Microbiologists are transitioning from the study and characterization of individual strains or species to the profiling of whole microbiomes and microbial ecology. Equipped with high-throughput methods for studying the taxonomic and functional characteristics of diverse samples, they are just beginning to encounter the conceptual, theoretical, and experimental problems of comparing taxonomy to function, and extracting useful measures from such comparisons. Although still unresolved, these problems are well studied in macro-ecology and are reiterated here as an historical precautionary for microbial ecologists. (...) Beyond expected and unresolved terminological vagueness, we argue that assessments and comparisons of taxonomic and functional profiles in micro-ecology suffer from theoretically unresolvable arbitrariness and ambiguities. We divide these into problems of scale, individuation, and commensurability. We argue that there is no technically/theoretically “correct” scale, individuation, or comparison of taxonomy and function, but there are nonetheless better and worse methodologies for profiling. (shrink)

Here we endorse Hull’s replicator/interactor framework as providing the overarching understanding sought by MacCord and Maienschein. We suggest that difficulties in seeing the regeneration of limbs by salamanders and of forest ecosystems after fires as similar evolutionary processes can be overcome in this framework. In generalizing Dawkins’s “selfish gene” perspective, Hull defined natural selection as “a process in which the differential extinction and proliferation of interactors causes the differential perpetuation of the replicators that produced them”. Although genes and bacteria are (...) simultaneously both replicators and interactors, communities and ecosystems are generally only interactors. As reproducers, members of sexual species are intermediate. Within such species, organisms are indeed the interactors whose “differential extinction and proliferation” causes the “differential perpetuation” of replicators. But sexually-reproducing organisms do not individually replicate, persist, or recur as interactors, and in consequence it is only those genes causing an interactor differential that are specifically perpetuated in the long run. Higher-level interactors may seldom if ever reproduce, but their recurrence does enable the “differential perpetuation” of replicators specifically responsible for their “differential extinction and proliferation”. In offering answers to the question “What are the replicators specifically responsible for the differential extinction and proliferation of such higher-level entities?” we hope to unify adaptive regeneration across scales, from organisms to ecosystems. (shrink)

Diverse living systems possess the capacity for regeneration; that is, they can under some circumstances repair, re-produce, and maintain themselves in the face of disturbance or damage. Think of systems as diverse as forests, microbial biofilms, corals, salamanders, hydra, and human skin cells. This capacity is fundamental to life—without it, many biological systems would be too fragile to cope with stress and would frequently collapse—but because it is multiply realized in wildly different living systems at many scales, finding a common (...) understanding may seem futile, and in fact research has proceeded along independent lines. For example, the sciences of organismal regeneration and ecological regeneration appear to have little more than a nominal relationship. Progress towards unification can be made, we think, by turning to evolutionary theory, specifically by synthesizing recent discussions of the evolution of individuals versus collectives with older literature about replicators versus interactors. This allows us to provide a partial answer in response to MacCord and Maienschein’s call for “basic units and mechanisms” of regeneration, relevant when that process is “adaptive.” We argue that the basics of adaptive regeneration can be understood and generalized through a modification of David Hull’s replicator-interactor framework. (shrink)

Koonin, in an article in this issue, claims that CRISPR–Cas systems are mechanisms for the inheritance of acquired adaptive characteristics, and that the operation of such systems comprises a “Lamarckian mode of evolution.” We argue that viewing the CRISPR–Cas mechanism as facilitating a form of “directed mutation” more accurately represents how the system behaves and the history of neoDarwinian thinking, and is to be preferred.

