Due to the potential ethical and psychological implications of screening, and especially inregard of screening on children without available and acceptable therapeutic measures, there is a common view that such procedures are not advisable. As part of an independent research- and bioethical case study, our aim was therefore to explore and describe bioethical issues among a representative sample of participant families (n = 17,055 children) in the ABIS (All Babies In South-east Sweden) research screening for Type 1 diabetes (IDDM).The primary (...) aim is the identification of risk factors important for the development of diabetes and other multifactorial immune-mediated diseases. Four hundred, randomly chosen, participant mothers were asked to complete a questionnaire exploring issues of information, informed consent, bio-material, confidentiality and autonomy, and of prevention/intervention. 293 completed the questionnaire, resulting in a response rate of 73.3%. The majority of questions had the form of 6-point Likert-type response scales (1–6).We found that the majority of respondents felt calm in regard of samples and written material, and also concerning the possibility of their child in the future being identified as having high risk of developing Type 1 diabetes. An important finding concerning access and control of mainly biological data was indicated, with the respondents expressing concern for potential future use. We believe our findings indicate that this kind of empirical studies can substantially contribute to our understanding of bioethical issues of medical research involving genetics. Issues, such as safeguards ensuring theethical criteria of autonomy and respect, were emphasised by our respondents. We believe theissues brought up may promote further discussion, and do suggest issues for consideration by, among others, researchers, bioethicists and Institutional Review Boards. (shrink)

Based on extensive clinical questionnaire data, this paper explores the relation between research subjects’ self-assessed understanding and actual knowledge of a large-scale predictive screening study, and its implications for the proper handling of information and consent routines in longitudinal studies. The intitial data show that low self-assessed understanding among participants was correlated with limited knowledge, concern over participation and collected samples, less satisfaction with information, and feeling passive or negative towards the study. Among those reporting high understanding, a non-negligible number (...) displayed a lack of knowledge regarding central aspects of the study. Regarding high assessed understanding, the multivariate analysis identified the main predictor variables to be knowledge, having a positive attitude towards participation and the study itself, being satisfied with information, having a stable psychosocial background and feeling calm regarding the handling of samples. These findings indicate that to evaluate participants' understanding through self-assessment may not be reliable method. Self-assessed understanding may rather be a good indicator of general attitudes than a tool for analysing content. The data also show that actual understanding varies considerably among participants, suggesting that more effort needs to be put into adjusting the information to the needs of different subgroups. It is argued that when doing this, researchers in longitudinal studies must be careful not to exhaust participants with excessive information that they do not want and that may cause them to drop out. The ethical relevance of obtaining repeated consents in longitudinal research is discussed. (shrink)

The knowledge of an object under observation will have no concrete meaning unless we can work out a logical model the similarities of which are known in relation to the analysed structures. The logical model, when dealing with complex structures, is drawn out by similarity starting from an analogical model worked out in relating local dimensions in the object to physical dimensions of a different nature which restrict the number of variables and can be arranged and modified as required.Any operating (...) similarity and behaviour comparisons come actually down to an apparent functional analogy. The difference between the thin structure of the natural and artificial systems makes it illusive to hope that a strict isomorphism between these two fields may thus be sorted out. However, the fact of achieving analogical models widens our knowledge and shows new possibilities to the human creative mind. (shrink)

The author discusses a number of perspectives concerning the politicization of public administration. Firstly, he argues that it be hardlyadequate to confine the concept of politicization to the increasing penetration of political par ties into the sphere of public administration. The politicization of public administration refers to more intensive patternsof bureaucratie polities as well. Secondly, he warns against a too easy acceptance of the idea that a politicization of public administration has taken place. One might say that what is aften (...) considered as a growing penetration of political factors into the administrative sphere actually pertains to the increasing awareness and visibility regarding the frequent and intensive relations between polities and administration. Same of the theoretical perspectives are applied to the subject of administrative reorganization. (shrink)

Emotions and feelings affect economic systems. This is well known as e.g. stock markets tend to react to sudden political and emotional events. However, the link between emotions, consciousness, and economic systems at a deeper level than the aggregate resulting action of people at large is yet to be explored and understood. In this paper, a first building block is presented as it is shown that a variable derived from the random numbers obtained by the Global Consciousness Project is statistically (...) related to various well-known stock market index returns. The relationship is shown to be non-linear and that variations in the variable, to some extent, predate the underlying trade. The results presented are found to be robust and qualitatively unaffected by the removal of outliers. Apart from the pure economic value of these findings, the results have truly baffling implications. This is the case as they confirm some previous unorthodox research suggesting that consciousness stretches out beyond the locally confined space of our heads and that consciousness can affect hardwaregenerated random numbers at a distance. Thus, these results put doubt on the existing paradigm with regards to consciousness and highlight the need for further research. (shrink)