Monitoring of clinical trials is important to ensure adherence to protocol, to safeguard the rights of research participants and to achieve compliance with principles of good clinical practice. Recent regulatory changes in India require Ethics Committees to keep an oversight of ongoing clinical trials including on-site monitoring. In this article, we share the experience of on-site monitoring of clinical trials by the Ethics Committee of a tertiary care, academic and research centre in India. We found a large number of shortcomings (...) in the areas of informed consent, adverse events, insurance and reimbursement, which would not have been detected by off-site document review. Interestingly, many shortcomings were also not detected by on-site monitoring arranged by clinical trial sponsors. We therefore conclude that on-site monitoring of ongoing clinical trials is a highly important activity for Indian Ethics Committees. (shrink)

This is a conversation that took place at Dr. Vladimir Safatle’s São Paulo home on 16 February, 2019, during Dr. Samir Gandesha’s time as a Visiting Professor at the Faculdade de Filosofia, Letras e Ciências Humanas -FFLCH-USP. It addresses the South American roots of the authoritarian Neoliberalism that has now become a truly global phenomenon.

This essay assesses the opposition of pluralism and monism with respect to politics and architecture, developing the argument within three general areas: the spurious association between political intentions and architectural character, the distinctions and commonalties between political freedom and artistic freedom, and the adverse effect of inappropriate associations between political content and artistic form in general and, in particular, the perceptual impairment of the processes by which buildings come to be endowed with their suitable character.

Today, anxiety is usually thought of as a pathology, the most diagnosed and medicated of all psychological disorders. But anxiety isn't always or only a medical condition. Indeed, many philosophers argue that anxiety is a normal, even essential, part of being human, and that coming to terms with this fact is potentially transformative, allowing us to live more meaningful lives by giving us a richer understanding of ourselves. In Anxiety, Samir Chopra explores valuable insights about anxiety offered by ancient (...) and modern philosophies-Buddhism, existentialism, psychoanalysis, and critical theory. Blending memoir and philosophy, he also tells how serious anxiety has affected his own life-and how philosophy has helped him cope with it. Chopra shows that many philosophers-including the Buddha, Kierkegaard, Nietzsche, Freud, and Heidegger-view anxiety as an inevitable human response to existence: to be is to be anxious. Drawing on Karl Marx and Herbert Marcuse, Chopra examines how poverty and other material conditions can make anxiety worse, but he emphasizes that not even the rich can escape it. Nor can the medicated. Inseparable from the human condition, anxiety is indispensable for grasping it. Philosophy may not be able to cure anxiety but, by leading us to greater self-knowledge and self-acceptance, it may be able to make us less anxious about being anxious. Personal, poignant, and hopeful, Anxiety is a book for anyone who is curious about rethinking anxiety and learning why it might be a source not only of suffering but of insight. (shrink)

Does natural selection act primarily on individual organisms, on groups, on genes, or on whole species? The question of levels of selection - on which biologists and philosophers have long disagreed - is central to evolutionary theory and to the philosophy of biology. Samir Okasha's comprehensive analysis gives a clear account of the philosophical issues at stake in the current debate.

Derrida and the Inheritance of Democracy provides a theoretically rich and accessible account of Derrida's political philosophy. Demonstrating the key role inheritance plays in Derrida’s thinking, Samir Haddad develops a general theory of inheritance and shows how it is essential to democratic action. He transforms Derrida’s well-known idea of "democracy to come" into active engagement with democratic traditions. Haddad focuses on issues such as hospitality, justice, normativity, violence, friendship, birth, and the nature of democracy as he reads these deeply (...) political writings. (shrink)

Using the databases created under Education Watch, a civil society initiative to monitor primary and basic education in Bangladesh, this paper explores trends, socioeconomic differentials and cost in private supplementary tutoring among primary students and its impact on learning achievement. The rate of primary school students getting access to private supplementary tutoring is increasing at two percentage points per year and reached 31% in 2005. Incidence of private tutoring was greater among boys and urban students than respective counterparts. Educated parents (...) and well‐off families were more likely to arrange supplementary tutoring for their children. A wide variation in the cost for private tutoring prevailed. The tutees spent 46% of their total private expenditure for education on supplementary tutoring. Supplementary tutoring helped students learn more than those who had no such support. Private tutors for primary school students have become a well‐accepted norm. Finally, a number of social implications are discussed. (shrink)

Samir Okasha offers a critical study of agential thinking in biology, where evolved organisms are seen as agents pursuing a goal. He examines the justification for transposing concepts from rational humans to the biological world, and considers whether agential thinking is mere anthropomorphism or plays a more intellectual role in the science.

