A stereospecific binding site is not the only determinant governing the selectivity of transport proteins. An understanding of transport across cellular membranes requires a description of the different compartments within a transmembrane channel; evidence for the existence of these compartments comes from the selectivity properties of genetically modified maltoporin. Such compartments may also be of significance in determining the specificity of other transport proteins.

This article attempts to study cost minimizing multi-objective fractional solid transportation problem with fuzzy cost coefficients c ˜ i j k r {\tilde{c}}_{ijk}^{r}, fuzzy supply quantities a ˜ i {\tilde{a}}_{i}, fuzzy demands b ˜ j {\tilde{b}}_{j}, and/or fuzzy conveyances e ˜ k {\tilde{e}}_{k}. The fuzzy efficient concept is introduced in which the crisp efficient solution is extended. A necessary and sufficient condition for the solution is established. Fuzzy geometric programming approach is applied to solve the crisp problem by defining membership (...) function so as to obtain the optimal compromise solution of a multi-objective two-stage problem. A linear membership function for the objective function is defined. The stability set of the first kind is defined and determined. A numerical example is given for illustration and to check the validity of the proposed approach. (shrink)

In Southeast Asian countries (SEA), road transport accounts for the main energy consumption and CO2 emission. Air pollution is a major concern in densely populated cities such as Bangkok, Manila, and Kuala Lumpur. The main objective of this paper is to give insights on trends of transport development, car ownership, and CO2 emissions in Southeast Asia. This study also attempts to review the successful transportation policies around the globe and to introduce the possible instruments that can help reduce (...) air pollution in Southeast Asian countries. Economic instruments to estimate the benefits of a cleaner environment due to new policies are introduced as well. The results of this research could help policy makers consider approaches that could internalize external costs of transportation and maximize the societal welfare. (shrink)

New numerical solutions of 3+1D covariant kinetic theory are reported for nuclear collisions in the energy domain Ecm∼200 AGeV. They were obtained using the MPC 0.1.2 parton transport code employing high parton subdivision to retain Lorentz covariance. The solutions are compared to those of relativistic hydrodynamics employing Cooper–Frye isotherm freeze-out. The transport solutions follow a different dynamical path than hydrodynamics due to large dissipative effects when pQCD scattering rates and HIJING initial conditions are assumed. The transport freeze-out (...) four-volume is sensitive to the reaction rates. The final transverse momentum distributions are found to deviate by up to an order of magnitude from those of Cooper–Frye frozen hydrodynamics. (shrink)

This paper presents an axiomatic characterization of the Owen set of transportation games. In the characterization we use six properties including consistency (CONS2) and splitting and merging (SM) which are firstly proposed and defined for this setup in the present paper.

We all know that problems of transportation and allocation appear frequently in practical life. We need to transfer materials from production centers to consumption centers to secure the areas’ need for the transported material or allocate machines or people to do a specific job at the lowest cost, or in the shortest time. We know that the cost factors Time is one of the most important factors that decision-makers care about because it plays an “important” role in many of the (...) practical and scientific issues that we face in our daily lives, and we need careful study to enable us to avoid losses. For this, the linear programming method was used, which is one of the research methods. Processes, where the problem data is converted into a linear mathematical model for which the optimal solution achieves the desired goal. Since these models are linear models, we can solve them using the direct simplex method and its modifications, but the specificity that these models enjoy has enabled scholars and researchers to find special methods that help us in obtaining the optimal solution. Whatever the method used, the goal is to determine the number of units transferred from any material from production centers to consumption centers, or to allocate a machine or person to do a job so that the cost or time is as short as possible. These issues were addressed according to classical logic, but the ideal solution was a specific value appropriate to the conditions in which the data was collected and does not take into account the changes that may occur in the work environment. In order to obtain results that are more accurate and enjoy a margin of freedom, we present in this book a study of transport issues and neutrosophic allocation issues and some methods for solving them. By neutrosophic issues we mean These are the problems in which the data are neutrosophic values, i.e. the required quantities and the available quantities. (shrink)

We all know that problems of transportation and allocation appear frequently in practical life. We need to transfer materials from production centers to consumption centers to secure the areas’ need for the transported material or allocate machines or people to do a specific job at the lowest cost, or in the shortest time. We know that the cost factors Time is one of the most important factors that decision-makers care about because it plays an “important” role in many of the (...) practical and scientific issues that we face in our daily lives, and we need careful study to enable us to avoid losses. For this, the linear programming method was used, which is one of the research methods. Processes, where the problem data is converted into a linear mathematical model for which the optimal solution achieves the desired goal. Since these models are linear models, we can solve them using the direct simplex method and its modifications, but the specificity that these models enjoy has enabled scholars and researchers to find special methods that help us in obtaining the optimal solution. Whatever the method used, the goal is to determine the number of units transferred from any material from production centers to consumption centers, or to allocate a machine or person to do a job so that the cost or time is as short as possible. These issues were addressed according to classical logic, but the ideal solution was a specific value appropriate to the conditions in which the data was collected and does not take into account the changes that may occur in the work environment. In order to obtain results that are more accurate and enjoy a margin of freedom, we present in this book a study of transport issues and neutrosophic allocation issues and some methods for solving them. By neutrosophic issues we mean These are the problems in which the data are neutrosophic values, i.e. the required quantities and the available quantities. (shrink)

Scientists are typically responsible for greater greenhouse gas emissions than the general population. These ‘extra’ emissions are largely due to frequent travel, often by airplane, to professional and academic meetings. In the following commentary, we explore how employing mixed modes of transportation, particularly by prioritizing train travel, can significantly reduce the environmental costs associated with attending conferences. Estimating travel distances for attendants to recent meetings, we demonstrate that the proposed strategy has the potential to decrease emissions, even when considering exotic, (...) remote (and potentially enticing) locations. Our suggestions are easy to implement, can be combined with previous proposals for reducing emissions, and provide an opportunity for scientists to convey an important message to the general public. This message is not confined to our particular example and we hope that it will encourage ecologists, sociologists and other scientists, historians and philosophers to pursue additional creative behavioural solutions in order to reduce our impact on an increasingly stressed ecosphere. (shrink)

Most people presume that government is always responsible for providing solutions to pollution problems, including transportation pollution. This paper examines the validity of this argument from a minarchist libertarian, property rights principles perspective, and concludes that government cannot solve these problems using command-and-control legislation. The primary policy suggested for government to adopt is the strict adherence to property rights protection and enforcement regarding polluters, including themselves. Further encouragement of market forces could be accomplished by stopping interference within the market at (...) critical points, namely the production of roads, production and sales of automobiles, and the subsidization of alternative fuels. (shrink)