In Act 1 scene iv of Macbeth, Duncan reflects that: 'There's no art to find the mind's construction in the face'. In contrast, the claim that Andy Young sets out in this book is that we are now developing a science of face perception which can indeed shed light on certain aspects of mental life. Face and Mind consists of a series of seminal research and review papers on face perception published by the author and his colleagues over the last (...) 12 years. A comprehensive introductory chapter, written especially for this volume, serves to draw together the various themes explored in the different contributions. The book examines the question of how faces are special, in terms of their social, biological, and theoretical roles. In particular, Face and Mind seeks to determine what our understanding of the face can tell us about the human brain. It discusses the evidence for an evolved neural substrate for face perception, and the question of whether we are innately predisposed to recognise faces, to find them attractive, and to decode the many social signals they give us. The ability of the human brain to process and remember the many different faces that we see and subsequently recall is analysed. Young includes detailed studies of the types of impairment to face perception which can follow brain injury or psychiatric illness, and uses them to address these questions, as well as other issues of high intrinsic and interdisciplinary interest. These include the extent to which our mental lives result from the operation of discrete components devoted to different purposes, the differences between conscious and non-conscious processes, and how we use evidence to support our beliefs about the world. Because of the huge variety of social signals read from the face, it can offer unique theoretical and philosophical insights into these questions. This fascinating book will be of interest not only to psychologists and neuropsychologists working in the field of visual perception, but to cognitive scientists generally. It provides an excellent summary of the most important theorietical and empirical work done on face perception in recent years, and as such will be of interest to advanced undergraduate and post-graduate students in psychology, philosophy, and cognitive science. (shrink)

Hastings Center Report, Volume 52, Issue 3, Page 9-17, May–June 2022.

This is a comprehensive reference source on 18th-century authors writing in the English language about philosophical ideas and issues. It features authors taken from 1689 through to the mid-19th century, the period beginning with John Locke and ending with Dugald Stewart. The word philosophical is used in a wide, 18th-century sense. Therefore, the Dictionary includes epistemology, ethics, aesthetics, education, politics, rhetoric, science, medicine, biology, geology, chemistry and theology.

This volume celebrates the career of John Martin Fischer, whose work on a wide range of topics over the past forty years has been transformative and inspirational. Fischer's semicompatibilist view of free will and moral responsibility is perhaps the most widely discussed view of its kind, and his emphasis on the significance of reasons-responsiveness as the capacity that underlies moral accountability has been widely influential. Aside from free will and moral responsibility, Fischer is also well-known for his work on freedom (...) and foreknowledge, the problem of evil, the badness of death, the meaning of life, and the allure of immortality. This volume gathers new essays by leading scholars on some of the major themes of Fischer's work, and it also includes a new piece by Fischer in which he offers a systematic reflection on and defense of the motivations that have shaped his theorizing about moral responsibility. Freedom, Responsibility, and Value will be of interest to scholars and students working on a variety of issues in metaphysics, ethics, and philosophy of religion. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

We present a short introduction to, and the first English language translation of, Theodor W. Adorno's 1964 article, "Meinungsforschung und Öffentlichkeit." In this article, Adorno situates the misunderstanding of public opinion within a dialectic of elements of publicness itself: empirical publicness' dependence on a normative ideology of publicness, and modern publicness' tendency to undermine its own principles. He also locates it in the dual role of mass media as both fora for the expression of opinion and, as he calls them, (...) "organs of public opinion." The introduction provides a discussion of Adorno's reception in the American academy, arguing that contemporary sociological practice should be concerned with the problems Adorno raises. We suggest that Adorno's relegation to the fields of philosophy and aesthetics belies his relevance to empirical sociological research. (shrink)

Understanding a patient’s story is integral to providing ethically supportable and practical recommendations that can improve patient care. Important skills include how to elicit an individual’s story, how to weave different narrative threads together, and how to assist the care team, patients, and caregivers to resolve difficult decisions or moral dilemmas. Narrative approaches to ethics consultation deepen dialogue and stakeholders’ engagement to reveal important values, preferences, and beliefs that may prove critical in resolving care challenges. Recognizing barriers to narrative inquiry, (...) such as patients who are unable or refuse to share their story, is also important. In this article we offer specific steps and guidelines that ethicists can follow to systematically elicit and construct patients’ stories. We provide a case example to illustrate how a narrative approach to ethics consultation illuminates salient ethical issues that may otherwise go unnoticed. We argue that this approach should be part of every consultant’s tool kit. (shrink)

This is a study of Frege's permutation argument in Part I, Section 10, of Frege's Basic Laws of Arithmetic.

