ZusammenfassungDie rasanten technischen Fortschritte in der Genomforschung ermöglichen heute schon die Sequenzierung des einzelnen menschlichen Genoms in wenigen Tagen und zu vertretbaren Kosten. In der Krebsforschung ermöglicht die genetische Sequenzanalyse, zunehmend die Defekte zu identifizieren, die für das Tumorwachstum bei jedem einzelnen Patienten verantwortlich sind. Auf dieser Basis können zielgerichteter Therapien entwickelt werden. Diese Forschung wirft jedoch auch neue, ethische Fragen auf. Diesen normativen Fragen widmet sich in Heidelberg das interdisziplinäre EURAT Projekt mit dem Ziel, ethisch und rechtlich informierte Lösungen (...) zu formulieren und zu etablieren.Dieser Beitrag gibt zum einen einen Überblick über die ethischen und klinischen Fragen, die für den Aufklärungs- und Einwilligungsprozess in die biobankbasierte Genomforschung relevant sind. Zum anderen wird als organisationsethische Antwort auf die Frage, wie eine Forschungsinstitution den verantwortungsvollen Umgang mit genetischen Informationen in Biobanken über die verschiedenen Berufsgruppen und beteiligten Institute hinweg sichern kann, ein Verhaltenskodex vorgestellt. Eine gut begründete, informierte Zustimmung und ein Verhaltenskodex sind beides Elemente einer „Best Practice Leitlinie“ und sollen den verantwortlichen Umgang aller beteiligten Mitarbeiter mit sensiblen genetischen Daten prägen. (shrink)

Data-sharing among genomic researchers is promoted for its potential to accelerate our understanding of the molecular basis of cancer. However, with genomic data sharing the risks of re-identifying study participants, revealing personal genomic information and data misuse might increase. This study aims at exploring perceptions of patients and physicians in Oncology regarding their assessment of the informational risks resulting from participating in whole genomic research studies in order to improve the informed consent process. For this purpose, we conducted a qualitative (...) focus group study at the National Center for Tumor Diseases. Patients and oncologists assessed the informational risks either as minimal or as greater than minimal, depending on the context factors of occupational status, age, and patients’ prognosis. Interestingly, even patients who assumed a greater risk did not refrain from participating in genomic research, provided that certain informational and institutional safeguards are implemented. Moreover, they expected comprehensive disclosure of the risks resulting from genomic data sharing. These results suggest comprehensive disclosure of the risks of genomic research to potential study participants in genomic research to facilitate risk assessment and sound decision making, establishing independent governance entities in order to minimize the informational risks of genomic research, and implementing data sharing policies which offer guidance for physicians and researchers involved in genomic research. (shrink)

Data-sharing among genomic researchers is promoted for its potential to accelerate our understanding of the molecular basis of cancer. However, with genomic data sharing the risks of re-identifying study participants, revealing personal genomic information and data misuse might increase. This study aims at exploring perceptions of patients and physicians in Oncology regarding their assessment of the informational risks resulting from participating in whole genomic research studies in order to improve the informed consent process. For this purpose, we conducted a qualitative (...) focus group study at the National Center for Tumor Diseases (NCT). Patients and oncologists assessed the informational risks either as minimal or as greater than minimal, depending on the context factors of occupational status, age, and patients’ prognosis. Interestingly, even patients who assumed a greater risk did not refrain from participating in genomic research, provided that certain informational and institutional safeguards are implemented. Moreover, they expected comprehensive disclosure of the risks resulting from genomic data sharing. These results suggest (1) comprehensive disclosure of the risks of genomic research to potential study participants in genomic research to facilitate risk assessment and sound decision making, (2) establishing independent governance entities in order to minimize the informational risks of genomic research, and (3) implementing data sharing policies which offer guidance for physicians and researchers involved in genomic research. (shrink)