Intelligent Transportation Systems are expected to automate how parking slots are booked by trucks. The intrinsic dynamic nature of this problem, the need of explanations and the inclusion of private data justify an agent-based solution. Agents solving this problem act with a Believe Desire Intentions reasoning, and are implemented with JASON. Privacy of trucks becomes protected sharing a list of parkings ordered by preference. Furthermore, the process of assigning parking slots takes into account legal requirements on breaks and driving time (...) limits. Finally, the agent simulations use the distances, the number of trucks and parkings corresponding to the proportions of the current European Union data. The performance of the proposed solution is tested in these simulations with three different distances against an alternative with complete knowledge. The difference in efficiency, the number of illegal breaks and the traveled distances are measured in them. Comparing the results, we can conclude that the nonprivate alternative is slightly better in performance while both alternatives do not produce illegal breaks. In this way the simulations show that the proposed privacy protection does not impose a relevant handicap in efficiency. (shrink)

This declaration ponders the impacts of Joule warm, separation, and warming radiation for the progression of MHD Sutterby nanofluid past over an all-inclusive chamber. The wonder of warmth and mass conduction is demonstrated under warm conductivity relying upon temperature and dispersion coefficients individually. Besides, the conventional Fourier and Fick laws have been applied in the outflows of warm and mass transport. The control model comprising of a progression of coupled incomplete differential conditions is changed over into a standard arrangement (...) of nonlinear coupled differential conditions by reasonable likeness changes. The subsequent arrangement of articulations is systematically treated through an ideal homotopic method. The impacts of various dimensionless stream boundaries on the speed, temperature, and focus fields are delineated through diagrams. The range of some parameters involved is assumed for the convergent solution as 0 < R e < 10, 0 < P r < 6.5, 0 < E c < 40, 0 < R d < 1.5, 0 < S 1 < 0.5, 0 < S 2 < 0.5, 0 < L e < 0.5, 0 < N t < 2.5, and 0 < N b < 2.0. The patterns of skin friction coefficient, local Nusselt, and Sherwood numbers are examined via bar charts. The principle consequence of the proposed study is that the decay of the speed for the Sutterby liquid boundary, the deterioration of the variable warm conductivity, the temperature, and the radiation increase the framework temperature. The delineation boundaries show the opposite conduct for the temperature and fixation outskirts layers. (shrink)

Freight transportation plays a critical role in improving company performance in the modern manufacturing industry. To reduce costs, companies must take advantage of the use of large vehicles. It caused fewer deliveries, but inventory costs and degradation quality are high. One of the joint economic lot size problems in supply chain is Integrated Single-Vendor Single-Buyer Inventory Problem. This study developed the I-SVSB-IP model that considers raw materials’ exponential quality degradation and transportation costs. The objective function of this research was to (...) maximize the Joint Total Profit. Three decision variables used were inventory cycle time, raw material ordering frequency, and frequency of delivery of finished products to buyers. This study proposed a sophisticated Chimp Optimization Algorithm procedure to solve the I-SVSB-IP problem. A case study on the food industry in Indonesia was presented to optimize the I-SVSB-IP. The results showed that the ChOA procedure had produced an optimal solution compared to the state-of-the-art algorithm. This study also demonstrated a sensitivity analysis of decision and transportation variables to cost, revenue, and JTP. The results show that increasing transport frequency of ordering raw materials and finished products to buyers enhances the total cost and reduces joint total profit. In addition, increasing the rate of quality degradation of raw materials reduces JTP. (shrink)

In this study, a new mathematical model is presented to solve the flexible flow shop problem where transportation is reliable and there are constraints on intermediate buffers, budgets, and human resource learning effects. Firstly, the model is validated to confirm the accuracy of its performance. Then, since it is an NP-hard one, two metaheuristic algorithms, namely, MOSA and MOEA/D, are rendered to solve mid- and large-scale problems. To confirm their accuracy of performance, two small-scale problems are solved using GAMS exact (...) solution software, and the obtained results have been compared with the output of the algorithms. Since the problem in this study is multiobjective, five comparative indices are used to compare the performance of algorithms. The results show that the answers achieved using the metaheuristic algorithms are very close to the ones achieved via the GAMS exact program. Therefore, the proposed algorithms are validated, and it is proved that they are accurately designed and useable in solving the real-world problems in logical calculation time. By comparing the obtained results, it can be seen that the MOEA/D algorithm performs better in terms of computational time and Mean ideal distance. The MOSA algorithm also performs better according to the index Spread of nondominated solutions, diversity metric, and number of Pareto solutions. Considering the confirmation of precision and accuracy of performance of the proposed algorithms, it can be concluded that MOSA and MOEA/D are useful in solving the mid- and large-scale modes of the problem in the study, which is very applicable in the real world. (shrink)

Different families of transport proteins catalyze transmembrane solute translocation, employing different mechanisms and energy sources. Several of these functionally dissimilar proteins nevertheless exhibit similar strutural units, consisting of six tightly packed α‐helices which may comprise all or part of a transmembrane channel. It is now recognized that some of these families arose independently of each other by convergence, while others arose from common precursors by divergence. The former families apparently arose at different times in evolutionary history, in different (...) groups of organisms, employing different routes. (shrink)

The intensification of debate over environmental ethics in recent years have clarified some ethical arguments such as autonomy, justice, beneficence, non-maleficence, trans-generational ethics and the rights of nature. However, we can ask if these ethical principles could become an incentive for people to act considering the environment. A questionnaire sheet for use in face-to-face interviews was developed to explore the ideas of the general public in order to describe the attitudes and behaviour towards transportation using private cars. People were interviewed (...) to ask how they think of the use of private cars in the future, and whether they have restricted their use of private cars considering the environment, using open-ended questions. According to this survey, it is suggested that while more than 90% of the general public in Japan think the environment faces serious problems, most lack concrete knowledge about why environmental problems are dangerous. Among those who object to restrictions on private car use, there are also many respondents who expect a solution from the development of science and technology, as well as the general state of mind and society that considers a convenient life to be most important. (shrink)

