Animal, protist and viral messenger RNAs (mRNAs) are most prominently modified at the beginning by methylation of cap‐adjacent nucleotides at the 2′‐O‐position of the ribose (cOMe) by dedicated cap methyltransferases (CMTrs). If the first nucleotide of an mRNA is an adenosine, PCIF1 can methylate at the N6‐position (m6A), while internally the Mettl3/14 writer complex can methylate. These modifications are introduced co‐transcriptionally to affect many aspects of gene expression including localisation to synapses and local translation. Of particular interest, transcription start sites (...) of many genes are heterogeneous leading to sequence diversity at the beginning of mRNAs, which together with cOMe and m6Am could constitute an extensive novel layer of gene expression control. Given the role of cOMe and m6A in local gene expression at synapses and higher brain functions including learning and memory, such code could be implemented at the transcriptional level for lasting memories through local gene expression at synapses. (shrink)

GPs usually care for their patients for an extended period of time, therefore, requests to not only discontinue a patient’s treatment but to assist a patient in a suicide are likely to create intensely stressful situations for physicians. However, in order to ensure the best patient care possible, the competent communication about the option of physician assisted suicide as well as the assessment of the origin and sincerity of the request are very important. This is especially true, since patients’ requests (...) for PAS can also be an indicator for unmet needs or concerns. Twenty-three qualitative semi-structured interviews were conducted to in-depth explore this multifaceted, complex topic while enabling GPs to express possible difficulties when being asked for assistance. The analysis of the gathered data shows three main themes why GPs may find it difficult to professionally communicate about PAS: concerns for their own psychological well-being, conflicting personal values or their understanding of their professional role. In the discussion part of this paper we re-assess these different themes in order to ethically discuss and analyse how potential barriers to professional communication concerning PAS could be overcome. (shrink)

Ein textnaher, fortlaufender Kommentar zu Kants Lehre von organisierten Wesen in der „Kritik der Urteilskraft“ ist ein Desiderat sowohl der Kantforschung als auch der Philosophie und Geschichte der Lebenswissenschaften. Auch gibt es bisher nur wenige Lesarten, die Kants Philosophie der Biologie im Ganzen erschließen und versuchen, sie in die vielschichtigen historischen Kontexte der frühneuzeitlichen Naturforschung einzuordnen. Das vorliegende Buch schließt diese Lücken. Es verteidigt die Thesen, dass Kant organisierte Wesen durch drei Arten von Kräften und Gesetzen charakterisiert – durch mechanische, (...) physisch teleologische und moralteleologische Krätfe und Gesetze – deren Vereinbarkeit im Bewusstsein des Menschen, und in der Erfahrungswelt, so, wie sie dem Menschen erscheint, auf der regulativen Idee ihrer Einheit im schöpferischen, theoretisch praktischen Bewusstsein Gottes beruht. Kants Lehre von organisierten Wesen kann als Verbindung einer gemäßigten, weder animalkulistisch noch ovistisch vereinseitigten, Präformationslehre mit einer vitalistischen Spielart der Epigenesislehre verstanden werden. – Weiterführende und provokative Einsichten für eine der bewegtesten Debatten der gegenwärtigen Kantforschung. (shrink)

Verse treatises on Advaita Jaina, and Nyaya philosophy.

