The aim of this book is to show how supramolecular complexity of cell organization can dramatically alter the functions of individual macromolecules within a cell. The emergence of new functions which appear as a consequence of supramolecular complexity, is explained in terms of physical chemistry. The book is interdisciplinary, at the border between cell biochemistry, physics and physical chemistry. This interdisciplinarity does not result in the use of physical techniques but from the use of physical concepts to study biological problems. (...) In the domain of complexity studies, most works are purely theoretical or based on computer simulation. The present book is partly theoretical, partly experimental and theory is always based on experimental results. Moreover, the book encompasses in a unified manner the dynamic aspects of many different biological fields ranging from dynamics to pattern emergence in a young embryo. The volume puts emphasis on dynamic physical studies of biological events. It also develops, in a unified perspective, this new interdisciplinary approach of various important problems of cell biology and chemistry, ranging from enzyme dynamics to pattern formation during embryo development, thus paving the way to what may become a central issue of future biology. (shrink)

Trichoderma ATCC 20476 based biofungicides have been marketed continuously on a small scale for 20 years. A more recently developed application for these biofungicides is the treatment of strawberries against the gray mold Botrytis cinerea. That application is examined in terms of Lockwood's criteria for ethics in biological control. Unaddressed risks resulting from the current scramble for market share in northern Europe are pointed out.