This book addresses the methodological issues involved in responsible innovation and provides an overview of recent applications of multidisciplinary research. Responsible innovation involves research into the ethical and societal aspects of new technologies (e.g. ICT, nanotechnology, biotechnology and brain sciences) and of changes in technological systems (e.g. energy, transport, agriculture and water). This research is highly multidisciplinary. It involves close collaboration between researchers in such diverse fields as ethics, social science, law, economics, applied science, engineering - as well as (...) innovative, design-oriented and policy-relevant. Although there is a trend to engage ethicists and social scientists early in technology development, most literature in the field of Technology Assessment or Ethics of Technology is still aimed at one discipline whereas this book incorporates different approaches and to discuss experiences, lessons and more general theoretical issues. (shrink)

We present a model of steady state solute and water reabsorption along the rat proximal tubule. Major co-and counter-transport systems in the apical and basolateral cell membranes are described using kinetic descriptions based on data from the flows and solute concentrations along the length of the proximal tubule as a function of filtration rate and peritubular solute concentrations. We show that for many aspects of proximal tubule transport physiology this kinetics-based model is an adequate representation (...) of the mammalian proximal tubule. (shrink)

Cities and towns are expanding and thriving as a result of urbanization, which also significantly changes the local climate. One of the most significant phenomena associated with urbanization is the Urban Heat Island (UHI) effect. This phenomenon is increasingly being studied worldwide. The paper aims to investigate the UHI phenomenon in the metropolitan area of Tirana, Albania. It analyses the impact of the UHI on four specific locations in Tirana, its causes and mitigation measures, as well as variations in surface (...) temperature, CO2 emissions, and relative humidity. The regions are measured and observed using a specific instrument such as the Testo 435. Considering the mean surface temperature variations between urban and rural regions ranging from 28.4°C to 33.7 °C, CO2 emissions from 302.9 ppm to 416.2 ppm, and relative humidity from 34.1% to 41.2%, it is found that the UHI impact in Tirana is significant. The lack of green spaces, high building density, urban patterns, building materials used, transport, and energy use are the main contributors to the UHI in central Tirana. Increasing green spaces, using reflective materials, and promoting sustainable urban design are some of the mitigation techniques suggested to reduce the UHI effect in Tirana. (shrink)

The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of insoluble TDP‐43 aggregates in the neuronal cytoplasm that lead to cell death. The dynamics between cytoplasmic and nuclear TDP‐43 are altered in the disease state where TDP‐43 mislocalizes to the cytoplasm, disrupting Nuclear Pore Complexes (NPCs), and ultimately forming large fibrils stabilized by the C‐terminal prion‐like (...) domain. Here, we review three emerging and poorly understood aspects of TDP‐43 biology linked to its aggregation. First, how post‐translational modifications in the proximity of TDP‐43 N‐terminal domain (NTD) promote aggregation. Second, how TDP‐43 engages FG‐nucleoporins in the NPC, disrupting the pore permeability and function. Third, how the importin α/β heterodimer prevents TDP‐43 aggregation, serving both as a nuclear import transporter and a cytoplasmic chaperone. (shrink)

Transportation systems that rely predominantly on privately owned automobiles are clearly unsustainable, yet the number of such vehicles continues to grow every year. This article explores the causes of this anomaly. The ineffectiveness of “end-of-pipe” solutions to automobile dominance is demonstrated, and more effective strategies are explored. A computer simulation of highway traffic clarifies the fragility of traffic management systems and the inevitability of traffic congestion.

An “insightful” and in-depth look at anti-science politics and its deadly results (Maria Konnikova, New York Times–bestselling author of The Biggest Bluff). Thomas Jefferson said, “Wherever the people are well informed, they can be trusted with their own government.” But what happens when they aren’t? From climate change to vaccinations, transportation to technology, health care to defense, we are in the midst of an unprecedented expansion of scientific progress—and a simultaneous expansion of danger. At the very time we need them (...) most, scientists and the very idea of objective knowledge are being bombarded by a vast, well-funded war on science, and the results are deadly. Whether it’s driven by identity politics, ideology, or industry, the result is an unprecedented erosion of thought in Western democracies as voters, policymakers, and justices actively ignore scientific evidence, leaving major policy decisions to be based more on the demands of the most strident voices. This compelling book investigates the historical, social, philosophical, political, and emotional reasons why evidence-based politics are in decline and authoritarian politics are once again on the rise on both left and right—and provides some compelling solutions to bring us to our collective senses, before it's too late. “If you care about attacks on climate science and the rise of authoritarianism, if you care about biased media coverage and shake-your-head political tomfoolery, this book is for you.”—The Guardian. (shrink)

Artificial Intelligence (AI) is transforming our world: today machines not only can mimic human actions but out-perform human agents in many activities, including learning and thinking. AI offers revolutionary solutions and new possibilities in transportation, business, communication, medicine, law, and other domains. While some welcome this brave new world, others fear the threats AI pose to people’s livelihoods, social relations, individuality, freedom, and perhaps even the very survival of the human species. No doubt some of this existential angst is exaggerated, (...) but AI does raise questions for our understanding of the world and ourselves that require serious reflection, including questions about adequacy of education in various aspects. This chapter offers, from the perspectives of John Dewey’s Pragmatism as well as Confucianism, some reflections on the role of the humanities in education in response to the opportunities and challenges of the development and widespread use of AI. It shows that Dewey and Confucius share similar views regarding the humanistic purpose of education and their philosophies of education offer arguments for why humanities education will be relevant, if not more important, when many jobs we are familiar with become obsolete. Their attitudes toward the economic motive in education will help us rethink the meaning of work in a “world without work.” At the same time, they offer a critical evaluation of contemporary humanities education, which have failed to realize their visions of personal cultivation and growth. Among its failings is the continued dichotomy between the humanities and the sciences. In the age of AI, it has become even more vital to integrate them to avoid science and technology from becoming materialistic and anti-human while the humanities become merely literary and without any means to transform the world. (shrink)

This Article describes a jurisprudential puzzle—what I call the puzzle of the beneficiary’s bargain—and contends that adequately resolving this puzzle will require significant revisions to basic premises of contract law. The puzzle arises when one party enters into two contracts requiring the same performance, and the promisee of the second contract is the third-party beneficiary of the first. For example, a taxi driver contracts with a woman to transport her parents from the airport next week, and then the driver (...) separately enters a contract with the parents to transport them when the time comes. Is the second contract valid and enforceable, or does it fail for lack of consideration? This specific question—on which courts have split—implicates several important contract law doctrines. Moreover, it highlights a deep tension in our modern understanding of contractual obligation. This Article argues that adequately resolving the puzzle necessitates a general reconsideration of the relationship between rights and liability in contract law. Surprisingly, the best solution requires abandoning the foundational understanding that contract liability arises out of breach of a promisee’s right to performance. The puzzle thus offers a lens through which to examine—and even revise—the central concepts of modern contract law. (shrink)