Medical-legal partnerships connect legal advocates to healthcare providers and settings. Maintaining effectiveness of medical-legal partnerships and consistently identifying opportunities for innovation and adaptation takes intentionality and effort. In this paper, we discuss ways in which our use of data and quality improvement methods have facilitated advocacy at both patient (client) and population levels as we collectively pursue better, more equitable outcomes.

Between inventing the concept of a universal computer in 1936 and breaking the German Enigma code during World War II, Alan Turing, the British founder of computer science and artificial intelligence, came to Princeton University to study mathematical logic. Some of the greatest logicians in the world--including Alonzo Church, Kurt Gödel, John von Neumann, and Stephen Kleene--were at Princeton in the 1930s, and they were working on ideas that would lay the groundwork for what would become known as computer science. (...) Though less well known than his other work, Turing's 1938 Princeton PhD thesis, "Systems of Logic Based on Ordinals," which includes his notion of an oracle machine, has had a lasting influence on computer science and mathematics. This book presents a facsimile of the original typescript of the thesis along with essays by Andrew Appel and Solomon Feferman that explain its still-unfolding significance. A work of philosophy as well as mathematics, Turing's thesis envisions a practical goal--a logical system to formalize mathematical proofs so they can be checked mechanically. If every step of a theorem could be verified mechanically, the burden on intuition would be limited to the axioms. Turing's point, as Appel writes, is that "mathematical reasoning can be done, and should be done, in mechanizable formal logic." Turing's vision of "constructive systems of logic for practical use" has become reality: in the twenty-first century, automated "formal methods" are now routine. Presented here in its original form, this fascinating thesis is one of the key documents in the history of mathematics and computer science. (shrink)

ObjectiveTo prospectively study the cingulate cortex for the localization and role of the grasping action in humans during electrical stimulation of depth electrodes.MethodsAll the patients with intractable focal epilepsy and a depth electrode stereotactically placed in the cingulate cortex, as part of their pre-surgical epilepsy evaluation from 2015 to 2017, were included. Cortical stimulation was performed and examined for grasping actions. Post-implantation volumetric T1 MRIs were co-registered to determine the exact electrode position.ResultsFive patients exhibited contralateral grasping actions during electrical stimulation. (...) All patients had electrodes implanted in the ventral bank of the right cingulate sulcus adjacent to the vertical anterior commissure line. Stimulation of other electrodes in adjacent regions did not elicit grasping.ConclusionGrasping action elicited from a localized region in the mid-cingulate cortex directly supports the concept of the cingulate cortex being crucially involved in the grasping network. This opens an opportunity to explore this region with deep brain stimulation as a motor neuromodulation target for treatment in specific movement disorders or neurorehabilitation. (shrink)

Introduction Understanding the views of the public is essential if generally acceptable policies are to be devised that balance research access to general practice patient records with protection of patients' privacy. However, few large studies have been conducted about public attitudes to research access to personal health information. Methods A mixed methods study was performed. Informed by focus groups and literature review, a questionnaire was designed which assessed attitudes to research access to personal health information and factors that influence these. (...) A postal survey was conducted of an electoral roll-based sample of the adult population of Ireland. Results Completed questionnaires were returned by 1575 (40.6%). Among the respondents, 67.5% were unwilling to allow GPs to decide when researchers could access identifiable personal health information. However, 89.5% said they would agree to ongoing consent arrangements, allowing the sharing by GPs of anonymous personal health information with researchers without the need for consent on a study-by-study basis. Increasing age (by each 10-year increment), being retired and primary level education only were significantly associated with an increased likelihood of agreeing that any personal health information could be shared on an ongoing basis: OR 1.39 (95% CI 1.18 to 1.63), 2.00 (95% CI 1.22 to 3.29) and 3.91 (95% CI 1.95 to 7.85), respectively. Conclusions Although survey data can be prone to response biases, this study suggests that prior consent agreements allowing the supply by GPs of anonymous personal health information to researchers may be widely supported, and that populations willing to opt in to such arrangements may be sufficiently representative to facilitate valid and robust consent-dependent observational research. (shrink)

