Results for 'proportional hazard'

993 found
Order:
  1.  84
    Proportional Hazards Modeling of Saccadic Response Times During Reading.Mattias Nilsson & Joakim Nivre - 2013 - Topics in Cognitive Science 5 (3):541-563.
    In this article we use proportional hazards models to examine how low-level processes affect the probability of making a saccade over time, through the period of fixation, during reading. We apply the Cox proportional hazards model to investigate how launch distance (relative to word beginning), fixation location (relative to word center), and word frequency affect the hazard of a saccadic response. This model requires that covariates have a constant impact on the hazard over time, the assumption (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  2.  31
    Physician workload associated with do-not-resuscitate decision-making in intensive care units: an observational study using Cox proportional hazards analysis.Shu-Chien Huang Kuan-Han Lin, Chau-Chung Chih-Hsien Wang & Yen-Yuan Chen Tzong-Shinn Chu - 2019 - BMC Medical Ethics 20 (1):15.
    Physicians play a substantial role in facilitating communication regarding life-supporting treatment decision-making including do-not-resuscitate in the intensive care units. Physician-related fact...
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  3.  15
    Mediation Analysis with Survival Outcomes: Accelerated Failure Time vs. Proportional Hazards Models.Lois A. Gelfand, David P. MacKinnon, Robert J. DeRubeis & Amanda N. Baraldi - 2016 - Frontiers in Psychology 7.
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  4.  20
    Compensation and hazard pay for key workers during an epidemic: an argument from analogy.Doug McConnell & Dominic Wilkinson - 2021 - Journal of Medical Ethics 47 (12):784-787.
    The COVID-19 pandemic has created unusually challenging and dangerous workplace conditions for key workers. This has prompted calls for key workers to receive a variety of special benefits over and above their normal pay. Here, we consider whether two such benefits are justified: a no-fault compensation scheme for harm caused by an epidemic and hazard pay for the risks and burdens of working during an epidemic. Both forms of benefit are often made available to members of the armed forces (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  5.  3
    HAVING A BABY:: Some Predictions of Maternal Employment Around Childbirth.Patricia Garrett & Deeann Wenk - 1992 - Gender and Society 6 (1):49-65.
    This analysis tests the influence of personal, job, and family status characteristics on maternal employment. We use the Merged Child/mother File from the National Longitudinal Survey of Youth to examine employment patterns of mothers who gave birth between 1979 and 1986. Logistic regression is used to estimate the probabilities; proportional hazards techniques are used to estimate rates of leaving and return to employment after childbirth. We find that family status factors and the proportion of the family income the mother (...)
    Direct download  
     
