Authors De Marco and colleagues have presented a new model on the concept of invasiveness, redefining both its technical definition and practical implementation.1 While the authors raise valid critiques regarding the discrepancy in definitions, I cannot help but wonder about the purpose of redefining terms for which little confusion, if any, exists? This commentary seeks to scrutinise the rationale supporting the new model in the absence of significant clinical confusion and to explore the implications for clinical practice. Initially, one may (...) notice there is no mention of clinical relevancy, confusion among patients or whether the discrepancy in terms is causing miscommunication. It seems reasonable that some clinical confusion may exist, but so too does a similar imbalance of terms when speaking technically across the specialties; take depression and its definition as a primary example. While I certainly agree with the illustration of non-invasive prenatal testing being compared with venous blood draws as a disparity in terminology, little evidence suggests confusion concerning the nosology.2 The medical community, including both physicians and patients, recognises that the terminology is specifically used within the …. (shrink)

Acknowledgments I wish to express my gratitude to Dr. Jakob Amstutz for his continual feedback during my writing of this work. ...

The American Journal of Bioethics, Volume 11, Issue 6, Page 60-62, June 2011.

O problema do conhecimento fácil tem sido definido na literatura epistemológica contemporânea com um problema que nasce de duas formas distintas. O propósito deste ensaio é mostrar que essas supostas maneiras diferentes de gerar o mesmo problema em verdade originam dois problemas distintos, que requerem respostas distintas. Um deles está relacionado à aquisição fácil (inaceitável) de conhecimento de primeira-ordem e o outro à aquisição fácil (inaceitável) de conhecimento de segunda-ordem. Além disso, é apresentada a maneira como o infinitismo, a teoria (...) epistêmica segundo a qual as razões que justificam uma opinião devem ser infinitas em número e não-repetidas, pode lidar com cada um desses problemas. (shrink)

Este artigo discute os textos de Hannah Arendt a partir de um problema particular: aquele relativo à procura da compreensão. Esse problema é importante não apenas porque seus textos realizam uma contribuição decisiva para a compreensão daquilo que a política se tornou a partir do século XX, mas, sobretudo, porque ele nomeia o ponto sensível de sua escrita.

ABSTRACT This essay presents the chief reasons for making a distinction between propositional and doxastic justification and, also, points out two things: no theory of propositional justification implies a theory of doxastic justification; infinitism is, essentially, a theory of propositional justification. Additionally, this paper tries to shed some light on the three conjointly sufficient conditions for a proper infinitist view of propositional justification.

It seems opportune to commemorate in ‘Augustinianum’ the centenary of the birth of Alan Turing, insofar as he is an outstanding figure whose theoritical insight gave birth to the computer revolution of the twentieth centur y. His theories are equally important for the methodology supporting studies in the humanities.

The collection of Coptic literary papyri of the Egyptian Museum of Turin is one of the most important in the world, if not for the number of codices, certainly for their contribution to the knowledge of Coptic literature and codicology. This paper makes an exhaustive list of the codices and of the works that they contain, with reference to their publication, especially that of Francesco Rossi , who could read more than is visible today. The tables provided are useful because (...) the papyri have been set in different order , after Rossi’s publication. (shrink)

This paper examines Derrida's critique of Husserl's notion of pure presence. Husserl's theory of temporality in _The Phenomenology of Internal Time Consciousness supports a philosophy of pure presence, but Husserl's notion of presence is not, as Derrida would have it, one which "reject(s) the 'after-event' of the becoming conscious of an 'unconscious content' which is the structure of temporality implied through-out Freud's texts". Husserl's notion of presence is, rather, transcendental, hyletic and unconscious. Dissemination, characterized by a lack of stable meaning, (...) nonorigin, and departure from the rules of logic, is constituted by the relation of transcendental presence to the mundane. (shrink)

Entification is now displayed in its nude and native state, and serves to explain the constant mental process, and the true nature of the representations of ...

