The Metaphysical Club, a gathering of intellectuals in the 1870s associated with Harvard, is widely recognized as the crucible where pragmatism, America's distinctively original philosophy, was refined and proclaimed. Louis Menand's bestseller about the group was a dramatic publishing success. However, only three actual members - Oliver Wendell Holmes Jr., Charles S. Peirce, and William James - appear in this book, alongside other thinkers such as John Dewey who were never in the Club. The Real Metaphysical Club (...) tells the full story of how this influential group shifted the course of philosophy in America. In addition to pioneering pragmatism, the group explored radical empiricism and idealism, and formulated personalism and process philosophy, equally important developments. This volume contains thirty-seven important writings dating from 1870 to 1885 by the real members of the Metaphysical Club. The first section centers on pragmatism and science; the second part collects writings of the lawyers; and the third part covers idealist and personalist philosophers. Many of these writings have never been reprinted before, and nothing like this impressive collection has ever been attempted. A general introduction provides a narrative history, and the editors' three introductions to the volume's sections vividly bring to life the intense meetings, sustained debates, and pioneering thought from the Metaphysical Club. (shrink)

SUMMARYHow do glaciers move? This seemingly straightforward question provided the backdrop for a heated debate between the physicists John Tyndall (1820–1893) and James David Forbes (1809–1868) in the late 1850s and early 1860s. Forbes described the motion of glaciers as that of a viscous fluid. After visiting the Alps, Tyndall proposed an alternative theory that combined fracture and regelation. The glacial controversy ensued. Yet the debate was never simply about whether glaciers moved like honey, or if they moved by continuously (...) breaking and re-attaching. This paper shows that the glacial controversy formed an important prelude to the strategies used by the X-Club in reforming science and establishing cultural authority. There was a central difference in the way Forbes and Tyndall presented their scientific arguments. Tyndall and his allies used the changes in the periodical press as part of their strategy for establishing and maintaining cultural and scientific authority. By contrast, Forbes and his supporters, including the North British physicists, were not as quick to make use of this new medium. This paper, therefore, examines in detail the significance of these two publishing strategies in shaping the nature and results of the glacial controversy. (shrink)

A summary of revisionist accounts of the contextual meaning of "professional" and "amateur," as applied to the mid-Victorian X Club, is followed by an analysis of the liberal goals and inner tensions of this coalition of gentlemen specialists and government teachers. The changing status of amateurs is appraised, as are the new sites for the emerging laboratory discipline of "biology." Various historiographical strategies for recovering the women's role are considered. The relationship of science journalism to professionalization, and the constructive (...) engagement of X Club publicists with their empowering audiences, are discussed. Finally, the article assesses how far the content and boundary closure of "biology," forged by Thomas Henry Huxley, were related to 'professional' and political goals. Pure biology's social and medical roots are examined, and the way inter-professional and wider Darwinian conflicts resulted in a new lexicon of words for the X Clubbers around 1870, including "evolution" and "agnosticism," as well as "biology." Biology's role in the forging of British national identity is discussed, as are its relationship to the social strategies of liberal, Dissenting, and industrial groups in the country, whose authority sustained the new laboratory rhetoric. (shrink)

In his book on P max [7], Woodin presents a collection of partial orders whose extensions satisfy strong club guessing principles on ω | . In this paper we employ one of the techniques from this book to produce P max variations which separate various club guessing principles. The principle (+) and its variants are weak guessing principles which were first considered by the second author [4] while studying games of length ω | . It was shown in (...) [1] that the Continuum Hypothesis does not imply (+) and that (+) does not imply the existence of a club guessing sequence on ω | . In this paper we give an alternate proof of the second of these results, using Woodin's P max technology, showing that a strengthening of (+) does not imply a weakening of club guessing known as the Interval Hitting Principle. The main technique in this paper, in addition to the standard P m a x machinery, is the use of condensation principles to build suitable iterations. (shrink)

