‘Neuroeconomics’ can be broadly defined as the research of how the brain interacts with the environment to make decisions that are functional given individual and contextual constraints. Deciphering such brain-environment transactions requires mechanistic understandings of the neurobiological processes that implement value-dependent decision making. To this end, a common empirical approach is to investigate neural mechanisms of reward-based decision making. Flexible updating of choices and associated expected outcomes in ways that are adaptive for a given task (or a given set of (...) tasks) at hand relies on dynamic neurochemical tuning of the brain’s functional circuitries involved in the representation of tasks, goals and reward prediction. Empirical evidence as well as computational theories indicate that various neurotransmitter systems (e.g., dopamine, norepinephrine, and serotonin) play important roles in reward-based decision making. In light of the apparent aging-related decline in various aspects of the dopaminergic system as well as the effects of neuromodulation on reward-related processes, this article focuses selectively on the literature that highlights the triadic relations between dopaminergic modulation, reward-based decision making, and aging. Directions for future research on aging and neuroeconomoics are discussed. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral (...) NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

The article is a review of Hauke Brunkhorst’s book on a _Critical Theory of Legal Revolutions_. The author addresses three points: Hauke Brunkhorst’s notion of history, and of what remains unseen; the dialectics of evolution and revolution, and whether the approach is sufficiently dialectic, according to its own promise; and the implicit notion of critique.

The psychological writing of Jung and the post-Jungians is all too often ignored as anachronistic, archaic and mystic. In Jung and the Postmodern, Christopher Hauke challenges this, arguing that Jungian psychology is more relevant now than ever before - not only can it be a response to modernity, but it can offer a critique of modernity and Enlightenment values which brings it in line with the postmodern critique of contemporary culture. After introducing Jungians to postmodern themes in Jameson, Baudrillard, (...) Jencks and Foucault, the author introduces postmodernists to Jung's cultural critique and post-Jungian discussions of representation, individuation, consciousness, and the alternatives to Enlightenment rationality. He also takes a totally fresh approach to topics such as hysteria and the body, Jung and Nietzsche, architecture and affect, Princess Diana and the 'death' of the subject, postmodern science and synchronicity, and to psychosis and alternative 'rationalities'. Jung and the Postmodern is vital reading for everyone interested in contemporary culture, not only Jungians and other psychotherapists who want to explore the social relevance of their discipline, but anyone who shares a assionate concern for where we are heading in postmodern times. (shrink)

Reason and Value collects 15 new papers by leading contemporary philosophers on themes from the work of Joseph Raz. Raz has made major contributions in a wide range of areas, including jurisprudence, political philosophy, and the theory of practical reason; but all of his work displays a deep engagement with central themes in moral philosophy. The subtlety and power of Raz's reflections on ethical topics make his writings a fertile source for anyone working in this area. Especially significant are his (...) explorations of the connections between practical reason and the theory of value, which constitute a sustained and penetrating treatment of a set of issues at the very center of moral philosophy as it is practiced today. The contributors to the volume acknowledge the importance of Raz's contributions by engaging critically with his positions and offering independent perspectives on the topics that he has addressed. The volume aims both to honour Raz's accomplishments in the area of ethical theorizing, and to contribute to an enhanced appreciation of the significance of his work for the subject. (shrink)

The Nature of God explores a perennial problem in the philosophy of religion.

Cartesian separation and enlightenment have led to a widespread conceptual separation of science and technology. Consequently a certain philosophical tradition holds pure science as a metaphysical striving for irrefutable truth that is morally neutral and only ( dirty?) applications as morally accountable. An opposite extreme position holds scientists responsible for everything that is done with their discoveries. Based on an interpretation of science to be a social construct and the observation that moral criteria are the results of social processes the (...) paper demonstrates by the example of synthetic chemistry that science is not an elite end in itself and as such is not free from obligation to moral criteria. The moral responsibility of a scientist, which arises from his professional expertise, is limited to the available knowledge of his discipline. The moral responsibility, which he carries beyond that as responsible acting human, derives from the cultural identity and the normative values under which his action is carried out. This conclusion is illustrated by the examples of DDT, Aspirin and Heroin. (shrink)