    Export citation  
     
    Bookmark   2 citations  
  6.  19
    Treaty Commitment as a Signaling Device: Explaining the Ratification of the International Covenant on Economic, Social, and Cultural Rights.Zhiyuan Wang - 2016 - Human Rights Review 17 (2):193-220.
    This study investigates the determinants of the ratification of International Covenant on Economic, Social, and Cultural Rights (ICESCR). To do so, it proposes an explanation that postulates that states employ treaty ratification as a device to signal their resolve to implement polices required by the treaty at issue in order to appease demanding domestic constituencies, predicting that states with lower compliance capacity tend to commit faster than states with higher compliance capacity. Applying this explanation to the ICESCR leads to two (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  7.  7
    Predictive maintenance of vehicle fleets through hybrid deep learning-based ensemble methods for industrial IoT datasets.Arindam Chaudhuri & Soumya K. Ghosh - forthcoming - Logic Journal of the IGPL.
    Connected vehicle fleets have formed significant component of industrial internet of things scenarios as part of Industry 4.0 worldwide. The number of vehicles in these fleets has grown at a steady pace. The vehicles monitoring with machine learning algorithms has significantly improved maintenance activities. Predictive maintenance potential has increased where machines are controlled through networked smart devices. Here, benefits are accrued considering uptimes optimization. This has resulted in reduction of associated time and labor costs. It has also provided significant increase (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  8.  3
    Historical Mortality Dynamics on the Baja California Peninsula.Shane J. Macfarlan, Ryan Schacht, Isabelle Forrest, Abigail Swanson, Cynthia Moses, Thomas McNulty, Katelyn Cowley & Celeste Henrickson - 2024 - Human Nature 35 (1):1-20.
    Historical demographic research shows that the factors influencing mortality risk are labile across time and space. This is particularly true for datasets that span societal transitions. Here, we seek to understand how marriage, migration, and the local economy influenced mortality dynamics in a rapidly changing environment characterized by high in-migration and male-biased sex ratios. Mortality records were extracted from a compendium of historical vital records for the Baja California peninsula (Mexico). Our sample consists of 1,201 mortality records spanning AD 1835–1900. (...)
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  9.  29
    Are physicians on the same page about do-not-resuscitate? To examine individual physicians’ influence on do-not-resuscitate decision-making: a retrospective and observational study.Yen-Yuan Chen, Melany Su, Shu-Chien Huang, Tzong-Shinn Chu, Ming-Tsan Lin, Yu-Chun Chiu & Kuan-Han Lin - 2019 - BMC Medical Ethics 20 (1):1-13.
    Background Individual physicians and physician-associated factors may influence patients’/surrogates’ autonomous decision-making, thus influencing the practice of do-not-resuscitate orders. The objective of this study was to examine the influence of individual attending physicians on signing a DNR order. Methods This study was conducted in closed model, surgical intensive care units in a university-affiliated teaching hospital located in Northern Taiwan. The medical records of patients, admitted to the surgical intensive care units for the first time between June 1, 2011 and December 31, (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  10.  8
    Childhood adversity and cognitive impairment in later life.Xiaoling Xiang, Joonyoung Cho, Yihang Sun & Xiafei Wang - 2022 - Frontiers in Psychology 13.
    ObjectivesThis study examined the association between childhood adversity and cognitive impairment in later life and explored the potential moderation effect of gender and race.MethodsThe study sample included 15,133 participants of the Health and Retirement Study who had complete data on key study measures and were more than 50. The outcome variable is a dichotomous indicator of cognitive impairment as assessed by the Telephone Interview for Cognitive Status for self-respondents and the 16-item Informant Questionnaire on Cognitive Decline in the Elderly for (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  11.  14
    Association of Chinese herbal medicine use with the depression risk among the long-term breast cancer survivors: A longitudinal follow-up study.Shu-Yi Yang, Hanoch Livneh, Jing-Siang Jhang, Shu-Wen Yen, Hua-Lung Huang, Michael W. Y. Chan, Ming-Chi Lu, Chia-Chou Yeh, Chang-Kuo Wei & Tzung-Yi Tsai - 2022 - Frontiers in Psychology 13.
    BackgroundBreast cancer patients are at elevated risk of depression during treatment, thus provoking the chance of poor clinical outcomes. This retrospective cohort study aimed to investigate whether integrating Chinese herbal medicines citation into conventional cancer therapy could decrease the risk of depression in the long-term breast cancer survivors.MethodsA cohort of patients aged 20–70 years and with newly diagnosed breast cancer during 2000–2008 was identified from a nationwide claims database. In this study, we focused solely on survivors of breast cancer at (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  12.  36
    Treatment and survival from breast cancer: the experience of patients at South Australian teaching hospitals between 1977 and 2003.Colin Luke, Grantley Gill, Stephen Birrell, Vlad Humeniuk, Martin Borg, Christos Karapetis, Bogda Koczwara, Ian Olver, Michael Penniment, Ken Pittman, Tim Price, David Walsh, Eng Kiat Yeoh & David Roder - 2007 - Journal of Evaluation in Clinical Practice 13 (2):212-220.
