This study suggests that unrelated diversification has a positive influence on the probability of fraudulent reporting whereas related diversification has a negative influence on the probability of fraudulent reporting. The strength of the influence of these corporate level strategies is contingent on the moral character of the firm. Unrelated diversification provides opportunity for financial innovation within the firm’s internal capital market, which can result in fraudulent reporting. This is more likely when the moral character of (...) the firm is driven by a conscienceless financial self-interest motive, as implied by the firm’s contempt toward the larger community (in terms of damage inflicted on the interests of people outside the firm). In contrast, related diversification, where product divisions focus on mutual sharing and monitoring of operational activities, can reduce the probability of fraudulent reporting. This is more likely when constituents within the firm view themselves as moral citizens, as implied by the firm’s benevolence toward the larger community. Hence, while unrelated diversification focuses the energies of managers within the firm on financial manipulation, related diversification focuses these energies on productive purposes. (shrink)

Tumor‐cell diversification mechanisms insure that malignant neoplasms contain diversified tumor‐cell subpopulations. Because of the instability of tumor cell phenotypes, some malignant cells will evolve with the most favorable properties for their progression to highly metastatic cells. The rates of cellular phenotypic diversification vary greatly among different tumors, and they are probably modulated, in part, by genetic and chromosome defects and by epigenetic events that may vary widely depending upon the nature of the tumor cells and their microenvironments. As (...) tumor diversification and selection proceed, the most malignant cell subpopulations may eventually become dominant and gradually lose their microenvironmental responsiveness. Tumor‐cell diversification mechanisms may be similar or identical to normal, developmentally regulated diversification mechanisms that are used during embryonic cell diversification and differentiation. (shrink)

Task unrelated thought (TUT) refers to thought directed away from the current situation, for example a daydream. Three experiments were conducted on healthy participants, with two broad aims. First, to contrast distributed and encapsulated views of cognition by comparing the encoding of categorical and random lists of words (Experiments One and Two). Second, to examine the consequences of experiencing TUT during study on the subsequent retrieval of information (Experiments One, Two, and Three). Experiments One and Two demonstrated lower levels (...) of TUT and higher levels of word-fragment completion whilst encoding categorical relative to random stimuli, supporting the role of a distributed resource in the maintenance of TUT. In addition the results of all three experiments suggested that experiencing TUT during study had a measurable effect on subsequent retrieval. TUT was associated with increased frequency of false alarms at retrieval (Experiment One). In the subsequent experiments TUT was associated with no advantage to retrieval based on recollection, by manipulating instructions at encoding (Experiment Two), and/or at retrieval (Experiment Three). The implications of the results of all three experiments are discussed in terms of recent accounts of memory retrieval and conscious awareness. (shrink)

Task unrelated thought refers to thought directed away from the current situation; for example, a day dream. Encapsulated models of cognition propose that qualitative changes in consciousness, i.e., the production of TUT, can be explained in terms of changes in the quantity of resources deployed for task completion. In contrast, distributed models of cognition emphasize the importance of holistic processes in the generation and maintenance of task focus and are consistent with the effects of higher order variables such as (...) schemata. Three experiments were conducted on healthy participants using a categorical stimulus organization to contrast distributed and encapsulated views of cognition. Experiments 1 and 2 showed that despite the increased difficulty of the alphabetical verbal fluency task fewer TUTs were produced during category fluency condition. Experiment 3 replicated the categorical suppression of TUT while encoding and recalling information in a memory task. The results of these three experiments support the predictions derived from models of cognition emphasizing the importance of stimulus organization in the generation and maintenance of task focus and have potential importance for the scientific evaluation of cognition. (shrink)

