The proliferation of personal data collection practices fundamentally reshapes how society is ordered and commercialized, and demands reconsideration of the possibilities for a just and equitable s...

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

Books Reviewed in this Article: Beyond Ideology: Religion and the Future of Western Civilization. By Ninian Smart. Pp.350, London, Collins, 1981, £9.95. Neophtonism and Indian Thought. Edited by R. Baine Harris. Pp.xiii, 353, Albany, State University of New York Press, 1982, $39.00, $12.95. Monotheism: A Philosophic Inquiry into the Foundations of Theology and Ethics. By Lenn Evan Goodman. Pp.122, Totowa, Allenheld, Osmun, 1981, $13.50. Neoplatonism and Christian Thought. Edited by Dominic J. O'Meara. Pp. xviii, 297, Albany, State University of New (...) York Press, 1981, $39.00, $12.95. The Path to Transcendence: From Philosophy to Mysticism in Saint Augustine. By Paul Henry, introduction and translation by Francis F. Burch. pp.xxix, 120, Pittsburgh, The Pickwick Press, 1981, $10.95. The Adequacy of Christian Ethics. By Brian Hebblethwaite. Pp. 144, London, Marshall, Morgan & Scott, 1981, £5.95. Ethics. By Wolfhart Pannenberg. Pp. 220, Philadelphia, The Westminster Press, 1981, $10.95. Human Nature, Election, and History. By Wolfhart Pannenberg. Pp. 116, Philadelphia, The Westminster Press, 1982, £2.95. Ethics, Religion and Politics. By G.E.M. Anscombe. Pp.ix, 161, Oxford, Basil Blackwell, 1981, £12.00. Moral Thinking: its Levels, Method and Point. By R.M. Hare. Pp.viii, 242, Oxford University Press, 1982, £11.00, £3.95. Utilitarianism and Beyond. Edited by Amartya Sen and Bernard Williams. Pp.vii, 290. £7.50. Cambridge University Press, 1982, £20.00. Language and Political Understanding. By Michael J. Shapiro. Pp.253, New Haven, Yale University Press, 1981, £18.20. Marx's Politics. By Allan Gilbert. Pp.xv, 326, Oxford, Martin Robertson, 1981, £16.50. Feuerbach. By Marx W. Wartofsky. Pp.xx, 460, Cambridge University Press, 1977, £30.00, £9.95. Nietzsche, Vol. 1: The Will to Power as Art. By Martin Heidegger, translated with notes and an analysis by D.F. Krell. Pp.xvi, 263, London, Routledge and Kegan Paul, 1981, £11.50. Freedom and Karl Jaspers's Philosophy. By Elizabeth Young‐Bruehl. Pp.xiv, 233, New Haven & London, Yale University Press, 1981, £14.00. ‘Being and Meaning’: Paul Tillich's Theory of Meaning, Truth and Logic. By I.E. Thompson. Pp.x, 244, Edinburgh University Press, 1981, £15.00. The Rationality of Science. By W.H. Newton‐Smith. Pp.xii, 294, London, Routledge and Kegan Paul, 1981, £9.95, £5.95. Realism and the Progress of Science. By Peter Smith. Pp.viii, 135, Cambridge University Press, 1981, £12.50. Angels and principalities. By Wesley Carr. Pp.xii, 242, Cambridge