Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The paper focuses on processes of normalization through which dis/ability is simultaneously produced in specific collectives, networks, and socio-technological systems that enable the construction of such demarcations. Our point of departure is the cochlear implant, a neuroprosthetic device intended to replace and/or augment the function of the damaged inner ear. Unlike hearing aids, which amplify sounds, the CI does the work of damaged hair cells in the inner ear by providing sound signals to the brain. We examine the processes of (...) the CI’s genesis as well as its specific uses by and interrelations to the different and divergent actors that the CI assembles. We argue that the technological device and the implicated normalization process mobilize complex effects in varying socio-technical arrangements. The CI is conceived as a “boundary object” [89] or a “quasi-object” [49, 83], i.e., a metastabilized medium of translation that coordinates social, cultural, and technological action. Although intended to transform non-hearing or hard of hearing people into competent and “normal” hearing subjects, the CI system reproduces the asymmetrical structures of the disability discourse [14] through its function of “developing and maintaining coherence between intersecting social worlds” [89, 393]. Additionally, it initiates controversial discourses that have resulted in new forms of biosocial collectivities ranging from cochlear implantees with normal human hearing to human configurations who have passed through human enhancement. Our approach is thus situated at the intersection of disability and media studies and tackles the particular conditions technological media configurations impose upon the production of dis/ability. (shrink)

Against the backdrop of an aging world population increasingly affected by a diverse range of abilities and disabilities as well as the rise of ubiquitous computing and digital app cultures, this paper questions how mobile technologies mediate between heterogeneous environments and sensing beings. To approach the current technological manufacturing of the senses, two lines of thought are of importance: First, there is a need to critically reflect upon the concept of assistive technologies as artifacts providing tangible solutions for a specific (...) disability. Second, the conventional distinction between user and environment requires a differentiated consideration. This contribution will first review James Gibson’s concept of “affordances” and modify this approach by introducing theories and methods of Science and Technology Studies and Actor-Network Theory. Then, we present two case studies where we explore the relations between recent “assistive” app technologies and human sensory perception. As hearing and seeing are key in this regard, we concentrate on two specific media technologies: ReSound LINX2, a hearing aid which allows for direct connect with iPhone, iPad, or iPod Touch, and Camassia, an IOS app for sonic wayfinding for blind people. We emphasize the significance of dis-/abling practices for manufacturing novel forms of hearing and seeing and drawing on sources like promotional materials by manufacturers, ads, or user testimonials and reviews. Our analysis is interested in the reciprocal relationships between users and their socio-technical and media environments. By and large, this contribution will provide crucial insights into the contemporary entanglement of algorithm-driven technologies, daily practices, and sensing subjects: the production of techno-sensory arrangements. (shrink)

Scientific perspectivism, or perspectival realism, is a view according to which scientific knowledge is neither utterly objective nor independent of the world “as it is”, but always tied to some particular ways of conceptualization and interaction with Nature. In the present paper, I employ Robert Rosen’s concept of the modeling relation for arguing that there are two basic reasons why our knowledge of natural systems is perspectival in this sense. The first of these pertains to the dualism between a (...) system and its environment, which is necessarily imposed by a scientist focusing on the former. The second pertains to the complexity of complex systems; a complex system understood as a system in which different kinds of causal entailments intertwine together. As I discuss in the paper besides developing the argument, perspectivism thus understood ties together several issues ranging from organicism to emergentism and to processual philosophy, and from the ceteris paribus talk of biology to the measurement problem of quantum mechanics. I also discuss Rosen’s relational formalisms as a concrete example of how perspectival epistemology might directly suggest novel strategies and practices of doing theoretical science. (shrink)

In the debate about the moral status of human beings at the margins of life, arguments of species membership are often considered to be the least plausible ones. Against this backdrop, this article explores two possible ways to formulate feasible arguments of species membership. The first is an (in the broadest sense of the word) Aristotelian or neo‐Aristotelian argument; the second is an argument from the intrinsic logic of human rights, which Robert Spaemann refers toas a ‘transcendental‐pragmatic’ argument. On (...) these grounds, the article proposes a philosophical justification for an at least moderate speciesism. (shrink)

