_Riassunto_: La _Deep Brain Stimulation _(DBS) è un dispositivo annoverato tra le interfacce-cervello computer e che si qualifica come una promettente soluzione medica per far fronte al decorso di alcune malattie neurodegenerative come il Parikinson. Decenni di utilizzo clinico della DBS hanno permesso di comprenderne gli effetti collaterali e il loro impatto sul PIAAAS (_Personality, Identity, Agency, Authenticity, Autonomy and Self_). In tal senso, per sondare cambiamenti psicologici legati all’uso della DBS si è fatto ricorso a metodi quantitativi, come (...) questionari incentrati su valutazioni di ordine numerico, e metodi qualitativi, che si appoggiano alle esperienze riportate dai pazienti tramite interviste. Questo articolo ha l’obiettivo di evidenziare come, a prescindere dai metodi di indagine utilizzati, la ricerca sia stata sempre focalizzata sugli effetti collaterali della DBS e gli eventuali cambiamenti sulle dimensioni comprese nel PIAAAS, lasciandosi sfuggire l’occasione di usare i numerosi dati raccolti per effettuare un’analisi fenomenologica che potesse restituirci una descrizione della sintesi uomo-macchina. Per colmare questo iato, proponiamo l’utilizzo sinergico di due metodi di raccolta e analisi dati di origine fenomenologica. _Parole chiave_: Deep Brain Stimulation; Effetti collaterali; Sintesi uomo-macchina; Fenomenologia _Deep Brain Stimulation and the human-machine synthesis: A possible phenomenological perspective_ _Abstract_: Deep Brain Stimulation (DBS) is a device included among the brain-computer interfaces and that qualifies as a promising medical solution to cope with the course of some neurodegenerative diseases such as Parikinson’s. Decades of clinical use of DBS have allowed us to understand its side effects and their impact on PIAAAS (_Personality, Identity, Agency, Authenticity, Autonomy and Self_). In this sense, to investigate psychological changes related to the use of DBS, quantitative methods, such as questionnaires focused on numerical assessments, and qualitative techniques, which are based on experiences by patients through interviews, have been used. This article aims to highlight how, regardless of the survey methods used, research has always been focused on the side effects of DBS and possible changes in the concepts included in the PIAAAS, missing the opportunity to use the numerous data collected to carry out a phenomenological analysis that could give us a description of the human-machine synthesis. To bridge this hiatus, we propose the synergistic use of two phenomenological methods of data collection and analysis. _Keywords_: Deep Brain Stimulation; Side Effects; Human-machine synthesis; Phenomenology. (shrink)

This paper reviews moral and cultural assessments which led to the definition of brain death and calls for a similar normative consensus regarding the moral recognition and legal protection of embryonal life related to criteria of brain life. This paper differentiates between cortical brain life I, i.e., the first existence of post-mitotic stationary neurons forming the early cortical plate (54th day post conception), and cortical brain life II, i.e., the beginning of cortical neuro-neuronal synapses (after the (...) 70th day p.c.). The latter are preconditional for establishing the communicative network within the cortex and with subcortical structures. The paper conservatively calls for a tentative moral consensus that could recognize brain life I, i.e., the 54th day p.c., as a stage prior to which embryo research generally would be acceptable in accordance with principles similar to those which led to the acceptance of brain death. Other developmental stages such as fertilization, nidation, viability, as well as the ‘potentiality’ principle are less significant for the moral recognition of early human life. Keywords: brain death, brain life, embryo research, embryonal tissue CiteULike Connotea Del.icio.us What's this? (shrink)

Computational neuroscientists not only employ computer models and simulations in studying brain functions. They also view the modeled nervous system itself as computing. What does it mean to say that the brain computes? And what is the utility of the ‘brain-as-computer’ assumption in studying brain functions? In previous work, I have argued that a structural conception of computation is not adequate to address these questions. Here I outline an alternative conception of computation, which I call the (...) analog-model. The term ‘analog-model’ does not mean continuous, non-discrete or non-digital. It means that the functional performance of the system simulates mathematical relations in some other system, between what is being represented. The brain-as-computer view is invoked to demonstrate that the internal cellular activity is appropriate for the pertinent information-processing task.Keywords: Computation; Computational neuroscience; Analog computers; Representation; Simulation. (shrink)

