This paper suggests that the energy flow on which all living structures depend only started up slowly, the low-energy, initial phase starting up a second, slightly more energetic phase, and so on. In this way, the build up of the energy flow follows a bootstrapping process similar to that found in the development of computers, the first generation making possible the calculations necessary for constructing the second one, etc. In the biogenetic upstart of an energy flow, non-metals in the lower (...) periods of the Periodic Table of Elements would have constituted the most primitive systems, their operation being enhanced and later supplanted by elements in the higher periods that demand more energy. This bootstrapping process would put the development of the metabolisms based on the second period elements carbon, nitrogen and oxygen at the end of the evolutionary process rather than at, or even before, the biogenetic event. (shrink)

This paper compares two approaches that attempt to explain the origin of life, or biogenesis. The more established approach is one based on chemical principles, whereas a new, yet not widely known approach begins from a physical perspective. According to the first approach, life would have begun with—often organic—compounds. After having developed to a certain level of complexity and mutual dependence within a non-compartmentalised organic soup, they would have assembled into a functioning cell. In contrast, the second, physical type of (...) approach has life developing within tiny compartments from the beginning. It emphasises the importance of redox reactions between inorganic elements and compounds found on two sides of a compartmental boundary. Without this boundary, “ life ” would not have begun, nor have been maintained; this boundary—and the complex cell membrane that evolved from it—forms the essence of life. (shrink)

We analyse theories and research approaches in ecology and find that they fall into two internally homogeneous groups of linked ideas, each comprising a unique set of premises. The two sets of interpretive statements are thus mutually exclusive; they constitute alternative theoretical developments in ecology and should not be seen as complementary. They can, therefore, be considered two paradigms (Kuhn, 1962). Our interpretation is supported by the minimal overlap, if any, in the premises and research directions of the two approaches. (...) We label the dominant group of ideas the demographic paradigm and the less developed one the autecological paradigm. The internal logic of the demographic paradigm of ecology is strongly developed and consistent. Its premises and logic extend into current models of population genetics, biogeography, palaeontology, evolutionary theory and conservation biology. Nevertheless, many phenomena contradict the premises of the demographic paradigm; these contradictions cannot be accommodated within its theoretical framework without major disruptions in logic ensuing. Such phenomena can, in contrast, be understood in terms of the autecological paradigm. Because the status and strengths of the autecological paradigm are generally unrecognised and because autecology is frequently misrepresented in the literature, we redefine its premises and clarify its structure and aims as an aid to its future development. (shrink)

This paper reviews and extends ideas of eukaryotization by endosymbiosis. These ideas are put within an historical context of processes that may have led up to eukaryotization and those that seem to have resulted from this process. Our starting point for considering the emergence and development of life as an organized system of chemical reactions should in the first place be in accordance with thermodynamic principles and hence should, as far as possible, be derived from these principles. One trend to (...) be observed is the ever-increasing complexity resulting in several layers of compartmentalization of the reaction system, either spatial (of which the eukaryotic cell is an example), or functional (as in the gradually deepening distinction between metabolic, enzymatic and information-storing functions within the cell). One of the causes of this complexification of living systems will have been the changes in environmental conditions, particularly the geochemical impoverishment of the biosphere during geological history, partly brought about by living systems themselves, and partly by the trend towards increasing efficiency and specificity of the reactions that occur. (shrink)

Ecological theory is built upon assumptions about the fundamental nature of organism-environment interactions. We argue that two mutually exclusive sets of such assumptions are available and that they have given rise to alternative approaches to studying ecology. The fundamentally different premises of these approaches render them irreconcilable with one another. In this paper, we present the first logical formalisation of these two paradigms.The more widely-accepted approach - which we label the demographic paradigm - includes both population ecology and community ecology (...) (synecology). Demographic ecology assumes that the environment is relatively stable and that biotic processes, governed predominantly by resource availability, are the most important of ecological and evolutionary influences. Moreover, ecological processes are assumed to translate into directional selection pressures that drive significant evolutionary change on a local scale through the process of optimisation. (shrink)

