Graphical AbstractThe loosening of chromatin structures gives rise to unrestricted access to DNA and thus transcription factors (TFs) can bind to their otherwise masked target sequences. Regions bound by the same set of TFs tend to be located in close proximity and this might increase the probability of activating illegitimate genomic rearrangements.

Argues that educators should help students piece together authentic narratives about themselves and about society, and not to focus so much on teaching students to process information.

Second, this collection of cognitive programs evolved in the Pleistocene to solve the adaptive problems regularly faced by our hunter-gatherer ancestors-...

Is jealousy eliminable? If so, at what cost? What are the connections between pride the sin and the pride insisted on by identity politics? How can one question an individual's understanding of their own happiness or override a society's account of its own rituals? What is wrong with incest? These and other questions about what sustains and threatens our identity are pursued using the resources of philosophy, psychoanalysis, and other disciplines. The discussion throughout is informed and motivated by the Spinozist (...) hope that understanding our lives can help change them, can help make us more free. (shrink)

Cet ouvrage est le premier d'une série de quatre études consacrées aux liens que Kant, Hegel, Nietzsche et Freud établissent entre éthique et esthétique.

Mgr Félix Hedde (1879-1960), o.p., est un personnage-clé de la mission des dominicains de Lyon dans le Haut-Tonkin. Son long ministère au Việt Nam (1926-1960) en fit un témoin privilégié d’une période dramatique de l’histoire du pays. Il a connu les années prospères de la colonisation française jusqu’en 1940, les souffrances de ses compatriotes pendant la Seconde Guerre mondiale et la guerre d’Indochine, leur humiliation face à la décolonisation forcée, et enfin la persécution ouverte ou larvée des chrétiens sous le (...) régime communiste. Chez Félix Hedde, l’amour pour la mission du Tonkin, le désir d’y implanter l’Église, se conjuguait à sa volonté d’honorer ses traditions familiales et nationales. L’épreuve de l’occupation japonaise, de la guerre d’Indochine, des défaites de l’armée française, autant que le réconfort de la fidélité des chrétiens vietnamiens de la mission dans une situation de plus en plus critique, détachant Mgr Hedde de ses rêves patriotiques, le conduisirent à l’accomplissement de sa vocation missionnaire. Les conditions particulières de son territoire de mission, où les ethnies montagnardes sont très largement majoritaires, l’amenèrent cependant à proposer pour lui succéder le Français André Jacq, privant ainsi d’évêque les chrétiens du lieu, de 1958 à 1990. (shrink)

Bruner sets forth nothing less than a new agenda for the study of the mind. He examines the irrepressibly human acts of imagination that allow us to make experience meaningful; he calls this side of mental activity the “narrative mode,” and his book makes important advances in the effort to unravel its nature.

This book, the product of a lifetime of research by one of the founders of developmental psychology, takes on the powerful assumptions behind these questions- ...

Surely since the Enlightenment, if not before, the study of mind has centered principally on how man achieves a “true” knowledge of the world. Emphasis in this pursuit has varied, of course: empiricists have concentrated on the mind’s interplay with an external world of nature, hoping to find the key in the association of sensations and ideas, while rationalists have looked inward to the powers of mind itself for the principles of right reason. The objective, in either case, has been (...) to discover how we achieve “reality,” that is to say, how we get a reliable fix on the world, a world that is, as it were, assumed to be immutable and, as it were, “there to be observed.”This quest has, of course, had a profound effect on the development of psychology, and the empiricist and rationalist traditions have dominated our conceptions of how the mind grows and how it gets its grasp on the “real world.” Indeed, at midcentury Gestalt theory represented the rationalist wing of this enterprise and American learning theory the empiricist. Both gave accounts of mental development as proceeding in some more or less linear and uniform fashion from an initial incompetence in grasping reality to a final competence, in one case attributing it to the work out of internal processes or mental organization, and in the other to some unspecified principle of reflection by which—whether through reinforcement, association, or conditioning—we came to respond to the world “as it is.” There have always been dissidents who challenged these views, but conjectures about human mental development have been influenced far more by majoritarian rationalism and empiricism than by these dissident voices. Jerome Bruner is research professor of psychology at New York University, where he is also serving as Meyer Visiting Professor of Law. His most recent book, Acts of Meaning, appeared in 1990. In 1987 he received the Balzan Prize for “a lifetime contribution to the study of human psychology.”. (shrink)