This paper reviews four current theories of brain-consciousness relations—classical Cartesian Dualism, the Identity Theory, Eliminative Materialism, and a new form of Substance Dualism that includes a modified form of the Cartesian theory. This entails a critical examination of our basic concepts of what consciousness is, of the nature of the body image, and the relation of phenomenal space to physical space. This investigation reaches the same result as that attained recently by the physicist Bernard Carr (2008)—that what is needed (...) is a paradigm shift in our basic concepts of the geometry of the Universe. In order to understand phenomenal consciousness we need to replace the present four-dimensional model with a higher-dimensional structure, in which a phenomenal space (with its contents) and physical space (with its contents) are different cross-sections (branes) of a higher-dimensional space (the bulk). Keywords: brain—consciousness—mechanisms—substance dualism—brane theory. (shrink)

The current debate regarding the suitability of anencephalics as organ donors is due primarily to misunderstandings. The anatomical and neurophysiological literature shows that the anencephalic lacks a cerebrum because of the failure of neuralplate fusion. However, even the incomplete function of an atrophic brain stem is currently accepted at law in most if not all countries as sufficient for brain life: which is to say, cessation of breathing is currently required in order to make the diagnosis of (...) class='Hi'>brain death. Because of the extensive incompleteness of the anencephalic's brain, it is not possible to postpone death significantly by mechanical ventilation and intravenous feeding. It is acceptable to maintain life for a short period of time in order to allow organ transplantation subsequent to the declaration of death at the point of cessation of the capacity for spontaneous respiration. The most important issue is not transplantation, but the issue of brain life raised by the case of anencephalics. Since brain life in any significant sense begins only after the closure of the neural tube on the 30th day after conception, it is reasonable to take this as the point at which brain life begins. Laws should be amended in all countries to allow the abortion of anencephalics at any time, in that they do not at any time possess brain life. Keywords: anencephaly, organ transplantation, beginning of life, brain death, abortion CiteULike Connotea Del.icio.us What's this? (shrink)

Background Debates and controversies have shaped the understanding and the practices related to death determined by neurological criterion . Confusion about DNC in the public domain could undermine this notion. This confusion could further jeopardise confidence in rigorous death determination procedures, and raise questions about the integrity, sustainability, and legitimacy of modern organ donation practices.Objective We examined the depictions of ‘brain death’ in major American and Canadian print media to gain insights into possible common sources of confusion about DNC (...) and the relationship between expert and lay views on this crucial concept.Methods We gathered 940 articles, available in electronic databases, published between 2005 and 2009 from high-circulation Canadian and American newspapers containing keywords ‘brain dead’ or ‘brain death’. Articles were systematically examined for content using the NVivo 8 software.Results Our results showed problematic aspects in American and Canadian media, with some salient differences. DNC was used colloquially in 39% of the articles and its medical meaning infrequently defined . The neurological criterion for determination of death was mentioned in less than 10% of the articles, and life support in about 20% of the articles. Organ donation issues related to DNC were raised more often in Canadian articles than in American articles .Interpretation Further discussion is needed to develop innovative strategies to bridge media representations of DNC with experts’ views in connection with organ donation practices. (shrink)

Definition of the problem:Truog’s critique of the ”brain death” concept outlines inconsistencies well understood in the U.S. ethical debate, while he is one of the first to suggest returning to the traditional, coherent concept of death, thus breaking with the ”dead-donorrule.” The German transplantation law of 1996 endorses equating ”brain death” with death. A defeated draft, however, had acknowledged that irreversible total brain failure is a death-near state with a zero prognosis; organ harvesting, then, was to be (...) allowed only in case of prior personal consent. The politically effective objection against this concept was its admitted violation of the dead-donorrule and thus its (incorrectly) alleged precedent potential for legalising active euthanasia. Truog’s suggestion to justify organ explantation on the grounds of ”consent and nonmaleficence” would have fuelled German counter-critics had they known it. The problem is how to justify organ harvesting after breaking the dead-donorrule. Arguments: With the allegation that ”imminent death” and ”irreversible coma” allow concluding that there is ”no harm,” Truog ironically returns to the weak arguments traditionally used to support the ”brain death” concept. His suggestion opens the door to a wide array of eligible organ donors (and, indeed, to a precedential case for active euthanasia). The euphemistic tradition of the ”brain death” concept, perhaps a prominent reason for public scepticism towards transplantation, will be perpetuated unless it is acknowledged that the interference of organ explantation with the donor’s dying process does as such constitute ”harm” to this individual. Organ harvesting, then, requires prior personal consent and needs to be clearly differentiable from any act of ”killing” if it is to be compatible with the law, acceptable to surgeons and not a precedent for active euthanasia. A close look at the actual procedure reveals that consent has invariably the effect of prolonging, not shortening the factual life span of the person in whom irreversible total brain failure has been diagnosed. This peculiarity distinguishes organ explantation from all other forms of terminating a person’s life and is not congruent with the ethical and legal notion of ”killing”. Conclusion: Breaking the dead-donorrule by allowing for the donor to give prior personal consent to organ explantation as a procedure that is going to interfere with his or her dying can be justified, informed consent provided, without setting foot on a slippery slope. (shrink)