In this paper, I investigate the relation of Kant's theory of biology to epigenetic accounts of organic generation and development. In the literature, a dispute about similarities between Blumenbach's epigenetic account and Kant dominated the debate for many years (see Lenoir 1980, 1981, and 1982, 17–34, Richards 2000; 2002, 207–37; Look 2006, and van den Berg 2009). Some more recent interpreters claim that Wolff's, more than Blumenbach's account plays the pivotal role in the development of a vitalistic conception of epigenesis (...) in Kant (see Dupont 2007 and Huneman 2007). Although I myself hold the view that Kant's position contains preformistic and epigenetic characteristics, in the current paper I focus solely on an investigation of epigenetic elements in Kant's account and compare them to the corresponding epigenetic elements in Wolff's theory. Section I of the paper is devoted to an analysis of Wolff's most important epigenetic theorems: the notion of the essential power (vis essentialis) and the conception of the part-whole composition of organized matter. Although Wolff describes the essential power vitalisticly, as a principle of life, he understands it as the cause of mechanical motions explaining the generation, nourishment, and the growth of an organism. Wolff's model of the part-whole composition of organic matter is subtle, but committed to fundamental mechanistic assumptions, such as that the organism as a whole is composed of inorganic parts. In section II, I analyze the corresponding elements in Kant's theory: the notion of the formative power and the conception of the whole-part composition of organized materials. Kant describes the formative power as a principle that causes the purposive form of an organized being such that matter and mechanism are the means to the purpose of the being as their end. The purpose of the whole is a functional unit which is in principle superior to the form and matter of the subordinate parts. The parts are combined into such a whole in being mutually cause and effect of each other and in being related to the superior whole. In section III, I respond to the debate in the literature. Against Dupont (2007) and Huneman (2007) I argue that, according to Wolff, the vis essentialis accounts for mechanic effects in matter, whereas, according to Kant, the formative power explains the intentional order (form, end, purpose) of an individual organized being, its parts, and its species. Since this view is closer to Blumenbach than to Wolff, the ongoing comparison between Kant and Blumenbach in the literature is justified. However, the emphasis on the specific part-whole composition that Kant considers to be the determining feature of an organized being can be found only in Wolff and not in Blumenbach—though Wolff and Kant describe it in opposing ways. This increases the systematic importance of Wolff for Kant. Thus, a fresh look on the historical debate is required. (shrink)

Absolute and relative outcome measures measure a treatment’s effect size, purporting to inform treatment choices. I argue that absolute measures are at least as good as, if not better than, relative ones for informing rational decisions across choice scenarios. Specifically, this dominance of absolute measures holds for choices between a treatment and a control group treatment from a trial and for ones between treatments tested in different trials. This distinction has hitherto been neglected, just like the role of absolute and (...) baseline risks in rational decision-making that my analysis reveals. Recognizing both aspects advances the discussion on reporting outcome measures. (shrink)

This chapter examines Kant's account of the nature of nonhuman and human animals in the "Critique of the Power of Judgement". It discusses how Kant thought that a complete account of the forms of explanation commit one to belief in God. It concludes, firstly, that Kant's account implies an unhealthy anthropocentrism and an Enlightenment prejudice in the form of the overestimation of reason, and secondly, that the Kantian model of God lacks one of the main characteristics of the Christian conception (...) of God: the universal divine love, a power that unifies and embraces all beings, including nonhuman and human animals and their orders. (shrink)

Food security is becoming an increasingly relevant topic in the Global North, especially in urban areas. Because such areas do not always have good access to nutritionally adequate food, the question of how to supply them is an urgent priority in order to maintain a healthy population. Urban and peri-urban agriculture, as sources of local fresh food, could play an important role. Whereas some scholars do not differentiate between peri-urban and urban agriculture, seeing them as a single entity, our hypothesis (...) is that they are distinct, and that this has important consequences for food security and other issues. This has knock-on effects for food system planning and has not yet been appropriately analysed. The objectives of this study are to provide a systematic understanding of urban and peri-urban agriculture in the Global North, showing their similarities and differences, and to analyse their impact on urban food security. To this end, an extensive literature review was conducted, resulting in the identification and comparison of their spatial, ecological and socio-economic characteristics. The findings are discussed in terms of their impact on food security in relation to the four levels of the food system: food production, processing, distribution and consumption. The results show that urban and peri-urban agriculture in the Global North indeed differ in most of their characteristics and consequently also in their ability to meet the food needs of urban inhabitants. While urban agriculture still meets food needs mainly at the household level, peri-urban agriculture can provide larger quantities and has broader distribution pathways, giving it a separate status in terms of food security. Nevertheless, both possess (unused) potential, making them valuable for urban food planning, and both face similar threats regarding urbanisation pressures, necessitating adequate planning measures. (shrink)

