The present study was motivated by the hypothesis that inputs from internal states in obsessive–compulsive individuals are attenuated, which could be one source of the pervasive doubting and checking in OCD. Participants who were high or low in OC tendencies were asked to produce specific levels of muscle tension with and without biofeedback, and their accuracy in producing the required muscle tension levels was assessed. As predicted, high OC participants performed more poorly than low OC participants (...) on this task when biofeedback was not available. When biofeedback was provided, the difference between the groups was eliminated, and withdrawing the monitor again reversed this effect. Finally, when given the opportunity, high OC participants were more likely than low OC participants to request biofeedback. These results suggest that doubt in OCD may be grounded in a real and general deficiency in accessing internal states. (shrink)

Smooth muscle cells have developed a contractile machinery that allows them to exert tension on the surrounding extracellular matrix over their entire length. This has been achieved by coupling obliquely organized contractile filaments to a more‐or‐less longitudinal framework of cytoskeletal elements. Earlier structural data suggested that the cytoskeleton was composed primarily of intermediate filaments and played only a passive role. More recent findings highlight the segregation of actin isotypes and of actin‐associated proteins between the contractile and cytoskeletal domains (...) and raise the possibility that the cytoskeleton performs a more active function. Current efforts focus on defining the relative contributions of myosin cross‐bridge cycling and actin‐associated protein interactions to the maintenance of tension in smooth muscle tissue. (shrink)

Most of us are familiar with the phenomenology of mental effort accompanying cognitively demanding tasks, like focusing on the next chess move or performing lengthy mental arithmetic. In this paper, I argue that phenomenology of mental effort poses a novel counterexample to tracking intentionalism, the view that phenomenal consciousness is a matter of tracking features of one’s environment in a certain way. I argue that an increase in the phenomenology of mental effort does not accompany a change in any of (...) the following candidate representational contents: representation of externally presented features, e.g. brightness, contrast, and so on representation of task difficulty, representation of the possibility of error, representation of trying to achieve some state of affairs, representation of bodily changes like muscle tension, or representation of change in cognitive resource availability and lost opportunity cost. While tracking intentionalism about some phenomenal experiences like pains might obtain, it does not seem to obtain for all phenomenal experiences. This puts the intentionalist into an uncomfortable position of trying to explain why some phenomenal experiences have representational content and not others. Since many believe that tracking intentionalism or something like it provides the best chance of naturalizing consciousness, these arguments deserve detailed consideration. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Fragments ENJOYING NEGATIVE EMOTIONS IN FICTIONS by John Morreall There is a puzzle going back to Aristotle and Augustine that has sometimes been called the "paradox of tragedy": how is it that nonmasochistic, nonsadistic people are able to enjoy watching or reading about fictional situations which are filled with suffering? The problem here actually extends beyond tragedy to our enjoyment of horror films and other fictional depictions (...) of situations which we would not enjoy in real life. What is it about fiction that turns intensely unpleasant situations into situations we can enjoy? Ofthe many solutions proposed to this puzzle, I shall mentionjust four. Aristotle held that in viewing tragedy we experience negative emotions — pity and fear — but get pleasure from the experience nonetheless because we are thereby purged of excess pity and fear. For Aristotle, too, there is a pleasure which tragedy shares with fiction in general, the delight we take in representations.1 Hume put more weight on this latter delight. Our pleasure in tragedy, he said, is based on our appreciation of the skill with which the literary or other artist has depicted the unpleasant scenes.2 Susan Feagin has recently located the pleasure we take in tragic art not in our direct responses to the work, which are "unpleasant experiences," she says, but in our meta-response of moral self-congratulation at these responses.3 The fourth solution to our puzzle is really a dissolution: it consists of denying that we actually feel fear, pity, and other negative emotions in our experience of fiction. The guiding principle here is that in order to have some emotion toward a situation, we must believe that it is a real situation. This principle is articulated in an influential article by Kendall Walton, though he does not apply it to our puzzle.4 95 96Philosophy and Literature I believe that this last solution is no solution at all because we do in fact feel emotions in our appreciation of fiction (a point I will develop later). The other three solutions above address the puzzle, and the pleasures they appeal to all have some explanatory power. But these solutions seem to me to overlook perhaps the most basic pleasure we take in tragedy, horror films, and the like — the direct pleasure of feeling (ear, pity, and similar emotions. The idea of enjoying negative emotions seems counterintuitive at first; indeed it may seem analytically false. But let us look more closely at those emotions to see what there might be to enjoy in them. Because the idea that we experience real emotions in response to fiction is controversial, we will begin not with fiction but with real life. After seeing how negative emotions can be enjoyed in real life, we can then consider their enjoyment in response to fiction. Fear is perhaps the most basic negative emotion, and at first glance one of the least likely to be enjoyed. To feel fear, many have claimed, we have tojudge that we are in danger, and danger is disturbing to us. And so it is natural that in fear there is the motivation to eliminate the danger, by fleeing, protecting ourselves, or attacking. Changes in the autonomic nervous system and the endocrine system equip us forjust such actions. They produce an increase in alertness and muscle tension, a faster and stronger heartbeat, a redistribution of the blood from the skin and internal organs to the voluntary muscles and brain, and a release of stored sugar from the liver into the bloodstream. Now although we may not be able to identify all these changes when we are in a state of fear, we can feel many of them directly, and we certainly feel the overall excitement which they produce. It is this excitement, I think, that makes fear potentially enjoyable. Especially for someone who leads a relatively dull life, the stimulation provided by fear can be pleasurable by contrast with the ordinary lack of stimulation. Many people, indeed, go to considerable trouble to put themselves into dangerous situations, in part, at least, for the thrill of fear that the danger will provide. Consider mountain climbers and skydivers, for instance. Now there are many sources... (shrink)

