling window with the latter (LSTMNA) are employed as (...) the forecasting techniques. Besides, two input approaches are evaluated: using only the data from the own time series of the pollutant in the first case or adding exogenous variables in the second one. Several window sizes are employed (24, 28 and 72 hours) with ANNs and LSTMNAs. Additionally, several feature ranking methods are applied in the exogenous approach to select the most relevant lagged variables to feed the models. Results show how the proposed exogenous approach increases the performance of the prediction models. Besides, the newly proposed method LSTMNA provides the best performances in most of the cases evaluated. Hence, it constitutes an exciting alternative to standard LSTMs and ANNs to predict pollutants concentrations and, consequently, the AQI. (shrink)

IN 1787, six years after the publication of the Critique of Pure Reason, one year before the publication of the Critique of Practical Reason, and three years prior to the appearance of the Critique of Judgment, Duke Karl August of Sax-Weimar was persuaded to establish at the University of Jena the world's first university chair designated for the promulgation and explication of the new Critical Philosophy associated with Immanuel Kant. The first occupant of this chair was Karl Leonhard Reinhold, an (...) Austrian ex-monk, whose main qualification for the new position was his fame as the author of a series of well-received magazine articles promoting the new philosophy. At Jena, however, Reinhold's own "Kantianism" underwent an interesting metamorphosis; in the books and lectures that he wrote during his seven year tenure there he profoundly revised the Kantian system and produced a new version of it which he called "Elementary Philosophy." It is altogether appropriate that when Reinhold finally left Jena his successor should have been an even more innovative follower of Kant and admirer of Reinhold's Elementary Philosophy, J. G. Fichte. Fichte arrived in 1794 and immediately began constructing and laying before the public what is perhaps the most imaginative and remarkable of all the great post-Kantian speculative systems: his Wissenschaftslehre, or "Theory of Scientific Knowledge." Concurrent with the widespread revival of interest in German Idealism generally, interest in Fichte's Wissenschaftslehre has increased remarkably in recent years. Often viewed as the first step "from Kant to Hegel," Fichte's system was in fact not the first attempt to convert Kant's philosophy into a more consistent and thoroughgoingly speculative system. The honor--or onus--of making the "first step" in this direction belongs to Reinhold, and the aim of this essay is to indicate why this is so by surveying the Elementary Philosophy and examining those of its features which most influenced other philosophers, most notably Fichte. Though it may be claiming too much to say that one cannot properly understand Fichte's early presentations of his system without some acquaintance with Reinhold's Elementary Philosophy, it is certainly true that a familiarity with the latter is a tremendous aid to anyone trying to penetrate the former. Though the chief purpose of this survey is to emphasize Reinhold's contributions to the development of German Idealism, an ulterior aim is to introduce contemporary readers, especially English-language readers, to Reinhold's Elementary Philosophy and to suggest reasons why this neglected and all but forgotten system might still merit serious study. (shrink)

Public discussions of political and social issues are often characterized by deep and persistent polarization. In social psychology, it’s standard to treat belief polarization as the product of epistemic irrationality. In contrast, we argue that the persistent disagreement that grounds political and social polarization can be produced by epistemically rational agents, when those agents have limited cognitive resources. Using an agent-based model of group deliberation, we show that groups of deliberating agents using coherence-based strategies for managing their limited resources tend (...) to polarize into different subgroups. We argue that using that strategy is epistemically rational for limited agents. So even though group polarization looks like it must be the product of human irrationality, polarization can be the result of fully rational deliberation with natural human limitations. (shrink)

ABSTRACT This paper is concerned with landmarks in the history of the idea of cancerous contagiousness from the Renaissance to the Enlightenment. The origins of the idea of cancerous contagiousness is considered on the basis of Galen’s distinction between scabiesleprosy, cancer and elephantiasis. Paul of Aegina (seventh century) established the association between these latter diseases. In the fourteenth century, a ‘new line of inquiry’ developed concerning the transmission of diseases like plague, and G. Fracastoro (1546) applied this approach by (...) stating that putrefaction and inflammation notably produce elephantiasis, which is obviously contagious, as inflammation and heat, without putrefaction, produce cancer. J. Fernel (1548) applied the process of syphilitic contamination to ulcerated cancer, whose vapour ‘is widely dispersed’ and which ‘quickly kills by its malignancy’. G. Cardano (1564) reacted against these views, and declared that cancer was could not be transmitted by contact. But A. Zacuth (1629–1634) and N. Tulp (1652) provided instances of such transmission. D. Sennert, who is often said to have accepted Zacuth’s testimony, was doubtful and suggested, rather than contagion, transmission by heredity. This type of explanation was privileged during Classical Age, until experiments on animals or human beings infected by cancerous liquid took place during the Enlightenment in France and England. Pichler (1786) finally recommended forbidding marriage between people suffering from cancer. (shrink)

