Meaning is a key foundation of human life. We yearn to make our life meaningful and have a proper understanding of the meaning of words and worlds, which help us in blossoming of life rather than being trapped in labyrinths of confusion and annihilated in varieties of killing and destruction. But this fundamental yearning for meaning has always been under stress in different periods and epochs of human history. In our contemporary world, we are also going through stress, vis-à-vis (...) the work of meanings in our lives, which is part of a global crisis of meaning. Our global crisis of meaning has multiple genealogies. Our contemporary crisis of meaning has its roots in both the way we relate to language and our worlds, which is discussed in this article. It also discusses how we can cultivate new movements and circles of meaning generation. This is linked to vision and practices of upholding our world and regenerating our earth. I then link processes of meaning generation to processes of coming together of people as well as soul, what is called Lokasamgraha in Indic tradition. I discuss how the global crisis of meaning calls for new cosmopolitan movements as well as building a planetary Lokasamgraha. (shrink)

Cet article analyse les évolutions des positions de Marx à propos de la colonisation. Il souligne tout d’abord l’invariant de ces réflexions : la dénonciation de la violence coloniale. Au départ, on trouve une interprétation de la colonisation comme processus de modernisation, puis comme dynamique de destruction-régénération, liée à l’« unification du monde ». L’auteur identifie spécialement les inflexions successives de la pensée de Marx – résolument critique –, au sujet des questions coloniale et nationale, du caractère non (...) linéaire de l’histoire, mais aussi de la différenciation des formations sociales. (shrink)

Definition The authors’ definition of the autopoietic system has evolved through the years. One of them states that an autopoietic system is organized (defined as a unity) as a network of processes of production (transformation and destruction) of components that produces the components which: (1) through their interactions and transformations regenerate and realize the network of processes (relations) that produced them; and (2) constitute it (the machine) as a concrete unity in the space in which they exist by specifying (...) the topological domain of its realization as such a network (Varela 1979, p. 13). Nearly the same formula was earlier used to define an autopoietic machine (Maturana and Varela 1973/1980, 1984/1987, p. 135). (shrink)

: Stem cell research that requires the destruction of human embryos is incompatible with Catholic moral principles, and with any ethic that gives serious weight to the moral status of the human embryo. Moreover, because there are promising and morally acceptable alternative approaches to the repair and regeneration of human tissues, and because treatments that rely on destruction of human embryos would be morally offensive to many patients, embryonic stem cell research may play a far less significant role (...) in medical progress than proponents believe. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Knock at the Door: Utopian Dreams for Post-Covid TimesPedro Mora-Ramírez, María Amo-Hernández, and Paula García-RodríguezAnswering the Knock at the Door, Welcoming Utopian Futures, The Knock at the Door: Utopian Dreams for Post-Covid Times, May 21–24, 2023, University of Huelva, Spain, and University of Calgary, CanadaThe COVID-19 pandemic has fostered new adversities and vulnerabilities, prompting reflection on the economic, social, and political paradigms that endanger human and nonhuman lives. (...) For many, it was anxiety and uncertainty that “knock[ed] at the door”; for others, however, those same feelings of unease prompted one of hopefulness: reflecting on the possibilities for resilience and regeneration in the process of changing our vision of the world.1 The Knock at the Door conference brought contemporary utopianism to the forefront of thinking about how to respond to global crises while remaining attentive to other adversities of daily life. Scholars and artists answered the knock in an attempt to examine paths toward utopia, and to take advantage of the regenerative and resilient potential of the present.The conference was the culmination of author/activist Larissa Lai’s fellowship period at the University of Huelva. The 2022–23 María Zambrano Fellowship for the academic year2 allowed Lai to complete the project “Utopian Dreams for Post-Covid Times,” carried out in collaboration with the Huelva research group led by Professor Pilar Cuder-Domínguez, who hosted a number of online and in-person seminars on speculative fiction with Lai. The Knock at the Door conference, marking the end of Lai’s fellowship, created yet another space for scholars, artists, and critics to discuss the potential of utopian narratives. Lai asks: “What does our cultural moment require, and how can we get where we need to go from where we are? How can literature, especially speculative fiction literature, help us get from here to there?”3 [End Page 641] The intention of the conference was to encourage others to continue Lai’s work on how to imagine futures where human and posthuman beings need to remain vigilant to adversities. Utopian scholars, among others, might find the complications of “getting there from here” closely related to Lai’s conception of “insurgent utopias,” or “emergent insurgency.” They could find Lai’s concept of “insurgent utopianism” interesting as it lays the foundations of futurity in terms of crisis responses.The aim of the conference was to explore the imagination of better futures through utopian thinking and practice. In addition, it focused on “the knock at the door,” which is “a moment of contingent arrival... open to cooptation, destruction, bastardization, incorporation, death, or defusal.” Yet, it presents “the powerful possibility of critique—narratively or discursively, in its very materiality.”4 One way of doing this might be to look back at the past century of utopianism and ask who or what has been missing. The conference took up Lai’s idea of insurgent utopianism as a method of paving a path toward a multitude of dreams and actions, all shaped by the unique circumstances of one’s positionality.After the COVID-19 pandemic, the need for utopian thinking has become more pressing than ever. New horizons of hope must be created in the face of emerging anxieties. In a world where anthropocentrism is showing signs of its deadly potential, conference participants reflected on the relevance of the utopian imagination to political resistance and resilience building.Utopian Visions: Contesting Better Worlds in Neoliberal and Feminist UtopiasThe first two panels of the conference addressed the critique of two dominant theoretical (and interrelated) frameworks: capitalism and neoliberalism. Speakers reflected on both in light of theoretical interventions by theorists Rosi Braidotti and Francesca Ferrando. Panelists Benjamin Ghan and Marc Lynch reflected on how creative writers envision ideal worlds and temporalities. In Ghan’s view, utopian narratives create a symphony of voices historically excluded from the category of “the human”: women; LGBTQ+ people; Indigenous peoples. In a similar vein, Lynch described his own novel, A Wasp’s Waist, as highlighting the impossibility of imagining utopias within the capitalist paradigm—and thus the necessity of imagining futures beyond capitalism, and beyond... (shrink)