: This paper uses Extended Mind Theory to explore Brain-Computer Interfaces, demonstrating how this conceptual framework provides a wide-ranging interpretation of the potential integration of user and computer. After a preliminary analysis of first- and second-wave EMT arguments and other pragmatic criteria, I present BCI technology, addressing the issues that arise. Can BCIs extend our mental processes and to what degree? What EMT criteria should be applied to this technology? What is the role of the body in the process (...) of integrating user and computer? What are current limits to complete cognitive and bodily extension by BCIs? In line with this discussion, I suggest a pluralist approach to BCIs, allowing for specific and appropriate application of the various models and paradigms. I also advocate greater focus on the integration of body and tool, primarily for clinical purposes, but also for applications that will meet daily needs in the future. Keywords : Extended Mind; Brain-Computer Interface; Embodiment; Parity Principle; Cognitive Artefacts. Mente estesa e brain-computer interface. Un approccio pluralista all’integrazione uomo-macchina Riassunto: Il presente articolo fa uso della Extended Mind Theory per indagare le Brain-Computer Interfaces, dimostrando che questo framework concettuale offre un’interpretazione ad ampio raggio della potenziale integrazione tra utente e computer. Dopo un’analisi preliminare degli argomenti della EMT di prima e seconda generazione e altri criteri pragmatici, presenterò la tecnologia delle BCIs, affrontando alcune questioni a essa collegate. Le BCIs possono estendere i nostri processi mentali e fino a che punto? Quali criteri della EMT dovrebbero essere applicati a questa tecnologia? Qual è il ruolo del corpo nel processo di integrazione utente-computer? Quali sono gli attuali limiti per completare l’estensione cognitiva e corporea da parte delle BCIs? In linea con questa discussione, suggerirò un approccio pluralistico alle BCIs che permetta un’applicazione specifica e appropriata dei vari modelli e paradigmi. Sosterrò inoltre la necessità di una maggiore attenzione all’integrazione tra corpo e strumento, principalmente per scopi clinici ma anche per applicazioni future che soddisfino le esigenze quotidiane. Parole chiave: Mente estesa; Brain-Computer Interface ; Incorporamento; Principio di Parità; Artefatti cognitivi. (shrink)

To explain consciousness as a physical process we must acknowledge the role energy plays in the brain. Energetic activity is fundamental to all physical processes and causally drives biological behaviour. Recent neuroscientific evidence can be interpreted in a way that suggests consciousness is a product of the organization of energetic activity in the brain. The nature of energy itself, though, remains largely mysterious, and we do not fully understand how it contributes to brain function or consciousness. According (...) to the prin-ciple outlined here, energy, along with forces and work, can be described in terms of actu-alized differences of motion and tension. By observing physical systems, we can infer there is something it is like to undergo states of actualized difference from the intrinsic perspective of the system. Consciousness occurs because there is something it is like, in-trinsically, to undergo a certain organization of actualized differences in the brain. (shrink)