It has become customary to conceptualize the living cell as an intricate piece of machinery, different to a man-made machine only in terms of its superior complexity. This familiar understanding grounds the conviction that a cell's organization can be explained reductionistically, as well as the idea that its molecular pathways can be construed as deterministic circuits. The machine conception of the cell owes a great deal of its success to the methods traditionally used in molecular biology. However, the recent introduction (...) of novel experimental techniques capable of tracking individual molecules within cells in real time is leading to the rapid accumulation of data that are inconsistent with an engineering view of the cell. This paper examines four major domains of current research in which the challenges to the machine conception of the cell are particularly pronounced: cellular architecture, protein complexes, intracellular transport, and cellular behaviour. It argues that a new theoretical understanding of the cell is emerging from the study of these phenomena which emphasizes the dynamic, self-organizing nature of its constitution, the fluidity and plasticity of its components, and the stochasticity and non-linearity of its underlying processes. (shrink)

We are bombarded with more information each day than our brains can process especially in election season. It's raining bad data, half-truths, and even outright lies. Daniel J. Levitin shows how to recognize misleading announcements, statistics, graphs, and written reports revealing the ways lying weasels can use them.

Theorists attending to the epistemic condition on responsibility are divided over whether moral ignorance is ever exculpatory. While those who argue that reasonable expectation is required for blameworthiness often maintain that moral ignorance can excuse, theorists who embrace a quality of will approach to blameworthiness are not sanguine about the prospect of excuses among morally ignorant wrongdoers. Indeed, it is sometimes argued that moral ignorance always reflects insufficient care for what matters morally, and therefore that moral ignorance never excuses. Furthermore, (...) quality of will theorists treat their skepticism about excuses for the morally ignorant as a natural implication of their approach. It is therefore unsurprising that, while many have argued for the blamelessness of certain morally ignorant agents on grounds concerning reasonable expectation, the possibility that morally ignorant agents might be blameless even according to quality of will views has not been adequately addressed. I illustrate and explain how it is possible for morally ignorant agents to display sufficient care for the morally relevant features of their wrong behavior. Thus, even if quality of will views are correct, moral ignorance sometimes excuses. (shrink)

We motivate a picture of social epistemology that sees forgetting as subject to epistemic evaluation. Using computer simulations of a simple agent-based model, we show that how agents forget can have as large an impact on group epistemic outcomes as how they share information. But, how we forget, unlike how we form beliefs, isn’t typically taken to be the sort of thing that can be epistemically rational or justified. We consider what we take to be the most promising argument for (...) this claim and find it lacking. We conclude that understanding how agents forget should be as central to social epistemology as understanding how agents form beliefs and share information with others. (shrink)

