Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

The author argues the following hypothesis: the medical clinic is an experimental practice, in the sense given to this term by Claude Bernard, and the clinic is its specific laboratory. Its object is not the disease, but the patient. Careful examination of the clinic attests to its very close proximity to the experimental method, and the comparison also raises a number of difficulties. The main obstacle arises from the specificity of medicine, which involves treating individual human subjects whose words cannot (...) be suppressed. Its main challenge is to combine a linguistic practice with an experimental method. (shrink)

The literature on organizational ethics has paved the way for a situated and intersubjective understanding of ethics through caring practices. In this article, we try to extend this perspective by looking beyond the interactions of caregivers among themselves or with care seekers to reveal ethics as the ongoing collective accomplishment of a variety of actors. We do so by mobilizing Strauss’s theoretical perspective of articulation work in the context of healthcare. Based on an ethnography, we show how actors of care (...) (e.g., nurses, caregivers, or doctors) operate within care arrangements that need to be frequently rearticulated to face ethical threats and protect their patients’ well-being. We distinguish three types of rearticulation corresponding to different degrees of rearticulation, individual actor stance, and specific ways of working things out. We discuss their implications for the maintenance of organizational ethics. (shrink)

La question des frontières des arts plastiques et littéraires contemporains peut être approchée à travers l'exemple de la géopoétique de Kenneth White. Renonçant à réduire l'art à la production d'une représentation dominée par le plaisir de la vue, le mouvement esthétique de la géopoétique cherche à faire de la création artistique un geste de participation aux matières de la terre sur fond d'une expérience polysensorielle où la marche et le nomadisme constituent des explorations d'un proto-monde. L'oeuvre écrite ou plastique est (...) destinée à conserver des fragments et traces de cette aventure sensible, ouvrant ainsi la voie à une rencontre qui n'est plus un spectacle mais une expérience quasi chamanique. Reste à savoir dans quelle mesure on peut s'émanciper totalement de la représentation pour accéder à une auto-présentation du cosmos dont l'artiste serait le médium. (shrink)

The purpose of the article is to show how the questions of anomality and animality belong together in phenomenology. The figure of the human animal serves as the guideline of the study, namely the figure of a person who is not considered as similar to myself in the frame of a Husserlian characterization of normality. Husserl’s thinking is analyzed with respect to the problem of an intersubjective co-constitution of a common world. It is shown that Husserl only accepts animality and (...) anomality within the restrictive perspective of a so-called normal humanity, that of the adult man, healthy, reasonable and European. However, he constantly strives to include the anomality and animality into humanity as well, an intention that distinguishes him from Heidegger. Heidegger radicalized the question with respect to race, which serves him as a guideline for thinking the very own of the human being. Defending a thinking of exclusion, Heidegger refuses to animals as well as to anomals all right of citizenship in the community of human beings. The article ends by proposing to overcome this duality between an inclusive thinking and an exclusive thinking. (shrink)

Résumé André Gorz n’avait pas seulement une conception politique de l’écologie qui nous relie à l’histoire et aux luttes sociales, il proposait une véritable alternative écologiste au service de l’autonomie individuelle. S’il a pu paraître trahir son camp plusieurs fois, c’était à chaque fois pour y être plus fidèle malgré tout. Sa critique de l’aliénation du travail l’a mené à vouloir sortir du productivisme salarial grâce au revenu garanti et des « cercles de coopération », avant peut-être le règne de (...) la gratuité dans l’économie immatérielle... (shrink)

Issu de la thèse de l'auteur soutenue en 1987, cet ouvrage a pour visée de redéfinir l'anthropologie, en dissipant le malentendu instauré par le modèle galiléen de scientificité appliqué aux sciences sociales afin d'opérer un retour à la fondation historique de la discipline dans l'epistêmê politikê des anciens Grecs. Trois voies d'accès sont parcourues : G. Dumézil, M. Heidegger et G. Guillaume. ©Electre 2018.

