Health technology assessment (HTA) is often biased in the sense that it neglects relevant perspectives on the technology in question. To incorporate different perspectives in HTA, we should pursue agreement about what are relevant, plausible, and feasible research questions; interactive technology assessment (iTA) might be suitable for this goal. In this way a kind of procedural ethics is established. Currently, ethics too often is focussed on the application of general principles, which leaves a lot of confusion as to what really (...) is the matter in specific cases; in an iTA clashes of values should not be approached by use of such ethics. Instead, casuistry, as a tool used within the framework of iTA, should help to articulate and clarify what is the matter, as to make room for explication and consensus building. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Health technology assessment (HTA) is often biased in the sense that it neglects relevant perspectives on the technology in question. To incorporate different perspectives in HTA, we should pursue agreement about what are relevant, plausible, and feasible research questions; interactive technology assessment (iTA) might be suitable for this goal. In this way a kind of procedural ethics is established. Currently, ethics too often is focussed on the application of general principles, which leaves a lot of confusion as to what really (...) is the matter in specific cases; in an iTA clashes of values should not be approached by use of such ethics. Instead, casuistry, as a tool used within the framework of iTA, should help to articulate and clarify what is the matter, as to make room for explication and consensus building. (shrink)

From 1991 to 1994 the Dutch Health Insurance Council financed research on Extracorporeal Membrane Oxygenation (ECMO). This is a technique for providing cardiopulmonary bypass to patients with pulmonary and/or cardiac failure. Most often, these patients are premature neonates. During ECMO, blood is drained from the right atrium, pumped along a membrane where gas exchange takes place, and then redirected to the aorta. To prevent blood clotting, heparin is added. However, with the heparin added, the risk of hemorrhage is considerably increased. (...) Therefore, both the chance of surviving and the chance of severe disability are higher with ECMO than with conventional treatment (i.e., ventilator support). (shrink)

The article compares the attitude of the Irish Fianna Fait, the Flemish Volksunie, and the coalition of the Rassemblement Wallon and the Francophone Brussels' PDF, towards Europe and their programmes for the European elections.These parties do not define themselves on a socio-economic or religious basis, as most of the other European political parties do, but give ideological priority to the ethnic or national factor. Does this imply a common and distinctive attitude to European integration?The answer must be no; they disagree (...) not only on sectoral policies, but their fundamental outlook is different. FDF-RW and VU, on the one hand, though bitter opponents on the national level, both favour a federal Europe, in order to promote autonomy for their respective regions.Fianna Fait on the other hand, white recognizing the political and economic importance of Europe, is sceptical on the institutional level. Fianna Faits approach is essentially pragmatic, being a government party identifying its interests with the national interest, whereas the Belgian federalists cannot identify themselves with the existing Belgian state. Therefore it is unlikely at present that Fianna Fait wilt leave its European allies - the Gaullists - to join a hypothetic regionalist grouping in European Parliament. (shrink)

DI.1 On everything that lives, if one looks searchingly, is limned the shadow line of an idea – an idea, dead or living, sometimes stronger when dead, with rigid, unswerving lines that mark the living embodiment with the stern immobile cast of the non living. Daily we move among these unyielding shadows, less pierceable, more enduring than granite, with the blackness of ages in them, dominating living, changing bodies, with dead, unchanging souls. And we meet, also, living souls dominating dying (...) bodies – living ideas regnant over decay and death. Do not imagine that I speak of human life alone. The stamp of persistent or of shifting Will is visible in the grass blade rooted in its clod of earth, as in the gossamer web of being that floats and swims far over our heads in the free world of air. DI.2 Regnant ideas, everywhere! Did you ever see a dead vine bloom? I have seen it. Last summer I trained some morning glory vines up over a second story balcony; and every day they blew and curled in the wind, their white, purple dashed faces winking at the sun, radiant with climbing life. Higher every day the green heads crept, carrying their train of spreading fans waving before the sun seeking blossoms. Then all at once some mischance happened, some cutworm or some mischievous child tore one vine off below, the finest and most ambitious one, of course. In a few hours the leaves hung limp, the sappy stem wilted and began to wither; in a day it was dead, – all but the top which still clung longingly to its support, with bright head lifted. I mourned a little for the buds that could never open now, and tied that proud vine whose work in the world was lost. But the next night there was a storm, a heavy, driving storm, with beating rain and blinding lightning. I rose to watch the flashes, and lo! the wonder of the world! In the blackness of the mid NIGHT, in the fury of wind and rain, the dead vine had flowered. Five white, moon faced blossoms blew gaily round the skeleton vine, shining back triumphant at the red lightning. (shrink)