Table of contentsI1 Proceedings of the 4th World Conference on Research IntegrityConcurrent Sessions:1. Countries' systems and policies to foster research integrityCS01.1 Second time around: Implementing and embedding a review of responsible conduct of research policy and practice in an Australian research-intensive universitySusan Patricia O'BrienCS01.2 Measures to promote research integrity in a university: the case of an Asian universityDanny Chan, Frederick Leung2. Examples of research integrity education programmes in different countriesCS02.1 Development of a state-run “cyber education program of research ethics” in (...) KoreaEun Jung Ko, Jin Sun Kwak, TaeHwan Gwon, Ji Min Lee, Min-Ho LeeCS02.3 Responsible conduct of research teachers’ training courses in Germany: keeping on drilling through hard boards for more RCR teachersHelga Nolte, Michael Gommel, Gerlinde Sponholz3. The research environment and policies to encourage research integrityCS03.1 Challenges and best practices in research integrity: bridging the gap between policy and practiceYordanka Krastev, Yamini Sandiran, Julia Connell, Nicky SolomonCS03.2 The Slovenian initiative for better research: from national activities to global reflectionsUrsa Opara Krasovec, Renata SribarCS03.3 Organizational climate assessments to support research integrity: background of the Survey of Organizational Research Climate and the experience with its use at Michigan State UniversityBrian C. Martinson, Carol R. Thrush, C.K. Gunsalus4. Expressions of concern and retractionsCS04.1 Proposed guidelines for retraction notices and their disseminationIvan Oransky, Adam MarcusCS04.2 Watching retractions: analysis of process and practice, with data from the Wiley retraction archivesChris Graf, Verity Warne, Edward Wates, Sue JoshuaCS04.3 An exploratory content analysis of Expressions of ConcernMiguel RoigCS04.4 An ethics researcher in the retraction processMichael Mumford5. Funders' role in fostering research integrityCS05.1 The Fonds de Recherche du Québec’s institutional rules on the responsible conduct of research: introspection in the funding agency activitiesMylène Deschênes, Catherine Olivier, Raphaëlle Dupras-LeducCS05.2 U.S. Public Health Service funds in an international setting: research integrity and complianceZoë Hammatt, Raju Tamot, Robin Parker, Cynthia Ricard, Loc Nguyen-Khoa, Sandra TitusCS05.3 Analyzing decision making of funders of public research as a case of information asymmetryKarsten Klint JensenCS05.4 Research integrity management: Empirical investigation of academia versus industrySimon Godecharle, Ben Nemery, Kris Dierickx5A: Education: For whom, how, and what?CS05A.1 Research integrity or responsible conduct of research? What do we aim for?Mickey Gjerris, Maud Marion Laird Eriksen, Jeppe Berggren HoejCS05A.2 Teaching and learning about RCR at the same time: a report on Epigeum’s RCR poll questions and other assessment activitiesNicholas H. SteneckCS05A.4 Minding the gap in research ethics education: strategies to assess and improve research competencies in community health workers/promoteresCamille Nebeker, Michael Kalichman, Elizabeth Mejia Booen, Blanca Azucena Pacheco, Rebeca Espinosa Giacinto, Sheila Castaneda6. Country examples of research reward systems and integrityCS06.1 Improving systems to promote responsible research in the Chinese Academy of SciencesDing Li, Qiong Chen, Guoli Zhu, Zhonghe SunCS06.4 Exploring the perception of research integrity amongst public health researchers in IndiaParthasarathi Ganguly, Barna Ganguly7. Education and guidance on research integrity: country differencesCS07.1 From integrity to unity: how research integrity guidance differs across universities in Europe.Noémie Aubert Bonn, Kris Dierickx, Simon GodecharleCS07.2 Can education and training develop research integrity? The spirit of the UNESCO 1974 recommendation and its updatingDaniele Bourcier, Jacques Bordé, Michèle LeducCS07.3 The education and implementation mechanisms of research ethics in Taiwan's higher education: an experience in Chinese web-based curriculum development for responsible conduct of researchChien Chou, Sophia Jui-An PanCS07.4 Educating principal investigators in Swiss research institutions: present and future perspectivesLouis Xaver Tiefenauer8. Measuring and rewarding research productivityCS08.1 Altimpact: how research integrity underpins research impactDaniel Barr, Paul TaylorCS08.2 Publication incentives: just reward or misdirection of funds?Lyn Margaret HornCS08.3 Why Socrates never charged a fee: factors contributing to challenges for research integrity and publication ethicsDeborah Poff9. Plagiarism and falsification: Behaviour and detectionCS09.1 Personality traits predict attitude towards plagiarism of self and others in biomedicine: plagiarism, yes we can?Martina Mavrinac, Gordana Brumini, Mladen PetrovečkiCS09.2 Investigating the concept of and attitudes toward plagiarism for science teachers in Brazil: any challenges for research integrity and policy?Christiane Coelho Santos, Sonia VasconcelosCS09.3 What have we learnt?: The CrossCheck Service from CrossRefRachael LammeyCS09.4 High p-values as a sign of data fabrication/falsificationChris Hartgerink, Marcel van Assen, Jelte Wicherts10. Codes for research integrity and collaborationsCS10.1 Research integrity in cross-border cooperation: a Nordic exampleHanne Silje HaugeCS10.3 Research integrity, research misconduct, and the National Science Foundation's requirement for the responsible conduct of researchAaron MankaCS10.4 A code of conduct for international scientific cooperation: human rights and research integrity in scientific collaborations with international academic and industry partnersRaffael Iturrizaga11. Countries' efforts to establish mentoring and networksCS11.1 ENRIO : a network facilitating common approaches on research integrity in EuropeNicole FoegerCS11.2 Helping junior investigators develop in a resource-limited country: a mentoring program in PeruA. Roxana Lescano, Claudio Lanata, Gissella Vasquez, Leguia Mariana, Marita Silva, Mathew Kasper, Claudia Montero, Daniel Bausch, Andres G LescanoCS11.3 Netherlands Research Integrity Network: the first six monthsFenneke Blom, Lex BouterCS11.4 A South African framework for research ethics and integrity for researchers, postgraduate students, research managers and administratorsLaetus OK Lategan12. Training and education in research integrity at an early career stageCS12.1 Research integrity in curricula for medical studentsGustavo Fitas ManaiaCS12.2 Team-based learning for training in the responsible conduct of research supports ethical decision-makingWayne T. McCormack, William L. Allen, Shane Connelly, Joshua Crites, Jeffrey Engler, Victoria Freedman, Cynthia W. Garvan, Paul Haidet, Joel Hockensmith, William McElroy, Erik Sander, Rebecca Volpe, Michael F. VerderameCS12.4 Research integrity and career prospects of junior researchersSnezana Krstic13. Systems and research environments in institutionsCS13.1 Implementing systems in research institutions to improve quality and reduce riskLouise HandyCS13.2 Creating an institutional environment that supports research integrityDebra Schaller-DemersCS13.3 Ethics and Integrity Development Grants: a mechanism to foster cultures of ethics and integrityPaul Taylor, Daniel BarrCS13.4 A culture of integrity at KU LeuvenInge Lerouge, Gerard Cielen, Liliane Schoofs14. Peer review and its role in research integrityCS14.1 Peer review research across disciplines: transdomain action in the European Cooperation in Science and Technology “New Frontiers of Peer Review ”Ana Marusic, Flaminio SquazzoniCS14.2 Using blinding to reduce bias in peer reviewDavid VauxCS14.3 How to intensify the role of reviewers to promote research integrityKhalid Al-Wazzan, Ibrahim AlorainyCS14.4 Credit where credit’s due: professionalizing and rewarding the role of peer reviewerChris Graf, Verity Warne15. Research ethics and oversight for research integrity: Does it work?CS15.1 The psychology of decision-making in research ethics governance structures: a theory of bounded rationalityNolan O'Brien, Suzanne Guerin, Philip DoddCS15.2 Investigator irregularities: iniquity, ignorance or incompetence?Frank Wells, Catherine BlewettCS15.3 Academic plagiarismFredric