Simple extrapolation is the orthodox approach to extrapolating from clinical trials in evidence-based medicine: extrapolate the relative effect size from the trial unless there is a compelling reason not to do so. I argue that this method relies on a myth and a fallacy. The myth of simple extrapolation is the idea that the relative risk is a ‘golden ratio’ that is usually transportable due to some special mathematical or theoretical property. The fallacy of simple extrapolation is an unjustified argument (...) from ignorance: we conclude that the relative effect size is transportable in the absence of evidence to the contrary. In short, simple extrapolation is a deeply problematic solution to the problem of extrapolation. (shrink)

The increasing global demand for energy necessitates devoted attention to the formulation and exploration of mechanisms of thermal heat exchangers to explore and save heat energy. Thus, innovative thermal transport fluids require to boost thermal conductivity and heat flow features to upsurge convection heat rate, and nanofluids have been effectively employed as standard heat transfer fluids. With such intention, herein, we formulated and developed the constitutive flow laws by utilizing the Rossland diffusion approximation and Stephen’s law along with the (...) MHD effect. The mathematical formulation is based on boundary layer theory pioneered by Prandtl. Governing nonlinear partial differential flow equations are changed to ODEs via the implementation of the similarity variables. A well-known computational algorithm BVPh2 has been utilized for the solution of the nonlinear system of ODEs. The consequence of innumerable physical parameters on flow field, thermal distribution, and solutal field, such as magnetic field, Lewis number, velocity parameter, Prandtl number, drag force, Nusselt number, and Sherwood number, is plotted via graphs. Finally, numerical consequences are compared with the homotopic solution as a limiting case, and an exceptional agreement is found. (shrink)

This paper uses distinctions between differing senses of “private,” “public” and “political” in the United States to argue for the value of framing food issues as a collective problem that calls for broadscale demands for justice. We argue that food choices do not simply belong to the realm of private preferences and market transactions. Rather, they are a set of decisions that have systemic causes and public consequences. They are shaped and constrained by public policies that underwrite the transportation of (...) food over long distances as well as particular crops and foodstuffs, and by the vendors and advertisers who try to convince us to eat more of the foods they produce. Because the consequences of eating an abundance of empty calories are not easily remedied at the personal level, citizens need to demand public, systemic solutions, including better food information, youth food education, and a healthier food supply. (shrink)

Since 2016, drones have been deployed in various development projects in sub-Saharan Africa, where trials, tests, and studies have been rolled out in countries, including Tanzania, Uganda, Rwanda, Malawi, Ghana, and the Democratic Republic of the Congo. The use cases of drones vary, ranging from imagery collection to transportation of vaccines, lab samples, blood products, and other medical supplies. A wide range of stakeholders is involved, including governments, international organizations, educational institutions, as well as industry. Based on a field study (...) conducted in 2019, this article investigates how drones are used for medical supply delivery in Malawi-a country where the community is underserved for healthcare and related infrastructure underdeveloped, while airspace is largely open and regulations generally relaxed. The objective of presenting this case study is to contribute to the evidence regarding the rapid deployment of medical cargo drones across the African continent, and to spark critical reflections over the utility, suitability, and impacts of incorporating drones in the existing health supply chain systems in resource-poor settings. The discussion revolves around two aspects: 1) the emergent “African Drone Rise”-is it ok “as it is Africa”? and 2) the normative role of technology in the aid sector-is it “a solution looking for a problem”? In conclusion, a call for more structured guidance for the systematic examination and evaluation of the medical cargo drone case is raised. (shrink)

A large number of engineering problems involve several conflicting objectives, which today are often solved through expensive simulation calculations. Methods based on meta-models are one of the approaches to solving this group of problems. In this paper, multiobjective optimization in the extraction system of a copper open-pit mine complex is presented by the modified-NBI optimization method and regression meta-model. For this purpose, two objective functions of maximizing the amount of total extraction, which is the sum of the extraction of sulfide, (...) oxide, low-grade ores, and waste in this mine, and minimizing the transport time of haulage according to the limitation of its storage capacity, transport equipment, and budget are considered. The Central Composite Design method is used to build the Design of Experiments for the design variables. The considered design variables are the number of trucks of 120 tons, 240 tons, 35 tons, and 100 tons. The number of targets considered in each design combination is considered the response surface. The suitable meta-model to maximize the total extraction rate and minimize the transport time of the haulage, two modified functions of nonlinear regression have been determined. The accuracy of the models for selection has been done using PRESS and R 2 statistics. The most common PRESS error has also been used to validate the meta-models. Then the multiobjective optimization problem was solved using the modified-NBI method. Finally, Pareto and optimal solutions using the proposed approach were presented and discussed. (shrink)

Let G V, E be a simple undirected complete graph with vertex and edge sets V and E, respectively. In this paper, we consider the degree-constrained k -minimum spanning tree problem which consists of finding a minimum cost subtree of G formed with at least k vertices of V where the degree of each vertex is less than or equal to an integer value d ≤ k − 2. In particular, in this paper, we consider degree values of d ∈ (...) 2,3. Notice that DC k MST generalizes both the classical degree-constrained and k -minimum spanning tree problems simultaneously. In particular, when d = 2, it reduces to a k -Hamiltonian path problem. Application domains where DC k MST can be adapted or directly utilized include backbone network structures in telecommunications, facility location, and transportation networks, to name a few. It is easy to see from the literature that the DC k MST problem has not been studied in depth so far. Thus, our main contributions in this paper can be highlighted as follows. We propose three mixed-integer linear programming models for the DC k MST problem and derive for each one an equivalent counterpart by using the handshaking lemma. Then, we further propose ant colony optimization and variable neighborhood search algorithms. Each proposed ACO and VNS method is also compared with another variant of it which is obtained while embedding a Q-learning strategy. We also propose a pure Q-learning algorithm that is competitive with the ACO ones. Finally, we conduct substantial numerical experiments using benchmark input graph instances from TSPLIB and randomly generated ones with uniform and Euclidean distance costs with up to 400 nodes. Our numerical results indicate that the proposed models and algorithms allow obtaining optimal and near-optimal solutions, respectively. Moreover, we report better solutions than CPLEX for the large-size instances. Ultimately, the empirical evidence shows that the proposed Q-learning strategies can bring considerable improvements. (shrink)