Several logical puzzles, riddles and problems are defined based on the notion of games in informative contexts. Hintikka argues that epistemology or the theory of knowledge must be considered from the notion of information. So, knowledge cannot just be based on the notions of belief and justification. The present proposal will focus on the logical structure of information, and not only on the quantification of information as suggested by Claude A. Shannon. In many cases, the information bits, although seemingly or (...) factually contradictory, are quite relevant. The paraconsistent systems of logic offer a formalization of reasoning that can support certain contradictions. The well-known “Bar-Hillel–Carnap Paradox” causes embarrassment when it concludes that the informational content of a contradiction would be maximum, opposing the traditional notion that the semantic information must be true, and that contradictions are necessarily false. (shrink)

Architectural theory arises from building, when the mind considers its symbolic relations to its own constructions. The intent of this essay is to discuss the intellectual causes that precede building and precede theory. It considers certain fundamental dualities in our thinking about architecture—such as image and word; type and model; imitation and invention—and the role they play in its making, its perfection as an art, and the eventual elaboration of its tenets into a theory. At a time when theories of (...) architecture proliferate as expressions of ‘personal philosophies,’ a careful and incisive philosophical approach to if, how, and when does theory become formative of building, may ensure that architecture remain faithful to its intrinsic purposes. (shrink)

Resilience may be referred to as the capacity for positive adaptation and to quickly recover from difficulties and significant adversity. After examining operational definitions of related concepts, the article discusses resilience building exercises for functional fitness at the individual soldier level, to include among others, self-monitoring, self-evaluation, self-reinforcement, emotional regulation exercises, mindfulness training, relaxation and grounding exercises and importance of maintaining discipline and routine in the military. Using an acronym CARRIES, the article examines efforts to enhance resilience building through empirically (...) validated cognitive, behavioural and intrapersonal skills originating from best practices learned in the military. (shrink)

What is science? Is there a real difference between science and myth? Is science objective? Can science explain everything? This Very Short Introduction provides a concise overview of the main themes of contemporary philosophy of science. Beginning with a short history of science to set the scene, Samir Okasha goes on to investigate the nature of scientific reasoning, scientific explanation, revolutions in science, and theories such as realism and anti-realism. He also looks at philosophical issues in particular sciences, including (...) the problem of classification in biology, and the nature of space and time in physics. The final chapter touches on the conflicts between science and religion, and explores whether science is ultimately a good thing. (shrink)

Such obvious truth must be made even more obvious, and this is exactly what Samir Selmanovic is doing for all of us and for the future of humanity.

Editor's suggested further reading in BioEssays ftz Evolution: Findings, hypotheses and speculations (response to DOI 10.1002/bies.201100019) AbstractOn the border of the homeotic function: Re‐evaluating the controversial role of cofactor‐recruiting motifs AbstractControl of DNA replication: A new facet of Hox proteins? AbstractClassification of sequence signatures: a guide to Hox protein function Abstract.

En el presente artículo se pretende comprender el horizonte en el que la sociedad contemporánea construye su sentido de la cotidianidad, a partir de la positividad y negatividad del aburrimiento. El método empleado será la propuesta interpretativa de Heidegger, orientado por el concepto de cotidianidad en dialogo con Han, en lo referente a la manifestación del aburrimiento en la vida cotidiana de los sujetos. En una primera instancia se abordan las determinaciones de la racionalidad instrumental y el neoliberalismo en la (...) construcción de sentido en la de la sociedad contemporánea. Posteriormente, en un segundo lugar, se comprende la imposibilidad dialéctica de la positividad del aburrimiento, para luego entender cómo la negatividad del aburrimiento posibilita desde la dialéctica una negación del discurso neoliberal. Esta comprensión resulta relevante al momento de plantear la negatividad del aburrimiento como una posibilidad de mundo. Se concluye, que el aburrimiento es una apertura a los modos en los que la sociedad contemporánea construye su cotidianidad. (shrink)

Here, for the first time, development studies encounters the set of ideas popularly known as 'Chaos Theory'. Samir Rihani applies to the processes of economic development, ideas from complex adaptive systems like uncertainty, complexity, and unpredictability. Rihani examines various aspects of the development process - including the World Bank, debt, and the struggle against poverty - and demonstrates the limitations of fundamentally linear thinking in an essentially non-linear world.