M. Litto16. Research integrity in EuropeCS16.1 Whose responsibility is it anyway?: A comparative analysis of core concepts and practice at European research-intensive universities to identify and develop good practices in research integrityItziar De Lecuona, Erika Löfstrom, Katrien MaesCS16.2 Research integrity guidance in European research universitiesKris Dierickx, Noémie Bonn, Simon GodecharleCS16.3 Research Integrity: processes and initiatives in Science Europe member organisationsTony Peatfield, Olivier Boehme, Science Europe Working Group on Research IntegrityCS16.4 Promoting research integrity in Italy: the experience of the Research Ethics and Bioethics Advisory Committee of the Consiglio Nazionale delle Ricerche Cinzia Caporale, Daniele Fanelli17. Training programs for research integrity at different levels of experience and seniorityCS17.1 Meaningful ways to incorporate research integrity and the responsible conduct of research into undergraduate, graduate, postdoctoral and faculty training programsJohn Carfora, Eric Strauss, William LynnCS17.2 "Recognize, respond, champion": Developing a one-day interactive workshop to increase confidence in research integrity issuesDieter De Bruyn, Bracke Nele, Katrien De Gelder, Stefanie Van der BurghtCS17.4 “Train the trainer” on cultural challenges imposed by international research integrity conversations: lessons from a projectJosé Roberto Lapa e Silva, Sonia M. R. Vasconcelos18. Research and societal responsibilityCS18.1 Promoting the societal responsibility of research as an integral part of research integrityHelene IngierdCS18.2 Social responsibility as an ethical imperative for scientists: research, education and service to societyMark FrankelCS18.3 The intertwined nature of social responsibility and hope in scienceDaniel Vasgird, Stephanie BirdCS18.4 Common barriers that impede our ability to create a culture of trustworthiness in the research communityMark Yarborough19. Publication ethicsCS19.1 The authors' forum: A proposed tool to improve practices of journal editors and promote a responsible research environmentIbrahim Alorainy, Khalid Al-WazzanCS19.2 Quantifying research integrity and its impact with text analyticsHarold GarnerCS19.3 A closer look at authorship and publication ethics of multi- and interdisciplinary teamsLisa Campo-Engelstein, Zubin Master, Elise Smith, David Resnik, Bryn Williams-JonesCS19.4 Invisibility of duplicate publications in biomedicineMario Malicki, Ana Utrobicic, Ana Marusic20. The causes of bad and wasteful research: What can we do?CS20.1 From countries to individuals: unravelling the causes of bias and misconduct with multilevel meta-meta-analysisDaniele Fanelli, John PA IoannidisCS20.2 Reducing research waste by integrating systems of oversight and regulationGerben ter Riet, Tom Walley, Lex Marius BouterCS20.3 What are the determinants of selective reporting?: The example of palliative care for non-cancer conditionsJenny van der Steen, Lex BouterCS20.4 Perceptions of plagiarism, self-plagiarism and redundancy in research: preliminary results from a national survey of Brazilian PhDsSonia Vasconcelos, Martha Sorenson, Francisco Prosdocimi, Hatisaburo Masuda, Edson Watanabe, José Carlos Pinto, Marisa Palácios, José Lapa e Silva, Jacqueline Leta, Adalberto Vieyra, André Pinto, Mauricio Sant’Ana, Rosemary Shinkai21. Are there country-specific elements of misconduct?CS21.1 The battle with plagiarism in Russian science: latest developmentsBoris YudinCS21.2 Researchers between ethics and misconduct: A French survey on social representations of misconduct and ethical standards within the scientific communityEtienne Vergès, Anne-Sophie Brun-Wauthier, Géraldine VialCS21.3 Experience from different ways of dealing with research misconduct and promoting research integrity in some Nordic countriesTorkild VintherCS21.4 Are there specifics in German research misconduct and the ways to cope with it?Volker Bähr, Charité22. Research integrity teaching programmes and their challengesCS22.1 Faculty mentors and research integrityMichael Kalichman, Dena PlemmonsCS22.2 Training the next generation of scientists to use principles of research quality assurance to improve data integrity and reliabilityRebecca Lynn Davies, Katrina LaubeCS22.3 Fostering research integrity in a culturally-diverse environmentCynthia Scheopner, John GallandCS22.4 Towards a standard retraction formHervé Maisonneuve, Evelyne Decullier23. Commercial research and integrityCS23.1 The will to commercialize: matters of concern in the cultural economy of return-on-investment researchBrian NobleCS23.2 Quality in drug discovery data reporting: a mission impossible?Anja Gilis, David J. Gallacher, Tom Lavrijssen, Malwitz David, Malini Dasgupta, Hans MolsCS23.3 Instituting a research integrity policy in the context of semi-private-sector funding: an example in the field of occupational health and safetyPaul-Emile Boileau24. The interface of publication ethics and institutional policiesCS24.1 The open access ethical paradox in an open government effortTony SavardCS24.2 How journals and institutions can work together to promote responsible conductEric MahCS24.3 Improving cooperation between journals and research institutions in research integrity casesElizabeth Wager, Sabine Kleinert25. Reproducibility of research and retractionsCS25.1 Promoting transparency in publications to reduce irreproducibilityVeronique Kiermer, Andrew Hufton, Melanie ClyneCS25.2 Retraction notices issued for publications by Latin American authors: what lessons can we learn?Sonia Vasconcelos, Renan Moritz Almeida, Aldo Fontes-Pereira, Fernanda Catelani, Karina RochaCS25.3 A preliminary report of the findings from the Reproducibility Project: Cancer biologyElizabeth Iorns, William Gunn26. Research integrity and specific country initiativesCS26.1 Promoting research integrity at CNRS, FranceMichèle Leduc, Lucienne LetellierCS26.2 In pursuit of compliance: is the tail wagging the dog?Cornelia MalherbeCS26.3 Newly established research integrity policies and practices: oversight systems of Japanese research universitiesTakehito Kamata27. Responsible conduct of research and country guidelinesCS27.1 Incentives or guidelines? Promoting responsible research communication through economic incentives or ethical guidelines?Vidar EnebakkCS27.3 Responsible conduct of research: a view from CanadaLynn PenrodCS27.4 The Danish Code of Conduct for Research Integrity: a national initiative to promote research integrity in DenmarkThomas Nørgaard, Charlotte Elverdam28. Behaviour, trust and honestyCS28.1 The reasons behind non-ethical behaviour in academiaYves FassinCS28.2 The psychological profile of the dishonest scholarCynthia FekkenCS28.3 Considering the implications of Dan Ariely’s keynote speech at the 3rd World Conference on Research Integrity in MontréalJamal Adam, Melissa S. AndersonCS28.4 Two large surveys on psychologists’ views on peer review and replicationJelte WichertsBrett Buttliere29. Reporting and publication bias and how to overcome itCS29.1 Data sharing: Experience at two open-access general medical journalsTrish GrovesCS29.2 Overcoming publication bias and selective reporting: completing the published recordDaniel ShanahanCS29.3 The EQUATOR Network: promoting responsible reporting of health research studiesIveta Simera, Shona Kirtley, Eleana Villanueva, Caroline Struthers, Angela MacCarthy, Douglas Altman30. The research environment and its implications for integrityCS30.1 Ranking of scientists: the Russian experienceElena GrebenshchikovaCS30.4 From cradle to grave: research integrity, research misconduct and cultural shiftsBronwyn Greene, Ted RohrPARTNER SYMPOSIAPartner Symposium AOrganized by EQUATOR Network, Enhancing the Quality and Transparency of Health ResearchP1 Can we trust the medical research literature?: Poor reporting and its consequencesIveta SimeraP2 What can BioMed Central do to improve published research?Daniel Shanahan, Stephanie HarrimanP3 What can a "traditional" journal do to improve published research?Trish GrovesP4 Promoting good reporting practice for reliable and usable research papers: EQUATOR Network, reporting guidelines and other initiativesCaroline StruthersPartner Symposium COrganized by ENRIO, the European Network of Research Integrity OfficersP5 