Introduction Paul Boshears The following excerpt from Paul Amitai's In Between States: Field notes and speculations on postwar landscapes (2012) confounds its reader. Presenting an alternate history of the State of Israel as a space station orbiting Earth, the excitement of possibilities crackles across the texts and images. Like Chris Marker's La Jeteé , the accompanying static images distort the viewer's temporality: are these archaeological items, images from a past, or a future? Why isn't this our future? In Between States (...) can also be seen as complementing Larissa Sansour's provocative science fiction works, Space Exodus (2009) which "documents" the Palestinian space program, and her Nation Estate (2012), in which Palestine is relocated into a skyscraper. Amitai's vision opens onto an intergalactic diaspora, wherein the refugees of World War II are given the stars as Western Europe continues to fight over terrestial colonies. —PFB Auditorium, Hoechst AG headquarters, Industriepark-Höchst, 2011. In 1941 an investigation by the US Justice Department exposed a marriage cartel between John D. Rockefeller’s Standard Oil (now ExxonMobil) and I.G. Farben. The two corporations had formed a joint operation in 1927 called Standard IG Farben. It was revealed that the two had shared patents in order to control prices and markets in their respective regions. Standard was accused of hiding patents from the US Navy and supplying fuel to German submarines, which lead to charges of criminal conspiracy. The Pentagon intervened, requesting that President Roosevelt stop the investigation in order to protect war production and oil supply. Roosevelt agreed, and the Senate committee investigating the matter, headed by Senator Harry Truman, was halted. Standard Oil paid a fine of $5000 and promised to stop supplying fuel to the enemies. Auditorium, Hoechst AG headquarters, Industriepark-Höchst, 2011. Furious at the decision to terminate the investigation of acts he considered treason, Truman initiated a new inquiry into Standard Oil’s war-time practices after succeeding Roosevelt as president in 1945. With the chief executives of I.G Farben simultaneously on trial at Nuremburg, Truman brokered a deal with the Allies that reduced or withdrew criminal charges leveled against both corporations in exchange for Standard Oil and I.G. Farben’s sponsorship of one of Truman’s most ambitious postwar projects—the relocation of the Jewish people. Detail, Sanofi-Aventis advertisement, 2011. The third critical player in this bold experiment was the nascent North Atlantic Space Agency. Formed by Allied forces using the seized assets and engineering expertise of Hitler’s hitherto classified space program (conquer Earth, then the stars), the North Atlantic Space Agency was a pre-NATO foray into interstellar nation building, with orbital occupation as the first point of order. By 1947, NASA was nearly ready to deploy the first manned space station. Standard Oil and I.G. Farben’s advanced fuel refinement capacities and deep, war-enriched financial resources allowed NASA to speed up their launch schedule significantly. Detail, Sanofi-Aventis advertisement, 2011. Diplomatic efforts to establish a Jewish homeland in Palestine were failing to gain traction, while post-colonial England held its ground on immigration restrictions and bands of Jews and Arabs battled over territory on the ground. More immediate was the issue of temporarily housing Holocaust survivors and refugees across scorched Europe. Leaders of the continental nations demonstrated, at best, reluctance to accommodate the Jews, who in turn were, at the least, resistant to returning to the same bloody cocktail from which they had fled. Truman used the impasse to advance a plan for NASA’s space station to be put to use as a temporary Jewish outpost, an orbital displaced persons camp, to be operated by the US Army. Detail, Infaserv Höchst advertisement, 2011. Final preparations advanced rapidly. Viewing the orbital displaced persons (ODP) camp as a solution to their immigration problem both at home and abroad, England came on board as a willing partner. Spaceship Exodus was positioned for takeoff on German farmland 20 kilometers southwest of Frankfurt. On December 30, 1947, one month after the UN General Assembly voted down the separation plan for Palestine, Exodus rocketed into the atmosphere hauling the first module of barracks designed to house 1,500 refugees. Transport vehicles arrived shortly thereafter, loaded down with leftover wartime military rations and 3,000 Jews of Russian and Polish origin. Detail, Infaserv Höchst advertisement, 2011. "The camp is the space that is opened when the state of exception begins to become the rule."—Giorgio Agamben, Homo Sacer , trans. Daniel Heller-Roazen, (Stanford: Stanford University Press, 1995), 96. Detail, Infaserv Höchst advertisement, 2011. The ODP camp proved to be a longer-term solution than originally envisioned. Additional installations were positioned to form swollen clusters of interlocking units – sleeping quarters, schools, clinics, canteens. The UN was brought in to monitor the camp following two chaotic years of US Army control in which food shortages, pandemic diseases, and rampant black market trade had brought the camp to near total collapse. No less bureaucratic or ineffectual, the UN relief agency at least had prior experience facilitating contexts of a similar magnitude and could potentially predict outcomes. Detail, Infaserv Höchst advertisement, 2011. What had been unexpected was the degree to which the camp would evolve into its own self-regulated, hive-like ecosystem where previously accepted rules of conduct were not applicable. The ODP camp was an exceptional space, a riverboat casino, an offshore research lab of social experimentation and entrepreneurial innovation. No longer Earth-bound, touching soil knotted by prescripts of Talmudic law, the camp residents were able to rationalize loopholes and detonate barriers standing in the way of absolute production. The Jewish archipelago was renamed Israel after the ancient homeland. If the temple couldn’t be rebuilt in the motherland, a post-national rhizome would sprout up in its stead. Eyes everywhere, beyond all borders. More information on the project at the author's site. (shrink)

Dear editorOrgans transplantation is the solution for many end stage insufficiencies, but organ shortage is still matter of debate. As a consequence, organ procurement (OP) remains currently the best way to provide organs in western countries. Besides, the news of the death of a loved one, especially when he is young and dies in violent circumstances, can be a devastating event for families. In those conditions, the process of donation request from the coordinators may be difficult and requires experience and (...) “tact”. Despite these precautions, refusals are not rare.An 18 year-old-patient was transported in shock after a car accident to our hospital. Emergent laparotomy was performed for mesenteric and hepatic trauma requiring liver packing. She also presented a cervical and cerebral trauma with a fast deterioration of the neurological status. A tentorial herniation was quickly suspected. The family had been contacted and the severity of the situation explained without mentioning brain. (shrink)

