Children with autism spectrum disorder show marked difficulties in reading comprehension, a complex cognitive skill fundamental to successful daily functioning that is associated with core executive functions. However, the neurophysiological mechanisms underlying reading comprehension deficits in these children remain elusive. Twenty-one right-handed males with high-functioning ASD and 23 age-, IQ-, educational level-, sex- and handedness-matched typically developing individuals underwent a reading comprehension test and the semantic verbal fluency test that tapped core executive functions underlying reading comprehension during concurrent prefrontal functional (...) near-infrared spectroscopy measurement. Participants’ information processing efficiency was also assessed. High-functioning ASD children exhibited general reading comprehension [main effect of group: F = 7.58, p = 0.009], selective verbal fluency deficits [Group × category interaction: F = 4.90, p = 0.032] and slower processing speed. Regarding the hemodynamics of the prefrontal cortex, although ASD individuals showed comparable patterns of PFC brain activation to their healthy counterparts, lower PFC intrahemispheric [main effect of group: F = 11.36, p = 0.002] and interhemispheric [main effect of group: F = 7.79, p = 0.008] functional connectivity were evident during the semantic verbal fluency test. At the whole-group level, poorer reading comprehension performance was associated with poorer performance in the semantic verbal fluency test. Moreover, poorer semantic verbal fluency test performance was associated with slower information processing speed, which is associated with reduced left medial PFC functional connectivity. Abnormal intrahemispheric and interhemispheric prefrontal hypoconnectivity is associated with deficits in executive processes essential for reading comprehension in ASD. Our study has provided important implications for the neuropsychological and neurophysiological mechanisms underlying reading comprehension deficits in ASD. (shrink)

Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

El presente estudio aclara la paradoja del espíritu humano tendido entre la finitud y la infinitud, como lo entiende Edith Stein, iluminado por Alberto el Grande. Esta paradoja constituye la dimensión originaria del espíritu humano, que es un espíritu finito más real y auténtico cuando se comprende a sí mismo como proveniente de Dios, revelando la simultaneidad dinámica del tiempo y la eternidad, capaz de colaborar con el Espíritu infinito en la medida en que es anticipado por este.

El presente artículo investiga el misterio del «ser» en el Comentario de Alberto Magno a la Teología Mística y las Epistulas de Dionisio Areopagita, a través de una lectura circular del Corpus Dionysianum, comentado en torno a 1250 por Alberto en su totalidad a diferencia de Tomás de Aquino. Dicho comentario pone de manifiesto la estructura propia de toda la obra albertina, su forma mentis y su método. Como tal, este estudio se suma al interés renovado por la obra albertina (...) en la línea de la «ciencia mística». This article investigates the mystery of «being» in the Comment Albertus Magnus the Mystical Theology and Epistulas of Dionysius, through a circular Dionysianum Corpus reading, said around 1250 by Alberto in its entirety a difference Aquinas. This comment reveals the structure of the entire albertina work, its forma mentis and method. As such, this study adds to renewed work in the Albertine line of the «mystical science» interest. (shrink)

Taking as a point of departure Sudbrack's affirmation regarding the task proposed by Hildegard of Bingen - that is to say, valuing the ambit of perception in the way that Kant valued the realm of reason in his critique ofpure reason - the present work presents a study of the relation between reason and love in Scivias. The rigorous analytic study of the concept «rationalitas» - to discover its relationship with love - shows itself, effectively, in «sensus rationalitatis», so that (...) it is the senses that mediate the problem of reason and love, and explain it according to the Incarnation and the mystery of the Trinity. Hence the exceptional trinitarian and pneumatological depth in Hildegard's Scivias effectively provides a new response to the problem of reason and love in the light of the formula «symphonia rationalitiatis». (shrink)

Behrendt & Young (B&Y) propose that a dysfunction in the reticular thalamic nucleus contributes to disinhibition of specific thalamic nuclei, allowing cortical attention mechanisms to engage thalamic relay neurons, causing underconstrained activation of the cortex and hallucinations. The following hypothesis challenges the notion of impaired sensory gating by providing the alternative view that hypofrontality reduces the power of incoming stimuli, causing internal drives to override consciousness, resulting in hallucinations.

Resumen El presente estudio investiga la importancia de la “experiencia originaria” husserliana para la comprensión del conflicto de las ciencias exactas con el problema de Dios, que Edith Stein califica de “angustia inconsciente de encontrarse” con Él. A través de su controversia con la Psicología del siglo XIX, la discípula de Husserl muestra en su obra Causalidad Psíquica que hace falta un adecuado conocimiento de la índole propia de la ciencia para remontar con rigor metódico a la originariedad de la (...) experiencia humana y el Dios presente allí. Esto conducirá a la ciencia al descubrimiento de su propia identidad por la superación del bloqueo consciente o inconsciente ante la revelación de Dios en el alma humana. De ahí que el presente estudio ofrezca un aporte relevante para la dilucidación filosófica de una cuestión teológica candente hoy ―aporte logrado a través de un esfuerzo interdisciplinario arduo.The present study investigates the importance of the Husserlian “originary experience” for the understanding of the conflict of the exacts sciences with the problem of God, which Edith Stein describes as “unconscious anguish of being” with Him. Through her controversy with of the 19th century Psychology, the disciple of Husserl shows in her work Psychic Causality that it is necessary to have an adequate knowledge of the nature of science to trace with methodical rigor the originarity of the human experience and the God present in there. This will conduct science to a discovery of its own proper identity by the overcoming of the unconscious or conscious blocking before the revelation of God in the human soul Hence, the present study offers a relevant contribution to the philosophical elucidation of a burning theological question today -a contribution achieved through an arduous interdisciplinary effort. (shrink)