The thesis of the paper is that the root cause of clash or reconciliation among civilizations is housed in the drama of consciousness! Two models of consciousness that highlight this drama are put forward here. First is Jean Gebser’s view, which asserts that the history of human civilization is nothing more than the manifestations of the development of consciousness. This development has taken place through five distinct stages: the archaic, magical, mythic, mental and integrative. Clash in civilizations is due to (...) the fixation on the first four stages whereas reconciliation is possible through the use of the integrative stage. The second is the Tantric Yoga view of consciousness in terms of the seven chakras or wheels of consciousness. These chakras are spread out in the body like seven colors of the rainbow—starting with the base of the spine to the genitals, the belly button, the heart, the throat, the forehead and ending in the crown of the head. Clash in civilizations is due to the fixation on the first three levels (chakras) of consciousness whereas reconciliation is possible through the use of the upper fourwheels of consciousness (chakras), which are focused at developing universal consciousness. Since religion and civilization are intimately connected and several of the prominent civilizational clashes have been due to the religious differences, religious consciousness will be taken as the paradigm of this paper.How can humanity move from clash towards reconciliation? Such a possibility is suggested by both Gebser and Tantric Yoga whose theories point towards the development of an integrative universal consciousness: an encompassing consciousness that will transcend as well as incorporate all limited religious consciousness perspectives in its fold! The views of Vivekananda, a scholar-monk of India, on “one religion/one spirituality” are of particular interest in this context. They indicate an approach, which might lead to a possible future solution thus paving a path towards one-world-spiritual-peaceful order! (shrink)

Samir Amin depicts a world in which NATO has taken over the role of the United Nations, in which US hegemony is more or less complete, in which millions are condemned to die in order to preserve the social order of the US, Europe and Japan. Amin's analyses of the Gulf War, the wars in former Yugoslavia and the war in Central Asia reveal the scope of US strategic aims. He argues that the political and military dimension of US (...) dominance is as significant as US economic preponderance in determining the future of capitalist development. (shrink)

We propose a new relevance sensitive model for representing and revising belief structures, which relies on a notion of partial language splitting and tolerates some amount of inconsistency while retaining classical logic. The model preserves an agent's ability to answer queries in a coherent way using Belnap's four-valued logic. Axioms analogous to the AGM axioms hold for this new model. The distinction between implicit and explicit beliefs is represented and psychologically plausible, computationally tractable procedures for query answering and belief..

Several authors have recently suggested that classic psychedelics might be safe and effective agents of moral enhancement. This raises the question: can we learn anything interesting about the nature of moral experience from a close examination of transformative psychedelic experiences? The interdisciplinary enterprise of philosophical psychopathology attempts to learn about the structure and function of the “ordinary” mind by studying the radically altered mind. By analogy, in this chapter we argue that we can gain knowledge about the everyday moral life (...) by studying extraordinary experiences of altered moral cognition and experience. We focus on a specific class of cases: experiences of forgiveness induced by psychedelics. We argue that close attention to such experiences reveals the importance of thought/emotion coherence and dissonance in the moral life and vindicates some heterodox ideas about moral phenomenology and psychology. (shrink)

Covering some of science's most divisive topics, such as philosophical issues in genetics and evolution, the philosophy of biology also encompasses more traditional philosophical questions, such as free will, essentialism, and nature vs nurture. Here, Samir Okasha outlines the core issues with which contemporary philosophy of biology is engaged.