Background:More and more adults in their fifties and sixties are confronted with the need to support their ageing parents. Although many aspects of filial caregiving have been researched, a well-documented and comprehensive overview of the caregiving experience is lacking.Aim:This study aims for a better understanding of the caregiving experience of adult children by generating an overview of main themes in international research.Method:A literature review of qualitative studies, focusing on the experiences of adult children caring for their ageing parents, was performed. (...) The electronic EBSCO databases Academic Search Premier, CINAHL and PsycINFO, and Google Scholar were searched to identify relevant qualitative studies published between 2000 and 2017. The ‘SPIDER’ eligibility criteria directed the approach. The quality of studies included was screened with the assessment sheet designed by Hawker and colleagues. The experiences reported were analysed and themes were synthesized.Ethical consideration:Ethical requirements were respected in every phase of the research process.Findings:Nineteen qualitative studies met the inclusion criteria. The quality of the relationship with the parent appears to be an important determinant of the children’s caregiving experience. Within this context, three themes were found: caregiving as an emotional rollercoaster, a normatively demanding experience and an opportunity for personal development.Discussion:Children caring for their ageing parents have to deal with a wide range of contradicting and conflicting norms and values. Implications for healthcare professionals and future research have been discussed.Conclusion:Caring for ageing parents is a continuous quest for giving the best possible care and living up to one’s personal values, within the context of the parent’s declining health. Professionals who support filial caregivers should address not only practical responsibilities but also the normative questions and moral considerations caregivers are dealing with. (shrink)

Depois de participar da revista Clima como ficcionista, dona Gilda de Mello e Souza dedicou-se ao ensaísmo, tratando, entre outros objetos, do teatro moderno no Brasil. Por sua independência intelectual, seus ensaios apresentam lições ainda hoje válidas para nós.

Over the last few years, the idea that we live in a globalized world has significantly gained ground. Across various disciplines, this had led to severe critiques not only of methodological nationalism, but also of methodological Eurocentrism. But what does it mean to leave Eurocentrism behind? What kind of theorizing can and should we engage in when we attempt to provincialize, decenter, or even decolonize our thinking? This article distinguishes, presents, and critically discusses four trajectories beyond Eurocentrism in political and (...) social theory: enlarging the canon, inter-contextual dialogue, taking the impacts of European colonialism and imperialism into account, as well as shifts in theoretical agenda setting. It argues that if political and social theory truly attempts to transcend methodological Eurocentrism, it must not only bring in non-Western thought, but must also critically address both discursive and institutional aspects of global power relations. (shrink)

Over the last few years, intersectionality has become not only one of the most prominent topics of feminist theory in Europe, but also one of its most serious challenges, pressing us to acknowledge that European nations are not homogeneous entities and calling for more complex accounts of gender relations and forms of gender injustice. Currently, many scholars embrace intersectionality as a concept, but there is no consensus about what adequate theoretical accounts of intersectionality with regard to European contexts should look (...) like. Drawing on theoretical positions that have been put forward within the current intersectionality debate in German-speaking countries, this article addresses two questions that are currently at stake: the what-question of intersectionality, asking what it is, which forms of inequality we focus on as intersecting; and the how-question of intersectionality, focusing on how we should conceptualize what is happening when forms of inequality intersect. (shrink)