A central issue of cognitive neuroscience is to understand how a large collection of coupled neurons combines external signals with internal memories into new coherent patterns of meaning. An external stimulus localized at some input spreads over a large assembly of coupled neurons, building up a collective state univocally corresponding to the stimulus. Thus, the synchronization of spike trains of many individual neurons is the basis of a coherent perception. Based on recent investigations of homoclinic chaotic systems and their synchronization, (...) a novel conjecture for the dynamics of single neurons and, consequently, for neuron assemblies is formulated. Homoclinic chaos is proposed as a suitable way to code information in time by trains of equal spikes occurring at apparently erratic times. In order to classify the set of different perceptions, the percept space can be given a metric structure by introducing a distance measure between distinct percepts. The distance in percept space is conjugate to the duration of the perception in the sense that an uncertainty relation in percept space is associated with time-limited perceptions. This coding of different percepts by synchronized spike trains entails fundamental quantum features which are not restricted to microscopic phenomena. It is conjectured that they are related to the details of the perceptual chain rather than depending on Planck's action. (shrink)

The chapter 'Of power' of Locke's Essay Concerning Human Understanding is a very fine discussion of agency and a very complex piece of philosophy. It is the result of the superimposition of at least three layers of text (those of the first, second and fifth editions of the Essay), expressive of widely differing views of the same matters. The argument concerning agency and free will that it puts forward (as it now stands, reporting Locke's last word on the subject) is (...) thus beset with problems, and even inconsistencies. But these textual and analytical difficulties should not hide from us the relevance and, in a way, the deep coherence of Locke's philosophy of action. In what follows, I will attempt to cast some light on this complicated interpretive and conceptual matter, by a careful reading of some parts of Locke's discussion. The first section shows how accounting for the evaluation and choice of remote goods, in terms of their real value and in preference to smaller, nearer ones, is a crucial problem for Locke's philosophy of action. The second section reads Locke's move from an internalist to an externalist view of motivation as a first, conceptually complex step towards such an account; and shows how this is linked to a change in the concept of will. The third and fourth sections reconstruct Locke's account (a pattern of suspension and examination of occurrent desire); discuss the role of the motivational and normative concept of happiness; and cast some doubt on the consistency of Locke's position. (shrink)

Hepatocellular carcinoma represents the third leading cause of cancer-related death. Because HCC is multicentric with time, excluding the few transplanted patients, sooner or later it becomes untreatable with loco-regional therapies and, until some years ago, it was not responsive to systemic therapies. In 2005 a randomized trial indicated the efficacy of a product containing stem cell differentiation stage factors taken from zebrafish embryos during the stage in which the totipotent stem cells are differentiating into the pluripotent adult stem cells. In (...) such a trial the patients, with “intermediate” and “advanced” HCC according to Barcelona Clinic Liver Cancer/American Association for the Study of Liver Diseases guidelines, presented benefit in terms of performance status and objective tumoral response, with some cases of complete response, that is, sustained disappearance of the neoplastic areas or blood supply therein, accompanied by normalization of alpha-fetoprotein... (shrink)

El principal objetivo del presente ensayo es analizar los conceptos y praxis del Mundo Mapuche y del País Mapuche las cuales, es posible argüir, constituyen la síntesis de la demanda y propuesta de parte significativa del movimiento mapuche autonomista. Síntesis que conlleva una modificación cualitativa en la estructuración de los marcos cognitivos del movimiento, lo que ha significado la articulación embrionaria de una visión mapuche de la realidad que trascendería la dimensión social y política del movimiento para instalarse como elemento (...) de índole más estructural, que ya no sólo enfrenta crecientemente a dos identidades distintas, sino que, también, a dos proyectos de sociedad, a dos países, a dos pueblos encapsulados en un mismo territorio geográfico, pero culturalmente diferenciados. La aproximación al sujeto de estudio se realizará a través de la aplicación de algunos elementos de las teorías de los movimientos sociales, específicamente los marcos cognitivos, y además, desde el concepto de memoria colectiva. (shrink)

Microinjection of frog oocytes, a technique whose usefulness for studies on gene expression is already established, may be similarly helpful for the unraveling of several enigmas of cellular metabolism and its organization.

This chapter contains section titled: Direct Passions Pleasure and Desire Reason and Passion References Further Reading.

Negative freedom (as opposed to positive freedom) has been widely considered an inherently non problematic notion. This paper attempts to show that, if considered as a good with a minimally objective structure, negative freedom can disrupt the capacity for deliberating in a substantively (that is, non purely formal, decision-theoretic) rational way. The argument turns on the notion of non-satiation, as a property of the objective value of some goods of not changing when the availability of the good is increased. Two (...) classes of non-satiating goods are distinguished, one of which has disruptive consequences for rational deliberation. Negative freedom belongs to this last class; and its non-satiating conceptual nature is defended by means of a simple dispositional analysis of value. It is suggested that also rationality itself can be regarded as a non-satiating good that can disrupt deliberation. (shrink)