In one of the first attempts at autobiography, Rousseau1s Confessions not only retells the facts of the author1s life, but reveals his innermost feelings & details the strengths & weaknesses of his character.

John Locke is recognized as a great and original thinker, but the attention paid to his philosophy has overshadowed the many other facets of this man's accomplishments in fields such as medicine, botany, economics and literature. The author has gathered together in A Locke Miscellany many unknown essays, articles and descriptive vignettes that offer new views of Locke - both as a multi-talented individual and as an ordinary human being, forced at one time to live in exile.

In Being and Nothingness (1943), Sartre explains love as a strategy for achieving control over "being-for-others," the objectified aspect of the self-imposed by others' defining looks. Two contemporaneous fictions by Sartre, The Room (1939) and Dirty Hands (1948), expand the notions of love and of being-for-others in surprising directions. Dirty Hands shows the creative, productive potential of being-for-others: Hugo's reliance on the other for his self-definition paradoxically generates his decisive embrace of being for-itself. The Room dramatizes the role of the (...) family in constituting a child's subjectivity: Eve's family situation explains her ontological imprisonment in the dimension of being-for-others. The two stories' tolerant vision of the complex social and psychological reasons for adopting being-for-others as one's dominant modality contrasts with Sartre's rigorous critique of reliance on being-for-others as a form of bad faith in Being and Nothingness. The fictions' enlarged perspective on human love and on being-for-others provides a framework for complicating and critiquing the ontological categories presented in Being and Nothingness. (shrink)

Baudrillard's bewildering thesis, a bold extrapolation on Ferdinand de Saussure's general theory of general linguistics, is in fact a clinical vision of contemporary consumer societies where signs don't refer anymore to anything except themselves. They all are generated by the matrix. Simulations never existed as a book before it was "translated" into English. Actually it came from two different bookCovers written at different times by Jean Baudrillard. The first part of Simulations, and most provocative because it made a fiction (...) of theory, was "The Procession of Simulacra." It had first been published in Simulacre et Simulations. The second part, written much earlier and in a more academic mode, came from L'Echange Symbolique et la Mort. It was a half-earnest, half-parodical attempt to "historicize" his own conceit by providing it with some kind of genealogy of the three orders of appearance: the Counterfeit attached to the classical period; Production for the industrial era; and Simulation, controlled by the code. It was Baudrillard's version of Foucault's Order of Things and his ironical commentary of the history of truth. The book opens on a quote from Ecclesiastes asserting flatly that "the simulacrum is true." It was certainly true in Baudrillard's book, but otherwise apocryphal.One of the most influential essays of the 20th century, Simulations was put together in 1983 in order to be published as the first little black book of Semiotext's new Foreign Agents Series. Baudrillard's bewildering thesis, a bold extrapolation on Ferdinand de Saussure's general theory of general linguistics, was in fact a clinical vision of contemporary consumer societies where signs don't refer anymore to anything except themselves. They all are generated by the matrix.In effect Baudrillard's essay was upholding the only reality there was in a world that keeps hiding the fact that it has none. Simulacrum is its own pure simulacrum and the simulacrum is true. In his celebrated analysis of Disneyland, Baudrillard demonstrates that its childish imaginary is neither true nor false, it is there to make us believe that the rest of America is real, when in fact America is a Disneyland. It is of the order of the hyper-real and of simulation. Few people at the time realized that Baudrillard's simulacrum itself wasn't a thing, but a "deterrence machine," just like Disneyland, meant to reveal the fact that the real is no longer real and illusion no longer possible. But the more impossible the illusion of reality becomes, the more impossible it is to separate true from false and the real from its artificial resurrection, the more panic-stricken the production of the real is. (shrink)