The characterisation of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a fluorescence‐activated cell sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the research field of cancer stem cells is a potential source of artefacts. In addition, normal stem cell therapy has the objective of regenerating (...) a tissue, while cancer stem cell‐centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell‐centred therapy and for upgrading the cancer stem cell paradigm accordingly. (shrink)

Shows how we must make deep changes to complete our paradigm shift from the old mechanistic worldview to the new organic worldview • Reveals the distinct stages of paradigm shifts through the ages, including the 18th-century Enlightenment and the critical stage of our current shift • Explains how the new organic worldview began with Goethe and Kant • Offers solutions for each of us to be able to realize and make the deep changes needed for global regeneration In Global Awakening, (...) Michael Schacker shows that hidden within our global crises is a positive future for the planet. Sharing his 30 years of intensive research into the history of change as well as the evolution of consciousness and regenerative science, Schacker explains how our current shift from the old mechanistic worldview to a new organic worldview based on biological models follows the same pattern as other paradigm shifts across history, including the 18th-century Enlightenment and the American Revolution. He reveals the creative geniuses who have contributed to the birth of the organic worldview, beginning with Goethe, Kant, and Hahnemann. Exposing the scientific and social forces that drive paradigm shifts, he details the stages every paradigm shift progresses through: the early Enlightenment, the conservative backlash, the intensive phase, and and the transformational phase leading to the Organic Shift. Explaining that we are currently in the throes of the paradigm flip, the critical last phase of our paradigm shift, Schacker shows how the mechanistic worldview is crumbling around us and nothing but a complete transformation in the way we think will keep us from the path of total self-destruction. Providing a map to overcome the allure of the simplistic mechanical model that has spawned countless unsustainable practices and problems--from global warming to intense economic disparities--the author offers concrete solutions showing how each of us can use our talents, skills, and time to make the deep changes needed for global regeneration. (shrink)

Two groups of scientists have just announced what is being described as a leap forward in human stem cell research.1–3 Both have found ways of producing what are being called “induced pluripotent cells” , stem cells that they hope will demonstrate the same key properties of regeneration and unrestricted differentiation that human embryonic stem cells possess, but which are derived from skin cells not from embryos. In simple terms, these scientists have succeeded in reprogramming skin cells to behave like hESCs.Stem (...) cell research has been hailed as one of the most important and exciting areas of science, because it is believed that these types of cells will not only play an important part in regenerative medicine, but also yield valuable scientific information. These latest developments in cell reprogramming represent a milestone for stem cell science. No longer does the paradigm of irreversible cell specialisation hold true; instead, almost any type of cell might have the potential to become any other.The advent of techniques for producing these iPCs has also been hailed as an ethical breakthrough. Up until now, the production of hESCs has required a process which involves the destruction of embryos. Many of these embryos are available as by-products of IVF; but in addition, the process of somatic cell nuclear transfer to produce cloned embryonic stem cells requires a supply of human oocytes, which must currently be harvested from female donors at no insignificant cost. In a nutshell, iPCs seem to enable us to produce “embryo-free” human pluripotent stem cells, and in a “gender-neutral” way—that is, without the need for human oocytes.The response from the scientific community, ethical commentators and the public has, however, reflected an inherent confusion over the ethical significance of this research. The anti-embryo …. (shrink)