The trade-off between force and length of muscle as adjusted by neural signals is a critical fact in the dynamics of motor control. Whether we call it “length-tension effect,” “feedback-like,” “invariant condition,” or “spring-like” is unimportant. We must not let semantics or details of representation obscure the basic physics of effects introduced by this trade-off in muscle.

In this unique and exhilarating autobiography, Allan Jones – Canada’s first blind diplomat – vividly describes how an untreatable eye disease slowly decimated his visual world, most challengingly during his postings in Tokyo and New Delhi, and how he discovered and took to heart the revelatory Indian philosophy that changed his life. Advaita Vedanta, the most iconoclastic and liberating of the classical Indian philosophies, profoundly altered the author’s experience of self and world. He found that the true self, as distinct (...) from the individual ego, far exceeds the boundaries of individuality. It lies beneath sightedness or blindness and is absolutely unaffected by the latter. This welcome shift of perspective was reinforced by startling discoveries in contemporary physics, evolutionary biology, and developmental psychology that are fully consistent with Advaitic metaphysics. As for the practical applications of metaphysics, this book demonstrates step by step how Advaitic insight and practice significantly reduce physical and psychological tension. The most telling examples have to do with adjustments compelled by extreme circumstances. Thus Jones describes how he drew upon Advaitic mindfulness techniques to maintain his white cane mobility skills in the teeth of permanent spinal, nerve, and muscle pain. The arc of Beyond Vision moves from the claustrophobically personal to the openness of the transpersonal. It begins in a dysfunctional family background, breaking out into a full life encompassing an adventurous foreign service career, spiritual exploration, and an unconventional kind of marital love. (shrink)