La comprensión del conocimiento como sistema en el Tratado de la naturaleza humana de David Hume reconoce tres aspectos: primero, el conocimiento implica su distancia de la idea de sustancia y de ideas generales abstractas. Segundo, el conocimiento comprende la conexión entre impresiones e ideas. El enlace de nuestras impresiones e ideas surge del principio de asociación el cual ordena y reconfigura el conocimiento en virtud de la atracción, conexión articulada por las facultades de la memoria y la imaginación. Tercero, (...) el conocimiento constituye un sistema constituido por la reiteración de hábitos y costumbres configurados por el principio de asociación desde la relación integrada de impresiones e ideas. (shrink)

Begriffsschrift, a formula language, modeled upon that of arithmetic, for pure thought (1879), by G. Frege.--Some metamathematical results on completeness and consistency; On formally undecidable propositions of Principia mathematica and related systems I; and On completeness and consistency (1930b, 1931, and 1931a), by K. Gödel.--Bibliography (p. [111]-116).

We analyse the behaviour of definite descriptions and proper names terms in mathematical logic. We show that in formal arithmetic, wether some axioms are fixed or not, proper names cannot be considered rigid designators and have the same behaviour as definite descriptions. In set theory, sometimes two names for the same object are introduced. It seems that this can be explained by the notion of meaning. The meaning of such proper names can be considered as fuzzy sets of equivalent co-designative (...) definite descriptions and their references as sets of all equivalent co-designative definite descriptions. (shrink)

‘I should like to show here that the Ego is neither formally or materially in consciousness: it is outside, in the world.’ _Jean-Paul Sartre _ _The Transcendence of the Ego_ is one of Jean-Paul Sartre's earliest philosophical publications and essential for understanding the trajectory of his work as a whole. When it first appeared in France in 1937 Sartre was still largely unknown, working as a school teacher in a provincial French town. Attacking prevailing philosophical theories head on, Sartre (...) offers a brilliant and radical account of the self as a product of consciousness, situated in the world. He introduces many of the themes central to his major work, Being and Nothingness: the nature of consciousness, the problem of self-knowledge, other minds, and anguish. This translation includes a thorough and illuminating introduction by Sarah Richmond, placing Sartre's essay in its philosophical and historical context. _Jean-Paul Sartre_. The foremost French thinker and writer of the early post-war years. His books, which include _Being and Nothingness, Nausea, The Age of Reason _and _No Exit_ have exerted enormous influence in philosophy, literature, politics and drama. __. (shrink)

‘No matter how long I may look at an image, I shall never find anything in it but what I put there. It is in this fact that we find the distinction between an image and a perception.' - Jean-Paul Sartre L’Imagination was published in 1936 when Jean-Paul Sartre was thirty years old. Long out of print, this is the first English translation in many years. The Imagination is Sartre’s first full philosophical work, presenting some of the basic (...) arguments concerning phenomenology, consciousness and intentionality that were to later appear in his master works and be so influential in the course of twentieth-century philosophy. Sartre begins by criticising philosophical theories of the imagination, particularly those of Descartes, Leibniz and Hume, before establishing his central thesis. Imagination does not involve the perception of ‘mental images’ in any literal sense, Sartre argues, yet reveals some of the fundamental capacities of consciousness. He then reviews psychological theories of the imagination, including a fascinating discussion of the work of Henri Bergson. Sartre argues that the ‘classical conception’ is fundamentally flawed because it begins by conceiving of the imagination as being like perception and then seeks, in vain, to re-establish the difference between the two. Sartre concludes with an important chapter on Husserl’s theory of the imagination which, despite sharing the flaws of earlier approaches, signals a new phenomenological way forward in understanding the imagination. The Imagination is essential reading for anyone interested in the philosophy of Jean-Paul Sartre, phenomenology, and the history of twentieth-century philosophy. This new translation includes a helpful historical and philosophical introduction by Kenneth Williford and David Rudrauf. Also included is Maurice Merleau-Ponty’s important review of L’Imagination upon its publication in French in 1936. Translated by Kenneth Williford and David Rudrauf. (shrink)