The “colored-brain thesis”, or strong qualitative physicalism, is discussed from historical and philosophical perspectives. This thesis was proposed by Thomas Case, in a non-materialistic context, and is close to views explored by H. H. Price and E. Boring. Using Mary’s room thought experiment, one can argue that physicalism implies qualitative physicalism. Qualitative physicalism involves three basic statements: perceptual internalism, and realism of qualia; ontic physicalism, charaterized as a description in space, time, and scale; and mind-brain identity thesis. In (...) addition, structuralism in physics, and distinguishing the present version from that suggested by H. Feigl and S. Pepper, realism of the physical description. The “neurosurgeon argument” is presented, as to why the greenness of a visually perceived avocado, which is present in the brain as a physical-chemical attribute, would not be seen as green by a neurosurgeon who opens the observer’s skull. This conception is compared with two close views, Russellian monisms and panprotopsychism. According to the strong qualitative physicalism presented here, the phenomenal experience of a quale q is identical to a physico-chemical quality q, which arises from a combination of the materiality wassociated with the brain, and the causal organization or structure of the relevant elements of the brain S, including in this organization the structure of the self: q. The “explanatory gap” between mental and physical states is shifted to a gap between the physico-chemical qualities q and the organized materiality of a specific brain region q, and is seen as being bridged only by a set of non-explanatory postulates. Keywords: Colored-brain thesis, qualitative physicalism, mind-brain identity thesis, qualia, panprotopsychism, sensorium. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.3 (2002) 261-264 [Access article in PDF] Mind, Meaning, and the Brain Thomas Fuchs, MD, PhD Keywords: Mind, brain, meaning, translation, depression. A Systemic View of the Mind Progress in brain research over the past two decades demonstrates the power of the neurobiological paradigm. However, this progress is connected with a restricted field of vision typical of any scientific paradigm. The (...) psychiatrist should be aware of this restriction, because, unlike the brain scientist, he deals with patients, not with brains. The restricted view may be described by the terms of (1) reductionism, (2) reification, and (3) isolation.Reductionism: Neurobiology tends to regard subjectivity as a mere by-product of the brain's activity as a symbol-manipulating machine or an information processor. Consciousness becomes an epiphenomon of the neuronal machinery that, operating behind our back, creates the illusion of a continuous self and of an autonomous will (Churchland 1995; Roth 1996).Reification: Mental or subjective states seem to be localizable in the brain; thoughts or feelings, it appears, may be observed in the colored illumination of cortical and subcortical structures. This results in the belief that brain images could also show the cause of a mental illness, or even the illness itself, which then manifests, for instance, in a reduced metabolic activity in certain areas of the cortex.Isolation: As a further consequence, this view isolates the individual patient and considers his illness separated from the interconnections with his environment. However, on these interconnections his personal experiences and dispositions are founded, and it is the actual interpersonal situation that has triggered his present illness.Walter Glannon's paper successfully counters these tendencies toward a neurobiological reductionism with an extended view of the mind: "... the mind is not located in any one place but is distributed among the brain, the body, and the environment." Of course, who observes someone's brain will never see his thoughts, his pain, or his anxiety. For consciousness is not a localizable object or state at all but a process of relating to something: a perceiving of, remembering of, wishing for, aiming at, and so on. Thus on the phenomenological level, there is nothing like a "mental event" that could be isolated from the world and from the stream of conscious experiences. The mind exists only embedded in the world and in the temporal process of life.The same applies to the biological level: Consciousness is based on the continuous interaction of the brain with the organism, and of the organism as a whole with the environment. The role of the brain for mental phenomena is thus comparable to the role of the heart in the circulatory system or of the lung in the respiratory system. Of course, the lung is the central organ of breathing, but respiration may not be restricted to the [End Page 261] lung, nor to the organism as a whole. It means constant exchange with the environment, and there is no sense in asking whether the air taken in still belongs to the surroundings or already to the organism. The same systemic unity is found in the circle of perception and action mediated by the brain: When I am writing a letter, there is no place in the unity of action where my "self" ends and the "world" begins, no border that separates inner and outer worlds.There is another argument to be raised against the reification of the mind if we consider the aspect of a historical biology. From birth on, our mind as well as the correlated brain structures are essentially formed by social and cultural influences. The brain is not inserted into the world as a prefabricated apparatus but through its plastic development in and from the world. Thus it adapts epigenetically to its specific natural and social environment like a key to a lock. This complementarity makes it impossible to restrict one's view to the anatomic organ and requires an interdisciplinary approach to brain-environment investigation, as for example, under the heading of a "social cognitive neuroscience" (Ochsner and Lieberman 2001).As Glannon goes on to argue, to overcome... (shrink)