Interoception in the broader sense refers to the perception of internal states, including the perception of the actual state of the internal organs and the motor system. Dimensions of interoception include interoceptive accuracy, i.e., the ability to sense internal changes assessed with behavioral tests, confidence rating with respect to perceived performance in an actual behavioral test, and interoceptive sensibility, i.e., the self-reported generalized ability to perceive body changes. The relationship between dimension of cardioceptive and proprioceptive modalities and their association with (...) affect are scarcely studied. In the present study, undergraduate students filled out questionnaires assessing positive and negative affect, interoceptive sensibility, and body competence. Following this, they completed a behavioral task assessing cardioceptive accuracy and two tasks assessing proprioceptive accuracy with respect to the tension of arm flexor muscles and the angular position of the elbow joint. Confidence ratings were measured with visual analog scales after the tasks. With the exception of a weak association between cardioceptive accuracy and the respective confidence rating, no associations between and within modalities were found with respect to various dimensions of interoception. Further, the interoceptive dimensions were not associated with state and trait positive and negative affect and perceived body competence. In summary, interoceptive accuracy scores do not substantially contribute to conscious representations of cardioceptive and proprioceptive ability. Within our data, non-pathological affective states are not associated with the major dimensions of interoception for the cardiac and proprioceptive modalities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 11.1 (2001) 91-112 [Access article in PDF] Scope Note 40 Animals in Research and Education: Ethical Issues Laura Jane Bishop and Anita Lonnes Nolen Scientific enquiry is inexorably tied to animal experimentation in the popular imagination and human history. Many, if not most, of the spectacular innovations in the medical understanding and treatment of today's human maladies have been based on research using animals. (...) However, the use of animals in research and experimentation has been debated, defended, and protested by both individuals and organizations at various levels. Responses range from personal lifestyle decisions and fervent philosophical treatises to strident arguments, violent demonstrations, and direct action. The continuum of attitudes about animals and the human relationship with animals spans the range between those who support no regulation of the human use of animals and those who advocate absolute animal liberation from all human use (see II, Orlans 1993, p. 22). History The first recorded experimentation on animals occurred in ancient Rome, but not until the Renaissance did scholars begin serious study of how the body works. Leonardo da Vinci (1452-1519) and other artists and anatomists pursued anatomical investigations of muscle and bone structure. William Harvey (1578-1657) discovered the circulation of the blood via his experiments on live deer. During this period, much live animal experimentation both in England and France was based on the view of French philosopher René Descartes (1596-1650) that animals are incapable of feeling pain. Jeremy Bentham (1748-1832), the English utilitarian philosopher, thought otherwise. In his "Introduction to the Principles of Morals and Legislation" in 1789, Bentham declared, "The question is not, can they reason? Nor, can they talk? But can they suffer? Despite Bentham and others, the belief that animals could not perceive pain persisted in many quarters into the twentieth century. Nineteenth century French physiologist Claude Bernard [End Page 91] (1813-1878)-and his teacher, François Magendie (1783-1855)-conducted wide-ranging animal experiments including surgery, use of drugs, and removal of body parts from many species. Bernard argued that while no amount of benefit could justify any harm to human research subjects, even extreme harm and pain for animal research subjects could be justified by the potential benefit to human beings. Although he did use anesthetics in his work after their discovery in 1847, even Bernard's later work was controversial because of the numbers of animals used and the repetitive nature of his research. The experiments of Magendie and Bernard both laid the foundations for animal experimentation as a practice for scientific advance and contributed in large measure to the emergence of the anti-vivisection movement. Public protests over animal experiments conducted in France and the fear that these might come to England led to the passage of the first law controlling animal experimentation, the "1876 Cruelty to Animals Act" in England. This history and the dynamic tension between scientific inquiry and public concern set the stage for the activism and scholarship of the twentieth century.Since the 1960s, the amount of attention, activism, and scholarship related to animal use has increased at a rapid pace. The modern animal protection movement, led by the Australian philosopher Peter Singer in his book, Animal Liberation (II, 1975), based its advocacy on animals' ability to experience pain and suffering (Bentham's argument). Singer's book and other investigations into animal research, such as LIFE magazine's photojournalism piece on pet theft, animal cruelty, and animal experimentation (Concentration Camps for Dogs. LIFE (4 February 1966), pp. 22-29), brought the use of animals in research, testing, and education to the attention of the general public. Activists, advocates, laypersons, scientists, lawmakers, and animals themselves, have created the interesting, complicated, and complex history of animal rights and animal welfare over the last several decades. Current Statistics Worldwide, approximately 35 million animals are used in research each year; the United States alone uses 12 million animals annually--more than any other country. In 1998, the official number of research animals recorded in the United States was 1... (shrink)

During the lengthy and complex process of human evolution our ancestors had to adapt to extremely testing situations in which survival depended on making rapid choices that subjected muscles and the body as a whole to extreme tension. In order to seize a prey traveling at speeds that could reach 36 km per hour Homo sapiens had just thousandths of a second in which to anticipate the right moment and position himself before the prey arrived. He also had to (...) prepare the appropriate gesture, tensing his muscles and overcoming the resistance determined by body weight. While we are no longer faced with an environment that is anything so threatening, our brain continues to use these mechanisms day in day out to save time and energy, enabling us to avoid situations of danger, sense in advance the intentions of an interlocutor, and more besides. In this article we set out to show that our brain is not only a reactive mechanism, capable of reacting quickly to the stimuli that arrive from the external environment, but is above all a pro-active mechanism that allows us to make hypotheses, anticipate the consequences of actions, and formulate expectations: in short, to wrong foot an adversary. (shrink)