Many people today glorify wild nature. This attitude is diametrically opposed to the denigration of wild nature that was common in the seventeenth century. One of the most significant initiators of the modern revaluation of nature was Anthony Ashley Cooper, the third Earl of Shaftesbury. I elucidate here Shaftesbury’s pivotal view of nature. I show how that view emerged as Shaftesbury’s solution to a problem he took to be of the deepest philosophical and personal importance: the problem of how worship (...) of God can be both transportingly emotional and entirely rational. In section 1 I sketch the denigration of wild nature in two of Shaftesbury’s predecessors: Burnet and Locke. I next turn to Shaftesbury’s problem, describing in section 2 the love of God he aspired to and in section 3 his commitment to rational religion. I then explain Shaftesbury’s solution, describing in section 4 his view of beauty in general and in section 5 his view of the beauty of nature. (shrink)

I. Language is a witness of change in the field of the knowledge. In its system of signs, also the “traces” that show “the movement of the signs” are conserved, meaning those dynamic signs that indicate problems and solutions of problems, and sometimes even the invention of new problems, which modify the paradigms of knowledge. In the case of the creativity problem, if we take language as the witness, we see the following: 1. In the first half of the 20 (...) th century, the term used to denote the innovatory phenomena is that of creation. This notion refers, most often, to the artistic works, but is step by step extended also to denote the great scientific discoveries or technical inventions and, more seldom, other types of activities which bear the mark of novelty or originality, generally with an “out of the ordinary character” . The word has an obvious value content and exactly by its evaluative significance, it is disseminated in the current cultural vocabulary. It can have more general meanings, due to the fact that it keeps, in its semantic memory, the archaic layers of the myths of creation, but also because it can be resignified metaphysically, as a cosmogony principle or one of the evolution of life . But its established place in the philosophical discourse is found mostly in the area of the philosophy of culture or in that of the philosophy of value and especially in the philosophy of art. From here, it is overtaken by the art sciences, as the psychology of art, the history of art or the sociology of art. The term creation means both the works, the products of the creation process, and the processes through which these works are accomplished. In the analysis of the creation process, the significance of the term become more psychological, and the rationalization to which it is subjected to seems to furthen it both from its religious origin as well as from the Romantic mythology of the genius. However, if we regard more attentively, we see that terms as “inspiration”, “incubation” or “invention”, from the so called explanations of the creation process, preserve the magic obscurity of the enigma. Generally, the idea of creation, even totally transferred to the human sphere, secularized, rationalized and psychologized, still keeps something from the history of a notion charged with “mystery”, “heroic admiration” and a sort of “sacred terror”, which can be understood by considering the religious origin of the idea of creation; because about creation, in the human sphere, it has been commenced to be talked at first by analogy to the divine creation, in the discourse about art of the Renaissance, and the semantic evolution of the notion has not, for a long time, furthen itself from it spiritual root. Creation – even when it denotes the human products- still remains a metaphor- which transports to something difficult to comprehend, rather than facilitates the understanding of what it denotes. 2. After the middle of the 20 th century, a new term, creativity, makes its way in the discourse, replacing the word creation. It comes from the vocabulary of the humanistic sciences, firstly from psychology and afterward by the other sciences which adopted it. It becomes, in a short period, a frequent term of the cultural world and of public communication. The discourse in which this neologism appears has completely changed suppositions: a). Firstly, it is a discourse of scientific nature ; b). Secondly, its notions are descriptive: creativity denotes the capacity to produce innovative works in any domain and is seen as a generally human dimension ; the creative products are described following criteria such as novelty, originality, relevance, adequacy or utility, attributes that are intelligible but also rationally computable. c). Thirdly, the suppositions of the discourse on creativity contains the idea that the creative phenomena can be understood rationally, described, analyzed, explained and measured, and their knowledge can be applied in the so called techniques to stimulate creativity or transferred in the methods of learning and education. The notion of creativity indicates thus a discourse articulated on a type of representations which we could call positive, to mark this way the change in knowledge on which they are based. 3. In the last decades of the 20 th century, in the vocabulary of the sciences on creativity appears a new notion: creatology . According to the significance that results from the terms which compose this linguistic invention, creatology can denote, in a general sense, the study or the theory of creation or creativity, accomplished in a discipline or other from the sciences which assumed it as a research problem. Still, the discussions on creatology have requested more - the constituting of an autonomous discipline of creativity. These three notions – creation, creativity and creatology - have an obvious “family resemblance”, although, as we have seen, the semantic differences are significant. Through these notions we can reconstruct not only the history of a problem which appeared as important to the knowledge of the 20 th century, but perhaps even the history of some ideas which have accompanied the understanding of the cultural history or, wider, the history of the mentalities of the 20 th century. It is exactly why the emergence of creatology can be researched from the perspective of cultural analysis. (shrink)

In this paper, we will address anonymity, privacy and trust issues that arise during the research on a communication platform for multi-modal transport. Though most logistic information is currently available in electronic form, it is not widely accessible yet to all the parties concerned with transport. The major goal of a communication platform is to improve the conditions for exchanging information, which should lead to better organisation/collaboration within the transport sector. We need to merit credibility by faithfully (...) modelling all the relevant real world interactions. Therefore, we opted for a connectivity solution in which software agents act as representatives of the parties involved. All agents can be equipped with human-like skills and qualities such as intelligence, autonomy, and the ability to cooperate, coordinate and negotiate. We will demonstrate how cooperation between different transport parties can be achieved without necessarily putting all the sensitive information on the web. (shrink)

Advertising is one of the commonly visible elements of the urban landscape (real and virtual). It also does not require proof that advertisements of cities as such are also part of their “cityscape.” Since at least the nineteenth century, cities have advertised themselves as attractive places to live, visit, or do business. Therefore, the following research question can be asked: How do Polish cities present themselves in advertisements one can find in the landscape? The study assumes that each advertisement should (...) clearly identify the sender and indicate its specific characteristics, distinguishing itself from its competitors. Polish cities began to use logos and slogans as a mecha­nism of description and distinction after 1990, when socioeconomic changes started. There are quite a few studies on this activity, but most of them are single case studies. Therefore, the authors decided to examine a relatively large sample of Polish cities, which allows for statistical analysis. Analysis of the logo and slogan content allows the authors to examine the desired image or the projected identity of Polish cities. The methods were chosen because they admit qualitative and quantitative analysis, especially when there is a sufficiently large sample. Therefore, the survey covered all towns and cities with more than 20,000 inhabitants in Poland. There are 218 such towns in total. The analysis was carried out in the first half of 2021. In conclusion, the authors find that the advertising of Polish cities is embedded in the past, promotes resources (substance), sometimes geographical location, but rarely refers to famous characters and human potential. And such a picture of these cities one may find on outdoor advertisements, which sometimes produce dissonance when accompanying modern buildings or new transport solutions in the city. (shrink)