University Press, 1981, £13.50. Rconciliation: A Study of Paul's Theology. By Ralph P. Martin. Pp.233, London, Marshall, Morgan and Scott, 1981, £8.95. Suffering and Martyrdom in the New Testament. Edited by William Horbury and Brian McNeil. Pp.xxi, 217, Cambridge University Press, 1981, £17.50. Constantine and Eusebius. By Timothy D. Barnes. Pp.viii, 458, Cambridge, Harvard University Press, 1981, £24.50. Songs of Glory: the Romanesque Façades of Aquitaine. By Linda Seidel. Pp.x, 220, figs.63, Chicago and London, University of Chicago Press. 1981, £17.50. Marsilio Ficino and the Phaedran Charioteer. Translated and edited by Michael J.B. Allen. Pp.x, 274, Berkeley‐Los Angeles, University of California Press, 1981, £18.50. The Letters of Marsilio Ficino, Volume 3. Pp.xiv, 162, London, Shepheard‐Walwyn, 1981, £8.00. The World of the Renaissance Jew: The Life and Thought of Abraham ben Mordecai Farissol. By David B. Ruderman. Pp.xvii, 265, Cincinatti, Hebrew Union College Press, 1981, $20.00. A Dialogue Concerning Heresies. Edited by T.M.C. Lawier, G. Marc'hadour and R.C. Marius. Pp.xiv, 888, New Haven, Yale University Press, 1981, £56.00. Canterbury and Rome, Sister Churches: A Roman Catholic Monk reflects upon Reunion in Diversity. By Robert Hale. Pp.xi, 188, London, Darton, Longman and Todd, 1982, £5.95. Rome and Canterbury through Four Centuries: A Study of the Relations between the Church of Rome and the Anglican Churches 1530–1981. By Bernard and Margaret Pawley. Pp.xi, 387, London and Oxford, Mowbray, 1981, £4.95. American Indians and Christian Missions. By H.W. Bowden. Pp.xix, 255, Chicago, University of Chicago Press, 1981, £10.50. Catholics in Western Democracies: A Study in Political Behaviour. By John H. Whyte. Pp.193, Dublin, Gill and Macmillan. 1981, £13.00. Päpstliche Unfehlbarkeit bei Newman und Döllinger: Ein historisch‐systema‐tischer Vergleich. By Wolfgang Klausnitzer. Pp.280, Innsbruck, Tyrolia Verlag, 1980, 54 DM. The Letters of Baron Friedrich von Hügel and Professor Norman Kemp Smith. Edited by Lawrence F. Barmann. Pp.353, New York, Fordham University Press, 1981, no price given. Merton: A Biography. By Monica Furlong. Pp.xx, 342, London, Collins, 1980, £6.95. The Autonomy of Religious Belief: A Critical Inquiry. Edited by Frederick J. Crosson. Pp.vii, 162, Notre Dame, University of Notre Dame Press, 1981, £8.95. The Theological Imagination: Constructing the Concept of God. By Gordon D. Kaufman. Pp.309. Philadelphia, The Westminster Press, 1981, $13.95. Spirits of Power: An Analysis of Shona Cosmology. By Hubert Bucher. Pp.231, Capetown, Oxford University Press, 1980, £8.75. Judaism: The Evidence of the Mishnah. By Jacob Neusner. Pp.xix, 419, Chicago, University of Chicago Press, 1981, £17.50. (shrink)