The trials of life can wear us down. Unexpected events force us to face a new reality and unanswered prayers lead us to a growing frustration about why God doesn't intervene. We wonder if anything good can come out of this painful, dark, winter season. Grace Wabuke Klein knows that there is purpose in our darkest days and seasons of waiting. In Flourish, Grace meets the reader in their heartache, disappointment, and pain and gives encouragement and a fresh perspective on (...) the winter seasons we all go through, as well as practical steps to not just survive but to find purpose in the unknown and unexpected. Drawing insight from her own winter seasons, Grace reveals the divine purpose in each season of our lives. She explains how: -Fall is a time of release-a necessary season of letting go of offenses, unhealthy relationships, hurts, bad habits, toxic friendships, pride, unforgiveness and other heart issues before we can ever move on to the next season -Winter is a time of unexpected challenges and unknown futures-yet lessons learned in life's storms are deep and full of growth to shape us and makes us stronger. -Spring is a time of new things that require us to be open to new experiences, people, ideas, and perspective-stepping out into the unknown and uncomfortable. -Summer is a time when everything is flourishing-we clearly see how each season cultivated a deeper level of faith and spiritual muscles, developing our character and perseverance. Grace discovered there is value and unseen gifts in each season, but only in the hard seasons and storms of life are vital spiritual disciplines developed. Flourish connects with the reader in the tension and storms of life to bring a word of hope. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Feminist Studies 47, no. 2. © 2021 by Feminist Studies, Inc. 419 Paul Amar Insurgent African Intimacies in Pandemic Times: Deimperial Queer Logics of China’s New Global Family inWolf Warrior 2 This essay offers a new paradigm of “deimperial queer analysis” that reveals the tension between the People’s Republic of China’s extractive expansionism in Africa and its claim to solidarity with Africans against white supremacy and Northern imperialism. (...) China has been labeled an “anti-imperial empire” that forcefully challenges previous Euro-American imperial legacies—all while it verges on reenacting them.1 A critical way it resolves this geopolitical tension is through the articulation of a mission for global China, and since 2017, the heroic filmic fictional figure of the “Wolf Warrior” anchors such an approach. The Wolf Warrior is a gorgeous, muscled, Chinese male rogue soldier in exile who adventures through the archipelago of the PRC’s shipping, mining, and medical projects across the Global South to battle white mercenaries, corrupt Asian businessmen, and local pirates—all while saving Africa from a ravaging pandemic. Extending a hugely popular film series, the release in 2017 of the blockbuster Wolf Warrior 2 (abbreviated below as Wolf 2) unleashed a worldwide social media frenzy as well as a revolution in diplomatic tone and protocol for China. In these ways, Wolf Warrior 2 came to mark the debut of the global PRC as a hegemonic structure 1. David Armitage, “The Anti-Imperial Empire?” Times Literary Supplement, no. 6018, August 3, 2018, https://www.the-tls.co.uk/articles/the-anti-imperialempire -american. 420 Paul Amar of feeling with an attendant popular cultural logic, launching a cast of military characters, humanitarian imaginaries, and gendered rebranding initiatives. These fused into a global cultural megaproject with the PRC presenting itself as a leader in responding to the COVID-19 pandemic in the Global South—a time the PRC has officially branded as its “Rejuvenation Era” of “Stepping Out into the World.” This essay shows how exactly this Wolf Warrior imagination has legitimized a new global regime, but I also reveal how, paradoxically, the Wolf Warrior regime has offered a distinct, more subversive worlding project. I argue here that the utopia immanent in this project can be revealed by interpretively turning this Wolf universe inside out through a deimperial queer analysis that honors and combines a Third World feminist lens and the “Asia as Method” approach with Danmei/BL and Slash queer-feminist fanfiction hacks. Danmei is a Chinese (originally mainly Tawainese) fanfiction genre that subverts mainstream heteronormative narratives by erotically aestheticizing and renarrating male-male intimacies within mainstream plotlines from feminist perspectives. BL (short for “boylove ”) is a similar Japanese fanfiction genre, and Slash is the term used in English for the queer/feminist hacking and excavation of sublimated and particularly utopian gender and sexuality plots from within seemingly conventional heteronormative or patriarchal popular-cultural texts. The everted or inside-out epistemology given expression here uses a set of non-phallogocentric lenses and decolonial feminist decoding practices. At stake is the urgency of not repeating the epistemic violence of conventional “anti-imperial” arguments, which tend to be heteronormative, statist, macho, and monolithic. Instead, the form of critique elaborated here brings questions of gender, race, and sexuality to the fore through a three-part approach. First, I identify the homoerotic register of the techno-infrastructural elements in the film. I generate close readings that detail the visual and genre codes of battle scenes, thug subjects, and piracy plots that forge a homoerotic model of rogue or “wolf” governmentality and that act as a metaphor for China’s techno -infrastructural rule. Second, this essay explores the gendered hauntings of supremacist humanism. I deploy a decolonial feminist lens to map the configuration of African women, female doctors, Maoist women insurgents, and feminized “flowerboys” as a rebel protectorate overseen by China’s phallic prerogative that is itself haunted by the specters of Euro-American humanist betrayal and white supremacy. Third, Paul Amar 421 I trace queer kinship utopias. I demonstrate that Wolf Warrior 2 rejuvenates a non-Western, queer, globalist kinship structure that triangulates Asian, white, and Black through adoption dramas and bromance bonds. Through these intimacies, an... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.1 (2003) 77-89 [Access article in PDF] Engaging Nature Aesthetically Joseph H. Kupfer Acting in Nature For the most part, most of us appreciate nature as spectators. Some portion of a natural scene is viewed as if it were a painting or photograph. We look for the picturesque in experiencing the real thing because our aesthetic approach toward nature has been filtered through pictures (...) — a canyon's spacious contours, a spectacular waterfall, a weeping willow swaying and billowing in the breeze. And there is certainly nothing wrong with this approach. I like a splendid sunset or majestic peak as much as the next person. However, thinking of nature solely or chiefly as an aesthetic scene to be observed is unnecessarily limiting. Regarding natural phenomena as material for detached, pictorial observation overlooks the aesthetic features revealed only through our active intercourse with nature.In what follows, I outline an active aesthetic of nature appreciation in particular, a series of physical responses to nature which yield a spectrum of aesthetic possibilities. Our active relationship toward nature is expressible by the relevant prepositions, as action can be in or into nature, against or with nature. Of course there will be overlap among these modes of dealing with nature aesthetically, but they are nevertheless fairly distinct and distinguishable. Moreover, the types of activity are arranged so that each succeeding way of addressing nature encompasses the aesthetic virtues of the preceding types of activity. As we move from acting in nature to acting with nature, therefore, our aesthetic experience becomes richer and more inclusive. 