Although written fairly early in his career, in 1939, _Sketch for a Theory of the Emotions_ is considered to be one of Jean-Paul Sartre's most important pieces of writing. It not only anticipates but argues many of the ideas to be found in his famous _Being and Nothingness._ By subjecting the emotion theories of his day to critical analysis, Sartre opened up the world of psychology to new and creative ways of interpreting feelings. Emotions are intentional and strategic ways (...) of coping with difficult situations. We choose to utilize them, _we_ control _them_, and not the other way around, as has been posited elsewhere. Emotions are not fixed; they have no essence and indeed are subject to rapid fluctuations and about-turns. For its witty approach alone, Sartre's _Sketch for a Theory of the Emotions_ can be enjoyed at length. It is a dazzling journey to one of the more intriguing theories of our time. (shrink)

O presente trabalho pretende investigar as veredas da estética da crueldade construídas no romance Venenos de Deus, remédios do Diabo, de Mia Couto, a partir da hibridização, desterriorização e dos percursos das identidades diaspóricas criadas e fragmentadas nos discursos existentes na Vila Cacimba, cenário que documenta a história de Bartolomeu Sozinho, sua esposa Dona Munda, o médico Sidónio Rosa e a mulher que este ama e busca reencontrar em Vila Cacimba, Deolinda. Nesse cenário é que os textos acerca da língua (...) enquanto colonização, da suposta epidemia enquanto multietnicidade, da diáspora, das miscigenações vistas com muita resistência, e certas inversões de significados tidos como maniqueísmos e tabus, como sugere o próprio título Venenos de Deus, remédios do Diabo, desvelam estéticas da crueldade nos cruzamentos de fronteiras e nas fronteiras que se cruzam em discursos identitários. (shrink)

La 4e de couverture indique : "Il faut revenir sur le concept de destruction créatrice formulé en 1942 par Joseph Schumpeter. Ce concept a eu une postérité extraordinaire. Aujourd'hui encore il fait office d'évidence pour les élites économiques et politiques de la mondialisation. Mais, à bien y réfléchir, il s'agit d'une ineptie. Comment a-t-on pu penser, durant plusieurs décennies, qu'une opération de destruction pouvait être créatrice? C'est cette fausse évidence qui explique la myopie écologique et anthropologiquéconomie mondialisée au début du (...) XXIe siècle. Il est indispensable d'enterrer définitivement l'illusion de la destruction créatrice. Mais pour cela il faut d'abord identifier toutes les sources de la culture occidentale auxquelles ce mythe vient s'abreuver. Mettre à jour les tenants et aboutissants de ce concept, pour en désamorcer la puissance ravageuse, est sans doute la première étape nécessaire à la reconstruction d'un projet de civilisation réellement soutenable sur le long terme.". (shrink)

O diálogo Fedro apresenta um difícil problema de interpretação para os leitores de Platão: como unificar as duas principais temáticas discutidas no texto – a do amor e a da arte dos discursos. Em trabalho recente, o comentador italiano Franco Trabattoni propõe como chave de leitura a ideia de que Platão vincula os temas do amor e da arte dos discursos por meio de uma tese acerca da natureza do pensamento e do discurso filosófico. Segundo Trabattoni, a tese em questão (...) implica um reconhecimento das limitações do conhecimento filosófico em sua pretensão de acesso à verdade. Ao longo deste artigo será argumentado que a leitura de Trabattoni, ao omitir aspectos importantes do texto de Platão, é inadequada. (shrink)

The relationship between the imaginary and the political has many aspects and it is not possible to address them all in this paper. We will choose to focus on the relationship between myth and national idea, on the one hand, and myth and political ideologies on the other. Before considering these questions, we will first present the work of Gilbert Durand from his articles “Le social et le mythique” and “La cité et les divisions du royaume” ; then we will (...) focus on the study of the two axes announced. This paper thus emphasizes the importance of the imaginary in politics and society. We will conclude with the current development, particularly in Western Europe, where myth no longer plays its unifying role for society. (shrink)