Die rasanten technischen Fortschritte in der Genomforschung ermöglichen heute schon die Sequenzierung des einzelnen menschlichen Genoms in wenigen Tagen und zu vertretbaren Kosten. In der Krebsforschung ermöglicht die genetische Sequenzanalyse, zunehmend die Defekte zu identifizieren, die für das Tumorwachstum bei jedem einzelnen Patienten verantwortlich sind. Auf dieser Basis können zielgerichteter Therapien entwickelt werden. Diese Forschung wirft jedoch auch neue, ethische Fragen auf. Diesen normativen Fragen widmet sich in Heidelberg das interdisziplinäre EURAT Projekt mit dem Ziel, ethisch und rechtlich informierte Lösungen (...) zu formulieren und zu etablieren.Dieser Beitrag gibt zum einen einen Überblick über die ethischen und klinischen Fragen, die für den Aufklärungs- und Einwilligungsprozess in die biobankbasierte Genomforschung relevant sind. Zum anderen wird als organisationsethische Antwort auf die Frage, wie eine Forschungsinstitution den verantwortungsvollen Umgang mit genetischen Informationen in Biobanken über die verschiedenen Berufsgruppen und beteiligten Institute hinweg sichern kann, ein Verhaltenskodex vorgestellt. Eine gut begründete, informierte Zustimmung und ein Verhaltenskodex sind beides Elemente einer „Best Practice Leitlinie“ und sollen den verantwortlichen Umgang aller beteiligten Mitarbeiter mit sensiblen genetischen Daten prägen. (shrink)

ZusammenfassungIn einem Modellprojekt soll durch die Einführung einer persönlichen, einrichtungsübergreifenden, elektronischen Patientenakte nicht nur die Behandlungskontinuität verbessert, sondern auch das Recht auf informationelle Selbstbestimmung dahingehend realisiert werden, dass jeder Patient zum Administrator einer Datencloud gemacht wird, die alle seine Gesundheitsdaten enthält. Eine systematische Literaturrecherche zum Thema „elektronische Patientenakten “ soll mögliche ethische Herausforderungen in Verbindung mit der oben genannten PEPA antizipieren. Von initial 2487 Publikationen wurden 51 Publikationen ausgewertet: 30 empirische Studien, 10 medizinethische Analysen und 11 Meinungspapiere. In den empirischen (...) Studien wurden als erste Effekte einer EPA vor allem eine vollständigere medizinische Aktenlage beschrieben. Mit der Einsichtsmöglichkeit für den Patienten in die EPA konnten zusätzlich ein besseres Krankheitsverständnis und damit erhöhte Compliance des Patienten nachgewiesen werden. Eine Verbesserung der Behandlungsqualität wurde auf die Fehlervermeidung durch Patienteneinsicht, effektivere Nutzung der Arzt-Patienten-Besuche und das verbesserte Verständnis für das Therapiekonzept zurückgeführt. Ebenfalls wurde in den Studien eine Stärkung des Vertrauensverhältnisses von Arzt und Patient beschrieben. Bedenken gab es im Vorfeld vieler Studien hinsichtlich des Datenschutzes, eines möglichen Verlustes der persönlichen Arzt-Patienten-Beziehung und einer potentiellen Überforderung des Patienten. In der Beurteilung der EPA spielte die Abwägung zwischen ärztlicher Fürsorge und Patientenautonomie eine große Rolle. Die von medizinethischer Seite geäußerten Bedenken bezüglich eines Vertrauensverlustes oder einer Störung des Arzt-Patienten-Verhältnisses konnten in den empirischen Studien nicht bestätigt werden. Die befürchteten Risiken im Datenschutz wurden von den Betroffenen zugunsten des potentiellen Nutzens einer EPA abgewogen. Unter Wahrung des Datenschutzes hat daher die PEPA das Potential, durch die Mitbeteiligung des Patienten das Arzt-Patienten-Verhältnis positiv zu beeinflussen. Die spezifischen ethischen Herausforderungen, die mit der Co-Verwaltung der PEPA einhergehen, werden im Modellprojekt untersucht. (shrink)

This paper addresses the ongoing debate over the relation between belief and credence. A proposal is made to reverse the currently predominant order of analysis, by taking belief as conceptually basic and credence as the phenomenon to be clarified. In brief, the proposal is to explicate an agent’s credence in a proposition P as the agent’s tendency toward believing P. Platitudinous as this reduction may seem, it runs counter to all of the major positions in the debate, including the Threshold (...) View, the Certainty View as conventionally understood, Dualism, Eliminativism, as well as Credence Primitivism. Section 1 gives an overview on the current state of the debate. Section 2 considers unsuccessful predecessors of the proposed belief-first approach to credence. Section 3 motivates and lays out the basics of a conceptual framework for thinking about doxastic states that characterizes such states in terms of two formally independent dimensions, one pertaining to the agent’s tendency toward believing P, the other to the level of resilience with which the agent manifests that tendency. Against this backdrop, it is argued in Sect. 4 that the present reduction satisfies a set of standard, theoretically neutral criteria of adequacy for theories of credence, at least once they are purged of a quite common conflation of tendency and resilience. Section 5 argues against all of the above competing accounts. (shrink)

How did the reception of Aristotelian logic in the Arabic and Latin Middle Ages shape the development of theology? And how did theological issues influence the debates about logic and theories of argumentation? The contributions in this volume examine these questions on the basis of key texts, thus shedding new light on the problematic relationship between logic and theology.