1The first active departure from the role of mere observer is found in acting in nature. When we act in or within nature, natural phenomena are the medium of our movement. Whether, hiking up the valley or swimming in the lake, we participate in the natural environment. And that participation [End Page 77] uncovers aesthetic features of nature not available to the mere spectator or observer. Walking through the valley, the prospect of wildflowers shifts from a distant, cascading carpet to a direct encounter with individual shapes, colors, fragrances, and textures. Our aesthetic experience includes appreciation of the shift in perspective itself, from long-range floral vista to more intimate perception.When we swim in the lake, it is no longer simply a thing viewed — a shifting montage of patterns of light playing on its surface. Instead, the lake is experienced as a translucent medium which alternately resists and yields to our arm, leg, and torso movement. Immersed in the water, we feel warm and cool patches, and hear sounds muffled and transmuted by the lake. The sound of our breathing is also modified by the watery medium, as well as by our physical labors.Acting in nature provides two aesthetic opportunities absent from mere spectating. First, the fact that we are active in the natural environment brings home a sense of ourselves as causal agents. Instead of change merely taking place in the natural environment, we are directly bringing about the change. Because we walk through the valley or swim in the lake, otherwise unavailable sensory experiences are enjoyed. Our movement, moreover, enables these experiences to develop from one moment to the next, at best, in an integrated sequence. In addition, there are the specific aesthetic features created for us by our physical activity — our bodily involvement beyond the more typical visual panorama. For example, tension and relaxation in our muscles, the feel and sound of our breathing and heartbeat correspond to change in our natural surroundings. Our bodies furnish us with responses to the natural environment because we are moving in it, not simply observing it.A more homey example of acting in nature is the case of standing or climbing "inside" a tree. Most of us enjoy the aesthetic experience of walking in the woods, among clusters of trees and other wildlife. But the individual tree also offers an opportunity for acting in or within nature. Enclosed within its branches and leaves, whether on the ground or alight a limb, we gain a new aesthetic perspective. The... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.1 (2003) 77-89 [Access article in PDF] Engaging Nature Aesthetically Joseph H. Kupfer Acting in Nature For the most part, most of us appreciate nature as spectators. Some portion of a natural scene is viewed as if it were a painting or photograph. We look for the picturesque in experiencing the real thing because our aesthetic approach toward nature has been filtered through pictures (...) — a canyon's spacious contours, a spectacular waterfall, a weeping willow swaying and billowing in the breeze. And there is certainly nothing wrong with this approach. I like a splendid sunset or majestic peak as much as the next person. However, thinking of nature solely or chiefly as an aesthetic scene to be observed is unnecessarily limiting. Regarding natural phenomena as material for detached, pictorial observation overlooks the aesthetic features revealed only through our active intercourse with nature.In what follows, I outline an active aesthetic of nature appreciation in particular, a series of physical responses to nature which yield a spectrum of aesthetic possibilities. Our active relationship toward nature is expressible by the relevant prepositions, as action can be in or into nature, against or with nature. Of course there will be overlap among these modes of dealing with nature aesthetically, but they are nevertheless fairly distinct and distinguishable. Moreover, the types of activity are arranged so that each succeeding way of addressing nature encompasses the aesthetic virtues of the preceding types of activity. As we move from acting in nature to acting with nature, therefore, our aesthetic experience becomes richer and more inclusive. 1The first active departure from the role of mere observer is found in acting in nature. When we act in or within nature, natural phenomena are the medium of our movement. Whether, hiking up the valley or swimming in the lake, we participate in the natural environment. And that participation [End Page 77] uncovers aesthetic features of nature not available to the mere spectator or observer. Walking through the valley, the prospect of wildflowers shifts from a distant, cascading carpet to a direct encounter with individual shapes, colors, fragrances, and textures. Our aesthetic experience includes appreciation of the shift in perspective itself, from long-range floral vista to more intimate perception.When we swim in the lake, it is no longer simply a thing viewed — a shifting montage of patterns of light playing on its surface. Instead, the lake is experienced as a translucent medium which alternately resists and yields to our arm, leg, and torso movement. Immersed in the water, we feel warm and cool patches, and hear sounds muffled and transmuted by the lake. The sound of our breathing is also modified by the watery medium, as well as by our physical labors.Acting in nature provides two aesthetic opportunities absent from mere spectating. First, the fact that we are active in the natural environment brings home a sense of ourselves as causal agents. Instead of change merely taking place in the natural environment, we are directly bringing about the change. Because we walk through the valley or swim in the lake, otherwise unavailable sensory experiences are enjoyed. Our movement, moreover, enables these experiences to develop from one moment to the next, at best, in an integrated sequence. In addition, there are the specific aesthetic features created for us by our physical activity — our bodily involvement beyond the more typical visual panorama. For example, tension and relaxation in our muscles, the feel and sound of our breathing and heartbeat correspond to change in our natural surroundings. Our bodies furnish us with responses to the natural environment because we are moving in it, not simply observing it.A more homey example of acting in nature is the case of standing or climbing "inside" a tree. Most of us enjoy the aesthetic experience of walking in the woods, among clusters of trees and other wildlife. But the individual tree also offers an opportunity for acting in or within nature. Enclosed within its branches and leaves, whether on the ground or alight a limb, we gain a new aesthetic perspective. The... (shrink)