Given any subset A of ω1 there is a proper partial order which forces that the predicate xA and the predicate xω1A can be expressed by -provably incompatible Σ3 formulas over the structure Hω2,,NSω1. Also, if there is an inaccessible cardinal, then there is a proper partial order which forces the existence of a well-order of Hω2 definable over Hω2,,NSω1 by a provably antisymmetric Σ3 formula with two free variables. The proofs of these results involve a technique for manipulating the (...) guessing properties of club-sequences defined on stationary subsets of ω1 at will in such a way that the Σ3 theory of Hω2,,NSω1 with countable ordinals as parameters is forced to code a prescribed subset of ω1. On the other hand, using theorems due to Woodin it can be shown that, in the presence of sufficiently strong large cardinals, the above results are close to optimal from the point of view of the Levy hierarchy. (shrink)

We develop the theory of Cκ, λi, a strongly normal filter over [MATHEMATICAL SCRIPT CAPITAL P]κλ for Mahlo κ. We prove a minimality result, showing that any strongly normal filter containing {x ∈ [MATHEMATICAL SCRIPT CAPITAL P]κλ: |x | = |x ∩ κ | and |x | is inaccessible} also contains Cκ, λi. We also show that functions can be used to obtain a basis for Cκ, λi.

During the 1840s and the 1850s botanist Joseph Hooker developed distinct notions about the proper characteristics of a professional man of science. While he never articulated these ideas publicly as a coherent agenda, he did share his opinions openly in letters to family and colleagues; this private communication gives essential insight into his and his X-Club colleagues' public activities. The core aspiration of Hooker's professionalization was to consolidate men of science into a dutiful and centralized community dedicated to national (...) well-being. The nation in turn owed the scientific community for its ministration. When the government bestowed funds and status on men of science it was rewarding science -- not purchasing it. His proposed reforms were piecemeal, immediate, and above all practical. He harbored no taste for vast millenarian transformation, and rested his conception of scientific professionalism upon a respectable High Victorian foundation of patronage and pillars of duty, reciprocity, intimacy, and inequality. The process of professionalization he envisioned was as much shrewd compromise between existing interests as a vindication of principle. His power and prestige from the mid-1850s onward gave him considerable ability to carry out his reform program, although his general success did occasion some undesired consequences for the status of natural-history pursuits. (shrink)

Henry Charlton Bastian's support for spontaneous generation is shown to have developed from his commitment to the new evolutionary science of Darwin, Spencer, Huxley and Tyndall. Tracing Bastian's early career development shows that he was one of the most talented rising young stars among the Darwinians in the 1860s. His argument for a logically necessary link between evolution and spontaneous generation was widely believed among those sympathetic to Darwin's ideas. Spontaneous generation implied materialism to many, however, and it had associations (...) in Britain with radical politics and amateur science. Huxley and the X Club were trying to create a public posture of Darwinism that kept it at arm's length from those negative associations. Thus, the conflict that developed when Huxley and the X Club opposed Bastian was at least as much about factional in-fighting among the Darwinians as it was about the experiments under dispute. Huxley's strategy to defeat Bastian and define his position as "non-Darwinian" contributed significantly to the shaping of Huxley's famous address "Biogenesis and Abiogenesis." Rhetorically separating Darwinism from Bastian was thus responsible for Huxley's first clear public statement that a naturalistic origin of life was compatible with Darwin's ideas, but only in the earth's distant past. The final separation of the discourse on the meaning of Brownian movement and "active molecules" from any possible link with spontaneous generation also grew out of Huxley's strategy to defeat Bastian. Clashes between Bastian and the X Club are described at the BAAS, the Royal Society, and in the pages of "Nature" and other journals. (shrink)

During the decades following the publication of Darwin's Origin of species in 1859, religious belief in England and in particular the Church of England experienced some of the most intense criticism in its history. The early 1860s saw the appearance of Lyell's Evidence of the antiquity of man , Tylor's research on the early history of mankind , Renan's Vie de Jésus , Pius IX's encyclical, Quanta cura, and the accompanying Syllabus errarum, John Henry Newman's Apologia , and Swinburne's notorious (...) Atalanta in Calydon ; it was in this period also that Arthur Stanley was appointed Dean of Westminster, and that Bills were introduced in Parliament to amend or repeal the ‘Test Acts’ as they affected universities. They were the years that witnessed Lyell present the case for geology at the British Association at Bath , the first meeting of the X-Club , and the award of the Royal Society's Copley Medal to Charles Darwin. These were the years in which, as Owen Chadwick has put it, ‘the controversy between “science” and “religion” took fire’. (shrink)