The article examines the social dimensions of poverty in the context of gender, dalit, tribal and Muslim minorities in the country. Reviewing the process of globalisation in the country, it notes that the largest section of workers continue to work in the unorganised sector. The shifting of global capital to the South and particularly to India has increased opportunities for women to work in the garment export industry. Characterised by low pay and poor working conditions, the industry exploits women. The (...) fear of job loss has led to new forms of resistance by women workers not only at the workplace but within the community linking with social movements for protection and advancement. Small and marginal farmers including women agricultural workers are impacted by global markets leading to destruction of rural livelihoods. Dalit women have demonstrated how to create household food security by internalising inputs and creating alternative markets. Policy planners need to learn from these experiences and upscale at a national level. Regenerating commons and promoting non-chemical agriculture are other means to restore ecological balance and economic health of the agriculture sector. Tribal, dalit and Muslim minority socio-economic rights are eroded further due to the process of globalisation. To move towards more inclusive growth, public spending on education and health has to increase. Responding to people's movements the state needs to implement pro-people policies and programmes. Mobilising women into SHGs is seen as a panacea to ensure women's development. Currently, it has created a debt burden on women. An alternative agenda for empowerment is outlined for action. (shrink)

Standing in front of perhaps the most crucial decade of the future to come, when mankind has just experienced three years of global pandemic, a raging war, extreme climate events and mass extinction of animals and plants, we have arrived at a crossroads. Decisions must be made on whether we charge at full speed to explore alternative social-ecological systems that lead to human well-being and regeneration of nature; or continue down a pathway built on resource extraction, unsustainable and unethical urbanization (...) and destruction of nature and lives. Recently, as countries seek to recover from the pandemic, many are contemplating large-scale infrastructure schemes and projects, which have been tried and proven means to drive extraction-based economic growth. This highlights the importance of environmental justice and resistance – an area from which voices are not often heard loud enough, yet offers fertile ground where radical, sustainable alternatives may emerge among people and communities that refuse to comply with the unjust development imposed on them. Our work seeks to contribute to research studying the potential of such phenomena, by designing a framework to capture key organizational, political and ethical features that make resistance a transformative practice. The outcome of this effort is a Resistance-Based Transformative Alternative (ReBasTA) Framework, which can be employed to inform both desktop-based data collection and analysis on resistance practices, as well as in-depth field research on deep drivers and leverage points for transformation. Moreover, the framework makes longitude study of transformative practice possible, by using a consistent set of criteria. This paper introduces the conceptual and methodological approach underlying our framework and the collaborative process employed in designing it and its key criteria. In the final section, we also discuss possible applications, with particular reference to resistance movements triggered by large-scale infrastructures. (shrink)

This paper compares the heuristic potential of three metaphorical paired concepts used in the relevant literature to characterise global relationships between the anthroposphere and the ecosphere. Methodologically, the guiding question is whether and to what extent metaphorical theses can support an arrival at hypotheses which accurately reflect reality and possess explanatory force. The predator-prey model implies that the populations of two species in such a relationship in principle exhibit coupled oscillations, giving prey populations the possibility of periodic regeneration. For some (...) time, however, the most important indicators of human destruction of nature have been showing a relentless upward trend which appears to render the tumour-host metaphor more appropriate. Another fact which favours this analogy is that a tumour develops within its host and from its host's normal cells, in a similar way to the emergence of the anthroposphere from within the biosphere. But the parasite-host analogy also allows the formulation of fruitful hypotheses, since ecological parasitology is equally familiar with varieties of autoaggressive interaction and provides a means of focusing particularly on the adelphoparasitic hierarchy within the anthroposphere. (shrink)

In organic farming animal welfare is one important aspect included in the internationally agreed organic principles of health, ecology, fairness and care (IFOAM 2006), reflecting expectation of consumers and farmers. The definition of organic animal welfare includes—besides traditional terms of animal welfare—‘regeneration’ and ‘naturalness’. Organic animal welfare assessment needs to reflect this and use complex parameters, include natural behaviour and a systemic view. Furthermore, various parties with seemingly conflicting interests are involved, causing ethical dilemmas, such as the use of nose (...) rings for outdoor sows (impaired animal welfare vs. destruction of humus). Solutions can only be found when foundational concepts are translated and applied to practical situations. On-farm animal welfare assessment and implementation of improvement strategies are increasingly relevant scientific areas. They combine on-farm welfare assessment, identification of key problem areas and connected risk factors. Constant communication between all parties is crucial for success. Animal health and welfare planning is one application of this approach, which was carried out on Austrian organic pig farms as well as organic dairy farms in seven European countries. The projects included welfare assessment, feedback and benchmarking as a tool for communication between farmers, advisors and scientists. Finally goals were set by the farmer and improvement strategies applicable to organic farming were implemented. This included prevention of disease by management strategies instead of routine treatment with pharmaceutical products. It appeared that next to problem structuring, multidisciplinary problem solving demands good communications skills to relate animal welfare science to value reflections. (shrink)