The lambda model provides a physiologically grounded terminology for describing muscle function and emphasizes the important influence of environmental and reflex-mediated effects on final states. However, lambda itself is only a convenient point on the length-tension curve; its importance should not be overemphasized. Ascribing movement to changes in a lambda-based frame of reference is generally valid, but it leaves unanswered a number of questions concerning mechanisms.

The philosopher Akeel Bilgrami’s notion of identity is original and challenging to liberal political theory, but still largely unaddressed by it. In a nutshell, Bilgrami characterizes identity as holding certain values and commitments with a crucial addendum: as we want to continue living by those values and commitments in the future, we erect some social and legal barriers to prevent them from change. Liberals of a Millian and/or Rawlsian cast of mind, in turn, arrange political institutions to enable such change, (...) as they assume that we are the kind of creatures that change their minds. In this sense, the identitarian and the liberal mindset are, as the philosopher claims, “mirror opposites”. This article engages with Bilgrami’s view in two senses: on the one hand, it highlights some potentially problematic areas that may call for further clarification and reinterpretation of the liberal canon, as well as offering other set of tensions that arise with non-liberal philosophical traditions. On the other hand, it contends that Bilgrami’s ultimate claim is not merely that the identitarian mindset is more rational than the liberal mentality, as he does, but that it makes political demands that should be assessed against the liberal ideal of justification. While it may be the case that identitarianism is rationally superior to certain versions of comprehensive liberalism, the paper concludes that it loses out to political liberalism, to the extent that Bilgrami’s identitarianism is willing to display the state’s coercive muscle in oppressive ways, in a way that political liberalism does not. (shrink)

Du point de vue méthodologique et épistémologique, la vision occupe une place privilégiée dans les œuvres de Galien de Pergame, ce qui explique les tentatives répétées de ce dernier pour en expliquer le fonctionnement. En partie grâce à la dissection et à la vivisection pratiquées sur des animaux de différentes espèces, il développa une connaissance détaillée de l’anatomie de l’œil, du nerf optique, du cerveau, des muscles oculaires et du système vasculaire cérébral et oculaire. Il utilisa avec habileté cet impressionnant (...) savoir anatomique pour élaborer une explication détaillée de la physiologie de la vision. Pour expliquer comment voient les êtres humains, il fit également appel à l’optique mathématique, notamment à l’optique euclidienne. Cependant, en dépit d’efforts remarquables pour intégrer anatomie, physiologie et mathématiques dans une unique théorie cohérente de la vision, une analyse plus attentive montre que son explication de la vision n’est pas exempte de lacunes non négligeables, de difficultés non résolues et de tensions internes. (shrink)

To controlforceaccurately under a wide range of behavioral conditions, the central nervous system would either require a detailed, continuously updated representation of the state of each muscle (and the load against which each is acting) or else force feedback with sufficient gain to cope with variations in the properties of the muscles and loads. The evidence for force feedback with adequate gain or for an appropriate central representation is not sufficient to conclude that force is the major controlled variable (...) in normal limb movements.Morton's hypothesis, thatlengthis controlled by a follow-up servo, has a number of difficulties related to the delays, gains, variability, and specificity in feedback pathways comprising potential servo loops. However, experimental evidence is consistent with these pathways providing servo assistance for some movements produced by coactivation of α- and static γ-motoneurons. Dynamic γ-motoneurons may provide an additional input for adaptive control of different types of movements.The idea that feedback is used to compensate for changes in musclestiffnesshas received experimental support under static postural conditions. However, reflexes tend to increase rather than decrease the range of variation in muscle stiffness during some cyclic movements. Theoretical problems associated with the regulation of stiffness are also discussed. The possibilities of separate control systems forvelocityorviscosityare considered, but the evidence is either negative or lacking. I conclude that different physical variables can be controlled depending on the type of limb movement required. The concept of stiffness regulation is also useful under some conditions, but should probably be extended to the regulation of the visco-elastic properties (i.e., the mechanical impedance) of a muscle or joint. (shrink)