"My argument is as follows. In the first section, I sketch briefly the ways in which intentionalism might provide a solution to the problem of vagueness. The second section describes the different areas in which counterfactuals must be invoked by intentionalism. In the third section I point out that on a classic analysis of counterfactuals - that of David Lewis and Robert Stalnaker - the truth conditions of counterfactuals depend on relations of similarity among possible worlds. Since similarity is vague, (...) so are counterfactuals. Finally, I show that there is no unique solution to the problem of vagueness for the specific types of counterfactuals required by intentionalists - those referring to authors' or legislators' mental states, and those attempting to transport historical authors into the present. Although some counterfactuals are relatively 'insensitive' - in Lewis's sense -- those required in intentionalist interpretation are at least moderately sensitive. This means taht different contexts will resolve the vagueness in different ways. The choice among contexts must be made by the interpreter and is not determined by author's intentions. Hence the vagueness due to counterfactual reasoning about author's intention leads to indeterminacies that cannot be resolved by intentionalism itself. Intentionalism is a solution neither to the problem of vagueness nor to the problem of indeterminacy." Distinguishes between strict intentionalism and moderate intentionalism. Both are often seen as a means for reducing vagueness in legal language. However, counterfactual intentions are needed to resolve certain problems. First, in combining actual intentions, e.g. in a legislature, where different combinations may result in different legislation. Second, it is needed to resolve conflicts between intentions, particularly between different levels of abstraction. Third, reducing vagueness, which will be necessary even with enactment intentions. Fourth, there may be no determinate intention that would even, in principle, resolve a borderline case - e.g. when intentions are conflated. [For discussion of application and enactment intentions, see Goldsworthy, "Originalism in Constitutional Interpretation," Federal Law Review 25: 1.] Lastly, counterfactuals may be necessary to distinguish between application and enactment intentions. Lewis on counterfactuals: "For Lewis and Stalnaker, the key idea in the explication of truth conditions of counterfactuals is that of 'comparative overall similarity' of possible worlds. A counterfactual is true if and only if in the closest, most similar world to the actual in which the antecedent of the conditional is true, the consequent of the conditional is also true." Thus, there may be a determinate relevant world for some cases - i.e. there may be a counterfactual that determines the answer to a counterfactual question. This, however, will not always be the case. For example, counterfactuals concerning Caesar being the leader of N. Korea. Here, for Lewis, where there are ties of closeness of counterfactuals, all tied CFs will be false. When considering counterfactual intentions for the sake of interpretation, some may be determinate or insensitive. Normally, however, this will not be the case. "For intentionalism to resolve the matter of whether the regulation prohibiting vehicles prohibits toy cars as well, one of these counterfactuals must be true and the other false. Imagine a possible world in which the oncsideration of the borderline case is added to the authors' mental states. It is likely that connected belief will be affected as well. For example consideration of the aim of the regulation will occur as a consequence of the consideration of whether the regulation applies to the borderline case: Is ensuring peace and quiet in the park overriding, or are there exceptions to accommodate children's games? When there are changes in a constellation of men tal states, we will have to imagine a situation in whichh the legislators' beleifs are very different from what they in fact were. This creates at least a profound epistemological problem, because, as Dworkin puts it: "[it] has the effect of sharply reducing the amount of historical evidence that is relevant to answering the counterfactual." More important, however, in some worlds in which the legislators consider the case of a child's toy car, they will treat the peace and quiet purpose as overriding, whereas in others they will treat the children's play purpose as overriding. This means that different worlds will resolve the truth-value of the counterfactuals differently." "If I am right that counterfactual reasoning is ubiquitous in intentionalism, intentionalism suffers from an extra dimension of vagueness and is therefore at a disadvantage when measured against theories that do not rely on counterfactuals.". (shrink)

Synthetic biology is a field of research that concentrates on the design, construction, and modification of new biomolecular parts and metabolic pathways using engineering techniques and computational models. By employing knowledge of operational pathways from engineering and mathematics such as circuits, oscillators, and digital logic gates, it uses these to understand, model, rewire, and reprogram biological networks and modules. Standard biological parts with known functions are catalogued in a number of registries (e.g. Massachusetts Institute of Technology Registry of Standard Biological (...) Parts). Biological parts can then be selected from the catalogue and assembled in a variety of combinations to construct a system or pathway in a microbe. Through the innovative re-engineering of biological circuits and the optimization of certain metabolic pathways, biological modules can be designed to reprogram organisms to produce products or behaviors. Synthetic biology is what is known as a “platform technology”. That is, it generates highly transferrable theoretical models, engineering principles, and know-how that can be applied to create potential products in a wide variety of industries. Proponents suggest that applications of synthetic biology may be able to provide scientific and engineered solutions to a multitude of worldwide problems from health to energy. Synthetic biology research has already been successful in constructing microbial products which promise to offer cheaper pharmaceuticals such as the antimalarial synthetic drug artemisinin, engineered microbes capable of cleaning up oil spills, and the engineering of biosensors that can detect the presence of high concentrations of arsenic in drinking water. One of the potential benefits of synthetic biology research is in its application to biofuel production. It is this application which is the focus of this entry. The term “biofuel” has referred generally to all liquid fuels that are sourced from plant or plant byproducts and are used for energy necessary for transportation vehicles (Thompson 2012). Biofuels that are produced using synthetic biological techniques re-engineer microbes into biofuel factories are a subset of these. (shrink)

Ion channels mediate ion flux across biological membranes and regulate important organellar and cellular tasks. A recent study revealed the presence of four new proteins, the MIM complex (composed by Mim1 and Mim2), Ayr1, OMC7, and OMC8, that are able to form ion‐conducting channels in the outer mitochondria membrane (OMM). These findings strongly indicate that the OMM is endowed with many solute‐specific channels, in addition to porins and known channels mediating protein import into mitochondria. These solute‐specific channels provide (...) essential pathways for the controlled transport of ions and metabolites and may thus add a further layer of specificity to the regulation of mitochondrial function at the organelle‐cytosol and/or inter‐organellar interface. Future studies will be required to fully understand the way(s) of regulation of these new channels and to integrate them into signaling pathways within the cells. (shrink)