This paper discusses a scenario borrowed from Williamson (2000) and repurposes it to argue for the possibility of conflict between two prima facie categorical norms of epistemic rationality: the norm to respect one’s evidence and the norm to be coherent. It is argued, pace Williamson, that in the conflict defining the scenario, the evidence norm overrides the coherence norm; that a rational agent with our evidence would lack evidence about some of their own credences; and that for agents whose evidence (...) is limited in this way, incoherence fails to entail irrationality. The above possibility claim has also been defended by Worsnip (2018), albeit on a quite different premise set and in conjunction with a coherence-centered account of epistemic rationality that issues predictions incompatible with those licensed by the evidence-centered account recommended here, as illustrated towards the end of the paper. (shrink)

Consider where κ is an uncountable regular cardinal. By a result of Shelah's we have for almost all witnessing this. Here we consider the question if there could be a similar result for. We will discuss some basic facts implying that this cannot hold in general. We will use these facts to construct an interesting example of a pseudo Prikry forcing, answering a question of Sinapova.

In the past several years, observational entropy has been developed as both a quantum generalization of Boltzmann entropy, and as a rather general framework to encompass classical and quantum equilibrium and non-equilibrium coarse-grained entropy. In this paper we review the construction, interpretation, most important properties, and some applications of this framework. The treatment is self-contained and relatively pedagogical, aimed at a broad class of researchers.

Toy models are highly idealized and extremely simple models. Although they are omnipresent across scientific disciplines, toy models are a surprisingly under-appreciated subject in the philosophy of science. The main philosophical puzzle regarding toy models concerns what the epistemic goal of toy modelling is. One promising proposal for answering this question is the claim that the epistemic goal of toy models is to provide individual scientists with understanding. The aim of this article is to precisely articulate and to defend this (...) claim. In particular, we will distinguish between autonomous and embedded toy models, and then argue that important examples of autonomous toy models are sometimes best interpreted to provide how-possibly understanding, while embedded toy models yield how-actually understanding, if certain conditions are satisfied. _1_ Introduction _2_ Embedded and Autonomous Toy Models _2.1_ Embedded toy models _2.2_ Autonomous toy models _2.3_ Qualification _3_ A Theory of Understanding for Toy Models _3.1_ Preliminaries and requirements _3.2_ The refined simple view _4_ Two Kinds of Understanding with Toy Models _4.1_ Embedded toy models and how-actually understanding _4.2_ Against a how-actually interpretation of all autonomous toy models _4.3_ The how-possibly interpretation of some autonomous toy models _5_ Conclusion. (shrink)

Toy models are highly idealized and extremely simple models. Although they are omnipresent across scientific disciplines, toy models are a surprisingly under-appreciated subject in the philosophy of science. The main philosophical puzzle regarding toy models is that it is an unsettled question what the epistemic goal of toy modeling is. One promising proposal for answering this question is the claim that the epistemic goal of toy models is to provide individual scientists with understanding. The aim of this paper is to (...) precisely articulate and to defend this claim. In particular, we will distinguish between autonomous and embedded toy models, and, then, argue that important examples of autonomous toy models are sometimes best interpreted to provide how-possibly understanding, while embedded toy models yield how-actually understanding, if certain conditions are satisfied. (shrink)

Many have claimed that epistemic rationality sometimes requires us to have imprecise credal states (i.e. credal states representable only by sets of credence functions) rather than precise ones (i.e. credal states representable by single credence functions). Some writers have recently argued that this claim conflicts with accuracy-centered epistemology, i.e., the project of justifying epistemic norms by appealing solely to the overall accuracy of the doxastic states they recommend. But these arguments are far from decisive. In this essay, we prove some (...) new results, which show that there is little hope for reconciling the rationality of credal imprecision with accuracy-centered epistemology. (shrink)

This study illuminates how a cross-sector social partnership legitimizes itself toward multiple internal and external stakeholders. Within a single-case study design, we collected retrospective and real time data on the partnership between Deutsche Post DHL and The United Nations Office for the Coordination of Humanitarian Affairs. Within this partnership, Deutsche Post DHL provides corporate volunteers that support disaster response after natural disasters on a pro bono basis. The main objects that needed legitimacy as well as the audiences from which legitimacy (...) was mainly sought changed over time. In addition, we identified legitimation work as occurring across objects, audiences, and time. Thus, we introduce legitimation work as the purposeful effort of the legitimacy seeker to avoid certain issues while ensuring other issues that are of importance to the conferrer of legitimacy. These findings contribute to micro-level considerations within institutional theory which view legitimacy as socially constructed between legitimacy seeker and conferrer. Hence, we add another perspective on legitimation to the previously existing conceptualizations of legitimacy as a deterministic consequence of institutionalization. (shrink)