The present study aims to elucidate whether insight problem solving could be facilitated by the cognitive component of humour. The authors take interest in whether the logical mechanisms of humour can affect how fast insight problems are solved. To that end, the authors conducted two experiments where participants solved insight problems after watching visual humorous stimuli such as videos and slideshows. The first experiment demonstrated the overall impact of facilitation by humour on insight problem solving; however, it did not show (...) any difference in how particular logical mechanisms of humour affect the solution time of insight problems. The second experiment showed that the cognitive component of humour could selectively affect insight problems whose difficulty stems from different sources. These results suggest that the cognitive component of humour, when operationalised as logical mechanisms and schema switching, contributes to solving insight problems. (shrink)

Background: Although ethics consultation has been introduced to clinical practice for many years, the results of empirical studies to evaluate the effectiveness of ethics consultation are still controversial. The design of randomised controlled trials is considered the best research design to evaluate the effect of a clinical practice on the outcomes of interests. In order to understand the effects of ethics consultation, we conducted this search for studies with the design of randomised controlled trials to evaluate ethics consultation.Objective: To provide (...) an integrated review of studies with the design of randomised controlled trials to evaluate the effectiveness of ethics consultation.Methods: PubMed was used to search for studies using the randomised controlled trial design to evaluate the effectiveness of ethics consultation. The search term used was “ethics consultation”. The selection criterion was limited to “randomised controlled trial”.Results: Four articles that met both search criteria were retrieved. One of these articles reported a study that did not actually use the design of a randomised controlled trial and is excluded from the following discussion.Conclusions: To apply randomised controlled trials to evaluate the effectiveness of ethics consultation is extremely difficult as long as two issues are not resolved: the standardisation of ethics consultation and a placebo for ethics consultation to eliminate the placebo effect. Thus, the results generated by the design of randomised controlled trials are always problematic. Furthermore, as long as the two issues exist, the results generated by the design of quantitative research methods always pose problems. (shrink)

Following Henkin’s discovery of partially-ordered (branching) quantification (POQ) with standard quantifiers in 1959, philosophers of language have attempted to extend his definition to POQ with generalized quantifiers. In this paper I propose a general definition of POQ with 1-place generalized quantifiers of the simplest kind: namely, predicative, or “cardinality” quantifiers, e.g., “most”, “few”, “finitely many”, “exactly α ”, where α is any cardinal, etc. The definition is obtained in a series of generalizations, extending the original, Henkin definition first to a (...) general definition of monotone-increasing (M↑) POQ and then to a general definition of generalized POQ, regardless of monotonicity. The extension is based on (i) Barwise’s 1979 analysis of the basic case of M↑ POQ and (ii) my 1990 analysis of the basic case of generalized POQ. POQ is a non-compositional 1st-order structure, hence the problem of extending the definition of the basic case to a general definition is not trivial. The paper concludes with a sample of applications to natural and mathematical languages. (shrink)

'This study is extremely authoritative and up-to-date... This book has much to offer linguists motivated by any one of several primary interests, particularly universals and the connection between language and cognition' -Journal of Linguistics 'Aikhenvald displays the rare gift of being able to inspire interest in new research through the success of her own results, without stifling those future possibilities through undue certitude in having discovered all of the answers already. The best thing about this very excellent book is precisely (...) the author's keen awareness that it is not the last word on the subject' -Journal of Linguistics 'Data presented in a clear, straightforward manner... also cutting edge research presented in the spirit of a work in progress' -Journal of LinguisticsAlmost all languages have some ways of categorizing nouns. Languages of South-East Asia have classifiers used with numerals, while most Indo-European languages have two or three genders. They can have a similar meaning and one can develop from the other. This book provides a comprehensive and original analysis of noun categorization devices all over the world. It will interest typologists, those working in the fields of morphosyntactic variation and lexical semantics, as well as anthropologists and all other scholars interested in the mechanisms of human cognition. (shrink)

In this article I argue that textual evidence from David Hume's A Treatise of Human Nature does not support J. Baird Callicott's professedly Humean yet holistic environmental ethic, which understands the community (e.g., the biotic community) as a ‘metaorganismic’ entity ‘over and above’ its individual members. Based on Hume's reductionist account of the mind and his assimilation of the metaphysical nature of the mind to that of the community, I also argue that a Humean account of the community should be (...) likewise reductionist. My conclusion is that Callicott's anti-reductionist holism is at least foreign to, and at worst incompatible with, Hume's philosophy. (shrink)

In Metaphysics E. 3. 1027a29–30 Aristotle states that there are some causes, the incidental ones, that are generable and destructible but they have no coming to be. Furthermore, he asserts that if we deny this thesis, then we will have to give into determinism (1027a30–32). There are three persistent puzzles surrounding this chapter. First, what does it mean to say that a cause is generable and destructible but it has no coming to be? Second, what exactly is the connection between (...) this claim and determinism? And third, if we accept that in Metaphysics E. 3 Aristotle deals with incidental causation, then how is this discussion related to the treatment of incidentalness in E. 2? This article puts forward answers for these puzzles. I argue that there is textual evidence in Physics II. 5 that shows that the claim in Metaphysics 1027a29–30 is meant to capture the non-teleological nature of incidental causation. Moreover, I argue that this same textual evidence indicates that the thesis expressed at Metaphysics 1027a29–30 is in effect Aristotle’s response to teleological determinism. Finally, I suggest that it is plausible to suppose that chapter 3 does not quite belong with the rest of Metaphysics E. (shrink)