The whole brain-death criterion of death now enjoys a wide acceptance both within the medical profession and among the general public. That acceptance is in large part the product of the contention that brain death is the proper criterion for even a conservative definition of death – the irreversible loss of the integrated functioning of the organism as a whole. This claim – most recently made in the report of the Presidential Commission and in a comprehensive article by (...) James Bernat and others – is based upon a series of fallacious arguments. Chief among these is the argument that whole brain-death is the proper criterion for the conservative definition because the brain is the organ that integrates the rest of the organism. A central part of the paper shows that this argument rests upon a confusion between a function and the mechanism that performs it, and replies to the defenses that the Presidential Commission makes on this point. The concluding portion of the paper argues that this issue is not merely of academic interest, but has the potential for undermining the present consensus that supports the use of whole brain-death criteria. * Keywords: brain-death, definition of death, determination of death * I would like to thank Howard Brody and Bruce Miller for helpful suggestions and criticisms. CiteULike Connotea Del.icio.us What's this? (shrink)

Background: By organizing and activating our passions with both hormones and experiences, the heart and mind of sexual behavior, sexual motivation, and sexual preference is the brain, the organ of learning. Despite decades of progress, this incontrovertible truth is somehow lost in the far-too-often biologically deterministic interpretation of genetic, hormonal, and anatomical scientific research into the biological origins of sexual motivation. Simplistic and polarized arguments are used in the media by both sides of the seemingly endless debate over sexual (...) orientation, equality, and human rights with such catch phrases as ‘‘born gay’’ contrasted against attempts of ‘‘reparative therapy’’ or ‘‘pray the gay away’’. Though long abandoned in practically every other area of psychology, this remnant of the nature-nurture controversy remains despite its generally acknowledged insufficiency in explaining any adult aspect of the human condition within the scientific community. Methods: This theoretical review article identifies three factors: 1) good intentions with regard to the argument from immutability; 2) false dichotomies limiting intellectual progress by oversimplification of theory and thus hypothesis, and most dangerously, interpretation and; 3) Tradition: a historical separation of the disciplines of biology and psychology, which, to this day, interferes with the effective translation of well-conducted science into good public understanding and policy. Results: Studies clearly demonstrate that progress toward sexual-orientation equality is being made, if slowly, despite the apparent irrelevance of the ‘‘born gay’’ argument from immutability. Evidence is further provided supporting the inadequacy of polarized, dichotic theories of sexual development, particularly those pitting ‘‘blank slate learning’’ against a fated, deterministic biological perspective. Results of this review suggest that an emerging interactionist perspective will promote both better scientific progress and better public understanding, hopefully contributing to progress toward nondiscriminatory public policy. Conclusion: Accepting that the brain is a highly plastic, modularly dimorphic, developmentally biased organ of learning, one which is organized and activated by both hormones and experiences across the lifespan, is essential for doing ‘‘good science’’ well. Interactionist theories of psychosexual development provide an empirically sound, strong, yet modifiable foundation for testable hypotheses exploring biologically biased sexual learning. Keywords: Brain; conditioning; controversy; dichotomy; differentiation; discrimination; equality; sex; sexual; orientation; learning; learned sexuality; born gay; hedonic evaluation; immutability; imprinting; incentive motivation; interactionism; predispositions; theory; therapy (Published: 15 March 2012) Citation: Socioaffective Neuroscience & Psychology 2012, 2 : 17334 - DOI: 10.3402/snp.v2i0.17334. (shrink)