In the wake of Clark and Chalmers famous argument for extended cognition some people have argued that willpower equally can extend into the environment (e.g. Heath and Anderson in The thief of time: philosophical essays on procrastination. Oxford University Press, New York, pp 233–252, 2010). In a recent paper Fabio Paglieri (Consciousness in interaction: the role of the natural and social context in shaping consciousness. John Benjamins, Amsterdam, pp 179–206, 2012) provides an interesting argument to the effect that there might (...) well be extended self control, but that willpower does not lend itself to extension. This paper argues that Paglieri is right in claiming that previous attempts to extend the will are flawed. It then provides an argument for extending the will that does not fall foul of Paglieri’s argument and actually provides us with an even stronger case for extension than the one that Clark and Chalmers provide for cognition. (shrink)

Cellular mechanisms whereby quiescent stem cells sense tissue injury and transition to an activated state are largely unknown. Quiescent skeletal muscle stem cells (MuSCs, also called satellite cells) have elaborate, heterogeneous projections that rapidly retract in response to muscle injury. They may therefore act as direct sensors of their niche environment. Retraction is driven by a Rac‐to‐Rho GTPase activity switch that promotes downstream MuSC activation events. These and other observations lead to several hypotheses: (1) projections are morphologically dynamic (...) at quiescence, providing a surveillance function for muscle damage; (2) quiescent projection dynamics are regulated by the relative balance of Rac and Rho activities promoted by niche‐derived cues; (3) projections, particularly their associated filopodia, sense tissue damage via changes to the biomechanical properties of the niche and/or detection of signaling cues released by damaged myofibers; and (4) the dynamic nature of projections results in a population of MuSCs with heterogeneous functional properties. These concepts may extend to other types of quiescent stem cells, as well as prove useful in translational research settings. (shrink)

The idea that the brain is a representational organ has roots in the nineteenth century, when neurologists began drawing conclusions about what the brain represents from clinical and experimental studies. One of the earliest controversies surrounding representation in the brain was the “muscles versus movements” debate, which concerned whether the motor cortex represents complex movements or rather fractional components of movement. Prominent thinkers weighed in on each side: neurologists John Hughlings Jackson and F.M.R. Walshe in favor of complex movements, neurophysiologist (...) Charles Sherrington and neurosurgeon Wilder Penfield in favor of movement components. This essay examines these and other brain scientists’ evolving notions of representation during the first eighty years of the muscles versus movements debate (c. 1873–1954). Although participants agreed about many of the superficial features of representation, their inferences reveal deep-seated disagreements about its inferential role. Divergent epistemological commitments stoked conflicting conceptions of what representational attributions imply and what evidence supports them. (shrink)

We hypothesise that the sarcolemma of an actively growing myofibre has different properties to the sarcolemma of a mature adult myofibre. Such fundamentally different properties have clinical consequences for the onset, and potential therapeutic targets, of various skeletal muscle diseases that first manifest either during childhood (e.g. Duchenne muscular dystrophy, DMD) or after cessation of the main growth phase (e.g. dysferlinopathies). These characteristics are also relevant to the selection of both tissue culture and in vivo models employed to study (...) such myopathies and the molecular regulation of adult myofibres. During growth, multinucleated myofibres increase enormously in size and volume with dramatic increases in length (up to ∼600 mm). This is in striking contrast with most mononucleated cells such as fibroblasts, that remain at a relatively small size (∼10–20 µm diameter). The consequences of a dynamic, expanding sarcolemma during growth, compared with that of an adult myofibre of a fixed length, are discussed with respect to various aspects of muscle biology. (shrink)

In recent years, live imaging has been adopted to study stem cells in their native environment at cellular resolution. In the skeletal muscle field, this has led to visualising the initial events of muscle repair in mouse, and the entire regenerative response in zebrafish. Here, we review recent discoveries in this field obtained from live imaging studies. Tracking of tissue resident stem cells, the satellite cells, following injury has captured the morphogenetic dynamics of stem/progenitor cells as they facilitate (...) repair. Asymmetric satellite cell division generated a clonogenic progenitor pool, providing in vivo validation for this mechanism. Furthermore, there is an emerging role of stem/progenitor cell guidance at the injury site by cellular protrusions. This review concludes that live imaging is a critical tool for discovering the distinct processes that occur during regeneration, emphasising the importance of imaging in diverse animal models to capture the entire scope of stem cell functions. (shrink)

MacNeilage's target article develops a theory for the evolution of human speech articulation along the lines of “slot- filler” structure. His content/frame schema commits him to the tenets of embodiment, muscle sense, and a memory for speech. My commentary ties these aspects together in their historical and current perspective.