    Rationale Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines.Aims and objectives To use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment with guidelines.Methods Registry data from three teaching hospitals were used to analyse trends in primary courses of treatment of breast (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  13.  13
    Hypoglycaemia with pioglitazone: analysis of data from the Prescription‐Event Monitoring study.Veronika Vlckova, Victoria Cornelius, Rachna Kasliwal, Lynda Wilton & Saad Shakir - 2010 - Journal of Evaluation in Clinical Practice 16 (6):1124-1128.
  14.  67
    Event history analysis of the duration of online public opinions regarding major health emergencies.Xiaoyan Liu, Jiarui Zhao, Ran Liu & Kai Liu - 2022 - Frontiers in Psychology 13.
    Based on event history analysis, this study examined the survival distribution of the duration of online public opinions related to major health emergencies and its influencing factors. We analyzed the data of such emergencies that took place in China during a period of 10 years. The results of the Kaplan-Meier method and Cox proportional hazards regression analysis showed that the average duration of online public opinions regarding health emergencies is 43 days, and the median is 19 days, which dispels (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  15.  14
    Applying a data duplication technique in linear regression analysis of waiting time to pregnancy.Halimah Awang - 2005 - Journal of Biosocial Science 37 (4):471-479.
    This analysis demonstrates the application of a data duplication technique in linear regression with censored observations of the waiting time to third pregnancy ending in two outcome types, using data from Malaysia. The linear model not only confirmed the results obtained by the Cox proportional hazards model, but also identified two additional significant factors. The method provides a useful alternative when Cox proportionality assumption of the hazards is violated.
    No categories
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark  
  16.  11
    Effects of Individual Mortality Experience on Out-of-Wedlock Fertility in Eighteenth- and Nineteenth-Century Krummhörn, Germany.Katharina E. Pink, Kai P. Willführ, Eckart Voland & Paul Puschmann - 2020 - Human Nature 31 (2):141-154.
    Life history theory predicts that exposure to high mortality in early childhood leads to faster and riskier reproductive strategies. Individuals who grew up in a high mortality regime will not overly wait until they find a suitable partner and form a stable union because premature death would prevent them from reproducing. Cox proportional hazard models were used to determine whether women who experienced sibling death during early childhood (0–5 years) reproduced earlier and were at an increased risk of (...)
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  17.  25
    With the Help of Kin?Paul P. P. Rotering & Hilde Bras - 2015 - Human Nature 26 (1):102-121.
    Relatives play an important role in human reproduction according to evolutionary theories of reproductive behavior, but previous empirical studies show large differences in the effects of kin on fertility outcomes. In our paper we examine the effect of co-resident kin and non-kin on the length of birth intervals over the reproductive life course of Dutch women born between 1842 and 1920. We estimate Cox proportional hazard models for parity progression based on the presence of kin and non-kin in (...)
    No categories
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark  
  18.  24
    The poverty of epidemiology.Petr Skrabanek - 1991 - Perspectives in Biology and Medicine 35 (2):182-185.
  19.  15
    The impact of record‐linkage bias in the Cox model.Ileana Baldi, Antonio Ponti, Roberto Zanetti, Giovannino Ciccone, Franco Merletti & Dario Gregori - 2010 - Journal of Evaluation in Clinical Practice 16 (1):92-96.
  20.  39
    The responsible shareholder: a case study.Richard C. Warren - 2002 - Business Ethics, the Environment and Responsibility 11 (1):14-24.
    Shareholders are sometimes considered to be, in moral terms, the owners of a company, they are after all the carriers of the residual liabilities and bear a higher proportion of the financial risk. However, in company law, the shareholders’ responsibility is limited, and in financial terms shareholders are only liable up to the fully paid value of the share certificate. Moreover, when the shares are sold, the responsibility and risk are transferred completely to the new bearer of the shares. Whether (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  21.  32
    The Tension between the Nature and the Norm of Voluntary Exchange.Thomas Christiano - 2016 - Southern Journal of Philosophy 54 (S1):109-129.
    I develop a conception of voluntary exchange and its value that helps us understand the fundamental source of difficulty with voluntary exchange. We can make a great deal of progress in understanding the promise and the perils of voluntary exchange by elaborating an analogy between voluntary exchange and democracy. To be sure, this is a hazardous activity since there are many differences between these areas. But a careful effort here will illuminate the domain of voluntary exchange in both normative and (...)
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   10 citations  
  22.  51
    Problems for Effort-Based Distribution Principles.Julian Lamont - 1995 - Journal of Applied Philosophy 12 (3):215-229.
    Many have argued that individuals should receive income in proportion to their contribution to society. Others have believed that it would be fairer if people received income in proportion to the effort they expend in so contributing, since people have much greater control over their level of effort than their productivity. I argue that those who believe this are normally also committed, despite appearances, to increasing the social product — which undermines any sharp distinction between effort- and productivity-based distributive proposals. (...)
    Direct download  
     