Substantial urban growth fueled by a strong economy often results in heavy traffic thus making streets less hospitable. Traffic calming is one response to the pervasiveness of the automobile. The issues concern built environments and involve multiple actors reflecting different interests. The issues are rarely technical and involve combinations of behavior, social structure, and differential resources. Traffic calming takes many forms by attempting to serve many purposes. It is complex and confusing and is used by different people with different agendas. (...) Traffic calming is not about applying techniques. It is a mindset. We must change both our perceptions and our behaviors. Instead of focusing on end-of-pipe solutions and on things, we must shift attention to the processes that generate things. Trying to accommodate more and more traffic is not the answer. Transportation is a means, not an end. What we are looking at is more people calming than traffic calming. (shrink)

Both entertaining and startling, The Pig That Wants to Be Eaten offers one hundred philosophical puzzles that stimulate thought on a host of moral, social, and personal dilemmas. Taking examples from sources as diverse as Plato and Steven Spielberg, author Julian Baggini presents abstract philosophical issues in concrete terms, suggesting possible solutions while encouraging readers to draw their own conclusions: Lively, clever, and thought-provoking, The Pig That Wants to Be Eaten is a portable feast for the mind that is sure (...) to satisfy any intellectual appetite. BACKCOVER: “Thinking again is what this taut, incisive, bullet-hard book is dedicated to promoting.” —The Sunday Times (London) “This book is like the Sudoku of moral philosophy: apply your mind to any of its ‘thought experiments’ while stuck on the Tube, and quickly be transported out of rush-hour hell.” —New Statesman. (shrink)

Acts of sexual violence in transit environments are everyday occurrences for women across the globe, and the fear of being on the receiving end of sexual violence severely impacts women’s mobility patterns. Gill Valentine, in her examination of women’s fear of male violence and women’s perception and use of public space, has argued that the impact on women’s mobility amounts to a spatial expression of patriarchy. The aim of this paper is to expand upon Valentine’s notion of “the spatial expression (...) of patriarchy” by engaging feminist philosophy within the context of sexual violence against women on public transportation. More specifically, I will argue for two particular interpretations of the spatial expression of patriarchy, one structural and one relational. It follows from my view that solutions to overcoming and ending sexual violence against women on public transportation hinge on both a structural and a relational understanding of the spatial expression of patriarchy. (shrink)

1. The Problem. In spite of the vast discussion which has been devoted to the theory of probability, the problem of the short run has received surprisingly little attention. Yet, the whole significance of the theory depends upon a solution of this problem, for without an answer to it we cannot say why it is useful to have knowledge of probabilities or why we should take account of this knowledge in making practical decisions. As far as I know, Charles Peirce (...) was the first to appreciate the importance and difficulty of the question, and his characteristically vivid formulation serves as an excellent starting point for its consideration. He says:According to what has been said, the idea of probability essentially belongs to a kind of inference which is repeated indefinitely. An individual inference must be either true or false and can show no effect of probability; and therefore, in reference to a single case considered in itself, probability can have no meaning. Yet if a man had to choose between drawing a card from a pack containing twenty-five red cards and a black one, or from a pack containing twenty-five black cards and a red one, and that of a red one were destined to transport him to eternal felicity, and that of a black one to consign him to everlasting woe, it would be folly to deny that he ought to prefer the pack containing the larger proportion of red cards, although from the nature of the risk, it cannot be repeated. [Collected Papers, 2.652]. (shrink)

This article concerns the implementation of new EU Directives coordinating the procedures for awarding public contracts in European Union Member States. In a number of countries, including Poland, the process of their implementation (Directive 2014/24/eu of the European Parliament and of the Council of 26 February 2014 on public procurement; Directive 2014/25/eu of the European Parliament and of the Council of 26 February 2014 on procurement by entities operating in the water, energy, transport, and postal services sectors; Directive 2014/23/eu (...) of the European Parliament and of the Council of 26 February 2014 on the award of concession contracts) was delayed. In most cases, the modernization of EU regulations on public procurement required a thorough modification of national regulations in this respect. As a result of the introduction of the package of new Directives, the European Union public procurement market has undergone substantial changes. The need to adjust legal regulations to the changing political, social, and economic situations in a better way has resulted in the transposition of the modernized EU Directives concerning public procurement to the Polish legal system, affecting the final shape of the new Polish Public Procurement Law. The implementation of the package of new Directives has significantly affected the functioning of the Polish public procurement market. For the entities operating in this market, this means the necessity to expand their knowledge, so as to become familiar with the new legal solutions in this respect. (shrink)

ABSTRACT The approaches currently dominating sustainable urban planning are based on a paradigm which assumes that economic growth can be decoupled from economic degradation through smarter technological solutions and institutional reform within existing social structures. However, decoupling can only be partial. Environmental sustainability, therefore, requires that, sooner or later, growth in consumption and production must cease. Policies for combining environmental and social sustainability would be sharply at odds with key mechanisms inherent in the capitalist economy. Urban sustainability thus requires profound (...) changes. On the ontological plane, planning theory must move away from anti-realist constructivism and hermeneuticism, towards realism. On the empirical plane, it is necessary to move away from disciplinary tunnel vision towards a critical realist version of interdisciplinarity, within key research fields such as housing research and transportation research. On the political plane, urban sustainability must move from growth to degrowth, from inequality to equality, and from capitalism to eco-socialism. (shrink)

Nanotechnology (henceforth NT) is a rapidly advancing field with the potential of revolutionizing diverse areas such as electronics, healthcare, transport and energy production. NT products and applications come with (potential) benefits and (potential) harms. The presence of potential harms calls for regulation. Both under- and overregulation – I argue – are morally undesirable. In the case of underregulation, stakeholders fall victim to the harmful effects of the technology. In the case of overregulation, stakeholders are deprived of the benefits of (...) the technology. In this chapter, I identify the biases and factors that lead to under- and overregulation and offer solutions in response. More precisely, I argue that a lack of specific regulation, the presence of conflicts of interest and short-term economic incentives could lead to the underregulation of NT products and applications. Conversely, I argue that a negativity bias, harm aversion, the fear of opening ‘Pandora’s box’ and the intuition that what is natural is good and what is artificial (human-made) is bad could lead to overregulation. To avoid these pitfalls and the woes of under- and overregulation following in their wake, we need to set up a process – which I describe – in which policymakers and independent scientists closely collaborate. (shrink)