Because Francis Galton (1822-1911) was a well-connected gentleman scientist with substantial private means, the importance of the role he played in the professionalization of the Victorian life-sciences has been considered anomalous. In contrast to the X-clubbers, he did not seem to have any personal need for the reforms his Darwinist colleagues were advocating. Nor for making common cause with individuals haling from social strata clearly inferior to his own. However, in this paper I argue that Galton quite realistically discerned in (...) the reforming endeavors of the 1860s, and beyond, the potential for considerably enhancing his own reputation and standing within both the scientific community and the broader Victorian culture. In addition, his professionalizing aspirations, and those of his reformist allies, were fully concordant with the interests, ambitions and perceived opportunities of his elite social group during the Victorian period. Professionalization appealed to gentlemen of Galton's status and financial security as much as it did to the likes of Thomas Huxley and John Tyndall, primarily because it promised to confer on the whole scientific enterprise an unprecedented level of social prestige. (shrink)

Several situations are presented in which there is an ordinal γ such that ${\{ X \in [\gamma]^{\aleph_0} : X \cap \omega_1 \in S\,{\rm and}\, ot(X) \in T \}}$ is a stationary subset of ${[\gamma]^{\aleph_0}}$ for all stationary ${S, T\subseteq \omega_1}$ . A natural strengthening of the existence of an ordinal γ for which the above conclusion holds lies, in terms of consistency strength, between the existence of the sharp of ${H_{\omega_2}}$ and the existence of sharps for all reals. Also, an (...) optimal model separating Bounded Semiproper Forcing Axiom (BSPFA) and Bounded Martin’s Maximum (BMM) is produced and it is shown that a strong form of BMM involving only parameters from ${H_{\omega_2}}$ implies that every function from ω 1 into ω 1 is bounded on a club by a canonical function. (shrink)