Feminist research in ethics : an introduction -- Theology in fragmented time : reflections with the concept 'postmodernism' as a starting point -- On the material spirituality of housework and its political implications -- Neither trivial nor sentimental : de-trivialization as a method in women's studies -- Power that we have; power that we need -- Women's solidarity : a value with a future -- Androcentrism and where do we go from here? : perspectives for theological reflection on 'the human (...) being' -- The minor distinction between mothers and test tubes : on the concept of women in science -- Feminist ethics and the ecology question -- The debate on animal experiments -- Biotechnology and ethics -- Invitation to feminist reflection on the economy -- Femaleness as social work -- From the norm of marriage to a plurality of lifestyles. (shrink)

A middle-aged Swiss friend tells me that, for her, God is ‘a contaminated word, … loaded with the spirit of many hundreds of years and miles of library shelves, a word that has nothing to do with the holistic worldview she embraces today.’1 So, she says, she has simply ‘removed the word from her vocabulary’: It’s out, it’s past, it has become a word that is used by other people only. The mindset that is expressed in these words is typical (...) for the situation in contemporary Western Europe. Many feel alienated from the notions and lifestyles and have left the institutions – churches, synagogues, mosques – that traditionally represent what we call ‘religion’. Besides, there are, in this part of the world, so many alternatives that allow one to form a meaning of life and provide security, togetherness and entertainment: family brunches on Sunday morning, TV movies, festivals, excursions, concerts, meditation workshops, neopaganist or atheist meetings, political engagements, lonely walks in the woods…. (shrink)

Articles on different religious philosophies of pre-colonial Bengal, India.

Corporate Social Responsibility (CSR) has existed in name for over 70 years. It is practiced in many countries and it is studied in academia around the world. However, CSR is not a universally adopted concept as it is understood differentially despite increasing pressures for its incorporation into business practices. This lack of a clear definition is complicated by the use of ambiguous terms in the proffered definitions and disputes as to where corporate governance is best addressed by many of the (...) national bodies legislating, mandating, or recommending CSR. This article explores the definitions of CSR as published on the Internet by governments in four countries (United Kingdom (UK), France, the United States, and Canada). We look for a consensus of understanding in an attempt to propose a more universal framework to enhance international adoption and practice of CSR using the triple bottom line. Our results concur with the findings of both national and international bodies and suggest that both within and among the countries in our study there exists no clear definition of the concept of CSR. While there are some similarities, there are substantial differences that must be addressed. We present a number of proposals for a more universal framework to define CSR. (shrink)

This article considers the sexual politics of animal evidence in the context of German sexology around 1920. In the 1910s, the German-Jewish geneticist Richard B. Goldschmidt conducted experiments on the moth Lymantria dispar, and discovered individuals that were no longer clearly identifiable as male or female. When he published an article tentatively arguing that his research on ‘intersex butterflies’ could be used to inform concurrent debates about human homosexuality, he triggered a flurry of responses from Berlin-based sexologists. In this article, (...) I examine how a number of well-known sexologists affiliated with Magnus Hirschfeld, his Scientific-Humanitarian Committee, and later his Institute of Sexology attempted to incorporate Goldschmidt’s experiments into their sexological work between 1917 and 1923. Intersex butterflies were used to discuss issues at the heart of German sexology: the legal debate about the criminalisation of homosexuality under paragraph 175; the scientific methodology of sexology, caught between psychiatric, biological, and sociological approaches to the study of sexual and gender diversity; and the status of sexology as natural science, able to contribute knowledge about the sexual Konstitution of the organism. This article thus shows that butterfly experiments function as important and politically charged evidence for a discussion at the heart of the sexological project of those involved in the founding of the Institute of Sexology: the question of the nature and naturalness of homosexuality and its political consequences. In doing so, this article makes a case for paying attention to non-human actors in the history of sexology. (shrink)

This article is focused on the differences between shame and guilt examined through a psychological perspective. The purpose of this analysis developed here is to attain conceptual clarity about what is distinctive about shame and guilt. We claim that shame is erroneously included in the category of “moral emotions” and that, paradoxically, there is nothing moral in it. To this end, we emphasize that shame is produced by the failure to achieve a certain minimum, which is social in its nature. (...) It is therefore connected with low demands on one’s self and low self-esteem. Guilt, on the other hand, is based on the failure to achieve a subjective maximum and an ideal, so it tends to be observed in personalities that exhibit high demands upon themselves and a high self-esteem. (shrink)