The paper deals with multiple decision problems, which are similar to the task of guessing the color outcomes of five independent spinnings of a roulette wheel, 60% of whose slots are red and 40% white. Each correct guess yields a prize of $1. The guess of 5 Reds clearly first order stochastic dominates any other strategy. In contrast, subjects diversify their choices when facing a multiple decision problem in which the choice is between lotteries with clear objective probabilities. The (...) class='Hi'>diversification is stronger when the subjects face uncertainty without objective probabilities and weaker when the choice problem involves real life actions. c 2002 Elsevier Science B.V. All rights reserved. (shrink)

Rural diversification strategies in Zimbabwe are wide in nature but the environment plays an important role in ensuring that sustainability and structural transformation are achieved. A good understanding of the diversity of rural livelihoods choices and income sources among rural households would therefore inform policy makers on appropriate policy interventions. This paper delves to establish the role of rural diversification strategies in promoting structural transformation in Zimbabwe using Insiza district as a case study. A mixed methods research design (...) was used. Both qualitative and quantitative data collection methods were applied. The study utilized semi-structured interviews with key informants who were purposively sampled to take part in the study. A total of 100 questionnaires were distributed and 86 were returned thus giving the researcher a response rate of 86%. The study’s findings noted that rural diversification is an important component of the rural economy and it plays an important component in order to achieve structural transformation using Insiza district in Zimbabwe as a case study. The study also noted that though climate was negatively impacting on the Insiza district residents, households that diversified their income sources had enhanced income compared with farming households which do not diversify their income sources being vulnerable. The study recommends that the government should intervene by financing and educating the rural folk. Micro-policy should be targeted on rural households incomes that facilitate the provision of widening income options through small scale group schemes. (shrink)

This article explores the relationship between diversification and energy security risks. It uses portfolio theory to conceptualise energy security as an insurance mechanism against disruptions to energy import markets. It provides quantitative measures of systematic and specific risks associated with Japanese energy imports during the period 1970—99. It suggests that Japan's policy of diversification of energy import sources has reduced specific risks, although fundamental changes in the political and economic structure of international energy and, in particular, oil markets (...) have also significantly reduced systematic risks. The article concludes that, despite their limitations, portfolio measures provide a much more theoretically and methodologically robust indicator of energy import security than traditional measures of dependence. (shrink)

I argue in favour of object languages of logics to be diversely-generated, that is, not having identical immediate sub-formulas. In addition to diversely-generated object languages constituting a more appropriate abstraction of the use of sentential connectives in natural language, I show that such language lead to a simplifications w.r.t. some specific issues: the identity of proofs, the factual equivalence and the Mingle axiom in Relevance logics. I also point out that some of the properties of classical logic based on freely-generated (...) object languagest. (shrink)

The cytoskeleton has a central role in eukaryotic biology, enabling cells to organize internally, polarize, and translocate. Studying cytoskeletal machinery across the tree of life can identify common elements, illuminate fundamental mechanisms, and provide insight into processes specific to less‐characterized organisms. Red algae represent an ancient lineage that is diverse, ecologically significant, and biomedically relevant. Recent genomic analysis shows that red algae have a surprising paucity of cytoskeletal elements, particularly molecular motors. Here, we review the genomic and cell biological evidence (...) and propose testable models of how red algal cells might perform processes including cell motility, cytokinesis, intracellular transport, and secretion, given their reduced cytoskeletons. In addition to enhancing understanding of red algae and lineages that evolved from red algal endosymbioses (e.g., apicomplexan parasites), these ideas may also provide insight into cytoskeletal processes in animal cells. (shrink)

This article analyses the evolutionist discourses on the senses that emerged in the late 19th century, when theories on the evolution of species were in full sway. Drawing on newspapers, essays and medical literature, this article aims to set face to face the two currents of thought that I have identified regarding sensory evolution: the one that stressed the value of the progressive specialisation of the senses as evidence for human evolution mainly supported by Max Nordau, and the one which (...) regarded the sensory regrouping, exemplified by the phenomenon of synaesthesia, as the true symptom of evolution, strongly supported by Victor Segalen. A close examination of their arguments will provide clues concerning their relative position vis-à-vis the theory that stressed the exceptional nature of humankind among all living beings. Based on newspapers, essays and medical literature, this paper, which straddles several fields (history of science, philosophy, cultural history and aesthetics) aims to set both positions face to face, examining their arguments in detail and establishing their genealogies. This will lead to a better understanding of the scope and range of evolutionist discourses in the fin de siècle culture and on their impact upon artistic practices. (shrink)