Much of our understanding of human thinking is based on probabilistic models. This innovative book by Jerome R. Busemeyer and Peter D. Bruza argues that, actually, the underlying mathematical structures from quantum theory provide a much better account of human thinking than traditional models. They introduce the foundations for modelling probabilistic-dynamic systems using two aspects of quantum theory. The first, 'contextuality', is a way to understand interference effects found with inferences and decisions under conditions of uncertainty. The second, 'quantum entanglement', (...) allows cognitive phenomena to be modeled in non-reductionist ways. Employing these principles drawn from quantum theory allows us to view human cognition and decision in a totally new light. Introducing the basic principles in an easy-to-follow way, this book does not assume a physics background or a quantum brain and comes complete with a tutorial and fully worked-out applications in important areas of cognition and decision. (shrink)

A theory that treats language not as an abstract symbol system but as a function of our brains and experience, integrating recent findings from biology, ...

Closely related to this is Mr. Bruner's "evolutionary instrumentalism," his conception of instruction as the means of transmitting the tools and skills of a ...

Does Freud still have something to teach us? The premise of this volume is that he most certainly does. Approaching Freud from not only the philosophical but also historical, psychoanalytical, anthropological, and sociological perspectives, the contributors show us how Freud gave us a new and powerful way to think about human thought and action. They consider the context of Freud's thought and the structure of his arguments to reveal how he made sense of ranges of experience generally neglected or misunderstood. (...) All the central topics of Freud's work, from sexuality and neurosis to morality, art, and culture are covered. (shrink)

Nietzsche se défend de séparer "l'un de l'autre l'amour et la raison". Mais, dans son oeuvre, l'amour dont il est question n'est pas l'amour de la vie, mais l'amor fati, lequel est acquiescement à l'impermanence des choses, à leur contingence et au monde comme volonté de puissance. Il s'ensuit que la raison en devient elle-même raison de la fatalité, antithèse irréductible des rationalités logicienne ou morale. Cette raison tragique, dont les autres noms sont "passion philosophique", "pensée libre" ou "sagesse sauvage", (...) constitue la raison de vivre du philosophe dionysiaque. Telle est la thèse du présent essai."--Page 4 of cover. (shrink)

Il y a chez Platon, Montaigne, Spinoza et Freud une réflexion sur la vie et la mort qui présente une similitude : chez aucun d'eux, la vie n'est le bien le plus précieux que l'homme puisse connaître, car, chez tous, le seul bien réel est la liberté de penser le vrai. Dans cet ouvrage est mis au jour le fait que, pour un idéaliste et pour un fataliste, la mort délivre du faux avec, pour conséquence, qu'elle en devient désirable. Dans (...) un second ouvrage, La liberté, l'existence et la mort chez Spinoza et Freud, est analysée la transformation du rapport entre la philosophie et la mort, consécutive au rationalisme déterministe qui met fin à l'illusion que la philosophie et la pensée demeurent inconditionnées : il s'ensuit que le détachement spirituel de Platon et de Montaigne semble impraticable face à la vie et à la mort telles que la raison les conçoit. (shrink)

Dans un précédent ouvrage, La liberté, la pensée et la mort chez Platon et Montaigne, il a été montré que, chez Platon comme chez Montaigne, la mort, loin d'être le plus terrible des maux, est en fait une libération, car elle rend possible un détachement d'avec la vie qui leur est apparue soit contaminée par des fictions, soit cruellement angoissante. Les mêmes thèmes sont repris dans cet ouvrage avec Spinoza et Freud, mais dans un contexte déterministe qui les empêche de (...) croire encore à la possibilité d'une pensée humaine inconditionnée. La philosophie ne suffit plus à apprendre à mourir. Sans une analyse des causes qui déterminent l'activité mentale, à savoir le désir et les pulsions animiques, la pensée demeure asservie à des finalités imaginaires. Il s'ensuit que, pour philosopher, il faut d'abord renoncer au fantasme du sujet libre ou du moi maître de lui-même. Ce sont ces personnages qui doivent mourir pour penser et exister librement. En ce sens, la mort apparaît, ici aussi, comme une délivrance qui devient, de ce fait, désirable. (shrink)

Nietzsche a mené une double lutte, d'une part, contre la "sagesse insigne" subjuguée par le pouvoir de la logique et, d'autre part, mais en vertu de la même passion philosophique, contre la peur. Ce combat donne le jour à une liberté et à une rébellion surhumaines et solitaires contre le "ressentiment" et contre ce qu'il engendre : la cruauté de la culture. C'est à la description de cette insurrection tragique que cet ouvrage est consacré.