Benadering van enkele klassieke filosofische kwesties vanuit een door de Angelsaksische taalfilosofie geïnspireerde visie op de zingevende rede.

G. Deledalle is the author of a Histoire de la philosophie américaine, and of some excellent studies on Dewey, such as La pédagogie de Dewey, philosophie de la continuité, and "Durkheim et Dewey". These are all works that deserve full attention by students of the Golden Age of American philosophy. For a European, Deledalle has an unusual capacity to detect the vitality and freshness, but also the depth, of the growth of higher education in the U.S. in the first half (...) of this century. At the heart of this growth were philosophical ideas, and in particular those of Dewey. Philosophy did not have then dictatorial or competitive designs regarding education, the social and political sciences, psychology, or the natural sciences. It freely mingled with them, not just imparting methodological or epistemological rigor but also contributing some insights and giving the hypotheses and conclusions in these fields the character of "experiences." Experience is the guiding theme of this rich and complicated work, covering a multitude of subjects and positions. The treatment is divided into six parts dealing respectively with Dewey's leanings toward unitary experience, organic experience, dynamic experience, functional experience, instrumental experience, and transactional experience. In the study of the intellectual of Dewey's life practically all of his production is critically examined by Deledalle: a monumental task in itself, made possible by the critical bibliography of Milton Hasley Thomas. There is enough early biographical detail to make this work an effective and affectionate intellectual portrait. The best pages of this work are devoted to a thorough explication and comparative study of Dewey's final synthesis of experience. There are very helpful comparative references to Marx, Freud, Bergson, and Heidegger, and also indispensable parallels and contrasts with Peirce, James, and Whitehead. This is not a modest contribution from a regional point of view: Deledalle is, perhaps more than anybody else, aware of an ongoing international dialogue on Dewey, a dialogue that is preserving experience as a problem-complex at the front line of contemporary reflection.--A. de L. M. (shrink)

Conceived as a set of preliminary explorations to a future study of the problem of meaning and reference by the author, these "inquiries" clarify some questions raised by the specialists in linguistics, caution us about other questions that seem only too easily settled, and generally show, with great abundance of detail, the status of contemporary research on language. Much like Husserl's Logical Investigations, which pioneered the study of correspondences between grammar and logic-ontology, these explorations proceed in a zigzag sometimes emphasizing (...) semiotic issues ; other times tackling important syntactic and semantic problems ; and once coming close to an ontological characterization of language and of the human subject insofar as it uses language. Two features of this work are noteworthy. The first is the abundance of documentation as shown in the multitude of notes: the efforts of Ferrater Mora will spare many hours of work for those who need a guide in "the labyrinth of language." A second feature is the virtuoso performance by the author in the manipulation of, and exemplifications from, a variety of languages. Indagaciones sobre el Lenguaje certainly deserves publication in English.--A. de L. M. (shrink)