Translational ethics (TE) has been developed into a specific approach, which revolves around the argument that strategies for bridging the theory‐practice gap in bioethics must themselves be justified on ethical terms. This version of TE incorporates normative, empirical and foundational ethics research and continues to develop through application and in the face of new ethical challenges. Here, I explore the idea that the academic field of bioethics has not yet sufficiently analysed its own philosophical foundation for how it can, and (...) should, be practically relevant; neither has it comprehensively discussed the limitations on what impacts bioethicists should pursue. As a result, there has not been adequate training on how to suitably and appropriately impact real‐world practices. Moreover, bioethical perspectives are often competing with other strong interests, for example, economic and political, which may weaken their impact on policy‐making. The TE approach I propose can not only facilitate practical impacts of academic bioethics by being better informed by real‐world ethical issues but it also supports targeted and ethical justifications of the actual impact of academic work in real‐world contexts. In this paper, I clarify the premises for this TE approach, identify further challenges and sketch out potential solutions for the implementation of this methodological framework. (shrink)

In the face of environmental crises such as climate change, pollution and biodiversity loss—which all adversely impact on health—Gils-Schmidt and Salloch explore whether physicians can be justified in taking climate issues into account in clinical care.1 While their approach centres on the ‘climate-sensitive’ decisions, physicians can carry out on the micro-level of clinical decision-making, they encourage further discussions on how climate-related issues can be included across different levels of decision-making in healthcare. We propose a list of tasks and a model (...) to assist with navigating the range of factors and structural elements an environmentally sensitive ethics must address. Stephen Gardiner’s notion of a perfect moral storm is central to understanding these issues.2 Gardiner describes how a perfect moral storm occurs in the centre of three overlapping conditions for human action and policymaking in the face of climate change. This storm is driven by: (1) a lack of interest among current generations to meet global needs and accommodate the well-being of future generations, (2) a lack of ecological concerns for other parts of nature than humans and (3) weak ethical and political theories and institutions shaping policy decisions on issues with severe implications across borders and generations. Moreover, these conditions are embedded in the existing, complex world of ethically unjustified power imbalances and social injustice. The growing awareness of healthcare’s climate footprint has amplified and accelerated global, grassroots action to make healthcare more environmentally friendly. This includes incorporating environmental impacts into quality improvement methodologies, building communities of practice to explore how to make …. (shrink)

Some standards, such as moral and prudential standards, provide genuinely or authoritatively normative reasons for action. Other standards, such as the norms of masculinity and the mafia’s code of omerta, provide reasons but do not provide genuinely normative reasons for action. This paper first explains that there is a similar distinction amongst attitudinal standards: some attitudes (belief, desire) have standards that seem to give rise to genuine normativity; others (boredom, envy) do not. This paper gives a value-based account of which (...) attitudinal standards give rise to genuine normativity. It argues that this account has interesting implications before extending it to provide an account of which action-guiding standards are genuinely normative. It argues that this value-based account of which standards are genuinely normative is more plausible than alternatives suggested in the literature and has interesting implications for genuine normativity in law and aesthetics. (shrink)

Should we let personal responsibility for health-related behavior influence the allocation of healthcare resources? In this paper, we clarify what it means to be responsible for an action. We rely on a crucial conceptual distinction between being responsible and holding someone responsible, and show that even though we might be considered responsible and blameworthy for our health-related actions, there could still be well-justified reasons for not considering it reasonable to hold us responsible by giving us lower priority. We transform these (...) philosophical considerations into analytical use first by assessing the general features of health-related actions and the corresponding healthcare needs. Then, we identify clusters of structural features that even adversely affected people cannot reasonably deny constitute actions for which they should be held responsible. We summarize the results in an analytical framework that can be used by decision-makers when considering personal responsibility for health as a criterion for setting priorities. (shrink)