Addresses perceived irresolvable paradoxes regarding reality as presented by a number of philosophers.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 40.2 (2002) 268-270 [Access article in PDF] Book Review Fichte: The Self and the Calling of Philosophy, 1762-1799 Anthony J. La Vopa. Fichte: The Self and the Calling of Philosophy, 1762-1799. Cambridge: Cambridge University Press, 2001. Pp. xiv + 449. Cloth, $54.95. Few philosophers have led more dramatic lives than J. G. Fichte, whose serendipitous ascent from rural poverty to academic celebrity was (...) only the beginning of a career filled with conflict and punctuated by moments of public triumph and failure. Though Fichte's philosophical writings are among the most abstract and difficult in the history of modern philosophy, it is nevertheless possible to observe certain parallels between his technical "philosophy of striving" and his personal striving to establish himself financially and professionally, [End Page 268] to win an audience for his thought, and, above all, to have an effect upon his age. The links between Fichte's "times," career, and philosophy are the topic of Anthony La Vopa's fine new study of the first thirty-eight years of the philosopher's life. La Vopa is a historian, not a philosopher, and he has little to say about the specific details and originality of Fichte's philosophical contributions, and what he does say on this subject--for example, his claim that one of Fichte's advances over Kant was to assign the productive imagination a central role in cognition, or his assertion that Fichte collapsed the Kantian distinction between willing and cognizing--often betrays a certain naiveté on his part and an unfamiliarity with the specifically philosophical context of Fichte's project.Though La Vopa is not interested in the complex details of the foundational portion of Fichte's system and has nothing to say about the important evolution of the same during Fichte's tenure at Jena, he is quite concerned with Fichte's social, legal, and economic theories, as articulated in the Grundlage des Naturrechts and the ClosedCommercial State (despite the fact that the latter work really falls outside the "Jena period"), and he provides a detailed and enlightening account of Fichte's eccentric labor-based neo-mercantilism and its relationship to other economic theories. Even here, though, La Vopa is less interested in Fichte's own ideas than in the relation of the same to his life and the relation of both his life and his thought to larger intellectual and social currents. It is in this spirit that he attempts to show, for example, that Fichte's strategy of grounding both theoretical and practical reason upon an analysis of the "pure I" is best understood as a continuation of the "subjective turn" characteristic of Protestantism as a whole and that his Sisyphean efforts to create a Publikum for his philosophy were deeply rooted in the Protestant conception of a "calling."The aim of this volume, according to its author, is to "contextualize Fichte's construal of selfhood" and to view his thought through eighteenth-century lenses, rather than through "the distorting lenses of modern ideologies." La Vopa thus interprets the development of Fichte's thought as "a series of moments in the secularization of Lutheranism," a project that he finds most clearly expressed in Fichte's vision of spiritual regeneration and in his uncompromising moral rigor. This experiment in historical contextualization largely avoids the kind of anti-philosophical reductionism common to such efforts, and La Vopa never claims to have "explained" Fichte's philosophy simply by placing it so squarely in the context of its age. On the contrary, he displays a fine sensitivity to questions concerning the relationship between history and philosophy, and he wisely leaves it to his readers to judge for themselves the philosophical value of his enterprise. As an intellectual biography, this book is reliable, expertly informed, and genuinely readable. Any philosopher interested in early post-Kantianism will learn a great deal from La Vopa's account of the larger intellectual, social, economic, and political landscape of the period. To take but two examples: La Vopa's detailed discussion of... (shrink)

The neurophysiological evidence from the Miyashita group's experiments on monkeys as well as cognitive experience common to us all suggests that local neuronal spike rate distributions might persist in the absence of their eliciting stimulus. In Hebb's cell-assembly theory, learning dynamics stabilize such self-maintaining reverberations. Quasi-quantitive modeling of the experimental data on internal representations in association-cortex modules identifies the reverberations (delay spike activity) as the internal code (representation). This leads to cognitive and neurophysiological predictions, many following directly from the language (...) used to describe the activity in the experimental delay period, others from the details of how the model captures the properties of the internal representations. (shrink)

Referred to as the "bible of American lawyers," Blackstone's Commentaries on the Laws of England shaped the principles of law in both England and America when its first volume appeared in 1765. For the next century that law remained what Blackstone made of it. Daniel J. Boorstin examines why Commentaries became the most essential knowledge that any lawyer needed to acquire. Set against the intellectual values of the eighteenth century-and the notions of Reason, Nature, and the Sublime—Commentaries is at (...) last fitted into its social setting. Boorstin has provided a concise intellectual history of the time, illustrating all the elegance, social values, and internal contradictions of the Age of Reason. (shrink)

This collection of essays explores the metaphysical thesis that the living world is not made up of substantial particles or things, as has often been assumed, but is rather constituted by processes. The biological domain is organised as an interdependent hierarchy of processes, which are stabilised and actively maintained at different timescales. Even entities that intuitively appear to be paradigms of things, such as organisms, are actually better understood as processes. Unlike previous attempts to articulate processual views of biology, which (...) have tended to use Alfred North Whitehead’s panpsychist metaphysics as a foundation, this book takes a naturalistic approach to metaphysics. It submits that the main motivations for replacing an ontology of substances with one of processes are to be found in the empirical findings of science. Biology provides compelling reasons for thinking that the living realm is fundamentally dynamic, and that the existence of things is always conditional on the existence of processes. The phenomenon of life cries out for theories that prioritise processes over things, and it suggests that the central explanandum of biology is not change but rather stability, or more precisely, stability attained through constant change. This edited volume brings together philosophers of science and metaphysicians interested in exploring the consequences of a processual philosophy of biology. The contributors draw on an extremely wide range of biological case studies, and employ a process perspective to cast new light on a number of traditional philosophical problems, such as identity, persistence, and individuality. (shrink)