The saying that `Australia rode to prosperity on the sheep's back' never had more than a small measure of truth; it is better rephrased as `Australia has enjoyed limited periods of modest prosperity through the near-destruction by sheep of a fragile native vegetation'. Sheep, however, have had a cultural role in Australia that needs to be understood if the failures of the wool industry leadership are to be grasped. This role has had a long history, in part Biblical (the (...) Good Shepherd, the episcopal crosier, pastoral care), greatly reinforced by the Enclosures of the 18th century in Britain, promoting an idealized landscape of trees and grass. Settlers found Arcady in eastern Australia, often prepared for them by Aboriginal land use; in came the sheep, the lawn-mowers of the day, and up went the place names, from Camden Park on. `Parks' had social status. Landscapes of trees and grass were much admired, but lacking an understorey, essentially rather sterile from an ecological point of view. The grassy open woodlands were painted by the likes of Hans Heysen, while Tom Roberts painted the shearers. They became the very image of Australia, but the landscapes are dying, and the isolated trees are not regenerating. Many of the images remain potent. But sentiment will not pay the bills of the new century, so it is farewell to Arcady. The nymphs are long departed. This essay, like Gaul, is divided into three parts, the first of which considers sheep and the pastoral industry as a land use: the second is about the politics of wool; the third, about Arcady in Australia, is a theme that helps to explain the first two. (shrink)

Spallanzani was in contact with a large number of European scholars, but he never succeeded in forming a group around him. We must consider a true exception his research on animal regeneration, started in 1765 and which was harshly criticised in the intellectual community. Spallanzani replied shifting his engagement from the 'laboratory' to the creation of a 'net' of supporters and led them to repeat the most daring manoeuvres. Apparently, he delegated the destruction of adverse positions, but he skilfully (...) held control of the situation. Such a sharp dissociation between cultural politics and experimental activity was unique in his scientific career. The most numerous group in the net included unknown professors coming from provinces of Lombardy, quite often outsiders in sciences. Spallanzani's correspondence guided their methods and the letters reveal care in managing experiment material, cleverness in questions, awareness of objections, and even a certain amount of creativity. Totally different was the case of two first-rate professionals, the entomologist Giuseppe Rovatti and the physician Michele Girardi. Spallanzani disguised the net as a summation of individuals without an oriented programme. He concealed its most interesting aspect and he himself contributed to frame the view of his isolation in the supposed 'desert' of 18th century Italian sciences. (shrink)

Unlike machines, living systems are distinguished by the continual destruction and regeneration of their boundaries and other components. Stable Markov blankets may be a real feature of the world, or they may be merely a construction of particular models, but they are neither a feature of organisms nor of any model that can capture the necessary conditions of their existence.

While many recent readings of The Heat of the Day (1948) address Bowen’s indeterminate and unsettling prose style as a mirror or even an enactment of the destructive, nullifying forces at work in Blitz-weary London, this article posits that those same stylistic elements as well as the novel’s depictions of unstable subjectivities work against nullity to create complexly rendered regenerations, including two surreally conceived pregnancies. This article also suggests that the tensions often noted in Bowen’s negotiations between fictional realism and (...) what critics have classified as the hallucinatory or surreal can be better understood by exploring Bowen’s spiritual beliefs, which she elucidates in numerous nonfiction pieces. The provocative liminality of the material and the spiritual in The Heat of the Day offers a compelling critical space from which to further explore Bowen’s prolific hybrid creations and the ontological, epistemological, and metaphysical mysteries they engender. (shrink)

With unbridled exponential economic growth, earth systems and social systems are headed for catastrophic meltdown. Meanwhile, much of humanity is highly dependent on current institutions. Second-order cybernetics can help society come to grips with the enormous demand of adapting existing institutions for a regenerative economy. While the current trajectory of increasing consumption and rapid ecological decay will lead to collapse, the progress achieved by civilization can be vindicated by large-scale investment in regenerating natural capital assets, developing open-source technologies for the (...) public good, and rebuilding local agricultural economies dedicated to health and well-being. It is recommended that regenerative practices are supported by academic institutions centered on place-based service-learning. A regenerative economy, in contrast to a growth economy, is part of the pursuit of the long-term establishment of a steady-state economy. This vision does not limit the possibility that humanity will make outstanding technological progress, explore space or merge with artificial intelligence – but argues that appreciating the nature’s technology provided to humanity through eons evolution, and avoiding short-term self-destruction should be priorities. (shrink)

