Polycomb group proteins are evolutionary conserved chromatin‐modifying complexes, essential for the regulation of developmental and cell‐identity genes. Polycomb‐mediated transcriptional regulation is provided by two multi‐protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb‐mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub‐complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 (...) complexes. These mechanisms include PRC1‐catalytic activity toward monoubiquitination of histone H2AK119, a well‐established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1‐catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed. (shrink)

The coordinated expression of the Hox gene family encoding transcription factors is critical for proper embryonic development and patterning. Major efforts have thus been dedicated to understanding mechanisms controlling Hox expression. In addition to the temporal and spatial sequential activation of Hox genes, proper embryonic development requires that Hox genes get differentially silenced in a cell‐type specific manner as development proceeds. Factors contributing to Hox silencing include the polycomb repressive complexes (PRCs), which control gene expression through epigenetic modifications. (...) This review focuses on PRC‐dependent regulation of the Hox genes and is aimed at integrating the growing complexity of PRC functional properties in the context of Hox regulation. In particular, mechanisms underlying PRC binding dynamics as well as a series of studies that have revealed the impact of PRC on the 3D organization of the genome is discussed, which has a significant role on Hox regulation during development. (shrink)

The ovarian reserve defines female reproductive lifespan, which in humans spans decades. The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic prophase I and is maintained independent of DNA replication and cell proliferation, thereby lacking stem cell‐based maintenance. Largely unknown is how cellular states of the ovarian reserve are established and maintained for decades. Our recent study revealed that a distinct chromatin state is established during ovarian reserve formation in mice, uncovering a novel window of epigenetic (...) programming in female germline development. We showed that an epigenetic regulator, Polycomb Repressive Complex 1 (PRC1), establishes a repressive chromatin state in perinatal mouse oocytes that is essential for prophase I‐arrested oocytes to form the ovarian reserve. Here we discuss the biological roles and mechanisms underlying epigenetic programming in ovarian reserve formation, highlighting current knowledge gaps and emerging research areas in female reproductive biology. (shrink)

DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the (...) class='Hi'>Polycomb system is responsible for the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

Polycomb group (PcG) proteins maintain the expression state of PcG‐responsive genes during development of multicellular organisms. Recent observations suggest that “the H3K27me3 modification” acts to maintain Polycomb repressive complex (PRC) 2, the enzyme that creates this modification, on replicating chromatin. This could in turn promote propagation of H3K27me3 on newly replicated daughter chromatin, and promote recruitment of PRC1. Other work suggests that PRC1‐class complexes can be maintained on replicating chromatin, at least in vitro, independently of H3K27me3. (...) Thus, histone modifications and PcG proteins themselves may both be maintained through replication. (shrink)

The use of Drosophila chromosomal rearrangements and transposon constructs involving the white gene reveals the existence of repressive chromatin domains that can spread over considerable genomic distances. One such type of domain is found in heterochromatin and is responsible for classical position‐effect variegation. Another type of repressive domain is established, beginning at specific sequences, by complexes of Polycomb Group proteins. Such complexes, which normally regulate the expression of many genes, including the homeotic loci, are responsible for silencing, (...) white gene variegation, pairing‐dependent effects and insertional targeting. (shrink)

Paradoxically, DNA sequence polymorphisms in cancer risk loci rarely correlate with the expression of cancer genes. Therefore, the molecular mechanism underlying an individual's susceptibility to cancer has remained largely unknown. However, recent evaluations of the correlations between DNA methylation and gene expression levels across healthy and cancerous genomes have revealed enrichment of disease‐related DNA methylation variations within disease‐associated risk loci. Moreover, it appears that transcriptional enhancers embedded in cancer risk loci often contain DNA methylation sites that closely define the expression (...) of prominent cancer genes, despite the lack of significant correlations between gene expression levels and the surrounding disease‐associated polymorphic sequences. We suggest that DNA methylation variations may obscure the effect of co‐residing risk sequence alleles. Analysis of enhancer methylation data may help to reveal the regulatory circuits underlying predisposition to cancers and other common diseases.Editor's suggested further reading in BioEssays DNA methylation reprogramming in cancer: Does it act by re‐configuring the binding landscape of Polycomb repressive complexes? Abstract. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Fragments LITERARY STUDIES AND THE REPRESSION OF REPUTATION by John Rodden 6 6T A Thomakesorbreaks a writer's reputation?" asked Esquire during VV the mid-1960s. The editors' answer, titled "The Structure of the Literary Establishment," came in the form of a multicolored "chart of power." Included was "virtually everyone of serious literary consequence," whether "writer, editor, agent, or simple hipster." The center of power was indicated, noted the (...) editors, by "the hot red blob in the middle," which oozed over the names of the chief literary makers and breakers.1 In 1977 Esquire drove to the heart of the blob, asking a long list of "knowledgeable" writers, academic critics, andjournalists the question, "Which American writers of this century do you consider the most overand under-rated"? Running below the responses across four pages was a sketch of Father Time, busily at work inflating and bursting bubbles bearing the images of various candidates. No consensus was sought, though Dreiser and Willa Cather fared well, and Pound, Eliot, Hemingway, Mailer, and Edmund Wilson less well. The editors acknowledged that their respondents generously volunteered a number of nonAmericans too (and stretched "writers of this century" back to the Venerable Bede), "proving that once you get started on this kind of thing, it's hard to know where to stop." 2 Unfortunately, reflection on the matter seems to stop at the doorstep of literary studies. "Reputation" is one of those subjects that readers, 261 262Philosophy and Literature critics, and scholars love to talk about, but to which serious attention is rarely paid, even by sociologists of literature—and not at all by literary critics. Separate disciplines are devoted to the study ofwealth and power, yet none to honor or reputation, the third chiefcategory ofclass systems and human motivation.3 A few cultural critics have drawn attention to the ways in which the "institution of criticism"—book