A mechanism describing state reduction dynamics in relativistic quantum field theory is outlined. The mechanism involves nonlinear stochastic modifications to the standard description of unitary state evolution and the introduction of a relativistic field in which a quantized degree of freedom is associated to each point in spacetime. The purpose of this field is to mediate in the interaction between classical stochastic influences and conventional quantum fields. The equations of motion are Lorentz covariant, frame independent, and do not result in (...) divergent behavior. It is shown that the mathematical framework permits the specification of unambiguous local properties providing a connection between the model and evidence of real world phenomena. The collapse process is demonstrated for an idealized example. (shrink)

The concept of mechanism in biology has three distinct meanings. It may refer to a philosophical thesis about the nature of life and biology (‘mechanicism’), to the internal workings of a machine-like structure (‘machine mechanism’), or to the causal explanation of a particular phenomenon (‘causal mechanism’). In this paper I trace the conceptual evolution of ‘mechanism’ in the history of biology, and I examine how the three meanings of this term have come to be featured in the philosophy of biology, (...) situating the new ‘mechanismic program’ in this context. I argue that the leading advocates of the mechanismic program (i.e., Craver, Darden, Bechtel, etc.) inadvertently conflate the different senses of ‘mechanism’. Specifically, they all inappropriately endow causal mechanisms with the ontic status of machine mechanisms, and this invariably results in problematic accounts of the role played by mechanism-talk in scientific practice. I suggest that for effective analyses of the concept of mechanism, causal mechanisms need to be distinguished from machine mechanisms, and the new mechanismic program in the philosophy of biology needs to be demarcated from the traditional concerns of mechanistic biology. (shrink)

Popular discussions of faith often assume that having faith is a form of believing on insufficient evidence and that having faith is therefore in some way rationally defective. Here I offer a characterization of action-centered faith and show that action-centered faith can be both epistemically and practically rational even under a wide variety of subpar evidential circumstances.

Philosophy of biology is often said to have emerged in the last third of the twentieth century. Prior to this time, it has been alleged that the only authors who engaged philosophically with the life sciences were either logical empiricists who sought to impose the explanatory ideals of the physical sciences onto biology, or vitalists who invoked mystical agencies in an attempt to ward off the threat of physicochemical reduction. These schools paid little attention to actual biological science, and as (...) a result philosophy of biology languished in a state of futility for much of the twentieth century. The situation, we are told, only began to change in the late 1960s and early 1970s, when a new generation of researchers began to focus on problems internal to biology, leading to the consolidation of the discipline. In this paper we challenge this widely accepted narrative of the history of philosophy of biology. We do so by arguing that the most important tradition within early twentieth-century philosophy of biology was neither logical empiricism nor vitalism, but the organicist movement that flourished between the First and Second World Wars. We show that the organicist corpus is thematically and methodologically continuous with the contemporary literature in order to discredit the view that early work in the philosophy of biology was unproductive, and we emphasize the desirability of integrating the historical and contemporary conversations into a single, unified discourse. (shrink)

One challenge to the rationality of religious commitment has it that faith is unreasonable because it involves believing on insufficient evidence. However, this challenge and influential attempts to reply depend on assumptions about what it is to have faith that are open to question. I distinguish between three conceptions of faith each of which can claim some plausible grounding in the Judaeo-Christian tradition. Questions about the rationality or justification of religious commitment and the extent of compatibility with doubt look different (...) on accounts of faith in which trust or hope, rather than belief, are the primary basis for the commitments. On such accounts, while the person of faith has a stake in the truth of the content, practical as well as epistemic considerations can legitimately figure in normative appraisals. Trust and hope can be appropriate in situations of recognized risk, need not involve self-deception, and are compatible with the idea that one's purely epistemic opinions should be responsive only to evidence.Send article to KindleTo send this article to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service.Authentic faith and acknowledged risk: dissolving the problem of faith and reasonVolume 49, Issue 1DANIEL J. MCKAUGHAN DOI: https://doi.org/10.1017/S0034412512000200Your Kindle email address Please provide your Kindle [email protected]@kindle.com Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Dropbox To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox. Authentic faith and acknowledged risk: dissolving the problem of faith and reasonVolume 49, Issue 1DANIEL J. MCKAUGHAN DOI: https://doi.org/10.1017/S0034412512000200Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Google Drive To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive. Authentic faith and acknowledged risk: dissolving the problem of faith and reasonVolume 49, Issue 1DANIEL J. MCKAUGHAN DOI: https://doi.org/10.1017/S0034412512000200Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Export citation Request permission. (shrink)

