Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

This celebratory Festschrift dedicated to Charles Kahn comprises some 23 articles by friends, former students and colleagues, many of whom first presented their papers at the international "Presocratics and Plato" Symposium in his honor. The conference was organized and sponsored by the HYELE Institute for Comparative Studies, Parmenides Publishing, and Starcom AG, with endorsements from the International Plato Society, and the Dean of the School of Arts and Sciences, University of Pennsylvania. While Kahn's work reaches far beyond the Presocratics and (...) Plato, it is in these subject areas that the distinction of his scholarship has come to be regarded as virtually unrivaled. The articles contributed to this volume are by some of the most renowned scholars working on these topics today, their breadth and depth bearing witness to his profound impact and influence on the discipline of Ancient Greek Philosophy._ Charles Kahn taught Classics and Philosophy at Columbia University from 1957 to 1965, and has since been teaching in the Philosophy Department of the University of Pennsylvania. He spent a year as Visiting Professor at the American School of Classical Studies in Athens, and had additional Visiting Fellowships at Balliol College, Oxford and Clare Hall, Cambridge, and a term as Visiting Professor at Harvard. He is the recipient of several prestigious research grants, from the American Council of Learned Societies, the National Endowment for the Humanities, and the Guggenheim Foundation. In 2000 he was elected Fellow of the National Academy of Arts and Sciences. He is the author of _Anaximander and the Origins of Greek Cosmology, The Verb “Be” in Ancient Greek, The Art and Thought of Heraclitus, Plato and the Socratic Dialogue, Pythagoras and the Pythagoreans, and Essays on Being_. His latest book,_Plato and the Post-Socratic Dialogue_, is forthcoming from Cambridge University Press. _ Contributors: Julia Annas Sarah Broadie Lesley Brown Tomás Calvo-Martínez Diskin Clay John M. Dillon Dorothea Frede Arnold Hermann Carl A. Huffman Enrique Hülsz Piccone D. M. Hutchinson Paul Kalligas Vassilis Karasmanis Aryeh Kosman Anthony A. Long Richard McKirahan Susan Sauvé Meyer Alexander P.D.Mourelatos Satoshi Ogihara Richard Patterson Christopher J. Rowe David Sedley Richard Sorabji. (shrink)

In seiner Einladung zur Mitwirkung hatte der Herausgeber als Arbeitstitel für diesen Band formuliert: "Erziehungswissenschaft am Ausgang der Moderne"; von dieser Vorgabe sind meine Überlegungen an geregt worden. 2 Dahmer I Klafkis (1968) "Ausgangs' -Diagnose war fast noch druckfrisch als die Renaissance der geistes wissenschaftlichen Pädagogik einsetzte. 3 Auf die sich die Postmoderne-Debatte aber nicht reduzieren läßt. 4 Weitere Varianten sind im Kontext evolutionstheoretischer Entwürfe der Pädagogik oder im Anschluß an new-wave-philosophies entstanden, vgl. z.B. Treml 1987 sowie Huschke-Rhein 1988. Auf (...) diese Arbeiten will ich im folgenden nicht eingehen, weil dadurch eine immanente Diskussion von,System' -Denken not wendig würde, die nicht nur von erziehungswissenschaftlichen Problemen, sondern gelegentlich über haupt von Theorieproblemen wegführen würde. 5 Die Rezeptionsgeschichte bei Oelkers/Tenorth 1987 b; Seiler I Meyer 1987 können im übrigen durch den Bezug auf die Herbart-Rezeption zeigen, daß solche eigentümlich verzerrenden Formen der Aneignung von Theorie in der wissenschaftlichen Pädagogik keineswegs singulär sind. 6 Mit,Systemtheorie' sei im folgenden die Form bezeichnet, zu der sich die Systemtheorie modo Luh mann I Schorr in der Rezeption der Pädagogen gewandelt hat. Meine Bemerkungen gelten beiden Modi der Systemtheorie. 7 Ich nutze einen Begriff, mit dem Th. Luckmann den Effekt analysiert, den die phänomenologische Theo rie und Philosophie den Weltbildern der Sozialwissenschaften zugefügt habe. 8 In der Analyse pädagogischer Argumente liegen solche Erweiterungen vor, z.B. bei Künzli 1986, Paschen 1988. 9 Am bekanntesten vielleicht in der pädagogischen Formel vom,Implikationszusammenhang von Ziel, In halt und Methode' vertreten. (shrink)

Atmosphären stellen in der Naturästhetik mittlerweile ein zentrales Konzept dar. Der Beitrag gibt einen Überblick über den gegenwärtigen Stand dieses stetig anwachsenden Forschungsfeldes. Beginnend mit Hermann Schmitz, der den Atmosphären-.