Perhaps the topic of acceptable risk never had a sexier and more succinct introduction than the one Edward Norton, playing an automobile company executive, gave it in Fight Club: “Take the number of vehicles in the field (A), multiply it by the probable rate of failure (B), and multiply the result by the average out of court settlement (C). A*B*C=X. If X is less than the cost of the recall, we don’t do one.” Of course, this dystopic scene also (...) gets to the heart of the issue in another way: acceptable risk deals with mathematical calculations about the value of life, injury, and emotional wreckage, making calculation a difficult matter ethically, politically, and economically. This entry will explore the history of this idea, focusing on its development alongside statistics into its wide importance today. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:460 HISTORY OF PHILOSOPHY accurate understanding of the mind of Aristotle. Nifo's shift on the question of Aristotle and immortality thus represents a noteworthy chapter in the history of Renaissance Aristotelianism.6x EDWAKDP. MAHONEY Duke University 6x I should like to thank the United States Government for a Fulbright fellowship during 1962-1963; the National Foundation for the Humanities for a fellowship during 1968-1969; and the Duke UniversityResearch Council for grants (...) for microfilms. BIBLIOGRAPHY OF THE WRITINGS OF JACOB LOEWENBERG Compiled by Edwin S. Budge It is hoped that all of Professor Loewenberg's published writings, exclusive of his many book reviews, are listed herein. His unpublished doctoral dissertation, "The Genesis of Hegel's Dialectical Method" (1911), is available on loan from Harvard University, although the "gist" of this, as Dr. Loewenberg has indicated, may be found in the introduction to the first item cited in the bibliography. Dr. Loewenberg, it might be added, also translated a short work by Gilbert Chinard, France for the Soldier (Berkeley: University of California, 1918), and quite likely was consulted by his wife Kate in the course of her translation of Emile Meyerson's Identity and Reality (New York: Macmillan Company, 1930; reprinted by Dover, 1962, and Peter Smith, 1963). Jacob Loewenberg's personal papers are in the possession of his daughter, Mrs. Jeannot Nyles, of Berkeley, California. 1912 1916 BIBLIOGRAPHYOF THE WRITINGSOF JACOBLOEWENBERG "Vorwort," pp. v-vi; "Einleitung: 'Die jugendlichen Denkversuche Hegels'," pp. vii-xxii; in Hegels Entwiir/e zur Enzyklopiidie und Propiideutik nach den Handschri/ten der Harvard-Universitiit. Mit einer Handschri[tprobe. By Georg Wilhelm Friedrich Hegel. Herausgegeben yon Dr. J. Ltwenberg. Leipzig: Verlag von Felix Meiner, I912. xxiv, 59 pp. (Hegel-Archiv. Herausgegeben von Georg Lasson. Band I, Heft 1.) "Interpretation as a Self-Representative Process," The Philosophical Review, Vol. XXV, No. 3 (May, 1916), 420-423. "Mysticism and Idealism," University o/ California Chronicle, Vol. XVIII, No. 1 (January, 1916), 72-91. "An address before the Philosophical Union of the University of California, December 10, 1915." 1917 1918 1919 1920 1921 1922 1923 NOTES AND DISCUSSIONS 461 "The Spirit of Hegel's Philosophy," University of California Chronicle, Vol. XVIII, No. 3 (July, 1916), 373-393. "The Teachings of Royce," The California Alumni Fortnightly, Vol. IX, No. 14 (September 30, 1916), 216-217. "Classic and Romantic Trends in Plato," The Harvard Theological Review, Vol. X, No. 3 (July, 1917), 215-236. "An address before the Philosophical Union of the University of California, February 23, 1917." "Josiah Royce: Interpreter of American Problems," University of California Chronicle, Vol. XIX, No. 1 (January, 1917), 39-47. "The Prophetic Songs of Swinburne," University of California Chronicle, Vol. XX, No. 10anuary, 1918), 106-115. "Preface," pp. vii-xii in Lectures on Modern Idealism. By Josiah Royce. New Haven: Yale University Press, 1919. Pp. 259. (Semicentennial Publications of the University of California, 1868-1918.) "Ethics and the War," Mills Quarterly, Vol. I, No. 4 0anuary, 1919), 6-9. "An address delivered at Mills College, October 18, 1918." "Multiplicity and the Social Order," The Harvard Theological Review, Vol. XII, No. 2 (April, 1919), 137-164. "President Wilson's Americanism," University of California Chronicle, Vol. XXI, No. 1 (January, 1919), 1-15. "Introduction," pp. 3-37 in Fugitive Essays; with an Introduction by Dr. J. Loewenberg. By Josiah Royce. Cambridge: Harvard University Press, 1920. Pp. 429. (Semicentennial Publications of the University of California, 1868-1918.) "Philosophy and Humanism," University of California Chronicle, Vol. XXIH, No. 3 (July, 1921), 298-318. "Read before the Kosmos Club of the University of California, April 4, 1921." "The Apotheosis of Mind in Modern Idealism," The Philosophical Reviewj Vol. XXXI, No. 3 (May, 1922), 215-236. "A fragment of a larger essay." "The Idea of Mutability in Literature," University of California Chronicle, Vol. XXIV, No. 2 (April, 1922), 129-151. "The Metaphysics of Critical Realism," pp. 167-194 in Issues and Tendencies in Contemporary Philosophy. Edited by George P. Adams and J. Loewenberg. 462 HISTORY OF PHILOSOPHY Berkeley: University of California, 1923, Pp. 224. (University of California Publieations in Philosophy, VoL IV.) Read before the Philosophical Union of the University of California, March 30, 1923. "'The Metaphysics of Modern Scepticism," The Philosophical... (shrink)