Task unrelated thought (TUT) refers to thought directed away from the current situation, for example a daydream. Three experiments were conducted on healthy participants, with two broad aims. First, to contrast distributed and encapsulated views of cognition by comparing the encoding of categorical and random lists of words (Experiments One and Two). Second, to examine the consequences of experiencing TUT during study on the subsequent retrieval of information (Experiments One, Two, and Three). Experiments One and Two demonstrated lower levels (...) of TUT and higher levels of word-fragment completion whilst encoding categorical relative to random stimuli, supporting the role of a distributed resource in the maintenance of TUT. In addition the results of all three experiments suggested that experiencing TUT during study had a measurable effect on subsequent retrieval. TUT was associated with increased frequency of false alarms at retrieval (Experiment One). In the subsequent experiments TUT was associated with no advantage to retrieval based on recollection, by manipulating instructions at encoding (Experiment Two), and/or at retrieval (Experiment Three). The implications of the results of all three experiments are discussed in terms of recent accounts of memory retrieval and conscious awareness. (shrink)

The biannual international workshop entitled “The diversification of early emerging metazoans: A window into animal evolution?” took place at the Evangelische Akademie Tutzing, Germany, 11–14. September 2017. It was organized by Thomas Bosch (Kiel), Thomas Holstein (Heidelberg), and Ulrich Technau (Vienna), and it was sponsored by the Deutsche Forschungsgemeinschaft (DFG). The meeting gathered over 140 researchers to discuss the contribution of non‐bilaterian metazoan models (Porifera, Ctenophora, Placozoa, and Cnidaria) to our understanding of: a. The evolution of metazoan developmental processes; (...) b. Fundamental molecular mechanisms underlying metazoan features; and c. The complex interactions that animals establish with their environment. (shrink)

Socially responsible investment has grown enormously and has expanded globally in recent years. It allows SRI investors to reduce their portfolio risk assumptions through international diversification. In this context, the aim of this paper is twofold to examine price and volatility linkages among the most representative SRI indexes for North America, Europe, and Asia-Pacific employing a multivariate approach and to provide the out-of-sample performance of an optimal portfolio constructed on the basis of time-varying return and volatility forecasts from this (...) specification approach. Our overall results show that using this technique, it is possible to reduce risk and out-perform the naïve rule, which is usually employed in this type of investment. These findings are relevant not only for academics but also for practitioners, especially for professional managers of SRI portfolios. (shrink)

Market competition is intensifying. The necessity and path of adopting the diversified management model in the media industry are explored to delve into the influence of the media diversification model and entrepreneurship on enterprise financial performance. Besides, the relevant theories such as the media diversification model and entrepreneurial spirit are expounded. Furthermore, Time Publishing & Media is taken as the representative of the media diversification model. Finally, the influence of entrepreneurship on financial performance is discussed regarding entrepreneurship (...) in the Yangtze River Delta as the research object. The profitability, solvency, and operation ability of Time Publishing & Media are analyzed. It is found that there are problems in the profitability and operation ability of Time Publishing & Media. The solvency is good, and the risk of debt repayment is low. As a result, a diversified management model may not have a positive impact on enterprise performance. In addition, the entrepreneurial spirit of the Yangtze River Delta is studied, and the results reveal that the F values from 2017 to 2019 are about 66.24, 10.78, and 60.39, respectively, with a significance of 0.00. It implies that the stronger the entrepreneur’s ability to take risks, the better the financial performance of the enterprise, but the risk should be appropriate. Therefore, the research on the influence of the media diversification model and entrepreneurship on the financial performance of enterprises in the environment of sustainable development has guided significance for enterprises to improve their business performance and market competitiveness. (shrink)

A commentary on Ronald Sandler, 2013, "Climate change and Ecosystem Management." Rapid ecological change requires rethinking land management goals and strategies. We propose extending Sandler’s view. First, it is a false dichotomy to assume that a definitive choice must be made between reserve oriented and restoration approaches. Second, even more emphasis can be placed on the value of diversity in management approaches.