The structure of Chiodi's book is based on Vuillemin's important hermeneutical thesis that existentialism is one more step in the program of the romantics to give an absolute foundation to finite reality through the establishment of necessary relations between subjectivity and being. These relations, once revealed, would dispel the facticity and contingency in which the natural world is enshrouded. The role of Heidegger in this tradition involves one further dialectical twist, since Heidegger centers all Western Philosophy, including his own, around (...) the problem of ground in the manner proposed by the romantics. The suggested dialectical twist is then Heidegger's Kehre, a step beyond the radical contingency of Dasein in Sein und Zeit. Indeed, this contingency, once reached, shows unequivocally the failure of the romantic program. The ground cannot be ontologically connected with any object nor with the subject; it is rather the necessary history of the ground that determines all categorial differentiations in the world, including the reflective differentiation of subject-objects. Thus it becomes important to distinguish Heidegger from Hegel since, in both, history and necessity are characteristics of the ground. Chiodi gets to the bottom of this matter by pointing to the transfer of negativity from the process of history to the end of history. For Heidegger what is necessary is the repeated withdrawal of the ground so that it may never be confused with that which is known in any revelation or through all of them. This move, though clear, would still leave a fundamental ambiguity in the later philosophy of Heidegger: language, which acts as messenger from the ground to the world, must reflect the superabundance of Being from the standpoint of the ground while it only reflects possibilities of being from the standpoint of the world. This is an ambiguity that Heidegger would want to maintain. Chiodi's interpretation of Heidegger as a neo-platonist totally destroys this ambiguity and with it the very delicate balance created by Heidegger between infinite meaning and the ability of finite words to dwell upon it.--A. de L. M. (shrink)

Intended as an introduction of the phenomenological writings of Pfänder to English-speaking readers, this work contains two major essays and two minor selections by Pfänder, plus an introduction and two appendixes by Spiegelberg. Because of its composition, this book should be classified as a Pfänder's anthology centered around a main essay titled "Motives and Motivation." As reasons for the translation and publishing of this main essay, Spiegelberg mentions first its influence on Ricoeur's phenomenology of the will, and secondly its topical (...) affinity with R. S. Peter's The Concept of Motivation, a work considered by Spiegelberg as capable of restoring the importance of the will in Anglo-American philosophy. The other major essay is, curiously enough, the introduction to a text-book in logic written by Pfänder in response to Husserl's own request. The two essays, though different, are not unrelated; they represent the theoretical and practical sides of the unique phenomenological method of constitution. The presence of these two essays, side by side, in this volume raises in fact the question of Pfänder's own understanding of the theoretical unity of thought and action that is the key to phenomenological subjectivity. A clarification of Pfänder's thought on this unity would certainly help us evaluate his contribution to phenomenology. Spiegelberg himself depicts Pfänder as a reasonable phenomenologist, accurate in analysis and moderate in speculative claims, a sober figure indeed in an environment sometimes seen as prone to intellectual excesses.--A. de L. M. (shrink)

El hombre crea su moral tomando en cuenta las aportaciones más íntimas de su espíritu. Así como la historia de la humanidad presenta una serie gradual y emocional de conquistas espirituales, así también la moral se ha logrado a través de la historia, pero siempre sobre el fundamento de la esencia humana, pues no cabe duda de que la jerarquía de los valores depende de cada ser humano. Ella orienta toda su conducta y señala sus grandes metas. El espíritu religioso (...) coloca, en primer término, a los valores de la religión, el moralista a los éticos, el pragmático a los útiles; el estético a las bellas artes, dando preferencia cada una a su valor favorito. (shrink)

Echte Freiheit läßt sich nach Leibniz nicht auf die Möglichkeit reduzieren, so zu handeln, wie man handeln will. Vielmehr muß echte Freiheit mit dem moralischen Verdienst in Verbindung gebracht werden. In diesem Zusammenhang erweist sich die Idee der logischen Kontingenz von besonderer Wichtigkeit. Eine Person hat kein moralisches Verdienst, wenn sie blindlings durch das Gute geleitet wird. Sie hat allein dann ein moralisches Verdienst, wenn sie das Schlechte zurückweist und bewußt das Gute wählt, das sich vom Schlechten abhebt. Insofern ist (...) derjenige, der moralisch richtig handelt, sich anderer Möglichkeiten bewußt. Leibniz trägt dieser Erfahrungstatsache durch den Gedanken Rechnung, daß eine freie Handlung logisch kontingent ist. Diesem Gedanken verleiht Leibniz einen metaphysischen Status: die möglichen Welten haben einen objektiven Gehalt. (shrink)