Through the analysis of an 18-month ethnography at an exotic dance club located in the Northeastern United States, I uncover how Latina exotic dancers manage their participation in exotic dance by deploying constructions of Latinidad as embodied cues. I focus on Playpen’s weekly event, “Latina Night,” to demonstrate how racialized, sexualized, and gendered constructs relative to Latinidad are produced and regulated in this exotic dance setting. Study participants draw on embodied markers to negotiate how their bodies are read. Those (...) markers include nationality-based appeals, time elapsed since migration, and the ability to express constructions of Latinidad through dance performance. I draw on intersectionality as a conceptual tool, filtered through a sensibility to Latina/o/x lives and experiences, to analyze the nuances of racialization as experienced by Latinas. This approach destabilizes the U.S. black–white racial binary and opens intersectionality to a more nuanced understanding of the production of Latinidad. By approaching racialization as an embodied phenomenon, I elucidate how bodily markers, beyond skin color, become imbued with racialized meaning and condition racialized erotic capital. No less important is how participants draw on racialized, gendered, and sexualized tropes to benefit racialized erotic capital. (shrink)

Assume [Formula: see text]. If [Formula: see text] is an ordinal and X is a set of ordinals, then [Formula: see text] is the collection of order-preserving functions [Formula: see text] which have uniform cofinality [Formula: see text] and discontinuous everywhere. The weak partition properties on [Formula: see text] and [Formula: see text] yield partition measures on [Formula: see text] when [Formula: see text] and [Formula: see text] when [Formula: see text]. The following almost everywhere continuity properties for functions on (...) partition spaces with respect to these partition measures will be shown. For every [Formula: see text] and function [Formula: see text], there is a club [Formula: see text] and a [Formula: see text] so that for all [Formula: see text], if [Formula: see text] and [Formula: see text], then [Formula: see text]. For every [Formula: see text] and function [Formula: see text], there is an [Formula: see text]-club [Formula: see text] and a [Formula: see text] so that for all [Formula: see text], if [Formula: see text] and [Formula: see text], then [Formula: see text]. The previous two continuity results will be used to distinguish the cardinalities of some important subsets of [Formula: see text]. [Formula: see text]. [Formula: see text]. [Formula: see text]. It will also be shown that [Formula: see text] has the Jónsson property: For every [Formula: see text], there is an [Formula: see text] with [Formula: see text] so that [Formula: see text]. (shrink)

We show it is consistent that there is a Souslin tree S such that after forcing with S, S is Kurepa and for all clubs $$C \subset \omega _1$$ C ⊂ ω 1, $$S\upharpoonright C$$ S ↾ C is rigid. This answers the questions in Fuchs (Arch Math Logic 52(1–2):47–66, 2013). Moreover, we show it is consistent with $$\diamondsuit $$ ♢ that for every Souslin tree T there is a dense $$X \subseteq T$$ X ⊆ T which does not contain (...) a copy of T. This is related to a question due to Baumgartner in Baumgartner (Ordered sets (Banff, Alta., 1981), volume 83 of NATO Adv. Study Inst. Ser. C: Math. Phys. Sci., Reidel, Dordrecht-Boston, pp 239–277, 1982). (shrink)

For a regular cardinal κ with κ<κ = κ and κ ≤ λ , we construct generically a subset S of {x ∈ Pκλ : x ∩ κ is a singular ordinal} such that S is stationary in a strong sense but the stationarity of S can be destroyed by a κ+-c. c. forcing ℙ* which does not add any new element of Pκλ . Actually ℙ* can be chosen so that ℙ* is κ-strategically closed. However we show that such (...) ℙ* itself cannot be κ-strategically closed or even <κ-strategically closed if κ is inaccessible. (shrink)

Several situations are presented in which there is an ordinal γ such that \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\{ X \in [\gamma]^{\aleph_0} : X \cap \omega_1 \in S\,{\rm and}\, ot(X) \in T \}}$$\end{document} is a stationary subset of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${[\gamma]^{\aleph_0}}$$\end{document} for all stationary \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${S, T\subseteq \omega_1}$$\end{document}. A natural strengthening of the existence of an ordinal γ for which the above (...) conclusion holds lies, in terms of consistency strength, between the existence of the sharp of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${H_{\omega_2}}$$\end{document} and the existence of sharps for all reals. Also, an optimal model separating Bounded Semiproper Forcing Axiom (BSPFA) and Bounded Martin’s Maximum (BMM) is produced and it is shown that a strong form of BMM involving only parameters from \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${H_{\omega_2}}$$\end{document} implies that every function from ω1 into ω1 is bounded on a club by a canonical function. (shrink)