publishing, book reviewing, literaryjournalism, scholarly criticism—has exerted influence on public literary taste or the profession of literary studies. But their work has typically criticized "the culture industry" or "the literary-industrial complex," rather than addressed the making of authors' and books' reputations.4 Although semesterly reading lists and even whole libraries testify to the exalted reputations of a few canonized authors, a near-total silence has prevailed in the academy on reputation as a literary issue in its own right.5 That such a central dynamic of literary life—in a sense the defining, controlling category for an essentially honorific activity like literature and literary criticism—should go virtually unattended by critics of literature might seem at first glance a professional conspiracy by Esquire's "blob." Yet the academy's neglectof"the problem ofreputation" is hardly due to outright professional collusion, but rather to a joint matter of institutional and historical factors. These have partly to do with the elusiveness of "reputation" as a concept, which has accommodated the more important repressive factors: the academy's preoccupation with literary interpretation and its persistent habit of averting its eyes from its own institutional history. This essay explores the problematics of literary reputation, the essence of which consists in our unrefiective tendency to assume that what is valued is invariably what is also reputed. II Few readers would deny that authors' reputations bear heavily on practices in publishing and literary journalism. Few even question Esquire 's buried point that "reputations get made" through institutional networks which exchange and distribute information. Yet the literary academy has traditionally relegated the subject to the slick magazines and, more recendy, to the sociology of art and occupations, where it has received scant attention and where literary canons are not made.6 On those rare occasions when journals like The American Scholar have taken up literary reputation as an issue, they have politely asked only the first of Esquire's questions (about underrated books and authors), John Rodden263 characterizing their discussion as "the game" ofrediscovering "neglected books." 7 Indeed the topic may well strike a bit too close to home, as observers as opposed in their literary politics as Norman Podhoretz and Richard Kostelanetz seem to agree.8 For elite institutions and star reputations exist in academe and in the literary... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Medusa Complex:Matricide and the Fantasy of CastrationJessica Elbert MayockThe theoretical structures of psychoanalysis have excluded the female subject by placing her outside of the Symbolic, and feminist theorists' responses to this problem have been divided. Some theorists (such as Kristeva) accept the notion of an unalterable Lacanian Symbolic, while others (such as Irigaray) maintain that the current Symbolic is a manifestation of male fantasy, and suggest that (...) feminist thinkers explore the possibility of reorganizing the Symbolic. Amber Jacobs, in her recent work On Matricide (2007), takes up this challenge by analyzing matricide in myth in order to reveal matricide as latent content untheorized within psychoanalysis. Jacobs claims that the structure of the Lacanian Symbolic illegitimately asserts the "law of the father" as the only possible law, excluding any possibility of a "law of the mother" by erasing the maternal role in theory and symbolization. Her project, following Irigaray, is to make visible those unconscious contents excluded by the patriarchal imaginary in order to "be able to intervene into psychoanalysis for the purpose of working toward theorization of unconscious structures that are not reducible to the structure of Oedipus alone" (Jacobs 2007, x). If Jacobs's suggestion is correct, then analysis of Freud's evidence for the Oedipus Complex (and its accompanying concepts) will reveal repressed contents and traces of these untheorized unconscious structures—particularly those associated with the maternal body.With these considerations in mind, I take up the Freudian case of Little Hans, where Freud finds his most seminal evidence for castration anxiety [End Page 158] and the Oedipus Complex. I will demonstrate Freud's systematic occlusion of the maternal body through his overvaluation of the male body/the phallus in order to expose the elements of male fantasy that construct the Oedipus Complex. I organize these psychical elements in a configuration called "The Medusa Complex," since Freud uses the image of Medusa to explain his theory of castration. In rereading the details of this case, a powerful male fantasy begins to emerge: the desire to appropriate the female generative power. This is achieved through the theory of castration, which the decapitation of Medusa symbolizes, and the unconscious wish for male parthenogenesis—one product of this wish is the Lacanian Symbolic structure, where only the male principle of the phallus is generative. The Medusa Complex is comprised of the two intertwined male fantasies of female castration and male parthenogenesis, as well as the associated resistances that result from initiation into this paradigm. The theory of castration and the Oedipus Complex are attempts to conceal the powerful maternal body and assert male superiority and dominance.In the case of Little Hans, "Analysis of a Phobia in a Five Year Old Boy" (1909), Little Hans develops a fear of horses (especially biting horses) and is afraid to go out into the street. Hans's treatment is undertaken by his father, a medical doctor, who keeps careful notes and acts under Freud's supervision (mostly via letters). The boy's phobia begins around the time his little sister Hanna is born, as Freud and the father eventually admit, though her role in their narrative is nonexistent.1 They interpret Hans's phobia as a classic Oedipal triangle in which he desires his mother and fears the hostility of his father; his fear is translated into fear of the castrating father. Throughout the case, Freud and the father emphasize the boy's alleged awe of the adult male genital organ. In this paper, I will revisit the case (preserved in careful detail by the boy's father) and systematically return the maternal body to its rightful place within the narrative, shifting both the structure and the meaning of the phobia.I am here reading the case as an example of manifest content—like the surface content of a dream—in order to expose the male desires that create it. The current Symbolic is essentially a dream of the male imaginary, and my method is to reveal the latent content of the dream, especially the fantasies that inform it. Desire is the generating force behind this dream, and until we encounter and understand this desire, it will continue to compulsively... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Toward a Radical Female Imaginary: Temporality and Embodiment in Irigaray’s EthicsEwa Plonowska Ziarek* (bio)An important intervention of Irigaray’s work on sexual difference into the postmodern debates on ethics is the mediation between two different lines of ethical inquiry: one represented by the work of Nietzsche, Deleuze, Foucault, and, to a certain degree, Castoriadis, and the other by the work of Levinas, Derrida, and Lyotard. Although the two trajectories both (...) depart from the notion of morality as a universal system of law and judgment, they represent different approaches to freedom and obligation. For Levinas, Derrida, and Lyotard, the ethical significance of alterity disrupts social systems of signification and, in this sense, marks transcendence as a break in discourse, whereas for Nietzsche, Deleuze, and Foucault, otherness is expressed within the endless variations of becoming. To elucidate this difference, it might be useful to recall John Caputo’s distinction between two kinds of postmodern ethics—the Nietzschean heteromorphism and the Levinasian heteronomy. In its emphasis on becoming and change, heteromorphism, Caputo claims, puts forward the claim of liberation but cannot accommodate an obligation to the other: “In heteromorphism, the aim is freedom from inhibition and blockage, freedom from... the weight of values... from everything that weighs the will down....” By contrast, the Levinasian ethics of alterity gives priority to the obligation to the other, which calls the freedom of the subject into question: “freedom is suspect, suspended, held in question, because it is aggressive, self-accumulative, and eventually, finally murderous. Heteronomism wants the other to be free while one is oneself held hostage” [Caputo 60].In my discussion of the radical female imaginary I would like to show that Irigaray’s work refuses to align itself with either side of this divide. Originating in the very gap between liberation and responsibility, self and other, immanence and transcendence, freedom and obligation, the feminist ethics of sexual difference cannot disregard any of these claims. For Irigaray, the ethics of sexual difference has to enable different trajectories of gendered becomings without forgetting the obligation to the other. In fact, Irigaray argues that the responsibility to the other who differs sexually is the very source of such becomings. Irigaray’s ethics maintains neither the rigid separation between freedom and obligation, as is the case in Levinas’s work, nor their symmetrical reversibility, as is the case in Kant’s ethics. By contesting the oppositions between carnal passions and ethical obligations, between the respect for the other and the becoming of the self, Irigaray allows us to think through the disjunction between the two main ethical trajectories of postmodernism and to find the means to negotiate between them. In this essay I would like [End Page 60] to focus on two moments of such negotiation: the becoming of sexed bodies and the temporality of the female imaginary.One of Irigaray’s famous claims is the charge of the forgetting of sexed bodies in the discourses of philosophy, science, linguistics, and politics. Although this claim is certainly not new in feminist theory, what is original in Irigaray’s work is the diagnosis of the numerous symptoms of such forgetting, for instance, the relation she makes between the erasure of the sexed body and the nihilism of Western culture. For Irigaray, the forgetting of sexual difference manifests itself not only in the disregard for the specificity of feminine embodiment, desires, and genealogies but also in the disembodied character of linguistic analyses, in the erasure of the drama of enunciation evident in the privilege given to predication, in the separation of the subject of knowledge from carnality and desire, in the infatuation with formalism and with its obverse side, the crippling nostalgia for the maternal body, and, finally, in the rigid separation between the immanence of flesh and the transcendence of the spirit. 1 Even more striking is the originality of Irigaray’s intervention, which links the question of sexual difference with the temporality of the body.An important element of Irigaray’s ethics of sexual difference is the recovery of “that repressed entity, the female imaginary” [TS 28]. Despite numerous excellent discussions of the imaginary in Irigaray’s work, the complexity of her negotiations around this... (shrink)

Notch signaling plays an essential role in the processes of embryogenesis and cellular differentiation, and it is believed that the oncogenic effects of dysregulated Notch signaling are an anomalous reflection of the normal functions of this cascade. Nonetheless, the cellular events associated with oncogenic Notch signaling have thus far remained elusive. In a recent report, Ferres‐Marco et al.1 described how they used the Drosphila eye as a model system and found that elevated Notch signaling in combination with activation of components (...) of the Polycomb complex of transcriptional repressors led to metastatic growth of tumors through epigenetic silencing of the Rbf gene. Rbf is the Drosophila homologue of the retinoblastoma tumor‐suppressor gene (Rb), thus it represents a novel link between Notch signaling, tumor growth and metastasis. BioEssays 28: 692–695, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The centerpiece of the first volume of Michel Foucault’s History of Sexuality is the analysis of what Foucault terms the “repressive hypothesis,” the nearly universal assumption on the part of twentieth-century Westerners that we are the heirs to a Victorian legacy of sexual repression. The supreme irony of this belief, according to Foucault, is that the whole time that we have been announcing and denouncing our repressed, Victorian sexuality, discourses about sexuality have actually proliferated. Paradoxically, as Victorian as we (...) allegedly are, we cannot stop talking about sex. Much of the analysis of the first volume of the History of Sexuality consists in an unmasking and debunking of the repressive hypothesis. This unmasking does not take the simple form of a counter-claim that we are not, in fact, repressed; rather, Foucault contends that understanding sexuality solely or even primarily in terms of repression is inaccurate and misleading. As he said in an interview published in 1983, “it is not a question of denying the existence of repression. It’s one of showing that repression is always a part of a much more complex political strategy regarding sexuality. Things are not merely repressed.”1 Foucault makes this extremely clear in the introduction to the History of Sexuality, Volume 1, when he writes. (shrink)

Recent findings indicate that substantial cross‐talk may exist between transcriptional and post‐transcriptional processes. Firstly, there are suggestions that specific promoters influence the post‐transcriptional fate of transcripts, pointing to communication between protein complexes assembled on DNA and nascent pre‐mRNA. Secondly, an increasing number of proteins appear to be multifunctional, participating in transcriptional and post‐transcriptional events. The classic example is TFIIIA, required for both the transcription of 5S rRNA genes and the packaging of 5S rRNA. TFIIIA is now joined by the Y‐box (...) proteins, which bind DNA (transcription activation and repression) and RNA (mRNA packaging). Furthermore, the tumour suppressor WT1, at first thought to be a typical transcription factor, may also be involved in splicing; conversely, hnRNP K, a bona fide pre‐mRNA‐binding protein, appears to be a transcription factor. Other examples of multifunctional proteins are mentioned: notably PTB, Sxl, La and PU.1. It is now reasonable to assert that some proteins, which were first identified as transcription factors, could just as easily have been identified as splicing factors, hnRNP, mRNP proteins and vice versa. It is no longer appropriate to view gene expression as a series of compartmentalised processes; instead, multifunctional proteins are likely to co‐ordinate different steps of gene expression. (shrink)