An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible for the remarkable regenerative capacity of adult bones. However, recent in vivo lineage‐tracing studies suggest that all stages of skeletal lineage cells, including dormant pre‐adipocyte‐like stromal cells in the marrow, osteoblast precursor cells on the bone surface and other stem and progenitor cells, are concomitantly recruited to (...) the injury site and collectively participate in regeneration of the damaged skeletal structure. Lineage plasticity appears to play an important role in this process, by which mature skeletal cells can transform their identities into skeletal stem cell‐like cells in response to injury. These highly malleable, long‐living mature skeletal cells, readily available throughout postnatal life, might represent an ideal cellular resource that can be exploited for regenerative medicine. (shrink)

Regeneration capabilities are found in most or all animals. Whether regeneration is part of the development of an animal or a distinct phenomenon independent of development is a debatable question. If we consider regeneration as a process belonging to development, similarly to embryogenesis or metamorphosis, the existence of regenerative capabilities in adults can be seen as an argument in favor of the theory that development continues throughout the life of animals. Here I perform a comparative analysis of regeneration versus “classical” (...) developmental processes in animals in order to determine to what extent these processes are inclusive or distinct. I identify the existence of regeneration-specific processes, i.e., processes that occur during the regeneration, but not the initial development, of a given structure. In addition, I find that seemingly similar processes acting during development and regeneration may have differential molecular and cellular bases. I thus conclude that there are significant differences between regeneration processes in adult animals and developmental processes occurring during earlier phases of the life cycle. The existence of regenerative capabilities in adult animals can therefore not be used as an argument in favor of the idea that development spans the whole life. (shrink)

• Aggregates of previously isolated cells of Hydra are capable, under suitable solvant conditions, of regeneration forming complete animals. In a first stage, ecto- and endodermal cells sort out, producing the bilayered hollow structure characteristic of Hydra tissue; thereafter, heads are formed (even if the original cell preparation contained no head cells), eventually leading to the separation of normal animals with head, body column and foot. Hydra appears to be the highest type of organism that allows for regeneration of the (...) entire structure from random cell aggregates. The system is particularly useful for studying cell interactions, tissue polarity, pattern formation, and cell differentiation. (shrink)

The convergence of morphogenesis into viable organisms under variable conditions suggests closed‐loop dynamics involving multiscale functional feedback. We develop the idea that morphogenesis is based on synergy between mechanical and bio‐signaling processes, spanning all levels of organization: molecular, cellular, tissue, up to the whole organism. This synergy provides feedback within and between all levels of organization, to close the loop between the dynamics of the morphogenesis process and its robust functional outcome. Hydra offer a powerful platform to explore this direction, (...) thanks to their simple body plan, extraordinary regeneration capabilities, and the accessibility and flexibility of their tissues. Our recent experiments show that structural inheritance of the actomyosin organization directs body‐axis formation during Hydra regeneration. Morphogenesis is then stabilized through dynamic cytoskeletal reorganization induced by the inherited structure. The observed cytoskeletal stability and reorganization capabilities suggest that mechanical feedback integrates with biochemical processes to establish viable patterns and ensure canalization. (shrink)

The African neo-Pentecostal teaching that Christians continue to suffer from generational curses or bloodline curses is analysed from the perspective of Christian salvation as spiritual recreation. The main question considered in this article is: Soteriologically, how may we evaluate the ANP view that ‘born again’ Christians remain vulnerable to generational curses? The article describes the ANP assertion that Christians live under the threat of generational curses. Furthermore, the ANP’s understanding of the nature of generational curses is examined. Attention is further (...) given to the ANP’s view of the role played by a person’s blood in the transmission of generational curses and how this makes Christians vulnerable to generational curses after their conversion. The article also analyses how the doctrine of generational curses expresses a notion of Christian salvation with limited creative powers in Africa. Lastly, some elements that should inform an understanding of Christian salvation when addressing the fear of generational curses among the ANPs are proposed. The significance of this article lies in contributing a theological analysis that will help African Christians find confidence in their Christian salvation.Contribution: The article attempts to contribute towards the formulation of a biblically informed systematic theological framework of analysing and critiquing the logic of salvation in the ANP teaching that generational curses remain on regenerated Christians. (shrink)

Diverse living systems possess the capacity for regeneration; that is, they can under some circumstances repair, re-produce, and maintain themselves in the face of disturbance or damage. Think of systems as diverse as forests, microbial biofilms, corals, salamanders, hydra, and human skin cells. This capacity is fundamental to life—without it, many biological systems would be too fragile to cope with stress and would frequently collapse—but because it is multiply realized in wildly different living systems at many scales, finding a common (...) understanding may seem futile, and in fact research has proceeded along independent lines. For example, the sciences of organismal regeneration and ecological regeneration appear to have little more than a nominal relationship. Progress towards unification can be made, we think, by turning to evolutionary theory, specifically by synthesizing recent discussions of the evolution of individuals versus collectives with older literature about replicators versus interactors. This allows us to provide a partial answer in response to MacCord and Maienschein’s call for “basic units and mechanisms” of regeneration, relevant when that process is “adaptive.” We argue that the basics of adaptive regeneration can be understood and generalized through a modification of David Hull’s replicator-interactor framework. (shrink)