Whilst agreeing with Robert Pippin that Hegel undertakes his philosophical enterprise in light of Kant's insights into the failings of pre-critical metaphysics, this paper outlines the shortcomings of Pippin's Hegel interpretation by contrasting what I call 'apperceptive idealism' on the one hand with 'transcendental ontology' on the other. By privileging subject over substance, Pippin commits Hegel to an ontologically modest form of Kantianism that, in missing how reality as a whole is the main topic of Hegel’s philosophy, leaves no (...) room for a crucial Hegelian task, namely accounting for the presence of self-conscious thinking in nature. Appreciating the nature of Hegel's true ambitions whilst remaining aware of how his Logic maps a 'realm of shadows', opens up the possibility of understanding his philosophy as forging a middle path: Hegel is neither the subjective idealist of Pippin's interpretation nor the advocate of a revival of first-order metaphysical theorising depicted by so many of Pippin's critics. (shrink)

This collection of essays provides an exemplary overview of the diversity and relevance of current scholarship on German Idealism. The importance of German Idealism for contemporary philosophy has received growing attention and acknowledgment throughout competing fields of contemporary philosophy. Part of the growing interest rests on the claim that the works of Kant, Fichte, Schelling, Hegel remain of considerable interest for cultural studies, sociology, theology, aesthetics and other areas of interest. In the domain of philosophy, the renaissance of innovative readings (...) of German Idealism has taken scholarly debates beyond merely antiquarian perspectives. This renaissance has been a major factor of current efforts to bridge the gap between so-called “analytic” and so-called “continental” philosophy. The volume provides a selection of well-chosen examples of readings that contribute to systematic treatments of philosophical problems. It contains contributions by Markus Gabriel, Robert Pippin, Anders Moe Rasmussen, Sebastian Rödl. (shrink)

As Professor of Philosophy at the University of Sydney for over 20 years, György Márkus exerted a profound influence on a generation of philosophers and students from many disciplinary backgrounds. His legendary lecture courses, spanning the history of modern philosophy from the Enlightenment through to the late 20th century, were memorable for their breadth, erudition, and philosophical drama. Always modest despite his mastery of the tradition, Márkus’s approach to this history of philosophy never failed to emphasize its continuing role in (...) shaping our inherited understanding of philosophy as ‘its own time comprehended in thoughts’. This is especially true of his contribution to the philosophical discourse of modernity, which we could summarize as comprising an original philosophy of cultural modernity. In what follows, I briefly reconstruct Márkus’s account of the adventures of the concept of culture, focusing on his definitive essay ‘The Path of Culture: From the Refined to the High, From the Popular to Mass Culture’ but also referring to other relevant Márkus texts, offering some critical remarks on his account of culture and its relationship with modern aesthetics, both classical and contemporary. (shrink)

In this paper we show that Audi’s fallibilist foundationalism is beset by three unclarities. First, there is a conceptual unclarity in that Audi leaves open if and how to distinguish clearly between the concepts of fallibility and defeasibility. Second, there is a general unclarity: it is not always clear which fallibility/defeasibility-theses Audi accepts or denies. Finally, there is an unclarity of self-application because Audi does not specify his own claim that fallibilist foundationalism is an inductivist, and therefore itself fallible, thesis. (...) The critical part of our paper is supplemented by a constructive part, in which we present a space of possible distinctions between different fallibility and defeasibility theses. These distinctions can be used by Audi as a toolkit to improve the clarity of fallibilist foundationalism and thus provide means to strengthen his position. (shrink)

ABSTRACTMy paper aims to situate and contextualize György Márkus’s key writings on cultural modernity on the one hand in relation to their theoretical antecedents in Kant and Hegel’s conception of modern society as a society of culture and in Lukacs’s reception of Kant and Hegel in his early pre-Marxist works, and on the other hand in relation to an examination of the contemporary ramifications of certain tendencies in modern culture highlighted in Márkus’s writings. The paper is accordingly divided into two (...) parts. Part I sets out to reconstruct the presuppositions of Márkus’s theory of the high culture of classical modernity in order to bring out the descriptive strength and the analytic contribution of his approach in relation to the tradition of cultural critique in modernity, in particular in Western Marxism. Part II aims to show how Márkus’s theory of modern culture from the late eighteenth century to the end of World War II contains elements crucial to the theorization of contemporary culture, characterized by new forms of paradoxicality that go beyond his own model. (shrink)

