In a publication of 1831 later seen as a milestone in the development of chemistry, Justus Liebig announced a new apparatus for the analysis of organic compounds and provided analytical results for fifteen substances. In this paper we used the detailed descriptions published by Liebig in 1837 to reconstruct his apparatus and methods for hydrogen, carbon and nitrogen analysis. Our replications of his analyses of racemic acid, cinchonine, narcotine, and urea reveal that his two pieces of apparatus give excellent results (...) for carbon and hydrogen content, but erratic results for nitrogen. The results corroborate the assessments of Liebig and his contemporaries, and show that the analytical method for carbon and hydrogen analysis was remarkably accurate. We offer this case, with its convincing replicability, not only to clarify the nature of Liebig's innovations, but also as a new model for understanding broader contested issues in the philosophy and sociology of science. Our analysis suggests that the great shift in science from gentlemanly avocation to professional vocation was tightly linked to laboratory practice, and not just to social networks and context. It also provides the basis for a critique of H. M. Collins's theory of the 'experimenters' regress'. (shrink)

In the course of his chemical investigation of crude platina ore, William Hyde Wollaston in 1802 isolated and characterized the metal palladium. In early 1803, he chose to make known his discovery by offering small samples of the metal for sale through a small shop in London. In the notice advertising the properties of the new metal, no information was given as to its source nor to its discoverer. The unique properties of the metal, and the secrecy surrounding its discovery, (...) led the Irish chemist Richard Chenevix to question the elemental nature of the new metal. His hasty but extensive investigation of the chemical properties of palladium convinced him that it was no more than an alloy of platinum and mercury, and he denounced the discovery as fraudulent. The president of the Royal Society, Joseph Banks, was drawn into the resulting furore, and correspondence between him and Chenevix reveals involved plans to obtain the identity of the palladium discoverer. The controversy is viewed as a significant episode in the continuing debate in the chemical community over the operational definition of a chemical element, and although Chenevix's concern over the growth in the number of new elements was justified, his choice of palladium as a test case was an unfortunate one, for his claim that the metal was an alloy was found to be erroneous. Motives for the actions of both Chenevix and Wollaston are sought, and the judgement that their careers were damaged by the incident is questioned. (shrink)

(1980). William Wollaston, John Johnson and Colombian alluvial platina: A study in restricted industrial enterprise. Annals of Science: Vol. 37, No. 3, pp. 253-268.

SummaryJohn Dalton's atomic theory, with its postulate of compound formation through atom-to-atom combination, brought a new perspective to weight relationships in chemical reactions. A presumed one-to-one combination of atoms A and B to form a simple compound AB allowed Dalton to construct his first table of relative atomic weights from literature analyses of appropriate binary compounds. For such simple binary compounds, the atomic theory had little advantages over affinity theory as an explanation of fixed proportions by weight. For ternary compounds (...) of the form AB2, however, atomic theory made quantitative predictions that were not deducible from affinity theory. Atomic theory required that the weight of B in the compound AB2 be exactly twice that in the compound AB. Dalton, Thomas Thomson and William Hyde Wollaston all published within a few years of each other experimental data that claimed to give the predicted results with the required accuracy. There are nonetheless several experimental barriers to obtaining the desired integral multiple proportions. In this paper I will discuss replication experiments which demonstrate that only Wollaston's results are experimentally reliable. It is likely that such replicability explains why Wollaston's experiments were so influential. (shrink)

In this updated and extended edition of their book, Goodale and Milner explore one of the most extraordinary neurological cases of recent years--one that profoundly changed scientific views on the visual brain. Taking us on a journey into the unconscious brain, this book is a fascinating illustration of the power of the 'unconscious' mind.

Although the mechanics of how the eye works are well understood, debate still exists as to how the complex machinery of the brain interprets neural impulses...

In a world in which everything is reduced "to the play of signs detached from what is signified," Levinas asks a deceptively simple question: Whence, then, comes the urge to question injustice? By seeing the demand for justice for the other—the homeless, the destitute—as a return to morality, Levinas escapes the suspect finality of any ideology.Levinas’s question is one starting point for In Proximity, a collection of seventeen essays by scholars in eighteenth-century literature, philosophy, history, and religion, and their readings (...) of Spinoza, Kant, Goethe, Wordsworth, Behn, Defoe, Fielding, Sterne, Diderot, Laclos, and Mendelssohn. The title In Proximity alone speaks volumes about Levinas’s philosophy and its relevance today. "If it is true that we are, through technology, moving closer and closer to one another," writes editor Melvyn New, then "the importance of proximity and our response to it cannot be overstated." For the contributors to this volume, the question of whether we may, ethically, appropriate the object of study for our own causes has become vital. Levinas asks us to see ourselves, our own reading, "in proximity" to what is not ourselves, not our understanding of the world.The dialogue created among the essays themselves establishes an enormous diversity of texts and ideologies to which Levinas can contribute something of significant value. At a time when the secondary literature on Levinas and his work is expanding explosively, the cross-disciplinary voices gathered together in In Proximity come at precisely the right time. (shrink)