Antimicrobial resistance is a critical public health challenge, and the contribution of the widespread use of antimicrobials in food animals to bacterial drug resistance and human infection demands greater policymaker attention. Global consumption of antimicrobials in food animal production by 2030 is projected to rise by two-thirds due to increases in both food animal production and demand for animal products. In the United States, the volume of antibiotics sold for use in food-producing animals is at least three times greater than (...) that sold for human use. A One Health approach that emphasizes the connections among the health of humans, animals, and the environment is needed to address antibiotic resistance in an integrated manner. This approach holds the promise of collaboration across multiple disciplines, including doctors, veterinarians, food safety professionals, and environmental health experts. (shrink)

“Public health legal preparedness” is a term born in the ferment, beginning in the late 1990s, that has led to unprecedented recognition of the essential role law plays in public health and, even more recently, in protecting the public from terrorism and other potentially catastrophic health threats.The initial articulation of public health has not kept pace with rapid evolution in the concept and in practical development of public health preparedness itself. This poses the risk that legal preparedness may fall behind (...) construction of general readiness in the public health system—and may, in fact, undercut achievement of comprehensive public health preparedness for massive threats to health in both the United States and world-wide. Inadvertent results might include both negative health impacts and infringement on individual rights. (shrink)

“Public health legal preparedness” is a term born in the ferment, beginning in the late 1990s, that has led to unprecedented recognition of the essential role law plays in public health and, even more recently, in protecting the public from terrorism and other potentially catastrophic health threats.The initial articulation of public health has not kept pace with rapid evolution in the concept and in practical development of public health preparedness itself. This poses the risk that legal preparedness may fall behind (...) construction of general readiness in the public health system—and may, in fact, undercut achievement of comprehensive public health preparedness for massive threats to health in both the United States and world-wide. Inadvertent results might include both negative health impacts and infringement on individual rights. (shrink)

The potential for biased responses that occur when researchers interact with their study participants has long been of interest to both academicians and practitioners. Given the sensitive nature of the field, researcher interaction biases are of particular concern for business ethics researchers regardless of their preference for survey, experimental, or qualitative methodology. Whereas some ethics researchers may inadvertently bias data by misrecording or misinterpreting responses, other biases may occur when study participants' responses are systematically influenced by the mere introduction of (...) researchers into the participants' environment. Although substantial empirical research has been conducted on the general topic of researcher interaction biases, none has focused specifically on business ethics research. In order to remedy this lack of empirical substantiation in the field, we review the related literature on researcher interaction biases, present an empirical example of how such biases can influence research results in an experiment assessing reactions to insurance fraud, and discuss the implications for business ethics research. (shrink)

Insurance claim fraud costs insurance companies, policymakers, and taxpayers billions of dollars every year and has been described as the second largest white collar crime. The most common insurance fraud activity and one that contributes a significant portion of dollar losses is the practice of padding claim amounts in the event of a loss. One of the largest issues insurance companies face is that policyholders often do not perceive insurance claim padding as an unethical behavior. However, very little research has (...) examined the factors that contribute to such perceptions. Considering how consumers often attempt to justify fraudulent behavior from a fairness perspective, the present work examines how the amount of the deductible in an insurance claim situation can influence feelings of fairness and ethicality. The results of an experimental study show that higher deductible amounts result in stronger perceptions that insurance claim padding is fair to the insurance company, weaker perceptions that the behavior is unethical, and higher proposed claim award amounts. The study also shows, however, that the deductible amount effects are attenuated for consumers who display higher ethical standards as reflected by their scores on the consumer ethics scale. Implications are discussed with respect to the insurance industry, deviant consumer behavior, and general business ethics theory. (shrink)

We used a retrospective survey to model the patterns of appraisal, motivation, and coping that uniquely correspond with 12 positive emotions (affection/love, amusement, awe, challenge/det...

I. INTRODUCTIONIs Jesus the perfect human being? An affirmative response seems unavoidable for classical Christology. Indeed, at the Council of Chalcedon in 451, the gathered bishops and representatives of the church across Africa, Asia, and Europe agreed that Jesus Christ was “perfect in divinity and perfect in humanity”: teleion…en Theótæti kai teleion…en anthropótæti.Theologians and patristics scholars alike often sort through the second part of this formula in the way that the remainder of the conciliar definition itself seems to indicate, interpreting (...) it to mean that nothing that belongs to the humanity we share can be lacking in the humanity of Jesus, and nothing belongs to Him that would compromise the human form. He does not, for instance, have a body animated by a divine spirit in place of a human will, or a superhuman ability to translocate. This is theologically appropriate as far as it goes, but it does not go far enough. (shrink)