Ethical principles and precepts -- The evolution of morality -- Ethics and law -- Exchange and reciprocity : conflict in personal relationships -- Ethics and the physical sciences -- Ethics and medicine -- Ethics and politics -- Ethics and business -- Ethics and war -- What does all this mean for the future? -- Appendix : relations to moral philosophy.

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

Pharmacy Ethics: A Foundation for Professional Practice provides a model for examining and resolving ethical dilemmas, thereby helping student pharmacists understand the ethical decision-making process in professional practice.

This paper explores the relationship between eugenics, disability, and dehumanization, with a focus on forms of eugenics beyond Nazi eugenics.

Written by the preeminent democratic theorist of our time, this book explains the nature, value, and mechanics of democracy. In a new introduction to this Veritas edition, Ian Shapiro considers how Dahl would respond to the ongoing challenges democracy faces in the modern world. “Within the liberal democratic camp there is considerable controversy about exactly how to define democracy. Probably the most influential voice among contemporary political scientists in this debate has been that of Robert Dahl.”—Marc Plattner, _New York (...) Times_ “An excellent introduction for novices, as well as a trusty handbook for experts and political science mavens.”—_Publishers Weekly_. (shrink)

This paper offers an overview of "the species problem", arguing for a view of species as homeostatic property cluster kinds, positioning the resulting form of realism about species as an alternative to the claim that species are individuals and pluralistic views of species. It draws on taxonomic practice in the neurosciences, especially of neural crest cells and retinal ganglion cells, to motivate both the rejection of the species-as-individuals thesis and species pluralism.

Essentialism is widely regarded as a mistaken view of biological kinds, such as species. After recounting why (sections 2-3), we provide a brief survey of the chief responses to the “death of essentialism” in the philosophy of biology (section 4). We then develop one of these responses, the claim that biological kinds are homeostatic property clusters (sections 5-6) illustrating this view with several novel examples (section 7). Although this view was first expressed 20 years ago, and has received recent discussion (...) and critique, it remains underdeveloped and is often misrepresented by its critics (section 8). (shrink)

Introduction The contemporary study of society is fired by our quest for scientific truth. The very spirit of our age is tangible evidence ...

In the good old days, when general philosophy of science ruled the Earth, a simple division was often invoked to talk about philosophical issues specific to particular kinds of science: that between the natural sciences and the social sciences. Over the last 20 years, philosophical studies shaped around this dichotomy have given way to those organized by more fine-grained categories, corresponding to specific disciplines, as the literatures on the philosophy of physics, biology, economics and psychology--to take the most prominent four (...) examples--have blossomed. In general terms, work in each of these areas has become increasingly enmeshed with that in the corresponding science itself, increasingly naturalistic (in at least one sense of that term), and in my view, increasingly interesting. (shrink)

An anthology of the life and teachings of Tsongkhapa that includes transcendental aspects of sutra, tantra, insight meditation, mystic conversations, spiritual songs, and a new introduction by Robert Thurman.

An overview of the philosophy of psychology.

Entrepreneurs sometimes make unethical decisions that have devastating effects on their companies, stakeholders, and themselves. We suggest that insights into the origins of such actions can be acquired through attention to personal motives and their impact on moral disengagement—a cognitive process that deactivates moral self-regulation, thus enabling individuals to behave in ways inconsistent with their own values. We hypothesize that entrepreneurs’ motivation for financial gains is positively related to moral disengagement, while their motivation for self-realization is negatively related to this (...) process. Results obtained with a sample of founding entrepreneurs offered support for the first prediction, as well as support for the prediction that moral disengagement is positively related to the tendency to make unethical decisions. (shrink)

This book provides a series of challenges to Jorge J. E. Gracia’s views on metaphysics and categories made by realist philosophers in the Aristotelian and Thomistic traditions. Inclusion of Gracia’s responses to his critics makes this book a useful companion to Gracia’s _Metaphysics and its Task: The Search for the Categorial Foundation of Knowledge_.