Der 1864 in Hirschberg/Schlesien geborene Karl JoëlJoël, Karl entstammte väterlicherseits einer bedeutenden Rabbiner- und Gelehrtenfamilie. Der 1881 verstorbene Vater Hermann JoëlJoël, Hermannwar ein Schüler SchellingsSchelling, Friedrich Wilhelm Joseph und wurde mit einer vergleichenden Studie zur Stellung der Patriarchen in Judentum, Christentum und Islam 1857 promoviert. Mit seinem Bruder DavidJoël, David schrieb er eine wichtige Monographie zum Sohar.

This volume is a Festschrift dedicated to Charles Kahn comprised of more than 20 papers presented at the conference "Presocratics and Plato: Festschrift Symposium in Honor of Charles Kahn", 3-7 June 2009. The conference was held at the European Cultural Center of Delphi, Greece, and was organized and sponsored by the HYELE Institute for Comparative Studies and Parmenides Publishing, with endorsement from the International Plato Society, and the Dean of the School of Arts and Sciences, University of Pennsylvania. Contributors: Julia (...) Annas - University of Arizona; Sarah Broadie - University of St. Andrews; Lesley Brown - University of Oxford; Tomás Calvo-Martínez - Universidad Complutense de Madrid; Diskin Clay - Duke University; John M. Dillon - Trinity College, Dublin; Dorothea Frede - Humbolt University, Berlin; Arnold Hermann - HYELE Institute for Comparative Studies; Carl A. Huffman - DePauw University; Enrique Hülsz Piccone - Universidad Nacional Autonoma de Mexico; D.M. Hutchinson - St. Olaf College; Paul Kalligas - National and Kapodistrian University, Athens; Vassilis Karasmanis - National Technical University, Athens; Aryeh Kosman - Haverford College; Anthony A. Long - University of California, Berkeley; Richard McKirahan - Pomona College; Susan Sauvé Meyer - University of Pennsylvania; Alexander P.D. Mourelatos - University of Texas at Austin; Satoshi Ogihara - Tohoku University, Japan; Richard Patterson - Emory University; Christopher J. Rowe - Durham University; David Sedley - University of Cambridge; Richard Sorabji - University of Oxford. (shrink)

Review of THEO C. MEYERING, Historical Roots of Cognitive Science : The Rise of a Cognitive Theory of Perception from Antiquity to the Nineteenth Century. Boston: Kluwer, xix + 250 pp. $69.00. Examines the author's interpretation of Aristotelian theories of perceptual cognition, early modern theories, and Helmholtz's theory.

Hermann Weyls "Philosophie der Mathematik und Naturwissenschaft" erschien erstmals 1928 als Beitrag zu dem von A. Bäumler und M. Schröter herausgegebenen "Handbuch der Philosophie". Die amerikanische Ausgabe, auf der die deutsche Übersetzung von Gottlob Kirschmer beruht, erschien 1949 bei Princeton University Press. Das nunmehr bereits in der 8. Auflage vorliegende Werk ist längst auch in Deutschland zum Standardwerk geworden.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections (...) in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Kants BegrUndung Der Aesthetik Hermann Cohen F. DUmmler, 1889 Aesthetics. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Die interdisziplinäre Forschungsgruppe "Poetik und Hermeneutik" und ihre Mitglieder haben die geistes- und kulturwissenschaftliche Landschaft der alten Bundesrepublik geprägt wie vielleicht sonst nur noch die Kritische Theorie. Zahlreiche Interviews mit den wichtigsten noch lebenden Akteuren erlauben einen ebenso erkenntnisreichen wie unterhaltsamen Blick hinter die Kulissen von Poetik & Hermeneutik. Unter welchen Bedingungen und mit welchen Absichten wurde die Gruppe von Hans Blumenberg, Clemens Heselhaus, Wolfgang Iser und Hans Robert Jauß ursprünglich gegründet? Wie entfalteten sich Diskussionen und Kontroversen? Wie kam P&H (...) zur Blüte und warum scheiterte ein möglicher Generationenwechsel? Als Zeitzeugen gehört werden unter anderen Aleida und Jan Assmann, Ferdinand Fellmann, Manfred Frank, Gerhart von Graevenitz, Hans Ulrich Gumbrecht, Anselm Haverkamp, Dieter Henrich, Helga Jauss-Meyer, Renate Lachmann, Thomas Luckmann, Hermann Lübbe, Christian Meier, Jürgen Schlaeger, Gabriele Schwab, Wolf-Dieter Stempel, Karlheinz Stierle, Rainer Warning und Harald Weinrich. (shrink)