: Moral cognition research has in part been taken to be a problem for moral sentimentalists, who claim that emotions are sensitive to moral information. In particular, Joshua Greene can be understood to provide an argument against moral sentimentalism on the basis of neuropsychological evidence. In his argument he claims that emotions are an unreliable source of moral insight. However, the argument boils down to circular claims: Rationalistic factors are assumed to be the only morally relevant factors; Emotions are not (...) sensitive to these factors; Thus, Moral Sentimentalism is false, because only rationalistic factors are justified. While this circularity makes so-called sourcing-arguments fallacious if applied against moral sentimentalism, moral cognition research has much to contribute. Indeed, moral cognition research will be instrumental for clarifying the sentimentalist position, shedding light on the mental mechanics underlying emotional moral processing. After all, evidence from moral cognition points to substantial involvement of affective processes in human moral cognizing and their embodied nature; thus, challenging long held beliefs about morality. Keywords : Moral Cognition; Moral Sentimentalism; Emotions; Embodied Cognition; Moral Brain Emozioni, Esperimenti e il cervello morale. L’errore degli argomenti basati sulla cognizione morale contro il sentimentalismo morale Riassunto: Si è spesso ritenuto che la ricerca nell’ambito della cognizione morale costituisse, almeno in parte, un problema per il sentimentalismo morale, il quale sostiene che le emozioni sono sensibili all’informazione morale. In particolare, si può pensare che Joshua Greene abbia portato un argomento contro il sentimentalismo morale basato su evidenza neuropsicologica. Secondo il suo argomento le emozioni non costituiscono una fonte affidabile di comprensione morale. E tuttavia questo argomento fa leva su una circolarità: gli unici fattori qualificati come moralmente rilevanti sono quelli razionali; le emozioni non sono sensibili a questi fattori; pertanto, considerato che solo i fattori razionali sono giustificati, il sentimentalismo morale è falso. Tale circolarità rende fallaci i cosiddetti argomenti sorgente, laddove questi siano applicati al sentimentalismo morale. Al contempo, la ricerca sulla cognizione morale ha molto da dire su questo argomento perché può contribuire a chiarire la posizione sentimentalista, gettando luce sulla meccanica mentale sottostante i processi morali che fanno leva su emozioni. Anzi questa prospettiva di ricerca evidenzia che i processi di carattere affettivo sono coinvolti in maniera sostanziale nella cognizione morale umana e hanno una natura incarnata; in questo modo essa mette in discussione convinzioni di vecchia data sulla morale. Parole chiave : Cognizione morale; Sentimentalismo morale; Emozioni; Cognizione incarnata; Cervello morale. (shrink)

ABSTRACT: Simon Baron-Cohen has argued that autism and related developmental disorders (sometimes called “autism spectrum conditions” or “autism spectrum disorders”) can be usefully thought of as the condition of possessing an “extreme male brain.” The impetus for regarding autism spectrum disorders (ASD) this way has been the accepted science regarding the etiology of autism, as developed over that past several decades. Three important features of this etiology ground the Extreme Male Brain theory. First, ASD is disproportionately male (approximately (...) 10:1 in the case of Asperger’s Syndrome or high-functioning autism (HFA) and approximately 4:1 in the case of autistic disorder). Second, ASD is not psychogenic but biological in origin, and hence is not the product of sexist conditioning or childrearing practices, although these may affect the development of the disorder. Third, ASD is regarded as a spectrum developmental disorder, unlike other disorders such as Down Syndrome that are diagnosed by a (nearly) binary criterion. Down Syndrome, for example, is diagnosed by the presence in all or most cells within a given individual of an extra copy of Chromosome 21. Autism, on the other hand, is diagnosed by the presence of a set of symptoms that vary in their intensity and in their milder forms seem to conform to purported sex differences in cognitive, emotional, and social functioning. -/- In this paper, I do not challenge accepted science regarding the etiology of autism, and I do not challenge the idea of ASD as a disorder. Nor do I wish to offer an alternative account of what autism is. Instead, I focus on the usefulness of thinking of a disorder as an extreme version of ordinary sex differences. Does it follow from the fact that a disorder is more often found in men that we should think of it as an extreme form of maleness? If not, what other conditions must be met in order to warrant this way of thinking about ASD? What does it mean to say that ASD is a form of “extreme male brain”? Feminists are rightly skeptical of theories that make claims about male and female brains, so how should we respond to the clear evidence that the differences between typical and ASD individuals are not caused by childrearing practices? I explain what I take to be Baron-Cohen’s central argument that autism should be seen as the extreme male brain, and critique that argument. I conclude that there is no good argument that autistic symptoms should be regarded as an extreme form of male mental traits, and that Baron-Cohen’s claim does not help us to understand autism, women, or men. His claim is a speculative thesis that is readily mobilized for sexist practices. As such it requires a higher threshold for evidentiary support and rigorous argumentation—support and argumentation that does not exist. -/- KEYWORDS: autism, brain, gender, neuroscience, feminism, male . (shrink)