The COVID-19 crisis opened up discussions on using online tools and platforms for academic work, e.g. for research (management) events that were originally designed as face-to-face interactions. As social scientists working in the domain of responsible research and innovation (RRI), we draft this paper to open up a dialogue on Responsible online Research and Innovation (RoRI), and deliberate particular socioethical opportunities and challenges of the onlineification in collaborative theoretical and empirical research. An RRI-inspired ‘going online’ approach would mean, we suggest, (...) trying to make academic events and research activities more inclusive, researchers’ attitude to their work more reflective and suggest processes that are more responsive to societal needs and ethical concerns. For such systematic reflection, we suggest using the RRI-heuristic provided by Owen et al., and applying the dimensions of ‘Anticipation, Inclusion, Reflection and Responsiveness’ (AIRR) in order to identify and reflect on the dilemmas involved in ‘going online’ in one’s research. (shrink)

Elliot R. Wolfson intervenes in the debate over Martin Heidegger and Nazism from a unique perspective, as a scholar of Jewish mysticism and philosophy who has been profoundly influenced by Heidegger's work. He reveals crucial aspects of Heidegger's thinking that betray an affinity with dimensions of Jewish thought.

In this chapter, Hankinson discusses the theory of Atomism, from Leucippus and Democritus to Epicurus and his followers. The early Atomists were concerned with the circumvention of the Eleatic denial of motion; they did so by positing unchanging atoms and the existence of the void in which the atoms move. Democritean Atomism is thoroughly mechanistic and reductionist; Epicurean Atomism is ontologically more generous, accepting, for instance, the reality of properties and guaranteeing, by virtue of the controversial notion of the ‘swerve’, (...) the exercise of free will. Thus, although strictly speaking it denies uncaused events, Epicureanism nevertheless holds that human action is not subject to determinism. The later Epicureans also reject the Stoic view that fundamental physical principles are logically necessary truths. (shrink)

In the paper “Translational Neuroethics: A Vision for a More Integrated, Inclusive, and Impactful Field,” Wexler and Sullivan provide an insightful analysis of challenges within the field and how t...

Professor Foot's Hart Lecture, now published (1995), is largely devoted to an attack on people she calls ‘subjectivists’ and ‘noncognitivists', among whom she includes myself, although she is so good as to allow me, in a footnote, to reject thenames.She seems to imply thereby that this is a mere matter of nomenclature or terminology. But in truth her use of these terms makes one suspect that she has not fully understood either the issues or what I have said about them.It (...) may therefore be useful to explain yet again why I reject these descriptions. I have done so already in a paper to a conference in Moscow which she heard, and to which she kindly refers (Hare 1993a). These explanations would not be important if she were the only person to be confused about this matter; but the confusions are so widespread, even among professional philosophers who should know better, and are so often taught to succeeding generations of students, that it is worth while to make yet another attempt to clear them up - though the confusions are so insidious that I have not much hope that they will ever be eradicated. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Will Many Be Saved? What Vatican II Actually Teaches and Its Implications for the New Evangelization by Ralph MartinR. Jared StaudtWill Many Be Saved? What Vatican II Actually Teaches and Its Implications for the New Evangelization. By Ralph Martin. Grand Rapids, Mich.: Eerdmans, 2012. Pp. 332. $24.00 (paper). ISBN: 978-0-8028-6887-9.The proper interpretation of the Second Vatican Council remains a pressing topic fifty years after the Council’s completion. Pope (...) Benedict XVI made it a hallmark of his pontificate to insist upon a hermeneutic of continuity in interpreting the council in relation to the past, opposing this view to one of discontinuity and rupture (see his “Christmas Address to the Roman Curia,” Dec. 22, 2005). Viewing the council in terms of rupture and correspondingly as an opportunity for disruptive innovation has been described by many as the “Spirit of the Council.” Recently, the conflict of these rival hermeneutics has resurfaced in vehement fashion in relation to proposals for innovation in pastoral practice and even in doctrine regarding marriage and sexuality.Ensuring a proper interpretation of the council requires not only a deep and thorough examination of texts themselves of the council, but also a careful placing of the texts within the Catholic tradition. In this endeavor, [End Page 147] Ralph Martin’s Will Many Be Saved? provides a needed analysis of the council’s teaching concerning salvation and its pastoral implications. In particular, Martin focuses on the meaning, historical and scriptural sources, and theological interpretation of Lumen Gentium (LG) §16. In doing so, he touches on a number of key issues relating to the legacy of Vatican II, most importantly the decline of the missions and evangelization in general. Martin argues that abandoning the proclamation of sin and the possibility of hell in favor of the universality of salvation has led to a serious crisis of evangelization.The first chapter, “Vatican II and the Priority of Evangelization,” places the theme of evangelization at the center of the council’s message. Pope Paul VI declared in Evangelii nuntiandi that the very purpose of the council was to make the Church more fit for the evangelization of the modern world. The topic of evangelization was taken up by Pope John Paul II in his own call for a New Evangelization. Although the New Evangelization focuses on restoring faith in the context of post-Christian cultures, John Paul also sought to reinvigorate the foreign missions, as seen in his encyclical Redemptoris missio. Martin contrasts this emphasis on evangelization with its diminishment in practice due to “a lack of conviction that being a Christian is really necessary in order to be saved. If it is not really necessary... why bother to evangelize?” (5). Although Martin recognizes that the Church teaches the possibility of salvation outside of the visible bounds of the Church, he also posits that “doctrinal ignorance or confusion about what the Church is actually teaching about the possibility of salvation” creates “one obstacle... to evangelization” (6). To respond to this confusion, he turns specifically to LG §16 to clarify the Church’s teaching.The second chapter provides Martin’s initial observations on this central text. Martin divides the text into three sections. The first, 16a, enunciates that those who have not received the gospel are still related to the people of God in various ways, mentioning Jews and Muslims explicitly, and affirms God’s universal will for salvation in 1 Tim 2:4. 16b deals with the possibility of salvation for those ignorant of the gospel, who live rightly in accord with conscience. 16c offers a sobering note, stating that “very often” the deception of the evil one and sin lead to “ultimate despair” and ending with the need to evangelize in order “to procure... salvation.” Martin notes that LG §16 was not controversial during the conciliar debates, though it did raise some concern from missionary bishops, who insisted on a strong reinforcement of the need for evangelization. Though LG only speaks of the possibility of salvation, Martin recognizes a leap from possibility to “probability or even certainty” in the later interpretation of the council (17, italics original), and he cites... (shrink)