Transcription in organisms as diverse as yeast and mammals is subject to chromosomal position effects that result in heritable and variegated patterns of gene expression. Two recent studies have employed a reversible protein‐DNA crosslinking method to identify the structural components of heterochromatin in budding yeast(1,2). The results show that a complex containing the proteins Rap1, Sir2p, Sir3p and Sir4p is physically associated with nucleosomes at telomere proximal regions, but that the repressive chromatin structure extended by Sir3p overexpression has (...) a different composition. (shrink)

Competence refers to the basic concepts of modern educational theory and practice of acquiring special importance in environmental education. Environmental education specificity is the accumulation of environmental science and pedagogy achievements that may become the basis of ecological competence formation as an integrated characteristics of an individual. Environmental competence refers to the general competence, but also includes a number of specific competencies aimed at solving specific and sometimes unusual tasks. Critical intellection is an essential characteristic of environmental competence, and the (...) formation of critical intellection combined with creativity is the basis of competence approach in education. Philosophy of Education by Paulo Freire is of a basis weight for understanding the essence of critical intellection in pedagogical theory and practice. "Banking "funded" model of education" concept by Paulo Freire demonstrates the disadvantages of prevailing oppressive, narrative, uncreative educational system and uncreative mechanical learning, which is opposed to the concept of modern education and critical understanding formation through the dialogue. The fundamental feature of the modern problematic oriented education has the following aspects: 1) it is based on the activities, but it is not based on the information transfer and assimilation; 2) the object of knowledge is a link between teacher and student. The teacher and student efforts are focused on the object of knowlege research that involves the dialogue in the educational process. There is an important thesis about better explaining and implement of ecological education and it points that problematic oriented method is charecterised by cognitive approach and critical intellection. It is also important for understanding and orientation in a particular situation, environmental protection and people's health and life saving. Information literacy as a complex of skills related to education and critical intellection is an important part of the ecological competence formation. From the time of national pedagogy, philosophical - educational ideas by the Brazilian educator P. Freire were widely developed and contributed the formation of new educational vision as a social partnership to overcome the disadvantages of the command, repressive, totalitarian, uncritical educational system. Instead of these there were critical educational concepts based on humanism, creation and various human experience. The concept of the modern problematic oriented education was aimed at the critical intellection formation and environmental competence. It covers not only the standard school educational system and it also involves educational sphere and public informing. (shrink)

continent. 2.2 (2012): 60–63 Translated by Rodrigo Maltez Novaes. From the forthcoming book Post-History , Minneapolis: Univocal Publishing, 2013. It is not necessary to have a keen ear in order to find out that the steps we take towards the future sound hollow. But it is necessary to have concentrated hearing if one wishes to find out which type of vacuity resonates with our progress. There are several types of vacuity, and ours must be compared to others, if the aim (...) is to understand it. The incomparable is incomprehensible. If we affirm that our situation is incomparable, we give up the effort to grasp it. The comparison that imposes itself is to the vacuity of the Baroque. There are innumerable traces in the present that evoke the Baroque. We bear the mark of the same somber rationalism (logics, informatics, cybernetics), and of the same magic and fanatic irrationalism (mass media, phantastic ideologies). But there is a decisive difference. Humanity advanced over a stage during the Baroque. All of its gestures, even the most sincere, were marked by theatricality. The vacuity that resonated under its feet was of the void under the stage. Baroque man represented. 1 For example he represented faith in waging religious wars. Baroque vacuity was the consequence of a medieval loss of faith in dogmas . Our vacuity is different. We do not represent anything. Our world is not a stage. We are not actors, and if we act, it is not to represent a drama, but to divert the audience's attention and our own from the subjects that really matter. We act like criminals that try to hide their tracks. We pretend. Our progress is a farce. The vacuity under our feet is not Baroque. We have not lost our faith in dogmas: we have lost faith in ourselves . We are as counter-reformists as was the Baroque (we want to cover up the recent revolution with warm cloths), but for different reasons. Although comparable with the Baroque, in certain aspects, our situation is in fact incomparable to any other. That is because an incomparable, unheard of, never before seen event happened recently, which emptied the ground we tread. Auschwitz . Other posterior events; Hiroshima, the Gulags, are nothing but variations of the first. Therefore every attempt to grasp the present leads to the following questions: how was Auschwitz possible? How can we live after this? Such questions relate not only to the ones directly or indirectly responsible, and not only to those who were directly or indirectly hit by it: they relate to everyone who takes part in our culture. Because what is so incomparable, unheard of, never before seen and therefore incomprehensible in Auschwitz, is that it was there that Western culture revealed one of its inherent virtualities. Auschwitz is a characteristic realization of our culture. It is neither the product of a particular Western ideology, nor of specific “advanced” industrial techniques. It springs directly from the depths of culture and of its concepts and values. The possibility to realize Auschwitzes is implicit within our culture from the very start: the Western “project” already harbored it, although as a remote possibility. Auschwitz lies within the initial program of the West, which progressively realizes all of its virtualities as history unfolds. That is why the question that Auschwitz poses before us is not: how did it happen? It serves no purpose to “explain” Auschwitz. The fundamental question is: how was it possible? Because what is being questioned is not the extermination camp, but the West. Thus one other question: how to live within a culture henceforth unmasked? Everything that happened afterwards resonates with such a question, with such vacuity. Every economic, social, political, technical, scientific, artistic, philosophic event is corroded by such an undigested question. The distance that separates us from the event does not mitigate the