Kuhn’s famous thesis that there is ‘no unique algorithm’ for choosing between rival scientific theories is analysed using the machinery of social choice theory. It is shown that the problem of theory choice as posed by Kuhn is formally identical to a standard social choice problem. This suggests that analogues of well-known results from the social choice literature, such as Arrow’s impossibility theorem, may apply to theory choice. If an analogue of Arrow’s theorem does hold for theory choice this would (...) refute Kuhn’s thesis, but it would also pose a threat to the rationality of science, a threat that is if anything more worrying than that posed by Kuhn. Various possible ‘escape routes’ from Arrow’s impossibility result are examined, in particular Amartya Sen’s idea of ‘enriching the informational basis’. It is shown that Sen’s idea can be applied to the problem of theory choice in science. This in turn sheds light on two well-known approaches to inductive inference in philosophy of science: Bayesianism and statistical model selection. (shrink)

The paper presents a comprehensive survey and critique of literature on human values and ethics in business across diverse cultures. According to the author, the key issue in this discourse is not about whose values and morality, but about what values and morality. The author argues for a holistic paradigm in this discourse, grounded in deep philosophy and drawing upon the spiritual values of humanism. The consumerist, market economy Western models of ethics cannot be the only answer to values issues (...) surfacing in the wake of increasing economic globalization. The most exciting thing about international business is that it offers the opportunity to discover the human values that resonate through all cultures.1 What is more ethical—considering all nations as if they were same or accepting different standards of behaviour in different contexts? (shrink)

While many models of ethical decision-making in marketing have been presented in the literature, no recent attempts have been made to explicitly account for ethical decision-making from a marketing research perspective. We present an ethical framework for marketing research, the various philosophies of ethics, and a few enduring marketing ethical decision-making models, thus laying the foundation for a descriptive model for ethics in marketing research. The authors then develop an integrated model of ethical decision-making that incorporates the perspectives of all (...) parties involved in the process of making ethical marketing research decisions, the various philosophies, and external variables. The proposed model is compared with some of the models considered in the literature and illustrated with a marketing research application. (shrink)

Hox proteins are part of the conserved superfamily of homeodomain‐containing transcription factors and play fundamental roles in shaping animal body plans in development and evolution. However, molecular mechanisms underlying their diverse and specific biological functions remain largely enigmatic. Here, we have analyzed Hox sequences from the main evolutionary branches of the Bilateria group. We have found that four classes of Hox protein signatures exist, which together provide sufficient support to explain how different Hox proteins differ in their control and function. (...) The homeodomain and its surrounding sequences accumulate nearly all signatures, constituting an extended module where most of the information distinguishing Hox proteins is concentrated. Only a small fraction of these signatures has been investigated at the functional level, but these show that approaches relying on Hox protein alterations still have a large potential for deciphering molecular mechanisms of Hox differential control. (shrink)

The paper gives a new light on the controversy between Popper and Carnap on the interpretation of probability and its use to solve the problem of induction. In his later work on probability and inductive logic, Carnap came nearer to the bayesian positions stressing an important shift from his ear..

Publié en 2004, l’ouvrage de l’historienne américaine Londa Schiebinger opère un rapprochement suggestif entre l’histoire des sciences, l’histoire du genre et l’histoire coloniale. À travers l’étude de la « bioprospection » dans l’espace caraïbe des xviie et xviiie siècles (Jamestown, Virginie, Bahia, Brésil, Jamaïque, Guyane, Surinam, Saint-Domingue) l’auteure aborde les facteurs culturels qui interviennent dans la transmission des savoirs naturalistes et pharmaceutiques entre indigènes et a...

If architectural judgment were a city, a city of ideas and forms, then it is a very imperfect city. When architects judge the success or failure of a building, the range of ways and criteria which can be used for this evaluation causes many contentious and discordant arguments. Proposing that the increase in number and intensity of such arguments threatens to destabilize the very grounds upon which judgment is supposed to rest, this book examines architectural judgment in its historical, cultural, (...) political, and psychological dimensions and their convergence on that most expressive part of architecture, namely: architectural character. It stresses the value of reasoned judgment in justifying architectural form -a judgment based on three sets of criteria: those criteria that are external to architecture, those that are internal to architecture, and those that pertain to the psychology of the architect as image-maker. External criteria include, philosophies of history or theories of modernity; internal criteria include architectural character and architectural composition; while the psychological criteria pertain to 'mimetic rivalry', or rivaling desires for the same architectural forms. Yet, although architectural conflicts can adversely influence judgment, they can at the same time, contribute to the advancement of architectural culture. (shrink)