    Export citation  
     
    Bookmark   13 citations  
  23.  85
    Responsibility to Protect and Militarized Humanitarian Intervention.Esther D. Reed - 2013 - Journal of Religious Ethics 41 (1):183-208.
    My essay “Responsibility to Protect and Militarized Humanitarian Intervention: When and Why the Churches Failed to Discern Moral Hazard” (JRE 40.2) called for more questioning engagement with R2P than the broadly uncritical welcome given by the churches to the doctrine between September 2003 and September 2008. In response to Luke Glanville's reply, this essay identifies further reasons for caution before accepting R2P and so-called humanitarian wars alongside defensive wars as paradigmatically justified. It is structured with reference to the tests (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  24.  19
    Redlining, racism and food access in US urban cores.Yasamin Shaker, Sara E. Grineski, Timothy W. Collins & Aaron B. Flores - 2023 - Agriculture and Human Values 40 (1):101-112.
    In the 1930s, the Home Owners’ Loan Corporation (HOLC) graded the mortgage security of urban US neighborhoods. In doing so, the HOLC engaged in the practice, imbued with racism and xenophobia, of “redlining” neighborhoods deemed “hazardous” for lenders. Redlining has caused persistent social, political and economic problems for communities of color. Linkages between redlining and contemporary food access remain unexamined, even though food access is essential to well-being. To investigate this, we used a census tract-level measure of low-income and low (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  25.  10
    The Uneasy Case of Multiple Injurers’ Liability.Shmuel Leshem & Ehud Guttel - 2014 - Theoretical Inquiries in Law 15 (2):261-292.
    When harm is caused by multiple injurers, damages are allocated among the responsible injurers in proportion to their relative responsibility for harm. This Article shows that a proportional allocation of liability between strictly-liable injurers distorts incentives to take precautions. The effects of this distortion depend on the nature of the injurers’ precautions. If precautions are complements, injurers compete for lower liability shares, which results in excessive care-taking. If precautions are substitutes, injurers are afflicted by moral hazard, which gives (...)
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  26.  12
    Flood Detection and Susceptibility Mapping Using Sentinel-1 Time Series, Alternating Decision Trees, and Bag-ADTree Models.Ayub Mohammadi, Khalil Valizadeh Kamran, Sadra Karimzadeh, Himan Shahabi & Nadhir Al-Ansari - 2020 - Complexity 2020:1-21.
    Flooding is one of the most damaging natural hazards globally. During the past three years, floods have claimed hundreds of lives and millions of dollars of damage in Iran. In this study, we detected flood locations and mapped areas susceptible to floods using time series satellite data analysis as well as a new model of bagging ensemble-based alternating decision trees, namely, bag-ADTree. We used Sentinel-1 data for flood detection and time series analysis. We employed twelve conditioning parameters of elevation, normalized (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  27. Non-Silences of Professor Hazard on" The Silences of the Restatement": A.Geoffrey C. Hazard Jr - 1997 - Legal Ethics 631:660-68.
     
    Export citation  
     
    Bookmark  
  28.  30
    Symbolism and Yeats's “A Vision”.Hazard Adams - 1964 - Journal of Aesthetics and Art Criticism 22 (4):425-436.
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark  
  29.  32
    The Blakean aesthetic.Hazard Adams - 1954 - Journal of Aesthetics and Art Criticism 13 (2):233-248.
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark  
  30.  30
    Canons: Literary Criteria/Power Criteria.Hazard Adams - 1988 - Critical Inquiry 14 (4):748-764.
    W. B. Yeats’ poem “Politics” has as its epigraph Thomas Mann’s remark, “In our time the destiny of man presents its meaning in political terms.”1 Yeats chose the epigraph in 1938, just before World War II, for a poem proclaiming that sexuality holds his interest more than politics. This still may be true for poets, but by the looks of things, not for many contemporary critics, who, if they do not choose one over the other, subsume one under the other. (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  31.  10
    Studies in Human Time.Hazard Adams - 1956 - Journal of Aesthetics and Art Criticism 16 (1):135-136.
  32.  18
    Setting a human rights and legal framework around ‘the ethics of consent during labour and birth: episiotomies’.Bashi Kumar-Hazard & Hannah Grace Dahlen - 2023 - Journal of Medical Ethics 49 (9):634-635.
    We commend the authors for their comprehensive discussion on consent and episiotomies.1 They correctly observe that informed consent for all proposed interventions in maternity care is always necessary. The claim that consent for maternity health services does not always have to be fully informed or explicit, however, is erroneous. We are especially concerned with, and surprised by, the endorsement of ‘opt-out consent’. ‘Opt-out consent’ (a.k.a. substitute decision making) is already standard practice in maternity healthcare, with obstetric violence a normalised response (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  33.  17
    Chaucer and the French Tradition, a Study in Style and MeaningStudies on Chaucer and His Audience.Hazard Adams, Charles Muscatine & Mary Giffin - 1958 - Journal of Aesthetics and Art Criticism 16 (4):534.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  34.  6
    Joseph Viscomi, Blake and The Idea of The Book.Hazard Adams - 1995 - Journal of Aesthetics and Art Criticism 53 (4):443-444.
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  35.  38
    The criteria of criticism in literature.Hazard Adams - 1962 - Journal of Aesthetics and Art Criticism 21 (1):31-34.
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark  
  36.  54
    Titles, titling, and entitlement to.Hazard Adams - 1987 - Journal of Aesthetics and Art Criticism 46 (1):7-21.
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  37.  13
    Vision and Verse in William BlakeThe Crowns of Apollo: Swinburne's Principles of Literary Art.Hazard Adams, Alicia Ostriker & Robert L. Peters - 1966 - Journal of Aesthetics and Art Criticism 25 (1):107.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  38.  64
    William Blake. A Reading of the Shorter Poems.Hazard Adams - 1965 - Journal of Aesthetics and Art Criticism 23 (3):394-395.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  39.  94
    Legal ethics: a comparative study.Geoffrey C. Hazard - 2004 - Stanford, Calif.: Stanford University Press. Edited by Angelo Dondi.
    Examining legal ethics within the framework of modern practice, this book identifies two important ethical issues that all lawyers confront: the difference between the role of lawyers and the role of judges in pursuing justice, and the conflicting responsibilities lawyers have to their clients and to the legal system more broadly. In addressing these issues, Legal Ethics provides an explanation of the duties and dilemmas common to practicing lawyers in modern legal systems throughout the world. The authors focus their analysis (...)
    Direct download  
     