Performing and listening to music occurs in specific situations, requiring specific media. Empirical research on music listening and appreciation, however, tends to overlook the effects these situations and media may have on the listening experience. This article uses the sociological concept of the frame to develop a theory of an aesthetic experience with music as the result of encountering sound/music in the context of a specific situation. By presenting a transdisciplinary sub-field of empirical studies, we unfold this theory for one (...) such frame: the classical concert. After sketching out the underlying theoretical framework, a selective literature review is conducted to look for evidence on the general plausibility of the single elements of this emerging theory and to identify desiderata. We refer to common criticisms of the standard classical concert, and how new concert formats try to overcome alleged shortcomings and detrimental effects. Finally, an empirical research program is proposed, in which frames and frame components are experimentally manipulated and compared to establish their respective affordances and effects on the musical experience. Such a research program will provide empirical evidence to tackle a question that is still open to debate, i.e., whether the diversified world of modern-day music listening formats also holds a place for the classical concert – and if so, for what kind of classical concert. (shrink)

Wie lässt sich der Bereich des Privaten heute genau beschreiben? Welchen Wert besitzt Privatheit in digitalisierten Gesellschaften für den Einzelnen und die Gesellschaft als Ganzes? Welche Werte und Lebensformen werden durch Privatheit geschützt, welche eingeschränkt? Entstehen durch die Informationsasymmetrie zwischen Technologieunternehmen, staatlichen Verdatungsinstitutionen und Verbrauchern/Bürgern möglicherweise neue Machtstrukturen? Welche rechtlichen Implikationen ergeben sich hieraus? Dieser Band geht diesen und anderen Fragen, die sich im Hinblick auf die etablierte Gleichung von Freiheit und Privatheit stellen, nach und versucht Antworten zu finden.

Despite All Critique (2014) -- World Politics and Western Reason (1980) -- The Doubled Outsides of the Modern International (2005) -- The Subject of Security (1995) -- The Protection of Nature and the Nature of Protection (2005) -- Social Movements/World Politics (1994) -- Europe is Not Where It is Supposed to Be (2000) -- They Seek it Here, They Seek it There : Looking for Politics in Clayoquot Sound (2003) -- Violence, Modernity, Silence : From Weber to International Relations (1993) (...) -- Hobbes, Origins, Limits (2011) -- War, Terror, Judgement (2002) -- International, Imperial, Exceptional (2005) -- Which Democracy for Which Demos? (2013) -- The Political Theory of Boundaries and the Boundaries of Political Theory : Interview With Raia Prokhovnik (2012). (shrink)

ABSTRACT: This paper presents a discourse analysis of 40 semi-structured interviews with scientists on their views of Occam's razor and simplicity. It finds that there are many different interpretations and thoughts about the precise meaning of the principle as well as many scientists who reject it outright, or only a very limited version. In light of the variation of scientists' opinions, the paper looks at the discursive uses of simplicity in scientists' thinking and how scientists' interpretations of Occam's razor impact (...) on philosophy's representation of the principle and affects the communication between philosophy and science. (shrink)

ABSTRACT: This paper presents a discourse analysis of 40 semi-structured interviews with scientists on their views of Occam's razor and simplicity. It finds that there are many different interpretations and thoughts about the precise meaning of the principle as well as many scientists who reject it outright, or only a very limited version. In light of the variation of scientists' opinions, the paper looks at the discursive uses of simplicity in scientists' thinking and how scientists' interpretations of Occam's razor impact (...) on philosophy's representation of the principle and affects the communication between philosophy and science. (shrink)

It is the purpose of this paper to address ethical issues concerning the development and application of Assistive Technology at Workplaces (ATW). We shall give a concrete technical concept how such technology might be constructed and propose eight technical functions it should adopt in order to serve its purpose. Then, we discuss the normative questions why one should use ATW, and by what means. We argue that ATW is good to the extent that it ensures social inclusion and consider four (...) normative domains in which its worth might consists in. In addition, we insist that ATW must satisfy two requirements of good workplaces, which we specify as (a) an exploitation restraint and (b) a duty of care. (shrink)

This paper asks how ‚image‘ and ‚imagination‘ relate to each other. The first part deals with important aspects such as ‚visuality‘, ‚reference‘, ‚order‘, ‚mediation‘ and ‚constructivity‘. The connection between ‚image‘ and ‚imagination‘ is then explored in texts on metaphysics and aesthetics by Christian Gottfried Bardili and Wilhelm Traugott Krug. With his ‚Law of Complementation‘, Bardili offers a solution to the problem of the mediation of the senses and the intellect. For Krug, ‚image‘ is a modality in which imagination in the (...) field of art proceeds with the aim of creating order and unity in diversity. (shrink)