Transparency and independence in research integrity investigations in EuropeKrista Varantola, Helga Nolte, Ursa Opara, Torkild Vinther, Elizabeth Wager, Thomas NørgaardPartner Symposium DOrganized by IEEE, the Institute of Electrical and Electronics EngineersRe-educating our author community: IEEE's approach to bibliometric manipulation, plagiarism, and other inappropriate practicesP6 Dealing with plagiarism in the connected world: An Institute of Electrical and Electronics Engineers perspectiveJon RokneP7 Should evaluation of raises, promotion, and research proposals be tied to bibliometric indictors? What the Institute of Electrical and Electronics Engineers is doing to answer this questionGianluca SettiP8 Recommended practices to ensure conference content qualityGordon MacPhersonPartner Symposium EOrganized by the Committee on Freedom and Responsibility in the Conduct of Science of ICSU, the International Council for ScienceResearch assessment and quality in science: perspectives from international science and policy organisationsP9 Challenges for science and the problems of assessing researchEllen HazelkornP10 Research assessment and science policy developmentCarthage SmithP11 Research integrity in South Africa: the value of procedures and processes to global positioningRobert H. McLaughlinP12 Rewards, careers and integrity: perspectives of young scientists from around the worldTatiana Duque MartinsPartner Symposium FOrganized by the Online Resource Center for Ethics Education in Engineering and Science / Center for Engineering, Ethics, and Society of the National Academy of EngineeringP13 Research misconduct: conceptions and policy solutionsTetsuya Tanimoto, Nicholas Steneck, Daniele Fanelli, Ragnvald Kalleberg, Tajammul HusseinPartner Symposium HOrganized by ORI, the Office of Research Integrity; Universitas 21; and the Asia Pacific Research Integrity NetworkP14 International integrity networks: working together to ensure research integrityPing Sun, Ovid Tzeng, Krista Varantola, Susan ZimmermanPartner Symposium IOrganized by COPE, the Committee on Publication EthicsPublication without borders: Ethical challenges in a globalized worldP15 Authorship: credit and responsibility, including issues in large and interdisciplinary studiesRosemary ShinkaiPartner Symposium JOrganized by CITI, the Cooperative Institutional Training InitiativeExperiences on research integrity educational programs in Colombia, Costa Rica and PeruP16 Experiences in PeruRoxana LescanoP17 Experiences in Costa RicaElizabeth HeitmanP18 Experiences in ColumbiaMaria Andrea Rocio del Pilar Contreras NietoPoster Session B: Education, training, promotion and policyPT.01 The missing role of journal editors in promoting responsible researchIbrahim Alorainy, Khalid Al-WazzanPT.02 Honorary authorship in Taiwan: why and who should be in charge?Chien Chou, Sophia Jui-An PanPT.03 Authorship and citation manipulation in academic researchEric Fong, Al WilhitePT.04 Open peer review of research submission at medical journals: experience at BMJ Open and The BMJTrish GrovesPT.05 Exercising authorship: claiming rewards, practicing integrityDésirée Motta-RothPT.07 Medical scientists' views on publication culture: a focus group studyJoeri Tijdink, Yvo SmuldersPoster Session B: Education, training, promotion and policyPT.09 Ethical challenges in post-graduate supervisionLaetus OK LateganPT.10 The effects of viable ethics instruction on international studentsMichael Mumford, Logan Steele, Logan Watts, James Johnson, Shane Connelly, Lee WilliamsPT.11 Does language reflect the quality of research?Gerben ter Riet, Sufia Amini, Lotty Hooft, Halil KilicogluPT.12 Integrity complaints as a strategic tool in policy decision conflictsJanneke van Seters, Herman Eijsackers, Fons Voragen, Akke van der Zijpp and Frans BromPoster Session C: Ethics and integrity intersectionsPT.14 Regulations of informed consent: university-supported research processes and pitfalls in implementationBadaruddin Abbasi, Naif Nasser AlmasoudPT.15 A review of equipoise as a requirement in clinical trialsAdri LabuschagnePT.16 The Research Ethics Library: online resource for research ethics educationJohanne Severinsen, Espen EnghPT.17 Research integrity: the view from King Abdulaziz City for Science and TechnologyDaham Ismail AlaniPT. 18 Meeting global challenges in high-impact publications and research integrity: the case of the Malaysian Palm Oil BoardHJ. Kamaruzaman JusoffPT.19 University faculty perceptions of research practices and misconductAnita Gordon, Helen C. HartonPoster Session D: International perspectivesPT.21 The Commission for Scientific Integrity as a response to research fraudDieter De Bruyn, Stefanie Van der BurghtPT. 22 Are notions of the responsible conduct of research associated with compliance with requirements for research on humans in different disciplinary traditions in Brazil?Karina de Albuquerque Rocha, Sonia Maria Ramos de VasconcelosPT.23 Creating an environment that promotes research integrity: an institutional model of Malawi Liverpool Welcome TrustLimbanazo MatandikaPT.24 How do science policies in Brazil influence user-engaged ecological research?Aline Carolina de Oliveira Machado Prata, Mark William NeffPoster Session E: Perspectives on misconductPT.26 What “causes” scientific misconduct?: Testing major hypotheses by comparing corrected and retracted papersDaniele Fanelli, Rodrigo Costas, Vincent LarivièrePT.27 Perception of academic plagiarism among dentistry studentsDouglas Leonardo Gomes Filho, Diego Oliveira GuedesPT. 28 a few bad apples?: Prevalence, patterns and attitudes towards scientific misconduct among doctoral students at a German university hospitalVolker Bähr, Niklas Keller, Markus Feufel, Nikolas OffenhauserPT. 29 Analysis of retraction notices published by BioMed CentralMaria K. Kowalczuk, Elizabeth C. MoylanPT.31 "He did it" doesn't work: data security, incidents and partnersKatie SpeanburgPoster Session F: Views from the disciplinesPT.32 Robust procedures: a key to generating quality results in drug discoveryMalini Dasgupta, Mariusz Lubomirski, Tom Lavrijssen, David Malwitz, David Gallacher, Anja GillisPT.33 Health promotion: criteria for the design and the integrity of a research projectMaria Betânia de Freitas Marques, Laressa Lima Amâncio, Raphaela Dias Fernandes, Oliveira Patrocínio, and Cláudia Maria Correia Borges RechPT.34 Integrity of academic work from the perspective of students graduating in pharmacy: a brief research studyMaria Betânia de Freitas Marques, Cláudia Maria Correia Borges Rech, Adriana Nascimento SousaPT.35 Research integrity promotion in the Epidemiology and Health Services, the journal of the Brazilian Unified Health SystemLeila Posenato GarciaPT.36 When are clinical trials registered? An analysis of prospective versus retrospective registration of clinical trials published in the BioMed Central series, UKStephanie Harriman, Jigisha PatelPT.37 Maximizing welfare while promoting innovation in drug developmentFarida LadaOther posters that will be displayed but not presented orally:PT.38 Geoethics and the debate on research integrity in geosciencesGiuseppe Di Capua, Silvia PeppoloniPT.39 Introducing the Professionalism and Integrity in Research Program James M. DuBois, John Chibnall, Jillon Van der WallPT.40 Validation of the professional decision-making in research measureJames M. DuBois, John Chibnall, Jillon Van der Wall, Raymond TaitPT.41 General guidelines for research ethicsJacob HolenPT. 42 A national forum for research ethicsAdele Flakke Johannessen, Torunn EllefsenPT.43 Evaluation of integrity in coursework: an approach from the perspective of the higher education professorClaudia Rech, Adriana Sousa, Maria Betânia de Freitas MarquesPT.44 Principles of geoethics and research integrity applied to the European Multidisciplinary Seafloor and Water Column Observatory, a large-scale European environmental research infrastructureSilvia Peppoloni, Giuseppe Di Capua, Laura BeranzoliF1 Focus track on improving research systems: the role of fundersPaulo S.L. Beirão, Susan ZimmermanF2 Focus track on improving research systems: the role of countriesSabine Kleinert, Ana MarusicF3 Focus track on improving research systems: the role of institutionsMelissa S. Anderson, Lex Bouter. (shrink)