The practice of early modern natural history depended on the collective collecting activities of a great variety of people. Among them, artisans played a major role in acquiring and distributing knowledge about the natural world and they contributed significantly to the scholarly labour in natural history. This distributed labour was both acknowledged by contemporaries as well as hidden from sight, reflecting the period′s dominant norms for class and gender. By combining an interpretation of the visual representation of labour in European (...) insect studies with an examination of written sources about natural history practices from about 1680 to 1810, this article decodes the often‐codified frontispieces and other more symbolic illustrations to offer new insights into the labour of natural history. Those who identified as scholars and artisans (or both) conceptualised their own intellectual and practical engagement with natural history within the semantic field of work. Some seemed to have even envisioned a new social role for academics as well as artisans. This article analyses the diversity of the “productive forces” in insect studies as they changed over time and it reconstructs what I will call the social imaginaries of participation. (shrink)

We develop a theoretical model of network formation where actors are limitedly farsighted. In this way we extend current models with a new set of micro-foundations. Computer simulations are used to predict the stable network structures that are likely to emerge under the new assumptions. The co-author model by Jackson/wolinsky (1996) is used as an example. The co-author model formulates a tension between stability and efficiency when actors are myopic. Limitedly farsighted actors can overcome this tension but only if the (...) network is small enough. Thus, changing the micro-foundations of the network formation model leads to new implications at the macro-level in the sense that different networks are predicted to be stable than for existing micro-foundations. (shrink)

Metodologický singularismus je jedním ze čtyř základních pilířů rakouské metodologie. Tato práce otevírá problematiku metodologického singularismu a argumentuje, že je pro ekonomii stejně důležitý jako dedukce, metodologický individualismus a metodologický subjektivismus. Dodržování metodologického singularismu je pro ekonomii zásadní, protože jeho nedodržení vede ke zjednodušení, na základě kterého se závěry ekonomické analýzy stávají nutně taktéž zjednodušenými. Je ukázáno, že tento koncept dokáže zamítnout sporné koncepty preferenčních škál, demonstrovaných preferencí či indiferenčních křivek. Metodologický singularismus je nutnou podmínkou k zachování apriorního charakteru ekonomie.

The efficient coding hypothesis posits that sensory systems are tuned to the regularities of their natural input. The statistics of natural image databases have been the topic of many studies, which have revealed biases in the distribution of orientations that are related to neural representations as well as behavior in psychophysical tasks. However, commonly used natural image databases contain images taken with a camera with a planar image sensor and limited field of view. Thus, these images do not incorporate the (...) physical properties of the visual system and its active use reflecting body and eye movements. Here, we investigate quantitatively, whether the active use of the visual system influences image statistics across the visual field by simulating visual behaviors in an avatar in a naturalistic virtual environment. Images with a field of view of 120° were generated during exploration of a virtual forest environment both for a human and cat avatar. The physical properties of the visual system were taken into account by projecting the images onto idealized retinas according to models of the eyes' geometrical optics. Crucially, different active gaze behaviors were simulated to obtain image ensembles that allow investigating the consequences of active visual behaviors on the statistics of the input to the visual system. In the central visual field, the statistics of the virtual images matched photographic images regarding their power spectra and a bias in edge orientations toward cardinal directions. At larger eccentricities, the cardinal bias was superimposed with a gradually increasing radial bias. The strength of this effect depends on the active visual behavior and the physical properties of the eye. There were also significant differences between the upper and lower visual field, which became stronger depending on how the environment was actively sampled. Taken together, the results show that quantitatively relating natural image statistics to neural representations and psychophysical behavior requires not only to take the structure of the environment into account, but also the physical properties of the visual system, and its active use in behavior. (shrink)

Student relativism is a widespread phenomenon in philosophy classes. While the exact nature of student relativism is controversially discussed, many authors agree on two points: First, it is widely agreed that SR is a rather problematic phenomenon, because it potentially undermines the very purpose of doing philosophy—if there is no objective truth, arguing seems to be pointless. Second, it is widely agreed that there will be some close connection between SR and a tolerant attitude towards conflicting opinions. In this paper, (...) I will argue that if these two assumptions are true, then discussing some basic philosophical insights about the concept of tolerance with students will be a promising new strategy of dealing with SR. (shrink)