The purpose of this paper is to defend an understanding of social participation that spells out inclusion as a dispositional property. I assume that an agent must occupy at least one position within a social order so that he is leastways partially included. The fact that a social position is open to someone means that he has the opportunity to take it. However, disputed is how "having the opportunity" should be understood exactly. My thesis, which I will develop and defend (...) in the context of this article, is: Since the appropriate application context decides whether the role characteristics of an agent actually become manifest, participation is a dispositional property. Therefore, a role is not open to someone only if he cannot claim a certain status for himself, even though he is in the relevant context. It is thus not a logical or metaphysical modality, but a normative modality that is relevant in terms of the openness of a role. Hence, social participation consists in a normative status that takes effect when certain conditions occure. (shrink)

How do we access the authentic self in order to live fulfilling, meaningful lives? In straightforward terms, The Heart of the Matter: Gifts in Strange Wrapping Paper explains a simple but extraordinarily powerful technique called the See, Feel, Hear Challenge that enables people to easily gain entry into the storehouse of their subconscious core beliefs. In the process, it cracks the coded messages that those beliefs release in the form of disease, suffering, addictions, unhappy relationships, and victimized circumstances. Based in (...) the latest findings in neuroscience and neurocardiology, this book guides readers to an uncomplicated understanding of the astounding power of our emotions and how life automatically delivers experiences that trigger negative reactions that subconsciously impact us. These emotions form the foundation of core beliefs that create unhealthy attitudes and dis-ease patterns that keep us from experiencing the authentic, satisfying lives we desire. Using clear examples and true stories from clients, Dr. Weissman’s latest work demonstrates how we can release these stored emotions and their wisdom via the See, Feel, Hear Challenge. It then explains how to use this simple method to evoke feelings that positively impact the quantum field, remolding our bodies, minds, and everyday lives into purposeful expressions of inner joy and radiant well-being. Whether you’re dealing with addictions, dysfunctional relationships, or illness, or are focused on becoming an Olympic champion, The Heart of the Matter gives you a potent tool for positive change and transformation that you can use for the rest of your life. (shrink)

The paper starts with a thesis on the dialectical structure of modern law that goes back the European revolutionary tradition and constitutes a legal structure that is at once emancipatory and repressive. Once it became democratic the modern nation states has solved more or less successfully the crises that emerged in modern Europe since the 16th Century. Yet, this state did not escape the dialectical snares of modern law and modern legal regimes. It’s greatest advance, the exclusion of inequalities presupposed (...) the exclusion of the internal other of blacks, workers, women etc, and the other that stemmed from the non-European world that furthermore was under European colonial rule or other forms of European, Northamerican and Japanese imperial control. Yet, the wars and revolutions of the 20th Century let to a complete reconstruction, new foundation and globalization of all national and international law. The evolutionary advance of the 20th Century was the emergence of world law, and this enabled the construction of international and national welfarism and the global expansion of the exclusion of inequalities. Nevertheless the dialectic of enlightenment came back again and led to new forms of postnational domination, hegemony, oppression and exclusion. The final section tries to detect some ideas and principles how to overcome the crisis. (shrink)

Most scholars dealing with neo-Kantianism emphasize the existence of an explicit origin that characterizes neo-Kantianism as a clearly defined ‘movement’ with certain objects. In spite of the fact that differences between various neo-Kantian authors are mentioned in the current discourse (e. g. ‘Südwestdeutsche’ and ‘Marburger Schule’) scholars claim a singular unity of all neo-Kantian debates represented in the problem of ‘Geltung’. This is used to construct a certain relevance of neo-Kantianism in today’s philosophy. My contribution will pursue a historical approach (...) following Klaus Christian Köhnke’s and Ulrich Sieg’s demands. Instead of sketching systematic topics I pay further attention to the context in which an essence of neo-Kantianism was claimed or rejected. In doing so I will examine the discussions on the doctrine of postulates in Kant’s philosophy mainly led by Hans Vaihinger’s ‘Philosophy of As If’ and the impact of Eduard von Hartmann on the genesis of neo-Kantianism. I conclude that the definition of a consistent neo-Kantian ‘movement’ was an effect of rejecting spiritualist interpretations of the doctrine of postulates and in the following a rejection of the whole doctrine as ‘mysticism’ in canonical Kant interpretations. (shrink)

Name der Zeitschrift: Deutsche Zeitschrift für Philosophie Jahrgang: 66 Heft: 4 Seiten: 573-579.

Elliot R. Wolfson intervenes in the debate over Martin Heidegger and Nazism from a unique perspective, as a scholar of Jewish mysticism and philosophy who has been profoundly influenced by Heidegger's work. He reveals crucial aspects of Heidegger's thinking that betray an affinity with dimensions of Jewish thought.

A political sociologist examines the concept of universal, egalitarian citizenship and assesses the prospects for developing democratic solidarity at the global level.