It is widely held that assertions are partially governed by an epistemic norm. But what is the epistemic condition set out in the norm? Is it knowledge, truth, belief, or something else? In this paper, I defend a view similar to that of Stanley (2008), according to which the relevant epistemic condition is epistemic certainty, where epistemic certainty (but not knowledge) is context-sensitive. I start by distinguishing epistemic certainty, subjective certainty, and knowledge. Then, I explain why it's much more plausible (...) to think that "certain", rather than "know", is context-sensitive. After that, I respond to an important worry raised by Pritchard, according to which the proposed view is too strong to accommodate our current practice of assertion. I then show that the main linguistic and conversational data advanced in the recent literature in favour of the knowledge condition are best explained by the certainty view. Finally, I offer two principled considerations: the certainty view is the only one compatible with three independently plausible claims and it fits very well with the common thought that knowledge does not entail certainty. (shrink)

Is knowledge the epistemic norm of action and assertion? Gettier and justified-false-belief cases have been raised as counterexamples to the necessity direction of that claim. Most knowledge normers reply by distinguishing permissibility from excusability. An important objection to this move, however, is that it requires a still lacking view of epistemic excuses sufficiently general to cover all the cases, correctly relating the supposed excuse to the subject's cognitive life, and not collapsing into an account of the fundamental normative standard (see (...) Gerken 2017). In this paper, I rely on independent work in epistemology and cognitive science to suggest a novel account of epistemic excuses in terms of epistemic feelings. In contrast to other existing accounts, this account is immune from the above objection and can thus be used to rescue the knowledge norm. (shrink)