In dem vorliegenden Beitrag möchte ich an aktuelle argumentationsdidaktische Überlegungen anknüpfen und einen spezifischen Aspekt genauer untersuchen, der von der philosophiedidaktischen Forschung bisher ein Stück weit vernachlässigt worden ist. Dieser Aspekt betrifft die Vermittlung sogenannter argumentativer Metakompetenzen, worunter ich grob gesprochen Fähigkeiten des angemessenen Gebrauchs bzw. der verantwortungsvollen Regulation von argumentativen Kompetenzen verstehe. Die grundlegende Idee ist in diesem Zusammenhang, dass die Ausbildung basaler argumentativer Fähigkeiten zwar grundsätzlich durchaus wichtig und wünschenswert ist, dass aber gleichzeitig ein Einsatz dieser Fähigkeiten in (...) unterschiedlichen Situationen ganz unterschiedliche Funktionen erfüllt. Dementsprechend müssen Lernende nicht nur mit argumentativen Kompetenzen ausgestattet, sondern darüber hinaus auch zu einem reflektierten und situativ angemessenen Gebrauch dieser Kompetenzen befähigt werden. (shrink)

Toleranz – eine Haltung, die in westlichen Gesellschaften wie kaum eine andere mit Nachdruck gefordert und mit Vehemenz verteidigt wird. Insbesondere eine tolerante Haltung gegenüber fremden Ansichten, Standpunkten und Überzeugungen wird von vielen als unverzichtbare Bedingung für das Gelingen eines demokratischen Miteinanders angesehen. Gleichzeitig wird kontrovers diskutiert, wo eigentlich die Grenzen einer toleranten Pluralität verschiedener Meinungen gezogen werden sollen. Welche Ansichten sind noch tolerabel, und welche nicht? Mit Blick auf aktuelle gesellschaftliche Diskurse und vor dem Hintergrund umfassender Kenntnisse der philosophischen (...) Toleranzforschung überprüft Dominik Balg kontrovers diskutierte Minderheitenpositionen auf ihre Tolerierbarkeit und entwickelt vor diesem Hintergrund einen klaren Kriterienkatalog, mit Hilfe dessen sich die Grenzen einer toleranten Haltung sinnvoll ziehen lassen. Darüber hinaus widmet er sich der Frage, was eigentlich jenseits unserer Toleranzgrenzen liegen sollte und wie man verantwortungsvoll mit Positionen umgehen kann, die nicht mehr tolerabel sind. (shrink)

Forming intimate relationships is a fundamental human motive. Emotions play a critical role in intimate relationships—they are central to the development and maintenance of these bonds, and these very bonds can influence both individual and interpersonal emotional dynamics across time. Investigating emotional dynamics in an interpersonal context provides unique insight into the functioning of intimate relationships and, at the same time, provides a window into the interdependence of partners’ daily experiences. Reviewing a selection of the literature involving emotional dynamics in (...) intimate relationships, we explore how intimate relationships shape partner’s emotional experiences and the implications this may have for their relationship across time. (shrink)

In eukaryotes, the messenger RNA (mRNA), the blueprint of a protein‐coding gene, is processed and packaged into a messenger ribonucleoprotein particle (mRNP) by mRNA‐binding proteins in the nucleus. The steps of mRNP formation – transcription, processing, packaging, and the orchestrated release of the export‐competent mRNP from the site of transcription for nuclear mRNA export – are tightly coupled to ensure a highly efficient and regulated process. The importance of highly accurate nuclear mRNP formation is illustrated by the fact that mutations (...) in components of this pathway lead to cellular inviability or to severe diseases in metazoans. We hypothesize that efficient mRNP formation is realized by a molecular mRNP packaging station, which is built by several recruitment platforms and coordinates the individual steps of mRNP formation. (shrink)

The essays in this Focus section expand the notion of writing insect histories of science by attending to matters of space and scale, ecological relationships, and institutional silences. They magnify diverse understandings about how the worlds of insects are noticed and understood by humans, what has historically counted as “insect,” and who narrates histories (of science). In doing so, the collection offers methodological suggestions for studying tiny animals in history that broaden the scope of often overlapping material, cultural, linguistic, political, (...) ethical, economic, and biological domains. It is precisely this magnified attention that foregrounds the domains’ interdependence and is necessary to make sense of additional bearers or forms of agency. (shrink)