Excerpt from Doxographi Graeci: Collegit Recensuit Prolegomenis Indicibusque Instruxit Ceterum in superioribus suis verbis dicebat: 'cuius para sub corruptione iacet, necesse id est totum quoque obnoxium esse corruptioni.' nec enim sine toto partes constare poseunt neque totum sine partibus. Nam mundus univeraua unum corpus est e multis partibus a deo compositum. Nec tamen ut alii qui dam sapientum animal esse mundus censeudus est sed arti ficinsa harmonia concretionem nactus. About the Publisher Forgotten Books publishes hundreds of thousands of rare and (...) classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Excerpt from Poetarum Philosophorum Fragmenta Plagulis correctis indicibusque non sine taedio confectis dum respiro et laetiore animo quid praefandum sit meditor, ecce nuntius longe tris tissimus afi'ertur, georgium kaibelium nobis litterisque acerba morte ereptum esse, qui non solum studiorum societate inde a beatissimo oon tu'oernio - Bonnensi mihi erat coniunctissimus, sed in hoc quoque communi amicorum opere velut auspex et signifer, cuius auctoritatem me aequi et decebat et iuvabat. Nam singularis graecae artis cognitio, quae in illo fuit, in nullo genere (...) litterarum magis enituit quam in Comicis, unde splendidum ante biennium factum est huius Corporis initium. Iam adu lescentem prima tirocinia in Aristophane ponere memini eundemque audio supremam fuisse moribundi curam ac querelem. Inter bos vitae laboriosae et fructuosae terminos omnem graecitatem peragravit et undique messem uberrimam rettulit; at nusquam libentius et intentius versabatur quam in atticae comoediae reliquiis. Dorienses enim, quos edidit, propter illos cpinor tetigerat.' quodsi verum est cum primi illins voluminis perfectione vix unam alteramve aequalium editionem recte posse eom parari, quid prasstaturum eum fuisse credimus, si fatum concessisset, ut ipsam 'atticam comoediam nobis ex fragmentis instauraret, in qua totus habitabat et spirabat! Aut nemo mortalium aut, si quisquam, ille et natus erat et paratus ad Menandri et aequalium umbras ex inferis citandas et in vitae lucem revocandas. Adeo in intimam eorum consuetudinem inde fesso labore atque fortasse magis etiam sensus quadam cognatione se insinuaverat. Nam tota eius indoles ad atticum istum saporem facta erat. Ut scripture eius elegantia apicum prae ceteris nitebat, ut suavissima sermocinatio mirum quantum amicos tenebat, priusquam morbi ingra veseentie tormentis animi serenitas obscurari coepta est, ita tota eius ars versus graecos et exblicandi et pangendi Praxiteleo quodam perfusa erat nitore. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

In this paper I explore the character and role of stereoformulas and models of the atom that appeared in the early history of stereochemistry, including those of Jacobus Henricus van't Hoff, Aemilius Wunderlich, Johannes Wislicenus, Victor Meyer, Arthur Hantzsch, Alfred Werner, and Hermann Sachse. I argue that stereochemists constructed and used stereoformulas in a pragmatic way that ignored the physical implications of the spatial distribution of valence, and that the models of the atom were created to reconcile the (...) physically curious concept of valence with known physical laws. Although such models were explanatory at a deeper level, they had little impact on the theory and practice of chemistry, and were not serious attempts to reduce chemical theory to physical laws. (shrink)

Excerpt from Elementum: Eine Vorarbeit zum Griechischen und Lateinischen Thesaurus Aber das Wasser, das ich rasch zu durchwaten dachte, reichte mir bald an den Hals. Das Bachlein schwoll zum Strome der Strom zum Meere an und die Kuste entschwand dem weiter Schwimmenden aus den Blicken. So hatte ich mich wohl noch lange nicht wieder zuruck an das rettende Ufer gefunden, wenn nicht der Wunsch Ihnen, themer Freund zur richtigen Zeit meine Gabe darzubringen dem Ermatteten neuen Mut gegeben und zur Auf (...) bietung aller Krafte angestachelt hatte. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)