A certain number of cases suggest that our willingness to ascribe “knowledge” can be influenced by practical factors. For revisionary proposals, they indicate that the truth‐values of “knowledge” ascriptions vary with practical factors. For conservative proposals, on the contrary, nothing surprising is happening. Standard pragmatic approaches appeal to pragmatic implicatures and psychological approaches to the idea that belief formation is influenced by practical factors. Conservative proposals have not yet offered a fully satisfactory explanation, though. In this article, I introduce and (...) defend a third conservative proposal which I call “Refined Invariantism”. The two main claims of this proposal are that (1) we should distinguish between high stakes cases in which the subject does not believe (that he knows) the target proposition and those in which he believes (that he knows) the target proposition and that (2) we should adopt a psychological treatment for the first kind of case and a pragmatic treatment based on the epistemic standards for appropriate assertion and action for the second kind of case. I argue that this new combined approach avoids the main pitfalls of its two conservative rivals and that it gives new life to the generality objection levelled against revisionary views. (shrink)

According to a widely discussed view, knowledge plays a significant normative role in action: It is epistemically rational to treat p as your reason for action if and only if you know that p. As many philosophers have observed, however, this view clashes with the claim that knowledge is moderate and stable. For, granting that claim, there will be high stakes cases in which knowledge seems insufficient. To deal with such cases, some philosophers embracing the knowledge norm combine three independently (...) plausible claims. First, they say that no non-trivial condition is luminous; second, they say that doing something while not being in a position to know that that is appropriate is bad (in high stakes cases); third, they say that in the high stakes cases in question, the subject knows but fails to be in a position to know that she knows (Williamson Philos Q 55:213–235, 2005). This paper argues that this account can overcome the main objections already raised in the literature, but that it still faces the apparently insurmountable challenge of providing a natural and helpful way of substantiating the second claim. (shrink)

Among the main reactions to scepticism, fallibilism is certainly the most popular nowadays. However, fallibilism faces a very strong and well-known objection. It has to grant that concessive knowledge attributions—assertions of the form “I know that p but it might be that not p”—can be true. Yet, these assertions plainly sound incoherent. Fallibilists have proposed to explain this incoherence pragmatically. The main proponents of this approach appeal to Gricean implicatures (Rysiew in Noûs 35(4):477514, 2001; Dougherty and Rysiew in Philos Phenomenol (...) Res 78(1):123132, 2009; Dougherty and Rysiew in Synthese 181(3):395403, 2011). Very recently, some philosophers have observed that fallibilists can also explain this apparent incoherence pragmatically if they embrace a (context-sensitive) certainty norm for assertion (Petersen in Synthese 196(11):4691–4710, 2019; Beddor in Philos Impr 20(8), 2020; Vollet in Dialectica 74:3, 2020). In this paper, I argue for the superiority of this latter explanation over its older rivals. (shrink)

The traditional view in epistemology has it that knowledge is insensitive to the practical stakes. More recently, some philosophers have argued that knowledge is sufficient for rational action: if you know p, then p is a reason you have (epistemically speaking). Many epistemologists contend that these two claims stand in tension with one another. In support of this, they ask us to start with a low stakes case where, intuitively, a subject knows that p and appropriately acts on p. Then, (...) they ask us to consider a high stakes version of the case where, intuitively, this subject does not know that p and could not appropriately act on p without double-checking. Finally, they suggest that the best explanation for our shifty intuitions is that p is a reason the subject has in the low stakes case but not in the high stakes case. In short, according to this explanation, having a reason (in the epistemic sense) is sensitive to the stakes. If so, either knowledge is sensitive to the stakes or else you can know that p even if p is not a reason you have (in the epistemic sense). In this paper, I consider more closely the relation between having a reason (in the epistemic sense) and having a reason to check. I argue that the supposition that if one has p as a reason (in the epistemic sense) then one has a reason not to check whether p, or no reason to check whether p, is highly doubtful. On the contrary, I suggest, it is plausible that, given our fallibility, one always has an epistemic reason to check whether p, whether or not p is a reason one has (in the epistemic sense). On the basis of this observation, I show that one can offer a new way of explaining the cases in question, allowing us to reconcile the traditional view about knowledge and the sufficiency of knowledge for rational action. (shrink)

Many philosophers agree that there is an epistemic norm governing action. However, they disagree on what this norm is. It has been observed that the word ‘know’ is prominent in ordinary epistemic evaluations of actions. Any opponent of the knowledge norm must provide an explanation of this fact. Gerken has recently proposed the most developed explanation. It invokes the hypothesis that, in normal contexts, knowledge-level warrant is frequently necessary and very frequently sufficient (Normal Coincidence), so that knowledge-based assessments would be (...) a good heuristic for practical reasoning and epistemic evaluations of action. In this paper, I raise three problems for this approach. First, I argue that Normal Coincidence is ad hoc: it relies on an unsupported frequency hypothesis that we should expect to be false given the warrant account that Gerken also endorses. Second, I argue that, in any case, Normal Coincidence is insufficient to support the hypothesis that knowledge-based evaluation of action constitutes a good heuristic. Third, I consider three other hypotheses close to Normal Coincidence apparently more likely to support the heuristic hypothesis, but I argue that they seem even more ad hoc than Normal Coincidence. (shrink)

A certain number of philosophers are attracted to the idea that knowledge is the epistemic norm of practical reasoning in the sense that it is epistemically appropriate to rely on p in one’s practical reasoning if and only if one knows that p. A well-known objection to the sufficiency direction of that claim is that there are cases in which a subject supposedly knows that p and yet should not rely on p. In light of the distinction between sufficient and (...) insufficient reasons, some philosophers contend that these cases are inconclusive. In this paper, I argue that this insufficient reason manoeuvre is defective because it either misconstrues the relevant cases or is at odds with strong intuitions about how we (should) reason. I then put forward further considerations relative to the instability of some pieces of reasoning and show how they can be explained by a certainty norm for practical reasoning. (shrink)