: This paper investigates epistemological differences in the cognitive neuroscientific and phenomenological approaches to outstanding questions in psychiatry. We argue that clinical neuroscience provides scientific explanation in line with a mechanistic approach and describe several examples from computational approaches that illustrate what research on neural processing can tell us about psychiatric diseases. By contrast, phenomenology offers complex descriptions of experiential phenomena. Through a discussion of executive function and the related construct of impulsivity, we show that both cognitive neuroscience and phenomenology (...) provide valuable types of explanation. Our focus on psychopathology also allows us to address some important epistemic differences between these two disciplines. Keywords: Phenomenology; Consciousness; Clinical Neuroscience; Computational Neuroscience; Cognitive Mechanisms Coscienza e meccanismi cerebrali: ricerche epistemologiche tra fenomenologia e neuroscienza clinica Riassunto: Il presente lavoro propone di esaminare le differenze epistemologiche tra la fenomenologia e le neuroscienze cognitive riguardo dibattiti psichiatrici. Le neuroscienze cliniche saranno discusse in linea con un approccio meccanicista della spiegazione scientifica, mentre descrizioni fenomenologiche saranno proposte nel momento in cui complessi fenomeni esperenziali dovranno essere indagati. Un’interpretazione meccanicista delle neuroscienze cognitive sarà esemplificata ricorrendo ad alcuni esempi dagli approcci computazionali che si occupano di questi temi, i quali ci aiuteranno a definire cosa le ricerche sui processi neurali ci stanno dicendo rispetto alle sintomatologie psichiatriche. Questi argomenti saranno sviluppati attraverso una discussione che verterà sulle funzioni esecutive e il costrutto di impulsività a esse legato. Sarà discusso come sia le neuroscienze cognitive sia la fenomenologia possano fornire specifiche forme di spiegazione. Allo stesso tempo, si proporrà un’argomentazione che consentirà di discernere differenze epistemiche che caratterizzano i suddetti approcci, le quali potranno con più facilità emergere nel dibattito psichiatrico. Parole chiave : Fenomenologia; Coscienza; Neuroscienza clinica; Neuroscienza computazionale; Meccanismi cognitivi. (shrink)

I argue that of the four kinds of quantitative description relevant for understanding brain function, a control theoretic approach is most appealing. This argument proceeds by comparing computational, dynamical, statistical and control theoretic approaches, and identifying criteria for a good description of brain function. These criteria include providing useful decompositions, simple state mappings, and the ability to account for variability. The criteria are justified by their importance in providing unified accounts of multi-level mechanisms that support intervention. Evaluation of (...) the four kinds of description with respect to these criteria supports the claim that control theoretic characterizations of brain function are the kind of quantitative description we ought to provide.Keywords: Neural computation; Control theory; Neural representation; Cognitive architecture; Cognitive models; Theoretical neuroscience. (shrink)

This paper is based on the hypothesis that the effort to establish new criteria for diagnosing human death, which has been taking place over the past twenty years or more, can be viewed as a paradigm case for the impact of scientific and technological progress on morality. This impact takes the form of three tendencies within the change in morality, which may be characterized as ‘denaturalization’, ‘functionalization’ and ‘homogenization’. The paper concludes with the view that these tendencies do not indicate (...) a decline of morality, as feared by some authors, but rather a structural change. Keywords: bioethics (Institutionalization and Professionalization of), brain death, brain life, moral reflexivity, organ transplantation CiteULike Connotea Del.icio.us What's this? (shrink)

The social brain hypothesis implies that humans and other primates evolved “modules“ for representing social knowledge. Alternatively, no such cognitive specializations are needed because social knowledge is already present in the world — we can simply monitor the dynamics of social interactions. Given the latter idea, what mechanism could account for coalition formation? We propose that statistical learning can provide a mechanism for fast and implicit learning of social signals. Using human participants, we compared learning of social signals with (...) arbitrary signals. We found that learning of social signals was no better than learning of arbitrary signals. While coupling faces and voices led to parallel learning, the same was true for arbitrary shapes and sounds. However, coupling versus uncoupling social signals with arbitrary signals revealed that faces and voices are treated with perceptual priority. Overall, our data suggest that statistical learning is a viable domain-general mechanism for learning social group structure. Keywords: social brain; embodied cognition; distributed cognition; situated cognition; multisensory; audiovisual speech; crossmodal; multimodal. (shrink)