En el socialismo de la transición, De los Ríos fue una figura a recuperar. Su sentido humanista del socialismo permitió al PSOE fundar en su propia historia republicana el nuevo compromiso del socialismo con la libertad. En el socialismo de los derechos civiles también tiene un lugar. De los Ríos apadrinó a Federico García Lorca, desde Granada a Nueva York y con La Barraca. El amor y el exilio acabó uniendo sus familias. También nombra a la primera mujer alto cargo (...) gubernamental: Victoria Kent, directora de prisiones.Se conoce menos otra dimensión de su trayectoria política de la que se ocupa este libro: su laicismo religioso. Dos rasgos que en la España de duelos a garrotazos parecen antagónicos. Sin embargo, ambos son característicos de su personalidad política e intelectual. Fue el ministro que lideró la política laicizadora de la II República, desde Justicia, primero, e Instrucción pública, después, llevando "siempre la batuta"?como informaba Tedeschini, el nuncio de la época -. Por otra parte, desde un cristianismo heterodoxo, no dejó de estimar la emoción religiosa, como lugar donde "fecundan los más hondos deseos del ideal". Se autodefinió "cristiano erasmista". Así le caracterizan Indalecio Prieto, en el obituario tras su muerte en el exilio, y el propio García Lorca, su poeta. (shrink)

This paper criticizes social revolution, by focusing on the reconfiguration of the notion from an ethical point of view. It is divided in three sections: Brother’s death; Remove the sandals; Thou wilt be as many as the stars. Each section contains Levinas’s thought as the main axis. Although it is well known that Levinas does not develop a theory of revolution, it is possible to find a fruitful analysis in light of his meditations about politics and ethics.

Levinas' view on ethical commitment seems at first sight incompatible with the cultivation of particularistic ideals. The Other from whom the moral imperative originates, is also a Stranger: in submitting ourselves to his appeal, we obey a law radically transcending our autonomy. Therefore, our responsibility for the Other is not a loyalty based on personal sympathies, preferences or common interests. From Levinas' stern universalistic perspective, particularistic loyalty might appear as a form of moral self-indulgence. In this article we draw attention (...) to two forms of particularistic attachment which can paradoxically be seen as a confrontation with a radical moral heteronomy. The moral obligation imposed on us by nearness in space and relations of close kinship are in a sense arbitrary and contingent. Just because they are beyond rational justification, they also transcend the autonomy of our rational will. In this sense it seems to be true that some forms of particularistic commitment can make us aware of the radical heteronomy as it is meant by Levinas. (shrink)

En este libro se estudia la disciplina filosófica que trata de los pensamientos. Se divide en diferentes etapas empezando con la Lógica de la Edad Antigua con Aristóteles, el fundador de la Lógica, Platón, Euclides y otros mas. La Edad Media con Porfirio y Santo Thomas de Aquino, La Edad Moderna con René Descartes y su nueva ciencia de la Geometria Analítica y la Edad Contemporanea con Auguste Comte, fundador de la doctrina del positivismo.

Pero queda, a través de este devenir, la luz mosaica, las Tablas de la Ley, las sentencias del Talmud, las profecías de la Biblia. Este es el Tesoro del pueblo Judaico, el único que se ha conservado a través de los siglos; el que todavía suena en los momentos de la mayor angustia para la Humanidad y que vése conmovido por el impetuoso torrente de la vida contemporánea que exige nueva vitalidad en todos los aspectos de la existencia humana. DR. (...) ADALBERTO GARCÍA DE MENDOZA. (shrink)

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

Physical superpositions exist both in classical and in quantum physics. However, what is exactly meant by ‘superposition’ in each case is extremely different. In this paper we discuss some of the multiple interpretations which exist in the literature regarding superpositions in quantum mechanics. We argue that all these interpretations have something in common: they all attempt to avoid ‘contradiction’. We argue in this paper, in favor of the importance of developing a new interpretation of superpositions which takes into account contradiction, (...) as a key element of the formal structure of the theory, “right from the start”. In order to show the feasibility of our interpretational project we present an outline of a paraconsistent approach to quantum superpositions which attempts to account for the contradictory properties present in general within quantum superpositions. This approach must not be understood as a closed formal and conceptual scheme but rather as a first step towards a different type of understanding regarding quantum superpositions. (shrink)