abyss, it erodes it even deeper. Because the distance progressively dissolves the aura of the horror that envelops the event, and it progressively opens up a vision of the scene. It progressively reveals that there all of our categories, all of our “models”, suffered an irreparable shipwreck. Auschwitz was a revolutionary event, in the sense that it overthrew our culture. Insofar as we seek ways to cover up such revolution with trips to the moon or with genetic manipulations, we are counter-revolutionaries: we are inverting the course of history in order to cover up the past. The unspoken in Auschwitz is not the mass murder, it is not the crime . It is the ultimate reification of people into amorphous objects, into ashes. The Western tendency towards objectification was finally realized and it was done so in the shape of an apparatus . The SS were functionaries of an extermination apparatus, and their victims functioned in function of their own annihilation. The extermination camp's program, once it started functioning, developed in an automatic fashion, autonomous from the decisions of the initial programmers, even if, as it effectively did, it contributed to the defeat of the programmers. The SS and the Jews functioned one in function of the other like cogwheels. The models for such functionality were provided by the highest of Western values: the SS behaved like “heroes” and the Jews like “martyrs”. This is an apparatus that functions at a borderline situation: objective even beyond death. What has just been said is intolerable. We cannot accept it and so we mobilize arguments against it. Good arguments. The SS behaved like criminals: they removed the gold teeth from the cadavers. The Jews behaved like victims: they rose up in the Warsaw ghetto. Such arguments are true, but they do not reach the nucleus, the “ eidos ” of the phenomenon: they do not grasp it. Although there was “normal” behavior: (theft, murder, revolt, heroism), there was also “abnormal” behavior: functionality during a borderline situation. And this is what counts. There, for the first time in the history of humanity, an apparatus was put into operation that was programmed with the most advanced techniques available, which realized the objectification of man, together with the functional collaboration of man. The previous horrors committed by Western society against other societies and against itself (and there are many) were crimes . They were violations of Western models of behavior: anti-Christian, anti-human, irrational. So that it is possible to condemn them and continue to be Western, even if the horror is so colossal, such as the enslavement of Africans. However, it is not possible to condemn Auschwitz and continue to adhere consciously to the West. Auschwitz is not a violation of Western models of behavior, it is, on the contrary, the result of the application of such models. Our culture allowed its mystifying mask to fall and must be rejected in toto if we admit that the purpose of every culture is to allow for the convivial existence of men that recognize each other mutually as subjects. However: it is not possible to reject one's own culture. It is the ground we tread . Those who seek to reject their own culture (as Nietzsche did in rejecting Judeo-Christianity), fall victim to madness. Those who reject their culture's models, are incapable of grasping the world in which they live. Cultural models are traps to catch the world. Those who seek to substitute their own models for other's (for example by shouting “Hare Krishna”) will find that such exotic models have already been caught by the very models to be substituted. There is no exit: we are condemned to use our models and to serve such models, even after they have been unmasked, if we wish to continue living. The only alternative would be to commit suicide. That is: we must continue our economic, political, scientific, artistic, philosophic activities despite Auschwitz. We must continue progressing despite everything . That is why there are those who recommend that we should seek to forget what happened, that we should repress the event. They sustain that enough has already been said and written about the subject and that it is time to “overcome” it. But such an ostrich strategy reveals itself disastrous. Because the result is that Auschwitz transfers itself from Poland of the 1940s to the post-industrial society of the future. What characterizes the extermination camp is precisely that it is not an event that can be “overcome”, because it is the first realization of an inherent virtuality within the Western project, which will repeat itself in other formats unless we become totally conscious of it. The advantage (if this is an appropriate term) that Auschwitz offers us, is to give us a concrete example of the West’s tendency towards the apparatus. For the first time in our history it is possible for us to experience concretely the utopia inherent in our culture. For the first time in our history we have the experience that utopia, no matter in what form, towards which we progress, is the extermination camp. Everywhere we can observe, as of now, the emergence of variations on the theme “Auschwitz”. Everywhere apparatus spring, just like mushrooms after a Nazi rain, from the ground that has become rotten. Certainly: such new apparatus are not externally similar to the Nazi extermination camps. Their labels are different, as are the ideologies that pretend to inspire them. Even the apparatus that admittedly envision extermination, such as the Gulags, the ones of a future nuclear war, or the ones that functioned in Vietnam, claim to be different from Auschwitz. Others claim to be “friends of mankind”, such as the scientific, technical and administrative apparatus. But such labels and such ideologies are deceptive and serve only to cover up the essence of apparatus. They are all just like Auschwitz, black boxes that function with complex inner-workings in order to realize a program. They all function according to an inertia that is inherent to them and such functionality escapes , from a certain point, the control of their initial programmers. In a final analysis such apparatuses function, all of them, towards the annihilation of all their functionaries, including their programmers. Exactly because they objectify and dehumanize man. Thus Western culture reveals itself as a project that seeks to transform itself into an apparatus. What characterizes the West is its capacity for an objectifying transcendence. Such transcendence allows for the transformation of all phenomena, including the human phenomenon, into an object of knowledge and manipulation. The space for such transcendence opened up thanks to Judeo-Christianity and resulted, in the course of our history, in science, technique and recently, in Auschwitz. The ultimate objectification of the Jews into ashes is the ultimate victory of the spirit of the West. It is social technique taken to the extreme. Certainly: the transformation of men into ashes is primitive, incipient social technique that progressively refines itself. It will be followed by less brutal objectifications, such as the robotization of society. But it does not matter which form it will assume: it will always be an objectifying manipulation of mankind. Although the apparatus of the immediate future are not necessarily incineration ovens, all will be, and not only the nuclear ones, apparatus for the annihilation of man. The Western program contains several virtualities, not only apparatus. Numerous virtualities have not yet been realized. In this sense the “history of the West” has not ended yet, the Western game continues. But all not-yet realized virtualities are infected by apparatus. That is why it has become currently impossible to engage ourselves in the “ progress of culture .” As it would be to engage ourselves in our own annihilation. We have lost our faith in our culture, in the ground we tread. That is: we have lost faith in ourselves. It is this hollow vibration that follows our steps towards the future. What remains is for us to analyze the event “Auschwitz” in all its details in order to discover the fundamental project that realized itself there for the first time, so that we may nurture the hope to project ourselves out of that project. Out of the history of the West. This is the “post- historical” climate in which we are condemned to live from hereon. NOTES 1. In Portuguese representar (to represent) also means “to act” or “to play a role.