Early in his career Thomas Hunt Morgan was interested in embryology and dedicated his research to studying organisms that could regenerate. Widely regarded as a regeneration expert, Morgan was invited to deliver a series of lectures on the topic that he developed into a book, Regeneration. In addition to presenting experimental work that he had conducted and supervised, Morgan also synthesized and critiqued a great deal of work by his peers and predecessors. This essay probes into the history of regeneration (...) studies by looking in depth at Regeneration and evaluating Morgan’s contribution. Although famous for his work with fruit fly genetics, studying Regeneration illuminates Morgan’s earlier scientific approach which emphasized the importance of studying a diversity of organisms. Surveying a broad range of regenerative phenomena allowed Morgan to institute a standard scientific terminology that continues to inform regeneration studies today. Most importantly, Morgan argued that regeneration was a fundamental aspect of the growth process and therefore should be accounted for within developmental theory. Establishing important similarities between regeneration and development allowed Morgan to make the case that regeneration could act as a model of development. The nature of the relationship between embryogenesis and regeneration remains an active area of research. (shrink)

Posthumanist and New Materialist thought attempts to undo the supremacy and distinction of the human being through accounting for the agential capacities of the animal and material world. New Materialism in particular constructs a vision of a vital natural world in order to turn us away from humanism and toward a more holistic understanding of nature, and political actants. In this article, I argue that there can be a humanist new materialist position that sees the vitalism of the natural world (...) while maintaining the uniqueness of the human being. This position can be found in the natural science of the eighteenth century in the work of Georges-Louis LeClerc de Buffon and Charles Bonnet. Reminding ourselves of this alternative mode of thinking about a vital nature, and its vision of a self-regenerating human being in a vital and regenerative universe, is a path toward regenerating humanism itself in contemporary scholarship. (shrink)

Here we review and discuss the link between regeneration capacity and tumor suppression comparing mammals (embryos versus adults) with highly regenerative vertebrates. Similar to mammal embryo morphogenesis, in amphibians (essentially newts and salamanders) the reparative process relies on a precise molecular and cellular machinery capable of sensing abnormal signals and actively reprograming or eliminating them. As the embryo's evil twin, tumor also retains common functional attributes. The immune system plays a pivotal role in maintaining a physiological balance to provide surveillance (...) against tumor initiation or to support its initiation and progression. We speculate that susceptibility to cancer development in adult mammals may be determined by the loss of an advanced regenerative capability during evolution and believe that gaining mechanistic insights into how regenerative capacity linked to tumor suppression is postnatally lost in mammals might illuminate an as yet unrecognized route to cancer treatment. (shrink)

In this paper I argue that the value attributed to coral reefs drives the characterisation of evidence for their regeneration or degradation. I observe that regeneration and degradation depend on an understanding of what an ecosystem looks like when undegraded (a baseline), and that many mutually exclusive baselines can be given for any single case. Consequently, facts about ecological processes are insufficient to usefully and non-arbitrarily characterise changes to ecosystems. By examining how baselines and the value of reefs interact in (...) coral and algal reef examples, I argue that considering the value of an ecosystem is a necessity when describing processes like regeneration and degradation. This connects value as studied in socio-ecological and economic research with values as discussed in the philosophy of science literature. It also explains why such a broad range of processes may be considered regenerative, including those which introduce significant novelty, as well as pointing towards ways to mediate related debates, such as those surrounding novel and ‘pristine’ ecosystems. (shrink)

Here we endorse Hull’s replicator/interactor framework as providing the overarching understanding sought by MacCord and Maienschein. We suggest that difficulties in seeing the regeneration of limbs by salamanders and of forest ecosystems after fires as similar evolutionary processes can be overcome in this framework. In generalizing Dawkins’s “selfish gene” perspective, Hull defined natural selection as “a process in which the differential extinction and proliferation of interactors causes the differential perpetuation of the replicators that produced them”. Although genes and bacteria are (...) simultaneously both replicators and interactors, communities and ecosystems are generally only interactors. As reproducers, members of sexual species are intermediate. Within such species, organisms are indeed the interactors whose “differential extinction and proliferation” causes the “differential perpetuation” of replicators. But sexually-reproducing organisms do not individually replicate, persist, or recur as interactors, and in consequence it is only those genes causing an interactor differential that are specifically perpetuated in the long run. Higher-level interactors may seldom if ever reproduce, but their recurrence does enable the “differential perpetuation” of replicators specifically responsible for their “differential extinction and proliferation”. In offering answers to the question “What are the replicators specifically responsible for the differential extinction and proliferation of such higher-level entities?” we hope to unify adaptive regeneration across scales, from organisms to ecosystems. (shrink)