Muscle synergies reflect the presence of a common neural input to multiple muscles. Steering small sets of synergies is commonly believed to simplify the control of complex motor tasks like walking and running. When these locomotor patterns emerge, it is likely that synergies emerge as well. We hence hypothesized that in children learning to run the number of accompanying synergies increases and that some of the synergies’ activities display a temporal shift related to a reduced stance phase as observed (...) in adults. We investigated the development of locomotion in 23 children aged 2–9 years of age and compared them with seven young adults. Muscle activity of 15 bilateral leg, trunk, and arm muscles, ground reaction forces, and kinematics were recorded during comfortable treadmill walking and running, followed by a muscle synergy analysis. We found that toddlers and preschoolers utilize a “walk-run strategy” when learning to run: they managed the fastest speeds on the treadmill by combining double support and flight phases. In particular the activity duration of the medial gastrocnemius muscle was weakly correlated with age. The number of synergies across groups and conditions needed to cover sufficient data variation ranged between four and eight. The number of synergies tended to be smaller in toddlers than it did in preschoolers and school-age children but the adults had the lowest number for both conditions. Against our expectations, the age groups did not differ significantly in the timing or duration of synergies. We believe that the increase in the number of muscle synergies in older children relates to motor learning and exploration. The ability to run with a FP is clearly associated with an increase in the number of muscle synergies. (shrink)

The paper considers apprenticeship as a model of education that both teaches technical skills and provides the grounding for personal formation. The research presented is based on long-term anthropological fieldwork with minaret builders in Yemen, mud masons in Mali and fine-woodwork trainees in London. These case studies of on-site learning and practice support an expanded notion of knowledge that exceeds propositional thinking and language and centrally includes the body and skilled performance. Crafts -- like sport, dance and other skilled physical (...) activities -- are largely communicated, understood and negotiated between practitioners without words, and learning is achieved through observation, mimesis and repeated exercise. The need for an interdisciplinary study of communication and understanding from the body is therefore underlined, and the paper suggests a way forward drawing on linguistic theory and recent neurological findings. It is argued that the validation and promotion of skilled practice as 'intelligent' is necessary for raising the status and credibility of apprenticestyle learning within our Western systems of education. (shrink)

Studies have shown that in the mammalian neuromuscular system stretch reflexes are localized within individual muscles. Neuromuscular compartmentalization, the partitioning of sensory output from muscles, and the partitioning of segmental pathways to motor nuclei have also been demonstrated. This evidence indicates that individual motor nuclei and the muscles they innervate are not homogeneous functional units. An analysis of the functional significance of reflex localization and partitioning suggests that segmental control mechanisms are based on subdivisions of motor nuclei–muscle complexes. A (...) partitioned organization of segmental control mechanisms could utilize (1) the potential functional diversity of muscle fiber types, (2) the variety of mechanical actions of individual muscles arising from their distributed origins and insertions, and (3) diverse architectural features such as intramuscular variations in pinnation and complex in-series and in-parallel arrangements of muscle fibers. The differentiated activity observed in some muscles during natural movements also calls for localized segmental control mechanisms. Partitioning may also play a role in mechanical interactions between contracting motor units and in increasing the stability of neuromuscular systems. The functional advantages of reflex localization and partitioning suggest they are probably common features of segmental systems, whose organization reflects the structure and function of their associated neuromuscular systems. (shrink)

In Hypatia's 3, issue, Xinyan Jiang describes a failed experiment in sexual equality conducted during the Chinese Cultural Revolution. She believes the lesson to be drawn from it is that males will continue to have an advantage in societies requiring much physical strength. In contrast, I argue here that this failed experiment shows that the Maoist attempt to force women into men's roles was not feminist. American pioneers are cited as a counterexample.

In Hypatia's 3, issue, Xinyan Jiang describes a failed experiment in sexual equality conducted during the Chinese Cultural Revolution. She believes the lesson to be drawn from it is that males will continue to have an advantage in societies requiring much physical strength. In contrast, I argue here that this failed experiment shows that the Maoist attempt to force women into men's roles was not feminist. American pioneers are cited as a counterexample.

In Hypatia's 3, issue, Xinyan Jiang describes a failed experiment in sexual equality conducted during the Chinese Cultural Revolution. She believes the lesson to be drawn from it is that males will continue to have an advantage in societies requiring much physical strength. In contrast, I argue here that this failed experiment shows that the Maoist attempt to force women into men's roles was not feminist. American pioneers are cited as a counterexample.