&rdquo. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Winnicott’s “Fear of Breakdown” : On and Beyond TraumaMax Hernandez (bio)y no hallé cosa en que posar los ojos / que no fuese recuerdo de la muerte[I could find no thing on which to rest my eyes / which was not a reminder of death]—Francisco de Quevedo, “Sonetos”The ubiquitous occurrence of violent events and the growing realization that the inscription of this violence in the psyches of those exposed (...) to these events remains to be known have helped to make trauma an emblematic issue at the end of a century saturated with unprecedented wounding events [see Caruth, Unclaimed Experience].1 Trauma’s enigmatic immediacy thrusts itself upon any attempt to encompass it within a theory. It is as though no one approximates (even the study of) trauma with impunity: complex affects are stirred. A precipitous interplay of cognitive and affective dispositions, a heightened tension between the intense identifications elicited and the need experienced for some protective distance from the pain evoked undermine the stability of the boundaries between witnessing and telling, event and historical narration, narrative and reading. Hence the ambivalent appeal of the notion of trauma for the historian as well as for the cultural and literary theorist.The most cursory description of trauma reflects the complex temporal structure that punctuates the psyche’s relation to the traumatic event. The asymmetrical relation between experience and memory and the gross disparity between their affective and cognitive components are evident at once. Trauma has been characterized by virtue of the disjunctions it manifests. Its very formulation bears the mark of a construction emerging as the narrative of a belated experience.2 In recent publications on trauma, the references to the works of Freud, Janet, Kardiner, Lacan, and Laplanche take pride of place. Also noticeable is the emphasis placed on certain psychoanalytic notions: deferred action, death instinct, repetition compulsion, the real.Along with the explorations of trauma by psychoanalysts, historians, and literary theorists and the ethical issues they bring to the fore, the research of neurobiologists and cognitive scientists has raised a number of epistemological issues. A new wave of radical questioning of psychoanalysis comparable to that of the beginnings of this century shows its force today. The notions of repression and the repressed are considered logical impossibilities; the operations of the unconscious are deemed entirely inexplicable; and [End Page 134] defense mechanisms are considered to be mere verbal paradoxes. In what appears to be a species of defensive tactics, a supposedly neurophysiological rephrasing of psychoanalysis is taking place in some quarters, seemingly oblivious to the possibility of profoundly altering the very cohesion of this theory through the process of revision.Otto Fenichel in the thirties and Masud Khan in the sixties have provided us with succinct yet comprehensive overviews of the manner in which, since the very beginnings of psychoanalysis, every phase of theory making has influenced and reciprocally been influenced by the current concept of trauma and its clinical evaluation. It could be said that psychoanalytic theories are themselves organized around some sort of trauma. This is clearly the case in Freud’s theorizing. After his initial theory where the interrelated aspects of trauma, repression, and symptom formation became problematic, he arrived at the conclusion that castration constituted what might be termed a nuclear structuring trauma. An analogous theoretical point is implied in the Lacanian notion of the splitting of the subject. A normative trauma defines the limits of these theories and establishes a fixed relation between historical structural events. One has to shift perspectives in reading the works of those analysts concerned particularly with object relations. For example, Melanie Klein’s clinical researches on early childhood led her to postulate that the traumatic pathogenic situation par excellence is the overriding triumph of the death instinct. Winnicott understood this situation as entailing the annihilation of the core self by intrusion, while defining the traumatic impingement as the failure of the holding environment.It is relevant to comment on these different perspectives, as they afford the psychoanalytic clinician the possibility of differentiating between structuring (sexual) trauma and narcissistic trauma. When the sexual seduction trauma theory was displaced by the theory that privileged psychic reality, the Oedipus complex became... (shrink)

RésuméDans une importante série de publications, et dans un ouvrage sous presse intituléThe instinctoid nature of basic needs, le Dr Maslow à développé une théorie de la motivation dont le présent article résume à grands traits ľune des thèses principales. – Contrairement à la tendance essentielle de la Psychologie américaine, qui est ?expliquer ľaction humaine à partir ?un très petit nombre de besoins purement physiologiques , ľauteur pense qu'il est indispensable de faire place à des besoins ?un ordre plus relevé. (...) Notamment, ľhomme désire la sécurité, ľamour, ľestime de soi, ľinformation, un système de valeurs, la beauté, enfin ľactualisation de soi‐même.