This volume captures the individuality, the national and personal identity, the cultural exchange, and the self-consciousness that have long been sensed as peculiarly potent in the Hellenistic world. The fields of history, literature, art, philosophy, and religion are each presented using the format of two essays followed by a response. Conveying the direction and focus of Hellenistic learning, eighteen leading scholars discuss issues of liberty versus domination, appropriation versus accommodation, the increasing diversity of citizen roles and the dress and gesture (...) appropriate to them, and the accompanying religious and philosophical ferment. The result is an arresting view of the incredible and unprecedented diversity of the Hellenistic world. (shrink)

1 Adaptationism is a research strategy that seeks to identify adaptations and the specific selective forces that drove their evolution in past environments. Since the mid-1970s, paleontologist Stephen J. Gould and geneticist Richard Lewontin have been critical of adaptationism, especially as applied toward understanding human behavior and cognition. Perhaps the most prominent criticism they made was that adaptationist explanations were analogous to Rudyard Kipling's Just So Stories. Since storytelling is an inherent part of science, the criticism refers to the acceptance (...) of stories without sufficient empirical evidence. In particular, Gould, Lewontin, and their colleagues argue that adaptationists often use inappropriate evidentiary standards for identifying adaptations and their functions, and that they often fail to consider alternative hypotheses to adaptation. Playing prominently in both of these criticisms are the concepts of constraint, spandrel, and exaptation. In this article we discuss the standards of evidence that could be used to identify adaptations and when and how they may be appropriately used. Moreover, building an empirical case that certain features of a trait are best explained by exaptation, spandrel, or constraint requires demonstrating that the trait's features cannot be better accounted for by adaptationist hypotheses. Thus, we argue that the testing of alternatives requires the consideration, testing, and systematic rejection of adaptationist hypotheses. Where possible, we illustrate our points with examples taken from human behavior and cognition. Key Words: adaptation; ADHD; brain allometry; constraint; epistemology; evolutionary psychology; exaptation; female orgasm ; optimization; special design; waist-hip ratio. Footnotes1 The authors contributed equally to this paper. Order of authorship was determined alphabetically. Correspondence may be addressed to any of the authors. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.1 (2002) 55-59 [Access article in PDF] One Stage Is Not Enough Andrew W. Young and Karel W. de Pauw Keywords: delusions, Cotard delusion, Capgras delusion, cognitive neuropsychiatry. WE WELCOME THE OPPORTUNITY to offer our reflections on Philip Gerrans' interesting paper. Our opinion is that on fundamental issues we agree quite a bit—but there are clear differences when it comes to details.The most basic issue (...) concerns the nature of the enterprise. Like Gerrans, we think that it is possible to create testable accounts of the formation and maintenance of what would otherwise seem bizarre and inexplicable delusions, and that these accounts should be grounded in theoretical models of factors that underpin our everyday perception and reasoning. This general approach certainly forms part of what has been called cognitive neuropsychiatry. However, we disagree with Gerrans in that we see cognitive neuropsychiatry as an attempt to draw on the underlying logic of cognitive neuropsychology, rather than (as Gerrans implies) its current methods. The underlying logic of cognitive neuropsychological approaches has been to try to understand the effects of brain injury in terms of disruption of different components of theoretical models of normal abilities. In this approach, a model of normal performance is tested by its ability to account for the effects of brain injury. Where the model of normal performance also provides a convincing account of brain injury it is retained, and when it fails to account for effects of brain injury, it is revised or abandoned. In cognitive neuropsychiatry, the key theoretical move has been to argue that an adequate model of normal performance should be able to account for any disordered pattern (Ellis and Young 1990). The same logic of seeking to explain disordered performance by reference to models of normal function is then attempted, but for disorders that would usually fall within the province of psychiatry.In our opinion, however, cognitive neuropsychiatry will not simply involve importing the methods of cognitive neuropsychology into the new domain; they will need to be developed and adapted to fit the new agenda (Young 2000).In cognitive neuropsychology, progress has often come from the careful investigation of people with stable, selective deficits of fundamental cognitive functions involved in sensory analysis, memory, and verbal or motor output. In contrast, delusional beliefs can be relatively unstable; often they are only held for a few weeks or even days. When the delusions change, patients may modify or abandon them as suddenly as they seemed to form them, or they may give them up much more slowly and reluctantly. At the very least, this creates difficulties in the timing of investigations and in interpreting the relation of deficits and symptoms, which may be recorded on separate dates. These methodological problems [End Page 55] are exacerbated by the fact that deficits linked to complex abnormal experiences such as delusions may be multifaceted and diffuse, even when the delusions themselves have a specific content or theme. Such complications do not invalidate cognitive neuropsychiatry, but they do mean it will need to develop its own methods for dealing with them and making appropriate inferences.One of the key complexities that has surfaced already involves the idea that delusional beliefs might reflect the interaction of two or more contributory factors. Gerrans discusses a particular variant of this idea, which had been suggested by Young and Leafhead (1996) as an approach to understanding the Cotard delusion: The Cotard delusion represents a depressed person's attempt to account for abnormal perceptual experiences. It follows that the delusion is based on an unfortunate interaction between different contributory factors. One set of factors creates the abnormal perceptual experiences, which are characterised by lack of emotional responses and feelings of emptiness, depersonalisation and derealisation. The other factors result in a misinterpretation of these perceptual changes, in which the patients' depressed moods lead them correctly to attribute the changes to themselves, but to exaggerate their consequences. (Young and Leafhead, 1996, 166) Gerrans describes this as a two-stage account, but argues that a one-stage account based only on abnormal perceptual... (shrink)