The controversy over the old ideal of “value-free science” has cooled significantly over the past decade. Many philosophers of science now agree that even ethical and political values may play a substantial role in all aspects of scientific inquiry. Consequently, in the last few years, work in science and values has become more specific: Which values may influence science, and in which ways? Or, how do we distinguish illegitimate from illegitimate kinds of influence? In this paper, I argue that this (...) problem requires philosophers of science to take a new direction. I present two case studies in the influence of values on scientific inquiry: feminist values in archaeology and commercial values in pharmaceutical research. I offer a preliminary assessment of these cases, that the influence of values was legitimate in the feminist case, but not in the pharmaceutical case. I then turn to three major approaches to distinguish legitimate from illegitimate influences of values, including the distinction between epistemic and non-epistemic values and Heather Douglas’ distinction between direct and indirect roles for values. I argue that none of these three approaches gives an adequate analysis of the two cases. In the concluding section, I briefly sketch my own approach, which draws more heavily on ethics than the others, and is more promising as a solution to the current problem. This is the new direction in which I think science and values should move. (shrink)

This chapter draws on insights from non-equilibrium thermodynamics to demonstrate the ontological inadequacy of the machine conception of the organism. The thermodynamic character of living systems underlies the importance of metabolism and calls for the adoption of a processual view, exemplified by the Heraclitean metaphor of the stream of life. This alternative conception is explored in its various historical formulations and the extent to which it captures the nature of living systems is examined. Following this, the chapter considers the metaphysical (...) implications of reconceptualizing the organism from complex machine to flowing stream. What do we learn when we reject the mechanical and embrace the processual? Three key lessons for biological ontology are identified. The first is that activity is a necessary condition for existence. The second is that persistence is grounded in the continuous self-maintenance of form. And the third is that order does not entail design. (shrink)

Although it may seem like a truism to assert that biology is the science that studies organisms, during the second half of the twentieth century the organism category disappeared from biological theory. Over the past decade, however, biology has begun to witness the return of the organism as a fundamental explanatory concept. There are three major causes: (a) the realization that the Modern Synthesis does not provide a fully satisfactory understanding of evolution; (b) the growing awareness of the limits of (...) reductionism in molecular biology; and (c) the renewed interest in the nature of life as a genuine scientific problem. This essay examines these recent developments and considers the new epistemological roles being played by the organism in each of them. It also reflects on what the present resurgence of the organism means for the philosophy of biology. (shrink)

There was a time when Greco-Roman culture recognized faith as an indispensable social good. More recently, however, the value of faith has been called into question, particularly in connection with religious commitment. What, if anything, is valuable about faith—in the context of ordinary human relations or as a distinctive stance people might take in relation to God? I approach this question by examining the role that faith talk played both in ancient Jewish and Christian communities and in the larger Greco-Roman (...) culture in which Christian faith talk evolved. I locate the value of faith and faithfulness in the context of relationships involving trust and loyalty and argue that what is most distinctively valuable about faith is the function it plays in sustaining relationships through various kinds of challenges, including through evidentially unfavorable circumstances and significant periods of doubt. In light of this discussion, I set out a view of relational faith and, taking Mother Teresa as an exemplar, argue for two further conclusions. First, faith can play the valuable role that it plays in sustaining relationships even without belief of the salient propositions. Second, in at least some circumstances, in order for faith to play this valuable role in a way that does not require epistemic opinions that fail to fit one’s evidence, it is important that faith does not require such belief. (shrink)