The social brain hypothesis implies that humans and other primates evolved “modules” for representing social knowledge. Alternatively, no such cognitive specializations are needed because social knowledge is already present in the world — we can simply monitor the dynamics of social interactions. Given the latter idea, what mechanism could account for coalition formation? We propose that statistical learning can provide a mechanism for fast and implicit learning of social signals. Using human participants, we compared learning of social signals with (...) arbitrary signals. We found that learning of social signals was no better than learning of arbitrary signals. While coupling faces and voices led to parallel learning, the same was true for arbitrary shapes and sounds. However, coupling versus uncoupling social signals with arbitrary signals revealed that faces and voices are treated with perceptual priority. Overall, our data suggest that statistical learning is a viable domain-general mechanism for learning social group structure. Keywords: social brain; embodied cognition; distributed cognition; situated cognition; multisensory; audiovisual speech; crossmodal; multimodal. (shrink)

BackgroundExercise is increasingly recognized as a key component of Parkinson’s disease treatment strategies, but the underlying mechanism of how exercise affects PD is not yet fully understood.ObjectiveThe activation likelihood estimation method is used to study the mechanism of exercise affecting PD, providing a theoretical basis for studying exercise and PD, and promoting the health of patients with PD.MethodsRelevant keywords were searched on the PubMed, Cochrane Library, and Web of Science databases. Seven articles were finally included according to the screening (...) criteria, with a total sample size of 97 individuals. Using the GingerALE 3.0.2 software, an ALE meta-analysis was performed using seven studies that met the requirements, and the probability of the cross-experiment activation of each voxel was calculated.ResultsThe meta-analysis produced seven clusters, and major activations were found in the cerebellum, occipital lobe, parietal lobe, and frontal lobe brain regions.ConclusionExercise for PD mainly results in the enhanced activation of the cerebellum, occipital lobe, parietal lobe, and frontal lobe. Exercise for PD does not cause a change in the activation of a single brain area, and the observed improvement may result from coordinated changes in multiple brain areas. (shrink)

This study discusses the mind-body problem, arguing that the human person is best understood as an animal who is also spirit. Braine suggests that human beings should be described holistically, in the tradition of Aristotle and Thomas Aquinas. His final chapter explores a doctrine of immortality.

Robert Brain traces the origins of artistic modernism to specific technologies of perception developed in late-nineteenth-century laboratories. Brain argues that the thriving fin-de-siècle field of “physiological aesthetics,” which sought physiological explanations for the capacity to appreciate beauty and art, changed the way poets, artists, and musicians worked and brought a dramatic transformation to the idea of art itself.

For more than two thousand years, almost all doctors in the West used bloodletting to treat a great variety of diseases and conditions. In an attempt to find out why they acted thus, Dr Brain has translated the three works on bloodletting by the second-century physician Galen, which provide by far the most comprehensive account of the practice in antiquity. This is the first published version of these works in a modern language. After a brief summary of Galen's medical (...) system, the author goes on to consider the origins of Galen's ideas and methods, with particular reference to the Hippocratic writings, and the question why Galen, in common with most of the ancient physicians, believed in the efficacy of the comedy. The effects of bloodletting are considered in terms of modem physiology and medicine, and the possibility is explored that it may indeed have been beneficial in the conditions prevailing in Galen's time. (shrink)

Galatea, or the Future of Darwinism W Russell Brain Originally published in 1927 "A brilliant exposition…of the evolutionary hypothesis." The Guardian "Should prove invaluable…" Literary Guide This non-technical but closely-reasoned book is a challenge to the orthodox teaching on evolution known as Neo-Darwinism. The author claims that although Neo-Darwinian theories can possibly account for the evolution of forms, they are quite inadequate to explain the evolution of functions. 88pp ************** Daedalus or Science and the Future J B S Haldane (...) Originally published in 1924. "The essay is brilliant. Sparkling with wit and bristling with challenges." British Medical Journal "Predicts the most startling changes." Morning Post This volume examines the future of scientific research from religious, philosophical social and economic standpoints. 94pp Automaton, or the Future of Mechanical Man H Stafford Hatfield Originally published in 1928 "It is impossible to do justice to his volume in a brief review…"Daily Herald At the time of original publication mankind’s chief inventions had been extensions of his senses or limbs. This work prophesies the dawn of an era in which substitutes will gradually be found even for the human brain. 96pp Gallio or the Tyranny of Science J W N Sullivan Originally published in 1927 "So packed with ideas it is not possible to give any adequate résumé of its contents." Times Literary Supplement "Remarkable monograph…devastating summary of materialism…" Spectator An attack on the values which science is so successfully imposing upon civilization. 90pp. (shrink)