BackgroundDepressive disorders are a common form of psychiatric illness and cause significant disability. Regulation authorities, the medical profession and the public require high safety standards for antidepressants to protect vulnerable psychiatric patients. Ketamine is a dissociative anaesthetic and a derivative of a hallucinogen. Its abuse is a major worldwide public health problem. Ketamine is a scheduled drug and its usage is restricted due to its abuse liability. Recent clinical trials have reported that ketamine use led to rapid antidepressant effects in (...) patients suffering from treatment-resistant depression. However, various flaws in study designs, and possible biased reporting of results, may have influenced those findings. Further analyses of ketamine use are needed to ensure patient safety.DiscussionThe use of ketamine in research and treatment of depressive disorders is controversial. Recently, mental health professionals raised ethical concerns about an ongoing ketamine trial in the UK. Also, a Canadian agency reviewed the existing evidence and did not recommend prescribing ketamine to treat depressive disorders. Findings obtained from tightly controlled research settings cannot be easily translated to clinical practice as substance abuse is commonly comorbid with depressive disorders. An effective antidepressant should reduce severity of depressive symptoms without liability problems. Although the US FDA has not approved the use of ketamine to treat depressive disorders, some psychiatrists offer off-label repeat prescription of ketamine. Prescribing ketamine for treating depressive disorders requires substantial empirical evidence. Clinicians should also consider research findings on ketamine abuse. Depressive disorders can be chronic conditions and the current evidence does not rule out the risk of substance abuse after repeat prescription of ketamine. Off-label ketamine use in treating depressive disorders may breach ethical and moral standards, especially in countries seriously affected by ketamine abuse. This article presents two real-world clinical vignettes which highlight ethical principles and theories, including autonomy, nonmaleficience, fidelity and consequentialism, as related to off-label ketamine use.ConclusionWe urge clinicians to minimise the risk of harming patients by considering the empirical evidence on ketamine properties and attempting all standard antidepressant therapies before considering the off-label use of ketamine. (shrink)

Vision, more than any other sense, dominates our mental life. Our visual experience is just so rich, so detailed, that we can hardly distinguish that experience from the world itself. Even when we just think about the world and don't look at it directly, we can't help but 'imagine' what it looks like. We think of 'seeing' as being a conscious activity--we direct our eyes, we choose what we look at, we register what we are seeing. The series of events (...) described in this book radically altered this attitude towards vision. This book describes one of the most extraordinary neurological cases of recent years--one that profoundly changed scientific views on consciousness. It is the story of Dee Fletcher--a woman recently blinded--who became the subject of a series of scientific studies. As events unfolded, Milner and Goodale found that Dee wasn't in fact blind--she just didn't know that she could see. Taking us on a journey into the unconscious brain, the two scientists who made this incredible discovery tell the amazing story of their work, and the surprising conclusion they were forced to reach. Written to be accessible to students and popular science readers, this book is a fascinating illustration of the power of the 'unconscious' mind. (shrink)

This sociological analysis of how we "play the morality game" sheds light on the informal rules governing our moral decisions.

When prophesy fails -- The origins of the dream -- Broken promises -- Liberal contradictions -- Ties that bind -- Back to the future -- The professionalized ideal -- Post-liberalism.

A critical edition of the correspondence between Astell and John Norris of Bemerton, which had a profound significance in 18th-century intellectual and religious circles and which represents a crucial step in the development of Norris and Astell's opposition to John Locke.

It is our contention that the concept of planning in Glover's model is too broadly defined, encompassing both action/goal selection and the programming of the constituent movements required to acquire the goal. We argue that this monolithic view of planning is untenable on neuropsychological, neurophysiological, and behavioural grounds. The evidence demands instead that a distinction be made between action planning and the specification of the initial kinematic parameters, with the former depending on processing in the ventral stream and the latter (...) on processing in the dorsal stream. (shrink)

O'Regan & Noë run into some difficulty in trying to reconcile their “seeing as acting” proposal with the perception and action account of the functions of the two streams of visual projections in the primate cerebral cortex. I suggest that part of the problem is their reluctance to acknowledge that the mechanisms in the ventral stream may play a more critical role in visual awareness and qualia than mechanisms in the dorsal stream.

The McCollough effect, an orientation-contingent color aftereffect, has been known for over 30 years and, like other aftereffects, has been taken as a means of probing the brain's operations psychophysically. In this paper, we review psychophysical, neuropsychological, and neuroimaging studies of the McCollough effect. Much of the evidence suggests that the McCollough effect depends on neural mechanisms that are located early in the cortical visual pathways, probably in V1. We also review evidence showing that the aftereffect can be induced without (...) conscious perception of the induction patterns. Based on these two lines of evidence, it is argued that our conscious visual experience of the world arises in the cortical visual system beyond V1. (shrink)

Dijkerman & de Haan (D&dH) propose a convincing model of somatosensory organization that is inspired by earlier perception-action models of the visual system. In this commentary, we suggest that the dorsal and ventral visual streams both contribute to the control of action, but in different ways. Using the example of grip and load force calibration, we show how the ventral stream can invoke stored information about the material properties of objects originally derived from the somatosensory system.

Visual systems first evolved not to enable animals to perceive the world, but to provide distal sensory control of their movements. Conscious sight is a relatively recent invention, but its emergence has enabled organisms such as humans and other primates to carry out complex cognitive operations on a detailed perceptual representation of the world. The two streams of visual processing that have been identified in the primate cerebral cortex are a reflection of these two functions of vision. The dorsal 'action' (...) stream projecting from early visual areas to the posterior parietal cortex mediates the visual control of skilled motor acts. The ventral 'perceptual' stream projecting from early visual areas to the temporal lobe provides a perceptual experience of the world beyond our bodies. Both streams work together in the production of adaptive behavior. (shrink)