Tout ce qui est dans l'oeuvre de Jacques, nous l'avons d'abord vécu à l'état de difficulté vitale et d'expérience, - les questions de l'art et de la morale, de la philosophie, de la foi, de la prière, de la contemplation. Cela nous a d'abord été donné à vivre, à chacun selon sa nature et la grâce de Dieu », notait Raïssa en 1934. Cette correspondance confirme le propos, qui nous fait pénétrer dans « l'amour fou » de deux vies (...) données l'une à l'autre, et la trame quotidienne de leur fécondité de pensée et de « grandes amitiés ».Leur conversion en 1906 scelle la vocation d'un couple venu déjà un peu d'ailleurs : lui, 18 ans, romantique, révolutionnaire et dreyfusard en diable, en rupture avec les élites républicaines laïques dont il est issu ; elle, 17 ans, comme sortie d'une peinture de Chagall, juive et slave en quête à la Sorbonne d'une nouvelle patrie spirituelle. Les premiers regards portés sur eux discernent déjà leur promesse : « Je les trouve absolument dignes l'un de l'autre ; ce sont même de si beaux types d'humanité qu'il faut se féliciter de les voir se rechercher. On ne trouve pas si souvent de couple bien assorti ; celui-là me paraît devoir donner un exemple lumineux. »Ils s'écrivent abondamment dès que les aléas de la vie les séparent et ce premier tome les suit dans la découverte d'eux-mêmes. Dans la discontinuité des circonstances, leur chemin métaphysique et mystique progresse, tandis que se révèle, derrière chaque ouvrage, chaque combat, chaque accompagnement spirituel, le secret de leur rayonnement : au fil de ces 712 lettres, c'est d'abord une histoire d'amour, dans un respect tendre et sacré de la singularité de l'autre. (shrink)

Many philosophers agree that there is an epistemic norm governing action. However, they disagree on what this norm is. It has been observed that the word ‘know’ is prominent in ordinary epistemic evaluations of actions. Any opponent of the knowledge norm must provide an explanation of this fact. Gerken has recently proposed the most developed explanation. It invokes the hypothesis that, in normal contexts, knowledge-level warrant is frequently necessary and very frequently sufficient (Normal Coincidence), so that knowledge-based assessments would be (...) a good heuristic for practical reasoning and epistemic evaluations of action. In this paper, I raise three problems for this approach. First, I argue that Normal Coincidence is ad hoc: it relies on an unsupported frequency hypothesis that we should expect to be false given the warrant account that Gerken also endorses. Second, I argue that, in any case, Normal Coincidence is insufficient to support the hypothesis that knowledge-based evaluation of action constitutes a good heuristic. Third, I consider three other hypotheses close to Normal Coincidence apparently more likely to support the heuristic hypothesis, but I argue that they seem even more ad hoc than Normal Coincidence. (shrink)

A prominent feature of American political consciousness is a desire to propagate democracy throughout the world. In our enthusiasm to share what we enjoy, Jacques Barzun sees that little attention is paid to exactly what we are trying to distribute. Through a brief historical survey of democracy, he shows that our popular conception of the term does not correspond with any particular definition. U.S. democracy has no central text and is distinctly different, in theory and in practice, from the (...) democracy of other states, both historical and contemporary. Democracy is an abstract ideal that is a function of time. Its present incarnation in the United States emphasizes freedom and equality through the means and language of specific personal rights. Barzun sees an internal tension in this formulation, one that ultimately threatens both freedom and equality if exported to the rest of the world. (shrink)

Pascal Engel défend explicitement le purisme (ou l’intellectualisme). Selon la version générale de cette thèse, les facteurs qui déterminent si une croyance est justifiée, ou si elle est une connaissance, ne concernent que la vérité. Ils sont totalement indépendants des désirs ou des préférences du sujet, ainsi que des conséquences pratiques potentielles du fait de posséder ces croyances. Dans son article « Pragmatic Encroachment and Epistemic Value » (2009), P. Engel concède que des facteurs pratiques peuvent déterminer la quantité de (...) données (ou la justification) dont on a besoin pour savoir ou croire, tout en maintenant que cela n’affecte pas le purisme épistémique (dans sa version évidentialiste) sur les notions de donnée ou de degré de justification. Mais cela ne revient-il pas tout simplement à concéder l’impurisme épistémique au moins à propos de la connaissance ou de la justification simpliciter des croyances ? Dans cet article, j’examine en détails la position de P. Engel. Je montre que, correctement comprise, elle est intégralement puriste. En considérant le principe connaissance-action, je soulève néanmoins un dilemme pour son approche, jetant ainsi un doute sur le potentiel qu’elle aurait à fournir une réponse puriste satisfaisante à l’argument fondamental motivant l’impurisme épistémique. (shrink)

Abstract Hannah Arendt frequently referred to herself as a phenomenologist in that she wished to reveal how action, in the Greek sense of praxis, engenders a public space of appearances or of phenomenality. The life of the Greek city?state, of the polis, was made possible through this activity, this bios politikos. However, beginning with Plato and continuing right down to Hegel and Heidegger, there has been a sustained attempt to cover up and conceal the specific phenomenality of the bios politikos (...) in favour of the bios theoretikos, involving the substitution of poiesis and theoria for the life of praxis. At the roots of this concealment of the active life is a misunderstanding of the true nature of the theoretical and its highest form, namely, thinking. (shrink)

This paper outlines a phenomenological approach for describing physiological reactions occurring immediately after vital threats. This exemplified by data taken from previous studies relative to chemical intoxications of rats by a neurotoxical drug. The survival rate of the animals and the variations of their cerebral acetylcholinesterese activity are both reported as a function of the drug concentration, and with respect to their age. The collecting of the results may be described as the cusp, a bifurcation set of Thom's Catastrophe Theory.The (...) young animals react by a vital burst which modifies the shape of the cusp. A new fold or pocket takes place, changing it to the butterfly bifurcation set. This pocket supports the survival attractor concept, which appears reactional, transitory and variable in its intensity. (shrink)

An accessible and thorough introduction to implicatures, a key topic in all frameworks of pragmatics. Starting with a definition of the various types of implicatures in Gricean, neo-Gricean and post-Gricean pragmatics, the book covers many important questions for current pragmatic theories, namely: the distinction between explicit and implicit forms of pragmatic enrichment, the criteria for drawing a line between semantic and pragmatic meaning, the relations between the structure of language and its use, the social and cognitive factors underlying the use (...) of implicatures by native speakers, and the factors influencing their acquisition for children and second language learners. Written in non-technical language, Implicatures will appeal to students and teachers in linguistics, applied linguistics, psychology and sociology, who are interested in how language is used for communication, and how children and learners develop pragmatic skills. (shrink)