Where does the mind begin and end? Most philosophers and cognitive scientists take the view that the mind is bounded by the skull or skin of the individual. Robert Wilson, in this provocative and challenging 2004 book, provides the foundations for the view that the mind extends beyond the boundary of the individual. The approach adopted offers a unique blend of traditional philosophical analysis, cognitive science, and the history of psychology and the human sciences. The companion volume, Genes and (...) the Agents of Life, explores the theme in the biological sciences. Written with verve and clarity, this ambitious book will appeal to a broad swathe of professionals and students in philosophy, psychology, cognitive science, and the history of the behavioural and human sciences. You can download the table of contents here. (shrink)

What place does freedom have in Confucianism? We find a wide spectrum of views on the matter: some deny that Confucians value or even conceive of freedom, while others celebrate uniquely exalted forms of Confucian freedom. This paper examines the range of proposals, finding consensus among these diverse views in that all identify distinctive Confucian emphases on (i) subjective affirmation of the good and (ii) the cultivation of desires and intentions to align with that good. The variation among views of (...) Confucian freedom does not result from disparate interpretations of Confucian teachings. Rather, their divergence lies in affirming or denying that these core aspects of Confucian thought should be seen as ‘freedom.’ This reveals an undiscussed, fundamental question regarding Confucian freedom: Can and should we see the traditional Confucian moral ideal—that is, Confucian goodness and sagely virtue—as versions of freedom? What do we gain by doing so? (shrink)

Kant’s theory of evil, presented most fully in his Religion within the Boundaries of Mere Reason, has been consistently misinterpreted since he first presented it. As a result, readers have taken it to be a mess of inconsistencies and eccentricities and so have tried to mine it for an insight or two, dismissed it altogether, or sought to explain how Kant could have gone so wrong. In this work, I provide an interpretation of Kant’s theory of evil that renders it (...) consistent and plausible. The main problem Kant tries to solve with his theory of evil is the problem of willful immorality: how can someone who sees her moral obligations as overridingly authoritative willingly (and so culpably) transgress them? Kant’s answer is that we do so by indulging various “moral fantasies” – ways of reconceiving the moral law or one’s status in relation to it. By entertaining, e.g., the fantasy that one is exempt from the moral law’s commands (“the exceptionalist fantasy”), or that one cannot live up to them (“despondency”), or that one need only to live up to society’s standards rather than moral demands (“the adequacy fantasy”) – one persuades oneself that the duty the moral law demands one to perform is only optional. Moral fantasies appeal only because of the presence, in everyone, of the “propensity to evil,” which makes the moral law’s commands seem less authoritative, thereby strengthening one’s sensuous desires. As a result, moral fantasies thereby diminish the urgency of moral obligations, and so tempt us to entertain them. Scholars of Kant have missed this explanation of wickedness because they have restricted their attention to the Religion, a work whose gnomic statements on evil are difficult to interpret when isolated from the larger context of Kant’s thinking. Assaying Kant’s thinking on immorality from the mid-1780s to the late 1790s shows that Kant’s main concern with evil was not so much its nature, but its very possibility. Evaluating the Religion in this context reveals it to be a fruitful resource for explaining the moral psychology of immorality, a problem we still deal with today, and that is possibly. (shrink)

Several recent commentators have suggested that for fully rational agents who find themselves in iterated prisoner's dilemmas of indefinite length, co-operation is the rational strategy. Their argument is that these fully rational agents can be taught, through the co-operative actions of other agents, to bypass the dominant move of noncooperation and co-operate instead. The proponents of the “teaching strategy” seem to have ignored the compelling argument of Jordan Howard Sobel. While the teaching argument may work for agents who are less (...) than purely rational, Sobel has pointed out that hyperrational utility maximizers cannot be taught; they reason deductively, not inductively, as the “teaching argument” requires. (shrink)