Foucault on Politics, Society and War interrogates Foucault's controversial genealogy of modern biopolitics. By insisting on 'life' as the key referent of power in the modern age, Foucault argues that politics grounds society in war, specifically race war, in ways that come to threaten the very human existence it is pledged to promote. These essays situate Foucault's arguments, clarify the correlation of sovereign- and bio-power and examine the relation of bios, nomos and race in relation to modern war.

This article aims to supplement our understanding of later developments within European universities, that is, Scholastic thought, by attending to how certain pre-Scholastics, namely, Peter Abelard and other twelfth-century philosophers, thought about artifacts and social constructions more generally. It focuses on the treatment of artifacts that can be cobbled together out of Abelard’s Dialectica. The article argues that Abelard attempts to sharply distinguish the world of things from the world of human-made objects. This is most apparent in his treatment of (...) creation and human acts of making. Yet there are places in his thought where we see some hesitancy. Many of Abelard’s peers seem to have drawn on the reasons why Abelard hesitates, and they blur the line between human-made objects such as houses and substances such as rocks and humans. Others seem to go further than Abelard—perhaps inspired by some of the thoughts that Abelard also entertains about social constructions such as days and speeches—and assert that even houses are merely convenient fictions. (shrink)

Anne Conway (1631–1679) is sometimes said to be a Monist. I present several kinds of Monism and then investigate whether any of these adequately capture Conway’s theory of substance and individuals. I outline Conway’s reasons for postulating that there are three irreducibly distinct kinds of essence or substance, which by itself demonstrates that she is not an unrestricted Token Monist. I then examine her various remarks about created substance, which she sometimes refers to as “a creature” and other times as (...) “creatures.” Here I argue that, while the texts are ambiguous, there are compelling reasons—especially given her views about salvation and justice—to believe that she is merely a Type Monist at the level of created substances. I then examine two theses that result from her relativized Type Monism. First, there are no substantial barriers between, say, horses and humans, and thus all created things can convert into one another as they improve or regress morally. Second, there is no substantial difference between minds and bodies. I suggest that Conway’s arguments against Descartes’ Type Pluralism could easily be included as part of a more inclusive philosophy syllabus. (shrink)