Ľexistence de ces besoins et leur caractére fondamental sont démontrés par ľexpérience clinique et par le fait que leur non‐satisfaction entraîne divers troubles. Dautres impulsions humaines, telles que ľagression, les perversions, etc., souvent présentées comme instinctives, constituent en réalité des réactions secondaires à la frustration des besoins fondamentaux.Ces higher needs ont apparu plus tardivement que les besoins physiologiques dans la vie de ľindividu aussi bien que dans celle de ľespèce. Ils sont moins urgents à satisfaire, plus fragiles, plus aisés à réprimer et àétouffer, plus dépendants de conditions complexes, internes aussi bien qu'externes. Leur satisfaction est essentielle pour le bonheur, la sérénité, la santé, la longévité de ľindividu et pour sa faculté de coopération avec autrui. Ce sont eux également qui jouent dans les psychothérapies les plus efficaces. II est à noter que, contrairement à la conception traditionnelle qui favorise un certain ascétisme, ľobservation clinique montre que c'est sur la base ?une satisfaction préalable des besoins biologiques, qu'apparaissent et se développent le mieux les besoins supéieurs.De cette vue nouvelle résultent une série de conséquences capitales:1. La dichotomie cognition‐conation est radicalement fausse et doit faire place à la thèse ?une interpénétration.2. Pareillement inacceptables sont les oppositions de ľégoïsme et de ľaltruisme, de ľinstinctif et du rationnel, de ľapollinien et du dionysiaque.3‐4. La morale devrait moins insister sur ľinhibition que sur la spontanéité, et la culture moins sur la répression des besoins que sur leur gratification.5. Le système des valeurs authentiques doit être déduit, non plus de spéculations logiques ou de ľautorité?une Révélation, mais de la pleine connaissance de ľhomme.6. Les besoins éievés étant affectés ?une certaine fragilityé, le rôle de la culture est, non pas de les inhiber, mais de les protéger.7. Education et psychothérapie doivent moins faire appel áľinhibition et au contrôle qu'à la spontanéité et àľépanouissement.8. Traditionnellement, aux deux directions fondamentales de la pensée politique, libérale ou réactionnaire, correspondent deux vues de ľindividu humain, dont ľune insiste sur ľinfluence du milieu et ľautre sur les facteurs internes héréditaires. Les considérations qui précèdent imposent au libéralisme de faire place aux facteurs innés et aux théoriciens des facteurs innés ?admettre un certain libéralisme. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 35.1 (2002) 1-21 [Access article in PDF] Turning Kant Against the Priority of Autonomy: Communication Ethics and the Duty to Community Pat J. Gehrke Communication ethics scholars afford Immanuel Kant significantly less attention than one might expect. This may be because, as Robert Dostal notes, Kant argues that rhetoric merits no respect whatsoever (223). This rejection of rhetoric, Dostal writes, is grounded in the significant emphasis (...) given to Kant's concept of autonomy (232). The focus on autonomy and, hence, rhetoricians' relative neglect of Kant's ethical theory are both connected to the separation of Kant's Critique of Pure Reason (hereinafter CPuR) from his subsequent ethical and moral philosophy. Kenneth Burke writes that Kant's first critique has no ethical implications, "no 'wills,' 'oughts,' 'shoulds,' or 'thou shalt nots'... nothing but an inevitable is, a description of conditions as they necessarily are for human experience" (191; emphasis in original). Such readings lose much of the richness and complexity of Kant's thought and tend instead to produce simple moral duties, such as Mike Markel's assertion that technical communicators must be truthful.Perhaps the most critical element of Kant's work lost in our focus on autonomy is his articulation of a ground for a duty to community. While Kant makes clear the importance of community for his metaphysics in the first critique (CPuR), the importance of community in Kant's moral philosophy often is overlooked. Some scholars claim that an ethical duty to community is either rejected by Kant's emphasis on the autonomy of will or simply ignored. This article combines a reading of Kant's metaphysics of experience with his moral philosophy to articulate a communication ethic grounded in community. This argument is made in three parts: first, the community of objects in experience—the Third Analogy of Experience—is an organizing principle of and a necessary condition for the possibility of all experience; second, this metaphysical principle of community is relevant [End Page 1] to community as developed in Kant's ethical writings; and finally, Kant's own work undermines the primacy of autonomy and better supports a communication ethic grounded in a duty to community.Scholars interested in Jurgen Habermas's theory of communicative action have special reason to take note of Kant's work. Kant is not only a figure that Habermas sees reflected in his own work, 1 but a constant point of contrast. Craig Calhoun writes that much of Habermas's own philosophy emerges by rejecting Kant's epistemology and elements of his metaphysics while still giving credence to Kantian moral philosophy (2). However, like most communication scholars and philosophers, Habermas believes that autonomy governs Kantian ethics: "Formalistic ethics (Kant) binds the criterion of generality of norms to the further criterion of autonomy, that is, independence from contingent motives" (Habermas, Legitimation 89). Since autonomy excludes or represses the contingent, if our readings of Kant give primacy to autonomy we leave little room for any notion of community as manifest in experience. In no small part, it is the criticism of Kant for privileging autonomy that has given Habermasians their break from Kantian ethics. However, if we turn to the first critique to guide our reading of the moral philosophy, there is another way to understand the role of autonomy and community in Kant's thought. By linking Kant's metaphysics with his moral philosophy, this article turns Kant away from the primacy of autonomy and uses Kant's own works to argue that autonomy is but one half of an antinomy that is organized under the principle of community. Thus, this article recuperates the possibility of deploying Kantian metaphysics and moral philosophy together as grounds for a communication ethic that privileges community and recovers the value of rhetoric.For rhetorical scholars, the resistance to the priority of autonomy may be related to the frequent expression of community through appeal to commonality, sameness, or identification. Today, feminist, race, postmodern, and poststructural communication scholars are questioning the value of commonality as a ground for ethics (e... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Richard J. Bernstein THE RAGE AGAINST REASON Recently, a number of phflosophers including Alasdair Maclntyre, Richard Rorty, Paul Ricoeur, and Jean-François Lyotard have reminded us about die centred (and problematic) role of narratives for philosophic inquiry. I say "reminded us" because narrative discourse has always been important for philosophy. Typically, every significant philosopher situates his or her own work by telling a story about what happened before he or (...) she came along— a story that has its own heroes and villains. This is the way in which philosophers are always creating and recreating dieir own traditions and canons. And die stories that they tell are systematically interwoven with what they take to be their distinctive contributions. Consider Aristotle's narrative in die first book of me Mdaphysics about the insights and blindnesses of his predecessors in grasping the multidimensional character of our scientific knowledge of causes. Or — to leap to the contemporary scene — think of the story that logical positivists told us about the confusions and linguistic blunders of most of their predecessors — with a few bright moments of anticipation of their own radical program for reforming phdosophy. Or again, there is the powerfully seductive story diat Husserl tells where the entire history of philosophy is viewed as a teleological anticipation of die new rigorous Wissenschaft of transcendental phenomenology. There is a common rhetorical pattern in these narratives. They tell stories ofanticipations, setbacks, and trials, but they culminate with the progressive realization of truth and reason, which is normally identified with what die philosopher/ storyteller now sees clearly — a "truth" which