The human being as a constituted objectivity is a fragile ‘figure’ who lives in through their individual and shared experience. As a constituted objectivity, it influences our experiences, actions and the constitution of our community. Nevertheless, it appears to us, who actually constitute it, as a completely independent and immutable object, as a mere fact our experience has to comply with, and as a normative representation of the human being. This paper inquires - from a phenomenological point of view - (...) about the structure that underlies the norm at work in our experience, as well as in the high- and low-level dimensions of the intersubjective community. Indirectly, such a structure can be identified through the connection between Husserl’s understanding of normality and objectivity. My claim is that normativity can be understood as a necessary function and thus can be distinguished from objectivity and normality. Normativity appears, therefore, as a function of objectivity, which allows one to distinguish the latter from normality. As such, normativity should not be confused with an active agreement or regulation, but rather identified as a necessary constitutive structure arising from experiential intersubjective sense-borrowing performance. At the same time, due to its connection to objectivity, normativity also appears to strongly influence the social production of validity, therefore being endorsed by institutions. (shrink)

The antinomy of teleological judgment is one of the most controversial passages of Kant’s "Critique of the Power of Judgment". Having developed the idea of an explanation of organized beings by mechanical and teleological natural laws in §§ 61-68, in §§ 69-78 Kant raises the question of whether higher order mechanical and teleological natural laws, which unify the particular empirical laws of organized beings, might pose an antinomy of conflicting principles within the power of judgment. I will argue against alternative (...) views that this antinomy is neither a conflict between objective constitutive principles of the determining power of judgment nor a conflict between an objective constitutive principle of the determining power of judgment and a subjective regulative maxim of the reflecting power of judgment nor does it consist in a confusion of a pair of subjective regulative maxims of the reflecting power of judgment with a pair of objective constitutive principles of the determining power of judgment, but does consist in an apparent conflict between mechanical and teleological natural laws as subjective regulative maxims of the reflecting power of judgment. I will further argue that Kant’s resolution of the antinomy consists in the regulative idea of a supersensible that represents the unity of both kinds of natural laws and justifies the unification of both kinds of natural laws in the human power of judgment. Kant uses three notions when he talks about the supersensible – the regulative idea of a divine artisan, the regulative idea of a divine intuitive understanding, and the regulative idea of an underdetermined, supernatural ground of nature. I will show how each of these notions accounts for the unity of both kinds of natural laws and will discuss possible correlations between them. I will then explain how the unity of both kinds of natural laws in the regulative idea of a supersensible accounts for the unification of both kinds of natural laws in the human power of judgment. While the divine intuitive understanding is perfect and uncreated and, thus, capable of a representation of the unity of both kinds of natural laws, the human discursive understanding is imperfect and created; it is capable only of the representation of the unification of both kinds of natural laws in form of a hierarchy of laws. (shrink)

A commentary on Sections XII–XVI of the “Introduction to the Doctrine of Virtue”.

In this contribution, Andrew Arato and Jean Cohen’s Populism and Civil Society is confronted with current gender studies research on populism. This research mainly focuses on right-wing populism and highlights strong links between right-wing populists and the religious right, which are to a large degree organized by “anti-gender,” a stance both against social constructivist notions of gender and against basic gender rights, especially in the fields of reproduction and of LGBTIQ concerns. Against the backdrop of this literature, I argue that (...) in Populism and Civil Society, right-wing populist anti-gender politics are not addressed in a way that takes account of their full complexity; and that these politics furthermore suggest to treat right-wing populism and left-wing populism as phenomena that do not only differ in content, but also in form. (shrink)