The recent review of the Unrelated Live Transplant Regulatory Authority provides administrative and statistical information regarding living donor kidney transplantation in the United Kingdom.1 However, it leaves much unsaid. For example, although the report does mention the number of live kidney donations from unrelated donors that ULTRA has approved, it fails to mention that the United Kingdom has a low live kidney donation rate compared with other European countries .2 More importantly, the report does not address the fundamental (...) question of whether the legal framework underlying ULTRA is morally justified. The legal regime in the United Kingdom proceeds on the tacit assumption that genetically unrelated donors are much more vulnerable to coercion than are related donors, and hence are more in need of protective regulation. In this article, we argue that the distinction drawn in the United Kingdom between genetically related and unrelated donors is difficult to justify, that it unnecessarily discourages live organ donation, and that the law should be changed.BACKGROUNDThe Unrelated Live Transplant Regulatory Authority is a creature of the Human Organ Transplant Act , which was enacted by parliament in 1989, and which came into force, with regulations, on 1 April 1990.3–5 The Human Organ Transplant Act was enacted hastily after the General Medical Council’s inquiry into the notorious case of a British physician’s involvement in transplants involving Turkish peasants.6 Young men were inveigled by an agent to travel to London, ostensibly to take up new jobs. In fact, they were being recruited as living donors of kidneys transplanted into fee paying foreign patients. The consequent debate in the media attracted an emotional …. (shrink)

Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} This article discusses a series of ethical and religious elements that occur in the debate concerning altruistic living unrelated organ donation. Our main focus is on the ethical attitude of altruist donation. In order to illustrate the connections between ethics and religion we use as a case study the (...) group of the so-called “Jesus Christians”. It is evident that this group, as a case study, is more important for the ethical and religious issues than for the medical issues related to organ donation and transplantation. However, it suggests the potential that, in certain cultural contexts, ethics and religion may have in promoting the idea of altruist donation. (shrink)

How can it be rational to work on a new theory that does not yet meet the standards for good or acceptable theories? If diversity of approaches is a condition for scientific progress, how can a scientific community achieve such progress when each member does what it is rational to do, namely work on the best theory? These two methodological problems, the problem of pursuit and the problem of diversity, can be solved by taking into account the cognitive risk that (...) is involved in theory choice. I compare this solution to other proposals, in particular T. S. Kuhn's and P. Kitcher's view that the two problems demonstrate the epistemic significance of the scientific community. (shrink)

In recent years, the number of studies examining mind wandering has increased considerably, and research on the topic has spread widely across various domains of psychological research. Although the term “mind wandering” has been used to refer to various cognitive states, researchers typically operationalize mind wandering in terms of “task-unrelated thought” (TUT). Research on TUT has shed light on the various task features that require people’s attention, and on the consequences of task inattention. Important methodological and conceptual complications do (...) persist, however, in current investigations of TUT. As we argue, these complications may be dampening the development of a more nuanced scientific account of TUT. Here, we outline three of the more prominent methodological and conceptual complications in the literature on TUT, and we discuss potential directions for researchers to take as they move forward in their investigations of TUT. (shrink)