Human cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity of organisms, one can conjecture that there is order in the cancer multiverse. Is there a way to capture the broad range of tumor types within a space of the possible? Here we define the oncospace, a coordinate system that integrates the ecological, evolutionary and developmental (...) components of cancer complexity. The spatial position of a tumor results from its departure from the healthy tissue along these three axes, and progression trajectories inform about the components driving malignancy across cancer subtypes. We postulate that the oncospace topology encodes new information regarding tumorigenic pathways, subtype prognosis, and therapeutic opportunities: treatment design could benefit from considering how to nudge tumors toward empty evolutionary dead ends in the oncospace. (shrink)

La primera cuestión a plantear en la resolución de conflictos es la percepción que las partes tienen de éste. Nos centraremos en el análisis del caso «0», en el cual las partes, o al menos una de ellas, no percibe o se niega a percibir el conflicto. Proponemos que este paso sea primero y prioritario para cualquier análisis de resolución de conflictos.

Cet ouvrage est une réédition numérique d’un livre paru au XXe siècle, désormais indisponible dans son format d’origine.

" Je veus qu'on m'y voie en ma façon simple, naturelle et ordinaire, sans contention et artifice : car c'est moy que je peins. Mes defauts s'y liront au vif, mes imperfections et ma forme naïfve (native, naturelle), autant que la reverence publique (la décence) me l'a permis. " Les Essais, on le sait, ne sont pas une autobiographie, mais un autoportrait emboîté dans un ensemble de digressions, de citations, d'anecdotes, de réflexions morales, présentés avec humour, ironie, parfois avec fausse (...) modestie, en se jouant des temps, des lieux, des circonstances. Lire Montaigne, c'est donc certes découvrir ce portrait que Montaigne fait de lui-même, mais aussi éprouver les forces et les failles de cette introspection : à quelles conditions peut-on se regarder avec lucidité? La lecture des Essais incite ainsi à vouloir avoir une meilleure idée de soi-même, plus exacte, plus précise. Tel peut être l'usage de Montaigne. Du moins, tel est l'exercice auquel s'est complu l'auteur par un dialogue fécond avec le philosophe. (shrink)

Derrière toute affirmation, derrière toute déclaration, derrière toute doctrine, se trouve toujours un je, même s'il ne se présente pas comme tel : un je qui pense, qui croit, qui sait. Nous faisons sans cesse usage de nous-même - de nos perceptions, de nos sentiments, de nos idées, de nos savoirs, de nos croyances, pour penser, agir, ou communiquer. La réflexion philosophique ne fait pas exception : ce livre examine les diverses modalités de l'usage de soi en philosophie."--Page 4 of (...) cover. (shrink)

L’introspection peut être conçue comme une manière de s’observer pendant qu’on se livre à une activité mentale et comme une méthode de recherche dans les sciences du mental, dans l’intention de comprendre et de décrire aussi précisément que possible les événements mentaux d’ordre divers qui ont lieu en nous. Les critiques de l’introspection mettent en cause aussi bien la méthode et ses résultats que la possibilité même d’user d’une telle procédure. Les premières objections ont trait au caractère « objectif » (...) de l’introspection. L’autre catégorie d’objections porte sur la possibilité d’observer un événement mental pendant que celui-ci a lieu. Il n’en reste pas moins que nous nous regardons penser, sentir, agir. Puisque l’introspection au sens restreint n’est pas possible, à cause justement des problèmes que posent l’objectivité des résultats et la simultanéité de l’observation, je propose d’élargir la portée de l’introspection en la renforçant en arrière, par la rétrospection, considérée comme un regard jeté sur ce qui vient d’avoir lieu dans mon monde mental ; et en avant, par la prospection, considérée comme un regard jeté sur ce qui se passe en général dans mon monde mental. En partant de ce double point de vue, on constate que l’introspection est non seulement possible mais qu’elle est même intéressante et féconde. (shrink)

Poete pour les Juifs, qui ne se sont pas reconnus dans sa philosophie, Salomon Ibn Gabirol a ete pour les chretiens le philosophe Avencebrol ou Avicebron. Dans le Fons Vitae, Ibn Gabirol cherche a concilier deux evidences qui se contredisent et auxquelles il adhere neanmoins absolument: l'evidence monotheiste d'un Dieu createur ex nihilo, et l'evidence neoplatonicienne de l'emanation graduelle de l'etre. Le Fons Vitae a joue un role important pour la scolastique chretienne, surtout dans la problematique de l'origine et de (...) la composition des substances spirituelles, l'Un, l'intellect et l'ame. Cette reprise de La philosophie de Salomon Ibn Gabirol, revue et mise a jour, s'accompagne de la nouvelle parution de la traduction francaise du Fons Vitae, sous le titre Le Livre de la Source de Vie. (shrink)

Quelqu'un sait quelque chose, voila la situation de depart de toute problematique cognitive. Dans toute situation cognitive, un sujet connaissant se trouve en relation cognitive avec un objet connu. Contrairement a l'approche analytique suivie par les disciplines cognitives classiques - logique, epistemologie, psychologie cognitive, et aujourd'hui l'intelligence artificielle - qui detachent l'objet de leur recherche de son contexte d'origine, la demarche de ce livre est integrante. Elle entend ne pas couper la problematique cognitive des situations cognitives effectives dans lesquelles cette (...) problematique prend corps et se deploie. (shrink)