Network theory arguably has its origins in Euler’s (1741) graph theory, which was first developed in the mid-1700s to solve the Königsberg bridge problem. Since then, the basic units of graph theory—vertices and edges—have been utilized by a number of scientific disciplines to describe and analyze a wide variety of phenomena. Mark Newman begins his clear and comprehensive introduction to networks with a sampling of various kinds that have been studied: information networks such as the World Wide Web, biological networks (...) such as neural connections, and social networks such as friendships among members of a club. As Newman highlights, network theory and methods are utilized not only within but also across scientific disciplines. The interdisciplinary nature of the scientific study of networks is a double-edged sword. On the one hand, it fosters the cross-pollination of ideas and methods across fields—for example, applying methods used to study computer networks to the investigation of brain networks (cf., Sporns, 2011). On the other hand, such interdisciplinarity can result in confusion and misapplication of theory and methods. Accordingly, Newman’s goal in “Networks: An Introduction” is to synthesize the current state of network theory into a “consistent language and notation” (2010, p. x, Preface). This is no easy task, but Newman gives an admirable attempt that is successful in many ways. (shrink)

Monitoring the environment for visual events while performing a concurrent task requires adjustment of visual processing priorities. By use of Bundesen's (1990) Theory of Visual Attention (TVA), we investigated how monitoring for an object-based brief event affected distinct components of visual attention in a concurrent task. The perceptual salience of the event was varied. Monitoring reduced the processing speed in the concurrent task, and the reduction was stronger when the event was less salient. The monitoring task neither affected the temporal (...) threshold of conscious perception nor the storage capacity of visual short-term memory nor the efficiency of top-down controlled attentional selection. (shrink)

Aim: To carry out an appropriate overview and inventory of the teaching of ethics within the European Union Schools of Medicine. Methods: A questionnaire was sent by email to 45 randomly selected medical schools from each of 23 countries in the European Union in February 2006. Results: 25 schools of medicine from 18 European countries were included (response rate = 56%). In 21 of 25 medical schools, there was at least one ethics module. In 11 of 25 medical schools, the (...) teaching of ethics was transversal. Only one of the responding schools did not teach ethics. The mean time invested in ethics teaching was 44 h during the overall curriculum. Conclusions: Ethics now has an established place within the medical curriculum throughout the European Union. However, there is a notable disparity in programme characteristics among schools of medicine. (shrink)

Background: Informed consent in clinical research is mandated throughout the world. Both patient subjects and investigators are required to understand and accept the distinction between research and treatment.Aim: To document the extent and to identify factors associated with therapeutic misconception in a population of patient subjects or parent proxies recruited from a variety of multicentre trials .Patients and methods: The study comprised two phases: the development of a questionnaire to assess the quality of informed consent and a survey of patient (...) subjects based on this questionnaire.Results: A total of 303 patient subjects or parent proxies were contacted and 279 questionnaires were analysed. The median age was 49.5 years, sex ratio was 1 and 61% of respondents were professionally active. Overall memorisation of the oral or written communication of informed consent was good , and satisfaction with the process was around 70%. Therapeutic misconception was present in 70% of respondents, who expected to receive better care and ignored the consequence of randomisation and treatment comparisons. This was positively associated with the acuteness and severity of the disease.Conclusion: The authors suggest that the risk of therapeutic misconception be specifically addressed in consent forms as an educational tool for both patients and investigators. (shrink)

In the first part of this article we briefly describe the design and development of a Consciousness Studies concentration at Goddard College, a student centered, progressive educational institution in the northeastern United States. We emphasize the tensions we experienced between different orientations in Consciousness Studies and especially the one related to the scientific and transpersonal ends of the spectrum of consciousness. In the second part, we relate the scientific‐transpersonal issue that we experienced at Goddard to the broader theory and practice (...) of Consciousness Studies. We also link the latter to the so‐called explanatory gap between third and first person forms of consciousness and the call for first person methods of exploring consciousness. Our conclusion is that the scientific approach has the edge and is at risk of assimilating other approaches to the detriment of Consciousness Studies. In our view, the future development of Consciousness Studies, both in theory and practice, requires several different approaches from the scientific to the transpersonal and privileging one is to narrow the field of possibilities and to risk falling prey to one‐sidedness. (shrink)