In Act 1 scene iv of Macbeth, Duncan reflects that: 'There's no art to find the mind's construction in the face'. In contrast, the claim that Andy Young sets out in this book is that we are now developing a science of face perception which can indeed shed light on certain aspects of mentallife. Face and Mind consists of a series of seminal research and review papers on face perception published by the author and his colleagues over the last 12 (...) years. A comprehensive introductory chapter, written especially for this volume, serves to draw together the various themes explored in thedifferent contributions. The book examines the question of how faces are special, in terms of their social, biological, and theoretical roles. In particular, Face and Mind seeks to determine what our understanding of the face can tell us about the human brain. It discusses the evidence for anevolved neural substrate for face perception, and the question of whether we are innately predisposed to recognise faces, to find them attractive, and to decode the many social signals they give us. The ability of the human brain to process and remember the many different faces that we see andsubsequently recall is analysed. Young includes detailed studies of the types of impairment to face perception which can follow brain injury or psychiatric illness, and uses them to address these questions, as well as other issues of high intrinsic and interdisciplinary interest. These include theextent to which our mental lives result from the operation of discrete components devoted to different purposes, the differences between conscious and non-conscious processes, and how we use evidence to support our beliefs about the world. Because of the huge variety of social signals read from theface, it can offer unique theoretical and philosophical insights into these questions. This fascinating book will be of interest not only to psychologists and neuropsychologists working in the field of visual perception, but to cognitive scientists generally. It provides an excellent summary ofthe most important theorietical and empirical work done on face perception in recent years, and as such will be of interest to advanced undergraduate and post-graduate students in psychology, philosophy, and cognitive science. (shrink)

Charles Sanders Peirce famously claimed that ‘The opinion which is fated to be ultimately agreed to by all who investigate is what we mean by the truth’ (W3: 273). Christopher Hookway has argued for a highly distinctive interpretation of this claim in terms of speech-acts and the normative commitments we incur in performing them. So-construed, Peirce’s conception of truth is difficult to compare with standard theories of the concept, which tend to focus instead upon some property or feature that is (...) shared by all and only true propositions, and with whether or not that property is substantive or metaphysically significant. This paper examines Hookway’s interpretation of Peirce’s conception of truth in an effort to clarify its position in logical space. It then raises some difficulties for the way Hookway tries to accommodate Peirce’s remarks about the special status of assertion and belief in science. (shrink)

In his influential book Truth, Paul Horwich deploys a philosophical method focused on linguistic usage, that is, on the function(s) the concept of truth serves in actual discourse. In doing so Horwich eschews abstract metaphysics, arguing that metaphysical or ontological conceptions of truth rest on basic misconceptions. From this description, one might reasonably expect Horwich's book to have drawn inspiration from, or even embodied philosophical pragmatism of some kind. Unfortunately Horwich relies upon Russell's tired caricature of pragmatism about truth (''p' (...) is true if and only if it is useful to believe p' (Ibid., p. 34, p. 47)), and as a result underestimates the challenge it poses to Minimalism. This paper develops a pragmatist critique of minimalism that focuses on the seemingly central, plausibly constitutive role played by the concept of truth in the speech-act of assertion. The critique suggests that Horwich's Minimalism does not and cannot accomplish its stated goal of explaining all of the facts involving truth. Indeed, the kind of thorough-going deflationism sought by Horwich and others (including pragmatist sympathizer Bob Brandom) is incompatible with an adequate account of assertion, and perhaps other concepts (like belief, judgement and inquiry) as well. (shrink)

Some cases of prosopagnosia involve a highly circumscribed loss of A-consciousness. When seen in this way they offer further support for the arguments made in Block's target article.