We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

By questioning the validity of some of our basic concepts, such as space, object, and causality, quantum physics contributes quite decisively to the dramatic changes now taking place in our world picture. Veiled Reality provides a detailed view of the reasons why such a questioning arises, a survey of the corresponding conceptual and theoretical problems, and a comprehensive, up-to-date account, useful to scientists and epistemologists alike, of the various ways present-day physicists tackle these problems.The book deals with the E.P.R. reality (...) criterion, local causality, and quantum measurement including relativistic quantum collapse, decoherence theories, consistent histories approaches, and ontologically interpretable theories. Questions bearing on the connection between counterfactuality and realism, intersubjective agreement, and limits of the bearing of the verbs “to have” and “to be,” follow naturally from the analysis and are thoroughly examined. Finally, distinguishing between empirical reality and a veiled independent reality whose only knowable features are structural yields a clue to a plausible interpretation of current physics.Accessible to readers with only very elementary background in modern physics, Veiled Reality offers nonspecialists, including students in physics and philosophy, easy access to basic problems in the foundation of physics. (shrink)

А. D. Emelianenko. Existentialist component of P. Tillich’s Protestant theology. The article deals with the specifics of the application of well-known Protestant theologian Paul Tillich postulates of existentialist and existentialist symbolism in the practice of creating his three-volume work 'Systematic Theology'. It is emphasized that these postulates play in the teaching of P. Tillich 'auxiliary', and mainly 'educate' rather than a system-role, that they played in the existential analytics by M. Heidegger, or the philosophy of Karl Jaspers.

Originally published in 1936, this book presents the ancient Greek text of the paraphrases and quotations of Zeno's philosophical arguments, together with a facing-page English translation and editorial commentary. Detailed notes are incorporated throughout and a bibliography is also included. This book will be of value to anyone with an interest in Zeno and ancient philosophy.

The subject of the present inquiry is the approach-to-the-truth research, which started with the publication of Sir Karl Popper's Conjectures and Refutations. In the decade before this publication, Popper fiercely attacked the ideas of Rudolf Carnap about confirmation and induction; and ten years later, in the famous tenth chapter of Conjectures he introduced his own ideas about scientific progress and verisimilitude. Abhorring inductivism for its apprecia tion of logical weakness rather than strength, Popper tried to show that fallibilism could serve (...) the purpose of approach to the truth. To substantiate this idea he formalized the common sense intuition about preferences, that is: B is to be preferred to A if B has more advantages andfewer drawbacks than A. In 1974, however, David Millerand Pavel Tichy proved that Popper's formal explication could not be used to compare false theories. Subsequently, many researchers proposed alternatives or tried to improve Popper's original definition. (shrink)

The path of those who would approach the study of Bentham's writings on Evidence has been considerably smoothed by the recent publication of William Twining's work on the evidence theories of Bentham and Wigmore. The material on evidence is now being tackled by the Bentham Project. It presents no easy task. The central core, The Rationale of Judicial Evidence, edited and published by John Stuart Mill in 1827, exists only in the printed version, the MSS from which Mill worked having (...) disappeared. But a substantial body of related material which survives has yet to be thoroughly investigated, though William Twining has made a gallant start. A new edition of the work hitherto known as ‘An Introductory View of the Rationale of Evidence’, first printed in full in the Bowring edition of the Works of Jeremy Bentham is in preparation. The first fruits of this endeavour is that the title of that work as it should appear in due course in the new Collected Works will be Introduction to the Rationale of Evidence: An Introductory View for the Use of Lawyers as well as Non-lawyers, the title in fact given to the work by Bentham. It is intended that what follows should similarly be of use to non-lawyers as well as lawyers. (shrink)

This selection of D. H. Mellor's work demonstrates the wide ranging originality of his work. It gathers together sixteen major papers on related topics. Together they form a complete modern metaphysics. The first five papers are on aspects of the mind: on our 'selves', their supposed subjectivity and how we refer to them, on the nature of conscious belief and on computational and physicalist theories of the mind. The next five papers deal with dispositions, natural kinds, laws of nature and (...) how they involve natural necessity, universals and objective chances, and the relation between properties and predicates. Then follow three papers about the relations between time, change and causation, the nature of individual causes and effects and of the causal relation between them, and how causation depends on chance. The last three papers discuss the relation between chance and degrees of belief, give a solution to the problem of induction, and argue for an objective interpretation of decision theory. (shrink)

While by no means intending to discount the importance of historical circumstances in motivating Bodin to change his definition of sovereignty, I suggest an alternative way for understanding this change. I study Bodin's writings in the intellectual context of his times, and argue that he proposed his absolutist theory of sovereignty as a way to preserve a minimal point of universal and immutable order for politics in a social world that he perceived as highly disorderly, corrupt and changing. I begin (...) by locating Bodin's thinking within the intellectual context of his times. Like many other sceptics of his generation, including Montaigne, Pasquier and Le Roy, Bodin no longer believed that human laws and society very closely reflected the immutable principles of the divine and natural orders, but instead argued that human affairs were generally detached from these orders and were characterized by a high degree of particularity, variability and mutability. However, in contrast to these more sceptical writers, he was unwilling to accept the possibility that human political order could subsist without some divine and natural foundation. In both the Methodus and Republique he therefore set out to identify a new universal foundation for human laws and society anchored in the divine and natural orders. (shrink)

In this essay, I claim that certain passages in Book IV of Benedict de Spinoza’s Ethics suggest a novel version of what is known as metaethical constructivism. The constructivist interpretation emerges in the course of attempting to resolve a tension between Spinoza’s apparent ethical egoism and some remarks he makes about the efficacy of collaborating with the right partners when attempting to promote our individual self-interest . Though Spinoza maintains that individuals necessarily aim to promote their self-interest, I argue that (...) Spinoza has an atypical conception of self that allows the interests of other people to be partially constitutive of one's own self-interest. In this way, Spinoza can account for the rationality of concern for the interests of others . This interpretation attributes to Spinoza a form of constructivism that differs in important ways from contemporary Humean and Kantian constructivisms and which can in principle be detached from Spinoza’s particular metaphysical commitments in order to yield a third general category of constructivist view . Though my treatment is necessarily brief, it is my hope that it can serve both to motivate a constructivist reading of Spinoza and, perhaps even more crucially, to suggest a Spinozistic variety of constructivism as a live theoretical option in metaethics. (shrink)

Salomon Maimon, a Lithuanian born philosophical autodidact who emigrated to Germany in the late eighteenth century, plays an increasingly important role in the research of classical German philosop...

A theory of true observation is developed as a generalization of the method of inter-observer agreement that scientists use to determine the objectivity and reliability of observations. A true observation is defined as a statement included in a set of statements in which there is statistical dependence and perfect agreement between the statements made by a universe of experimentally independent persons. Meaningfulness--the existence of an objective referent--for each form of statement included in the set is inferred from statistical dependence, correct (...) meaning within the universe of observers from the absence of disagreement. In this theory truth is inferred from a spatio-temporal pattern of statements as behavior rather than from the traditional correspondence between observation and object or logical relationships among statements. (shrink)