Early in his career Thomas Hunt Morgan was interested in embryology and dedicated his research to studying organisms that could regenerate. Widely regarded as a regeneration expert, Morgan was invited to deliver a series of lectures on the topic that he developed into a book, Regeneration (1901). In addition to presenting experimental work that he had conducted and supervised, Morgan also synthesized and critiqued a great deal of work by his peers and predecessors. This essay probes into the history of (...) regeneration studies by looking in depth at Regeneration and evaluating Morgan's contribution. Although famous for his work with fruit fly genetics, studying Regeneration illuminates Morgan's earlier scientific approach which emphasized the importance of studying a diversity of organisms. Surveying a broad range of regenerative phenomena allowed Morgan to institute a standard scientific terminology that continues to inform regeneration studies today. Most importantly, Morgan argued that regeneration was a fundamental aspect of the growth process and therefore should be accounted for within developmental theory. Establishing important similarities between regeneration and development allowed Morgan to make the case that regeneration could act as a model of development. The nature of the relationship between embryogenesis and regeneration remains an active area of research. (shrink)

Purpose. Research of the phenomenon of human destructiveness in the context of metaphysical images and violence practices of late Modernism. Theoretical basis. The problem is that the philosophical reflection of violence as objectified, realized destructiveness of man is usually contextual in nature and is on the periphery of understanding its external manifestations. Accordingly, anthropological crisis remains behind the scenes, as evidenced by the devaluation of the humanistic potential of modern culture. That is why one should turn the focus from the (...) obvious, objectively conditioned incarnations of violence in the XXI century to the internal factors that are in the realm of existential. The departure from the consideration of violence as an abstract, faceless or ideologically colored evil allowed us to focus on man, his way of thinking, life and social orientations, feelings and internal contradictions, which find their expression in one or another form of destructiveness. Originality. Based on the works of M. Scheler and E. Fromm defining for philosophical anthropology and psychoanalysis, for the first time the conceptualization of positive and negative forms of manifestation of human destructiveness against the background of sociocultural transformations of late Modernism was carried out. It has been proved that its ontological principles are rooted in specifically human existence and relations with other members of society, while anthropological ones are directly connected with the endless struggle of the life, the vital with the spirit in man. Conclusions. Violence is a tool and a product of man’s transition to more mature and complex forms of existence. The interdependence of the violence and nonviolence practices ensures the progressive movement of humanity towards society humanization. This progress is accompanied by a natural internal conflict of personality, which can be both progressive and regressive. At the metaphysical level, destructiveness appears as a connection between the entropy of world existence as a whole and the instability of human existence itself, which is a complexly organized and open to the world system. Self-transcendence as an anthropological prerequisite for human destructiveness has a dual nature and combines negative and positive characteristics, the content and significance of which were revealed in the study. The authors are convinced that there is no other way to overcome the negative, malignant destructiveness, except for the incessant, daily gathering of life meanings around them and their development. After all, the loss of such core structures of the existence as the meaning, purpose and value of life has become a truly global problem for the modern world. Emphasis is placed on the need to keep in harmony the trinity of body-soul-spirit, which will allow a person in any social transformation to preserve and increase his integrity. (shrink)

This study explored the influence of personal values on destructive leader behavior. Student participants completed a managerial assessment center that presented them with ambiguous leadership decisions and problems. Destructive behavior was defined as harming organizational members or striving for short-term gains over long-term organizational goals. Results revealed that individuals with self-enhancement values were more destructive than individuals with self-transcendence values were, with the core values of power (self-enhancement) and universalism (self-transcendence) being most influential. Results also showed that individuals defined and (...) structured leadership problems in a manner that reflected their value systems, which in turn affected the problem solutions they generated. (shrink)

Over the last 25 years, there has been an increasing fascination with the “dark” side of leadership. The term “destructive leadership” has been used as an overarching expression to describe various “bad” leader behaviors believed to be associated with harmful consequences for followers and organizations. Yet, there is a general consensus and appreciation in the broader leadership literature that leadership represents much more than the behaviors of those in positions of influence. It is a dynamic, cocreational process between leaders, followers, (...) and environments, the product of which contributes to group and organizational outcomes. In this paper, we argue that, despite this more holistic recognition of leadership processes within the broader leadership literature, current conceptualizations and analyses of destructive leadership continue to focus too heavily on behaviors and characteristics of “bad” leaders. In our view, to achieve a more balanced understanding of destructive leadership, it is important to adopt more integrative approaches that are based in the contemporary leadership discourse and that recognize flawed or toxic leaders, susceptible followers, and conducive environments as interdependent elements of a broader destructive leadership process. To this end, we offer a critique of the destructive leadership literature, propose a broader definition of destructive leadership, and highlight gaps in our understanding of leaders, followers, and environments in contributing to destructive leadership processes. Finally, we conclude by discussing strategies for examining destructive leadership in a broader, more holistic fashion. (shrink)