    Export citation  
     
    Bookmark   4 citations  
  40.  13
    Moral Foundations of American Law: Faith, Virtue and Mores.Geoffrey C. Hazard - 2013 - Intersentia. Edited by Douglas W. Pinto.
    This excellent book is about Western morality as it interacts with law. It is not contrasting the moral foundations of American law with other value systems. Rather the authors examine the history and great diversity of Western thought, the substance of moral ideas. They range from the ancients to the new old order of the New World. Hazard and Pinto see the various voices articulating moral, political and legal thought as "pregnant with future relevance" for practical decision-making. Thus their (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  41.  16
    European thought in the eighteenth century.Paul Hazard - 1954 - New Haven,: Yale University Press.
  42.  6
    Moshe Barasch, Theories of Art: From Plato To Winckelmann.Mary E. Hazard - 1986 - Journal of Aesthetics and Art Criticism 44 (3):296-296.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  43.  6
    Mental Child Abuse.Laura Hazard - 1985 - Hastings Center Report 15 (1):48-48.
  44.  9
    Patience and the Book of Jonah 'As Holy Wryt Telles'.Mark Hazard - 1997 - Mediaevalia 21 (2):295-325.
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  45.  14
    Ryukyu: A Bibliographical Guide to Okinawan Studies.Benjamin H. Hazard, Shunzō Sakamaki & Shunzo Sakamaki - 1964 - Journal of the American Oriental Society 84 (1):70.
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  46.  29
    The anatomy of "liveliness" as a concept in renaissance aesthetics.Mary E. Hazard - 1975 - Journal of Aesthetics and Art Criticism 33 (4):407-418.
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark  
  47.  9
    The American Occupation of Japan: A Retrospective View.Benjamin H. Hazard & Grant K. Goodman - 1971 - Journal of the American Oriental Society 91 (4):522.
    No categories
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark  
  48.  23
    The Conservation, Cataloguing and Digitization of Fr. Luke Wadding's Papers at University College Dublin.Benjamin Hazard - 2011 - Franciscan Studies 69:477-489.
    In lieu of an abstract, here is a brief excerpt of the content:At St. Isidore’s Franciscan College in Rome, the following maxim attributed to St. Patrick is inscribed above the door-way of the church: Si quae difficiles quaestiones in hac insula oriantur ad Sedem Apostolicam referantur; ut Christiani ita et Romani sitis.1 The college was founded in 1625 by Luke Wadding, O.F.M. and, under his direction, became a major seat of theological learning and political influence for the Irish in Rome.2 (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  49.  12
    This Is Kendo: The Art of Japanese FencingAn Introduction to KendōAn Introduction to Kendo.Benjamin H. Hazard, Junzō Sasamori, Gordon Warner, Ronald Alexander Lidstone & Junzo Sasamori - 1968 - Journal of the American Oriental Society 88 (3):625.
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  50.  16
    The Japanese Communist Party, 1922-1945.Benjamin H. Hazard, George M. Beckman & Okubo Genji - 1973 - Journal of the American Oriental Society 93 (3):406.
1 — 50 / 993