People with post-stroke motor aphasia know what they would like to say but cannot express it through motor pathways due to disruption of cortical circuits. We present a theoretical background for our hypothesized connection between attention and aphasia rehabilitation and suggest why in this context, Brain-Computer Interfaces (BCI) use might be beneficial for patients diagnosed with aphasia. Not only could BCI technology provide a communication tool, it might support neuronal plasticity by activating language circuits and thereby boost aphasia recovery. However, (...) stroke may lead to heterogeneous symptoms that might hinder BCI use which is why the feasibility of this approach needed to be investigated first. In this pilot study, we included five participants diagnosed with post-stroke aphasia. Four participants were initially unable to use the visual P300 speller paradigm. By adjusting the paradigm to their needs, all participants could successfully learn to use the speller for communication with accuracies up to 100%. We describe necessary adjustments to the paradigm and present future steps to further investigate the here presented approach. (shrink)

Injury to the central or peripheral nervous system is often associated with persistent pain. After ischemic injury to the spinal cord, rats develop severe mechanical allodynia-like symptoms, expressed as a pain-like response to innocuous stimuli. In its short-lasting phase the allodynia can be relieved with the [gamma]-aminobutyric acid (GABA)-B receptor agonist baclofen, which also reverses the hyperexcitability of dorsal horn interneurons to mechanical stimuli. Furthermore, there is a reduction in GABA immunoreactivity in the dorsal horn of allodynic rats. Clinical neuropathic (...) pain of peripheral and central origin often cannot be relieved by opiates at doses that do not cause side effects. The loss of sensitivity to opiates may be associated with the up-regulation of endogenous antiopioid substances, such as the neuropeptide cholecystokinin (CCK). CCK and its receptor (CCK-R) protein is normally not detectable in rat dorsal root ganglion cells. After peripheral nerve section, both CCK and CCK-R are up-regulated in the dorsal root ganglia. Furthermore, CI 988, an antagonist of the CCK-B receptor, chronically coadministered with morphine, reduces autotomy, a behavior that may be a sign of neuropathic pain following peripheral nerve section. Thus, opiate insensitivity may be due to the release of CCK from injured primary afferents. Similarly, in the chronic phase of the spinal ischemic model of central pain, the allodynia-like symptom is not relieved by systemic morphine, but is significantly reversed by the CCK-B antagonist. Consequently, up-regulation of CCK and CCK-R in the CNS may also underlie opiate drug insensitivity following CNS injury. Thus, dysfunction of central inhibition involving GABA and endogenous opioids may be a factor underlying the development of sensory abnormalities and/or pain following injury to neural tissue. (shrink)

Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage disorder treated with bone marrow transplantation or enzyme replacement therapy with laronidase, a high-cost orphan drug. Laronidase was approved by the US Food and Drug Administration and the European Medicines Agency in 2003 and by the Brazilian National Health Surveillance Agency in 2005. Many Brazilian MPS I patients have been receiving laronidase despite the absence of a governmental policy regulating access to the drug. Epidemiological and treatment data concerning MPS I (...) are scarce. This study aims to present a demographic profile of Brazilian patients with MPS I, describe the routes of access to laronidase in Brazil, and discuss associated ethical issues relating to public funding of orphan drugs. (shrink)

If it is true, as suggested by Sir Michael Marmot and other researchers, that status impacts health and therefore accounts for some of the social gradient in health, then it seems to be the case that it would be possible to bring about more equality in health by equalizing status. The purpose of this article is to analyze this suggestion. First, we suggest a working definition of what status precisely is. Second, following a luck egalitarian approach to distributive justice, we (...) consider whether and to which extent individuals are responsible themselves for their position in a status hierarchy. Third, we consider the contours of a difficult question, namely which political measures are feasible in order to reduce health-affective inequalities in status and fourth, whether or to what extent such measures are legitimate. We argue that on the basis of these considerations, we have at least some prima facie reasons to counter (at least some) status inequalities in order to equalize health. (shrink)