Many philosophers believe that there is a causal condition on perception, and that this condition is a conceptual truth about perception. A highly influential argument for this claim is based on intuitive responses to Gricean style thought experiments. Do the folk share the intuitions of philosophers? Roberts et al. (2016) presented participants with two kinds of cases: Blocker cases (similar to Grice’s case involving a mirror and a pillar) and Non-Blocker cases (similar to Grice’s case involving a clock and brain (...) stimulation). They found that a substantial minority agreed that seeing occurs in the Non-Blocker cases, and that in the Blocker cases significantly less agreed that seeing occurs. They thus hypothesized that folk intuitions better align with a no blocker condition than with a causal condition. This paper continues this line of enquiry with two new experiments. The paper investigates the generality and robustness of Roberts et al.’s findings by expanding the sense modalities tested from only vision to audition and olfaction as well. The paper also uses Gricean style thought experiments as a case study for investigating the “reflection defense” against the negative project in experimental philosophy. Our results replicate and extend Roberts et al.’s study and support their hypothesis that folk intuitions better align with a no blocker condition. They also provide an empirical reason to doubt the reflection defense. (shrink)

This is the first edition of Plato's Republic to be based on an exhaustive examination of all the textual evidence - manuscripts, including papyri; quotations and allusions in ancient authors; translations into Coptic, Arabic and Hebrew. The three primary manuscripts have been examined with particular care. Many new readings have been introduced in the text and a critical apparatus gives details for all relevant textual evidence.

Cost conversations are essential to informed consent because patients have a right to information that they think is relevant, and patients overwhelmingly report that cost information is relevant to their medical decisions. Providers have an ethical responsibility to provide necessary information for informed consent, and therefore must discuss costs. The Shared Decision Making model is ideal for enabling this exchange of information, and decision aids are also helpful. Although barriers exist, many useful tools can help providers fulfill this obligation, and (...) encouraging progress is being made to improve cost transparency from insurers and facilities. (shrink)

The author, who pioneered this argument in 1961, here places it in the context of traditional discussions of the problem, and answers various criticisms that have been made.