Mistrz Eckhart, postać niejednokrotnie bardzo kontrowersyjna, cieszy się ogromnym zainteresowaniem zarówno wśród teologów, filozofów, a przede wszystkim mistyków. Głównym powodem tej uwagi jest jego koncepcja dotycząca zjednoczenia mistycznego, która opiera się głównie na zagadnieniu iskierki duszy oraz niższej części duszy, która staje się wręcz tożsama z Bogiem. Według Eckharta z jednej strony jesteśmy zrodzeni, natomiast z drugiej strony nie jesteśmy, ponieważ powinniśmy oczekiwać zrodzenia w niższej części duszy. „Narodzenie Boga w duszy” - tak Mistrz Eckhart określa zjednoczenie mistyczne, które należałoby, (...) według niego, umieścić w swoistych kategoriach przebóstwienia. Źródłem zaś całej idei przebóstwienia jest nic innego, jak silne podobieństwo między Bogiem i człowiekiem, a dokładnie jego duszą. Nietrudno odnaleźć tu liczne podobieństwa, które z łatwością można dostrzec między myślą Eckharta i myślą neoplato- ników pogańskich - Plotyna czy Proklosa. Istnieje wiele przesłanek, że Mistrz Eckhart próbuje połączyć idealistyczną filozofię neoplatońską z czysto racjonalną filozofią Tomasza z Akwinu, jednak aspekty Akwinaty są w myśli Mistrza Eckharta niemal niezauważalne. Wydaje się, że liczne trudności związane z interpretacją jego poglądów wynikają z ewidentnego braku podstaw metafizyki w jego dziełach. Jest to nieco dziwne, biorąc pod uwagę fakt, że Mistrz Eckhart doskonale znał poglądy Tomasza z Akwinu, który w sposóbjednoznaczny wypracował koncepcję bytu.Proces zjednoczenia jest w myśli Eckharta przedstawiony w kontekście poznawania. Intelekt stanowi tę władzę w bycie ludzkim, dzięki któremu może on pozostawać w nieustannym związku z Bogiem, co pozwala mu na wznoszenie się. Droga do zjednoczenia z Bogiem zawsze zatem będzie drogą ku Najwyższemu Intelektowi poprzez doskonalenie intelektu w sobie samym. Jest to jednak proces, który wymaga swoistego wyjścia z siebie samego. Wyjście to polega na swego rodzaju dążeniu do jak największej prostoty, co polega na odrzuceniu wszelkiej różnorodności oraz inności. Pojawia się zatem ubóstwo rozumiane w sposób zupełnie paradoksalny, ponieważ w konsekwencji zjednoczenia z Bogiemjawi się onojako największe bogactwo.Warto jednocześnie pamiętać, że ów mistyczny kontakt z Bogiem nie jest czymś zupełnie zewnętrznym dla człowieka. Otóż zjednoczenie mistyczne nie polega na wznoszeniu się duszy do Boga, lecz na ujawnieniu Boga w niższej części duszy, wyższa bowiem część duszy, czyli iskierka duszy,jużjest tożsama z Bogiem. Narodziny Boga to uczestnictwo niższej części duszy w szczęściu iskierki duszy. Eckhart wyraźnie wskazuje, że są to narodziny Syna w duszy, które jednak nie oddala duszy od Ojca. Jest to nadal ten sam rodzaj jedności. Zostaje wręcz zniesiona wszelka jedno- stkowość człowieka, zaciera się jego tożsamość. Ta ontologiczna jedność z samym Bogiem jest jednocześnie jednością z dobrem w najwyższym wymiarze, dlatego też zacierają się wszelkie dylematy moralne, które rozstrzygają się dzięki zupełnej jedności, w której tożsamość bytu ludzkiego z Bogiem nie ma żadnego zróżnicowania. (shrink)