Law is indispensable to the public's health. The twentieth century proved this true as law contributed to each of the century's ten great public health achievements: vaccination, healthier mothers and babies, family planning, safer and healthier foods, fluoridation of drinking water, the control of infectious diseases, the decline in death from heart disease and stroke, recognition of tobacco use as a health hazard, motor vehicle safety, and safer workplaces.The readers of this journal can give examples of the relevant types of (...) laws with ease: Jacobson v. Massachusetts, the 1905 U.S. Supreme Court case that upheld the constitutionality of compulsory vaccination; mandatory immunization for school admission; authorization of state prenatal care programs; mandatory fortification of foods; Title X of the Public Health Service Act; the Pure Food and Drugs Act of 1906; the Safe Drinking Water Act of 1974, and hundreds of state and local enactments regulating food; fluoridation ordinanceswater, and sanitation; the Surgeon General's warning notices on cigarette packs and restrictions on marketing tobacco; seat belt laws and mandated vehicle and highway design features; and laws like the federal Occupational Safety and Health Act of 1970 that regulate working conditions. (shrink)

Law is indispensable to the public's health. The twentieth century proved this true as law contributed to each of the century's ten great public health achievements: vaccination, healthier mothers and babies, family planning, safer and healthier foods, fluoridation of drinking water, the control of infectious diseases, the decline in death from heart disease and stroke, recognition of tobacco use as a health hazard, motor vehicle safety, and safer workplaces.The readers of this journal can give examples of the relevant types of (...) laws with ease: Jacobson v. Massachusetts, the 1905 U.S. Supreme Court case that upheld the constitutionality of compulsory vaccination; mandatory immunization for school admission; authorization of state prenatal care programs; mandatory fortification of foods; Title X of the Public Health Service Act; the Pure Food and Drugs Act of 1906; the Safe Drinking Water Act of 1974, and hundreds of state and local enactments regulating food; fluoridation ordinanceswater, and sanitation; the Surgeon General's warning notices on cigarette packs and restrictions on marketing tobacco; seat belt laws and mandated vehicle and highway design features; and laws like the federal Occupational Safety and Health Act of 1970 that regulate working conditions. (shrink)

Theological language has always faced a fundamental dilemma: it seeks to put the divine reality into limited human language. While this dilemma can obfuscate our theological pathways, it can also generate a new awareness of the task and possibilities of the discipline. New testimonials, or uniquely accented human experiential utterances, have emerged in theological discourse in the past decades, greatly increasing our vision of the expansiveness of theology. The tools for integration into systematic or discursive development are still, however, lacking. (...) This article suggests that an extension of the innovative methodology of Thomas Aquinas, beginning and ending with ‘what seems’ to be the case, putting testimony into discursive forms, and testing for a fittingness with the mysterious and excessive mystery of the divine reality, offers a promising path for discerning common and trustworthy theological language. (shrink)

The “therapeutic obligation” is a physician’s duty to provide his patients with what he believes is the best available treatment. We begin by discussing some prominent formulations of the obligation before raising two related considerations against those formulations. First, they do not make sense of cases where doctors are permitted to provide suboptimal care. Second, they give incorrect results in cases where doctors are choosing treatments in challenging epistemic environments. We then propose and defend an account of the therapeutic obligation (...) that solves the problems that undermined previous efforts at formulating the TO. We conclude by considering how apparent problems with our proposal actually rest on difficulties with informed consent. (shrink)

Archer recognizes that sexual selection theory is sensitive to the effects of ecologies on sex differences, yet he does not explain the impact of such variation. For example, to what degree are there sex differences in aggression in polygynous and monogamous societies? I demonstrate how differences in mating perceptions affect the traditional dichotomy that males compete for and females choose mates.

Observing that standard accounts of constitutional law - both the "conservative" and "liberal" varieties - have lost their power to illuminate, The Constitution and the Pride of Reason explores how constitutional law hangs together (and how it falls apart) by investigating the perennial claim that the Constitution and its interpretation somehow embody a commitment to governance by "reason". What does this claim mean, and is it valid? In confronting these queries, Smith offers revealing and iconoclastic assessments of constitutionalists ranging (...) from Madison and Jefferson to Dworkin and Bork. Also detailed in these pages is a provocative overview of the whole constitutional project, from its noble aspirations to its tragic failures. (shrink)

George P. Fletcher, Rethinking Criminal Law Boston: Little, Brown and Co., 1978, xviii + 898 pp.