L'homme ne se rapporte droitement a lui-meme qu'en se rapportant a la totalite du monde qui l'entoure. Ce monde qui est unique selon Platon, sans qu'il soit double par le monde intelligible dont parlera le neoplatonisme, est rendu possible par la rencontre de l'intelligible et du sensible. Ainsi, le logos, par quoi l'homme a acces aux Formes, est ce qui permet d'operer la deliaison proprement philosophique du corps et de l'ame, selon les termes du Phedon, sans qu'il faille poser un (...) dualisme cosmique qui se retrouverait dans l'homme. De meme que le sensible s'intelligibilise par la Participation et ainsi se maintient comme phenomene stable, de meme l'homme peut avoir un usage harmonieux de son corps et de ses sensations. Deliaison n'est pas rupture. L'enfance, la sexuation, le sommeil, les reves, la mort et la parole, ici interroges, montrent que l'anthropologie de Platon ne condamne ni le plaisir, ni le corps. La vie de la pensee ne s'absente pas des mouvements corporels qu'elle accompagne. C'est pourquoi le corps est le signe de l'ame. (shrink)

In examining the puzzle of experience, and its possible solutions, Valberg discusses relevant views of Hume, Kant, Heidegger, Wittgenstein, and Strawson, as well as ideas from the recent philosophy of perception. Finally, he describes and analyzes a manifestation of the puzzle outside philosophy, in everyday experience.

This paper presents a general computational treatment of how mammals are able to deal with visual objects and environments. The model tries to cover the entire range from behavior and phenomenological experience to detailed neural encodings in crude but computationally plausible reductive steps. The problems addressed include perceptual constancies, eye movements and the stable visual world, object descriptions, perceptual generalizations, and the representation of extrapersonal space.The entire development is based on an action-oriented notion of perception. The observer is assumed to (...) be continuously sampling the ambient light for information of current value. The central problem of vision is taken to be categorizing and locating objects in the environment. The critical step in this process is the linking of visual information to symbolic object descriptions; this is calledindexing, from the analogy of identifying a book from index terms. The system must also identifysituationsand use this knowledge to guide movement and other actions in the environment. The treatment focuses on the different representations of information used in the visual system.The four representational frames capture information in the following forms: retinotopic, head-based, symbolic, and allocentric. The functional roles of the four frames, the communication among them, and their suggested neurophysiological realization constitute the core of the paper. The model is perforce crude, but appears to be consistent with all relevant findings. (shrink)

Three experiments explored the effects of word problem cueing on debiasing versions of the bat-and-ball problem. In the experimental condition order, participants solved a simpler isomorphic version of the problem prior to solving a standard version that, critically, had the same item-and-dollar amounts. Conversely, in the control condition order, participants solved the standard version prior to solving the isomorph. Across the first 2 experiments, participants cued with the isomorph were more likely to correctly solve the standard version of the problem. (...) In the third experiment, this cueing effect was not replicated, but importantly cued participants were more likely to correctly solve the standard version of the problem with other item-and-dollar amounts, indicating near transfer. Far transfer was evident in faster response times to other problems in the Cognitive Reflection Test following practice. Along with providing converging evidence for the cueing account, these results are consistent with recent attentional debiasing findings. (shrink)

First published in 1977, Emotion, Thought and Therapy is a study of Hume and Spinoza and the relationship of philosophical theories of the emotions to psychological theories of therapy. Jerome Neu argues that the Spinozists are closer to the truth; that is, that thoughts are of greater importance than feelings in the classification and discrimination of emotional states. He then contends that if the Spinozists are closer to the truth, we have the beginning of an argument to show that Freudian (...) or analytic therapies make philosophic sense. Throughout the book, careful attention is paid to modern discussions in philosophy of mind and psychology, and materials from anthropology and other relevant disciplines are considered. At the centre of the discussion is the notion of ‘thought-dependence’. Therapies for psychological disorders are placed along a spectrum in accordance with the role they assign to thoughts. The Spinozist view of the emotions can be seen as at the extreme thought end of a corresponding spectrum of theories of the emotions. The book suggests that this stream may help explain the spectrum of therapeutic theories and the possibilities that exist for psychological development and change. This book will be of interest to students of philosophy, psychology and counselling. (shrink)

Henry Sedgewick's The Methods of Ethics challenges comparison, as no other work in moral philosophy, with Aristotle's Ethics in the depth of its understanding of practical rationality, and in its architectural coherence it rivals the work of Kant. In this historical, rather than critical study, Professor Schneewind shows how Sidgewick's arguments and conclusions represent rational developments of the work of Sidgewick's predecessors, and brings out the nature and structure of the reasoning underlying his position.