Alterations in the expression of certain genes or in their products can render benign tumor cells metastatic. Experimentally this has been quickly performed by transferring dominantly acting oncogenes such as c‐H‐rasEJ into susceptible cells, but in vivo such a rapid qualitative change in a dominantly acting oncogene occurs only rarely, and progression to highly metastatic phenotypes is thought to occur through a slow stepwise process. Such slow changes can be reversible and need not involve known dominantly acting oncogenes, consistent with (...) clinical observations. An important element of the natural progression of tumors to malignancy may be their ability to circumvent microenvironmental controls that regulate growth and cellular diversity and to evolve into heterogeneous phenotypes, a process that appears to involve mainly quantitative changes in gene expression but which can be rapidly stimulated in cell culture by the introduction of a dominantly acting oncogene. It is proposed that the highly malignant cells that have slowly evolved in vivo with only a few qualitative gene changes have undergone extensive cycles of diversification and accumulation of quantitative changes in the expression of genes that encode products that are related to malignancy and metastasis. Thus, highly malignant cellular phenotypes can arise quickly through specific qualitative changes in critical controlling genes or more slowly by less critical qualitative genetic changes, coupled with cellular diversification and accumulation of quantitative changes in gene expression. (shrink)

This study examines the relationship between corporate diversification strategy and the pollution activity of subsidiaries within the U.S. chemical industry using TRI data (EPA's Toxic Release Inventory). The subsidiaries of conglomerates were found to exhibit higher pollution levels for direct emissions than those of firms pursuing more related diversification strategies. Additionally, the subsidiaries of conglomerates exhibited more variance in overall pollution emissions compared to related diversified firms.

Some models anticipate that liberalized agricultural trade will lead to increased crop diversity, while other models make the opposite claim. These positions were explored in southwestern British Columbia, Canada where, between 1992 and 1998, government subsidies and other measures designed to protect horticultural farmers were lifted, exposing these farmers to foreign competition. Public hearings on the future of agriculture provided an opportunity to tap the knowledge and experience of people affected by this transition. Analysis of transcripts from these hearings, which (...) was confirmed by industry data, shows that trade liberalization has led to the loss of the local fruit and vegetable processing industry. Stakeholders saw the loss as a major factor affecting the choice of crops grown locally. To test this assertion, crop diversity data were analyzed, differentiating crops grown for the processing industry from those grown for the fresh market. Results show that crop diversity increased for processing crops but not for fresh crops. Farmers who used to produce commodities for the fruit and vegetable processing industry seem to have been forced to find new crops to cope with the decline in the processing industry. Here then is a case where the effects of trade were indirect (they were mediated by another variable: the loss of the processing industry) and variable (they differed for the two groups of crops). This may have significant environmental implications as scientific research shows that diverse agro-ecosystems are better able to withstand pest outbreaks and require less agri-chemicals than simple systems. (shrink)

This paper investigates an under-researched relationship, that between corporate social performance (CSP) and geographical diversification. Drawingupon the institutional and stakeholder perspectives and utilising data on a sample of large UK firms, we develop a set of empirical models of CSP, and findevidence of a significant contemporaneous positive relationship between the two for some types of social performance and in some regions of the world. Overall,we provide evidence that firms shape their social performance strategies to their geographical profile.

The growth of niche markets in rural industries has been one response to the restructuring of established agricultural industries in developed countries. In some cases entry into niche markets is part of a diversification of activities from other areas of farm-based production or services. In other cases, operators have sought to diversify from niche market production into other areas, such as on-site selling and agritourism. This paper outlines the findings of an exploratory qualitative study of the factors that olive (...) farmers in Western Australia take into account when considering diversification, with a special focus on diversification into servicing visitors in the form of on-site selling and agritourism. Face-to-face and telephone interviews were conducted among 23 small olive growing operations located in the main olive growing region of Western Australia. Decision-making is shown to involve an assessment of risk, which is shaped by their appraisal of economic conditions, market opportunities, access to resources (including labor), and lifestyle factors. The argument is made that a fuller understanding of diversification is gained by studying both those who seek to diversify and those who do not, in contrast to most previous research that has only focussed on those who diversify. Also argued is that diversification is best seen as a continuum of adjustment strategies, which is guided by a combination of economic need, risk assessment (based largely on resource access), market potential, and lifestyle factors. (shrink)