In the present essay, I trace the way in which Derrida engages the theme of the destruction of philosophy in his reading of Heidegger’s work in the 1964-65 seminar, Heidegger: The Question of Being and History. Specifically, I focus on a close reading of the first three sessions in order to show the way in which the theme of the destruction of philosophy appears in relation to the posing of three questions, namely, the questions of being, history, and (...) metaphor. In all three sessions, I will show that the questions of being, history, and metaphor allow Heidegger, according to Derrida, to brush against the very limits of philosophy. However, Derrida’s own interpretation reveals an interesting emphasis on the destruction of philosophy that, while definitely inspired by Heidegger, slightly begins to go beyond him. For this reason, I will turn to his more critical appraisal of Heidegger’s trajectory in the final two sessions. In so doing, I claim that Derrida’s positions in these final sessions will show a critical distance vis-à-vis Heidegger that will foreshadow the very question that will remain decisive throughout his nearly 40 year engagement with Heidegger’s work, namely, the question of difference. (shrink)

Abstract:Enlightenment era optimism that technological and educational developments offer a progressive path to plenty and liberation supports a hope that human toil may be progressively reduced. The Development Thesis defended by G. A. Cohen is a piece of that Enlightenment optimism. The Development Thesis holds that productive forces tend to develop throughout history. The tendency for such an increase in productive forces to occur is, according to Cohen’s argument, due to persistent facts about human nature. If Cohen is correct, there (...) is a tendency toward progress of an important sort, and this progress is due in significant part to human nature. But the development of productive forces also destroys nonhuman natural value. In the era of the Anthropocene this is occurring on a planetary scale. The simultaneous development and destruction entails that claims of progress must rely on an all-things-considered judgment. But due to the plurality of the relevant values, which cannot be compared according to a common metric, rational disagreement about the existence of progress and our progressive nature can be expected to persist. (shrink)

In the scientific communities most criticisms are constructive, while they are destructive in the humanistic circles. Indeed, scientists circulate their drafts among colleagues and students, hoping to elicit their comments and suggestions before submitting their work to publication. In contrast, philosophers and political thinkers attack their rivals, without sparing arguments ad hominem or even insults. The reason for this difference is that scientists are after the truth, whereas most humanists fight for more or less noble causes, from swelling their own (...) curricula to joining crusades for or against rationality, realism, justice, or what have you. (shrink)

Justin Barrett and Kelly James Clark have suggested that cognitive science of religion supports the existence of a god-faculty akin to sensus divinitatis. They propose that God may have given rise to the god-faculty via guided evolution. This suggestion raises two theological worries. First, our natural cognition seems to favor false god-beliefs over true ones. Second, it also makes us prone to tribalism. If God hates idolatry and moral evil, why would he give rise to mind with such biases? A (...) Plantingian response would point to the noetic effects of sin. Such a response, however, would have to assume that God is restoring the minds of believers. This paper considers empirical reasons to doubt that such a process is taking place. (shrink)

It is posited that the initiating event of amphibian regeneration of a limb, is retrodifferentiation* of what are to become the developing cells of the blastema. These cells reiterate a larval or premetamorphic ontogenic repertoire, induced by elevated levels of prolactin with adequate innervation. Subsequent redifferentiation of the blastema cells occurs, controlled by thyroxine and innervation.This temporal displacement of cellular morphologic characters in regeneration should be looked upon as a function of the ability to reiterate larval characters and subsequently metamorphose. (...) If correct, this would explain why amphibians which metamorphose only once, lose the ability to postmetamorphically regenerate. An exception to this,Xenopus laevis, an anuran which can epimorphically regenerate, to some extent, will be discussed.[/p]. (shrink)

The emergence of COVID-19 has made it ever more onerous for the world economy to rethink the way things are done and to be done. The need and almost compulsory way of services being catered for will never have been made so practically obvious without the influence of a pandemic like COVID-19. The world at some point in time was almost brought to a standstill, with services pertaining to supply-chain deliverables, education / professional development and many more almost brought to (...) a halt. This paper has the platform for critically assessing the pathway SSA economies (SSA) should follow, notably creativity in new technologies, while adopting a stance on ISI approach in order to reduce its reliance on the importation of essential commodities, which seem to have been a worrying concern throughout the crisis of COVID-19. Suggestions for SSA economies to embrace the notion of creative destruction is the focal point in this paper for the realization of growth and development, while at the same time harnessing the power of human integrity to champion competitive innovation. (shrink)