The standard view says that epistemic normativity is normativity of belief. If you’re an evidentialist, for example, you’ll think that all epistemic reasons are reasons to believe what your evidence supports. Here we present a line of argument that pushes back against this standard view. If the argument is right, there are epistemic reasons for things other than belief. The argument starts with evidentialist commitments and proceeds by a series of cases, each containing a reason. As the cases progress, the (...) reasons change from counting in favor of things like having a belief to things like performing ordinary actions. We argue that each of those reasons is epistemic. If the argument succeeds, we should think there are epistemic reasons to consider hypotheses, conduct thought and physical experiments, extend one’s evidence, and perform mundane tasks like eating a sandwich, just as there are epistemic reasons to believe what one’s evidence supports. (shrink)

Epistemic consequentialists think that epistemic norms are about believing the truth and avoiding error. Recently, a number of authors have rejected epistemic consequentialism on the basis that it incorrectly sanctions tradeoffs of epistemic goodness. Here, I argue that epistemic consequentialists should borrow two lessons from ethical consequentialists to respond to these worries. Epistemic consequentialists should construe their view as an account of right belief, which they distinguish from other notions like rational and justified belief. Epistemic consequentialists should also make their (...) view ‘sophisticated,’ in the sense of Railton. Epistemic consequentialism, I conclude, is best construed as sharing much of its structure with prominent act-consequentialist views in ethics. Epistemic consequentialism has an advantage over its ethical counterpart though: the key claim of the view is practically universally accepted, which gives us an additional reason to think it’s true. (shrink)

This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for conceptualizing living systems, many biologists and philosophers continue to draw upon the MCO or tacitly accept it as the standard model of the organism. This paper analyses the specific difficulties that arise when the MCO is invoked in the study of development and evolution. In (...) developmental biology the MCO underlies a logically incoherent model of ontogeny, the genetic program, which serves to legitimate three problematic theses about development: genetic animism, neo-preformationism, and developmental computability. In evolutionary biology the MCO is responsible for grounding unwarranted theoretical appeals to the concept of design as well as to the interpretation of natural selection as an engineer, which promote a distorted understanding of the process and products of evolutionary change. Overall, it is argued that, despite its heuristic value, the MCO today is impeding rather than enabling further progress in our comprehension of living systems. (shrink)

An ongoing debate in the philosophy of action concerns the prevalence of moral luck: instances in which an agent’s moral responsibility is due, at least in part, to factors beyond his control. I point to a unique problem of moral luck for agents who depend upon Brain Computer Interfaces (BCIs) for bodily movement. BCIs may misrecognize a voluntarily formed distal intention (e.g., a plan to commit some illicit act in the future) as a control command to perform some overt behavior (...) now. If so, then BCI-agents may be deserving of punishment for the unlucky but foreseeable outcomes of their voluntarily formed plans, whereas standard counterparts who abandon their plans are not. However, it seems that the only relevant difference between BCI-agents and their standard counterparts is just a matter of luck. I briefly sketch different solutions that attempt to avoid this type of moral luck, while remaining agnostic on whether any succeeds. If none of these solutions succeeds, then there may be a unique type of moral luck that is unavoidable with respect to deserving punishment for certain BCI-mediated behaviors. (shrink)

Geared to preparing students to make the transition from solving problems to proving theorems, this text teachs them the techniques needed to read and write proofs. The book begins with the basic concepts of logic and set theory, to familiarize students with the language of mathematics and how it is interpreted. These concepts are used as the basis for a step-by-step breakdown of the most important techniques used in constructing proofs. To help students construct their own proofs, this new edition (...) contains over 200 new exercises, selected solutions, and an introduction to Proof Designer software. No background beyond standard high school mathematics is assumed. Previous Edition Hb (1994) 0-521-44116-1 Previous Edition Pb (1994) 0-521-44663-5. (shrink)

Can faith be valuable and, if so, under what conditions? We know of no theory-neutral way to address this question. So, we offer a theory of relational faith, and we supplement it with a complementary theory of relational faithfulness. We then turn to relationships of mutual faith and faithfulness with an eye toward exhibiting some of the ways in which, on our theory, faith and faithfulness can be valuable and disvaluable. We then extend the theory to other manifestations of faith (...) and faithfulness, propose a way to unify them under a theory of faith and faithfulness simpliciter, and explain how they can be neo-Aristotelian virtues and vices. We close with our solution to the value problem and avenues for further research. (shrink)