As part of the rationality debate, we examine the impact of deliberative and intuitive thinking styles on diversity preference behavior. A sample of 230 students completed the Rational Experiential Inventory and the Diversity Preference Questionnaire, an original measure of diversification behavior in different real-life situations. In cases where no normative solution was available, we found a clear preference for diversity-seeking in the gain domain and diversity-aversion in the loss domain, regardless of cognitive thinking style. However, in cases where one (...) alternative normatively dominated the other, participants high in deliberative thinking style were more calibrated to normative behavior, regardless of whether their intuitive tendency preference and the normative solution were contradictory or pointed in the same direction. Our findings support a model in which deliberative but not intuitive thinking style is the crucial predictor of rational behavior, since it enables people to better adjust their intuitive preference anchor when normative considerations require doing so. (shrink)

BackgroundBeta thalassemia major is a severe inherited form of hemolytic anemia that results from ineffective erythropoiesis. Allogenic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative therapy. Unfortunately, the subgroup of adult thalassemia patients with hepatomegaly, portal fibrosis and a history of irregular iron chelation have an elevated risk for transplantation-related mortality that is currently estimated to be about 29 percent.DiscussionThalassemia patients may be faced with a difficult choice: they can either continue conventional transfusion and iron chelation therapy or (...) accept the high mortality risk of HSCT in the hope of obtaining complete recovery.Throughout the decision making process, every effort should be made to sustain and enhance autonomous choice. The concept of conscious consent becomes particularly important. The patient must be made fully aware of the favourable and adverse outcomes of HSCT. Although it is the physician's duty to illustrate the possibility of completely restoring health, considerable emphasis should be put on the adverse effects of the procedure. The physician also needs to decide whether the patient is eligible for HSCT according to the "rule of descending order". The patient must be given full details on self-care and fundamental lifestyle changes and be fully aware that he/she will be partly responsible for the outcome.SummaryOnly if all the aforesaid conditions are satisfied can it be considered reasonable to propose unrelated HSCT as a potential cure for high risk thalassemia patients. (shrink)

In an era where the dominant implicitfarming policy has been ``get big or get out,''Titus Farms provides an exemplar to thecontrary. This paper explains the success storybehind a medium-sized 145-acre fruit andvegetable family farm in southeast Michigan.Using agroecosystems analysis, this case studydemonstrates a rigor and holism essential tofarming systems research and analysis. In-depthinterviews with the principal farm manager andowner were conducted during the fall and winterof 1999. Data, presented in the form ofvignettes, provide context and ascribe meaningto the rich and (...) imaginative voice of the smallfamily farmer. It is concluded that thissuccess is directly attributed to the conceptof flexible diversification.It is through flexible diversification thatTitus Farms has imbued stability andsustainability seldom seen by similar familyfarms of this type, and for that reason alone,Titus Farms is a successful enterprize. Assuch, it presents a unique case study andopportunity for farming systems researchanalysis. (shrink)

ABSTRACTMy goal in this article is to give a portrait of how modern sport philosophy, which started in 1972, developed from relatively narrow paradigmatic borders to become a diverse and multi-para...

The origins and evolution of the Archaea, Bacteria, and Eukarya remain controversial. Phylogenomic‐wide studies of molecular features that are evolutionarily conserved, such as protein structural domains, suggest Archaea is the first domain of life to diversify from a stem line of descent. This line embodies the last universal common ancestor of cellular life. Here, we propose that ancestors of Euryarchaeota co‐evolved with those of Bacteria prior to the diversification of Eukarya. This co‐evolutionary scenario is supported by comparative genomic and (...) phylogenomic analyses of the distributions of fold families of domains in the proteomes of free‐living organisms, which show horizontal gene recruitments and informational process homologies. It also benefits from the molecular study of cell physiologies responsible for membrane phospholipids, methanogenesis, methane oxidation, cell division, gas vesicles, and the cell wall. Our theory however challenges popular cell fusion and two‐domain of life scenarios derived from sequence analysis, demanding phylogenetic reconciliation. (shrink)