his or her predecessors saw only through a glass darkly. There is also die genre of philosophic narratives which has become so fashionable in the nineteenth and twentieth centuries and has dramatically reversed diis pattern. They tell of relentless decline, degeneration, catas186 Richard J. Bernstein187 trophe, and forgetfulness. A "classic" instance of this is Nietzsche's geneological unmasking of the "history" of reason, truth, and morality which culminates in the dominance and spread of a pernicious all-encompassing nihilism. But we also find variations of this pattern in Maclntyre's saga of the decline and degeneration of moral phdosophy and moral life since me Enlightenment. And — as we shall see — diis is die way in which Heidegger reads (in his "strong reading") the destiny of Western philosophy and metaphysics which is interwoven with the history of the forgetfulness and concealment of Being. It is not my intention to develop a typology of narrative patterns in philosophy, although I am convinced that such a typology would be extremely üluminating. Rather I want to set a context for what I will attempt to do in this article. For I want to oudine a narrative — or more accurately and modestly — a narrative sketch. Even diough I will be schematic, my tale is a complex one for several reasons. First, because it is a narrative about narratives, specifically narratives which themselves relate stories about the development of reason, or what thinkers such as Weber and Habermas call "rationalization" processes,1 Secondly, because it is a narrative that isolates different story lines, a plot and a counterplot that stand in an uneasy and unresolved tension with each odier. Thirdly, because it is not one of those narratives where all the loose threads are neady tied together at die end — or to switch metaphors, there is no grand Aufhebung because it is essentially an unfinished story. In the spirit of this prologue let me introduce die four main characters ofmyfirst story line, and tell you what I hope to achieve. The names of the main characters are Condorcet, Weber, Adorno, and Heidegger. My aim is to confront some deeply troubling contemporary questions, for I want to understand why today there are so many "voices" screeching about Reason. Why is there a rage against Reason? What precisely is being attacked, criticized, and damned? Why is it diat when "Reason" or "Rationality" are mentioned, they evoke images of domination, oppression, repression, patriarchy, sterility, violence, totality, totalitarianism, and even terror? These questions are especially poignant and perplexing when we realize that not so long ago, die call to "Reason" elicited associations with autonomy, freedom, justice, equality... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Testament of the Other: Abraham and Torok’s Failed Expiation of GhostsChristopher Lane (bio)Nicolas Abraham and Maria Torok. The Shell and the Kernel. Vol. 1. Ed., trans., and intro. Nicholas T. Rand. Chicago: U of Chicago P, 1994.Nicholas Rand and Maria Torok. Questions à Freud: Du Devenir de la Psychanalyse. Paris: Belles Lettres-Archimbaud, 1995.Nicholas Rand and Maria Torok. “Questions to Freudian Psychoanalysis: Dream Interpretation, Reality, Fantasy.” Trans. Rand. Critical (...) Inquiry 19.3 (1993): 567–94. [“QFP”]Truly the universe is full of ghosts, not sheeted churchyard spectres, but the inextinguishable and immortal elements of life, which, having once been, can never die, though they blend and change and change again for ever.—H. Rider Haggard, King Solomon’s MinesWhat haunts are not the dead, but the gaps left within us by the secrets of others.—Nicolas Abraham and Maria Torok, The Shell and the Kernel1. PrologueNicolas Abraham and Maria Torok may be best known for advancing a theory of transgenerational haunting. According to this theory, repressed secrets are passed from one generation to the next if they are “encrypted” as unprocessed and traumatic information. Before Abraham’s death in 1975, he and Torok saw their analytic role as reparative: Encouraging their analysands to mourn repressed secrets, they hoped to transform their analysands’ perspectives on family history.Abraham and Torok quickly became known for expanding Freud’s emphasis on the subject’s conflicting desires and identifications. From 1968 on, when Abraham published “L’écorce et le noyau” (“The Shell and the Kernel”) as an extended review of Laplanche and Pontalis’s The Language of Psychoanalysis, he and Torok published their claims in cheerful defiance of Freudian orthodoxy, acquiring a reputation in France—and, later, in England and the United States—for shattering such “doctrinaire” elements of psychoanalysis [End Page 3] as the Oedipus complex and death drive, penis envy, and the primal scene, as well as for criticizing Lacan’s alleged stranglehold on psychoanalysis in France and much of Europe. 1 After publishing L’écorce et le noyau (1987), a collection of their essays (many coauthored), and a radically new interpretation of Freud’s patient “the Wolf Man,” Cryptonymie: Le verbier de l’homme aux loups (1976; trans. The Wolf Man’s Magic Word: A Cryptonomy), Abraham and Torok were championed in Europe and the United States by theorists delighted to see a “poststructuralist” critique of Freudian and Lacanian psychoanalysis. Ironically, Abraham and Torok’s work received almost comparable support from analytical philosophers eager to denounce Freud’s “unscientific” precepts.Now that the first volume of Abraham and Torok’s essays has appeared in translation, non-Francophone readers have an opportunity to assess what Abraham and Torok contributed to psychoanalysis and to revisit the debates they staged with Freud and Lacan in the 1970s and—posthumously for Abraham—in the ‘80s. Reviewing this collection is not a simple task, however, because its conceptual interests are so diverse and because Torok’s coauthored work with Abraham differs radically from the essays and book she published recently with Nicholas Rand, editor and translator of The Shell and the Kernel. Rand’s interventions confirm Torok’s latest arguments but they also, occasionally, misleadingly frame the older work in terms of the new. Readers may therefore see Rand’s editorial notes and introduction as guides to how he and Torok now view Torok’s collaboration with Abraham. We can only speculate whether Abraham would have interpreted the collaboration the same way. 2How does Abraham and Torok’s account of psychic “encryptment” differ from Freud’s model of repression? Assessing their revision of Freud’s metapsychological project, Abraham and Torok declare, “It would be presumptuous indeed to allege that we have reached our goal. Yet it would be false modesty to deny our suspicion that we are finally entering an open road” [140]. 3 Echoing Freud’s conviction that in dreams he had discovered “the royal road to the unconscious,” Abraham and Torok encourage a comparative reading of their psychoanalytic “road” and Freud’s. The following essay undertakes this reading, but it also speculates on what Freud’s and Lacan’s emphasis on [End Page 4] psychic... (shrink)

The question naturally arises: Is public art inherently violent, or is it a provocation to violence? Is violence built into the monument in its very conception? Or is violence simply an accident that befalls some monuments, a matter of the fortunes of history? The historical record suggests that if violence is simply an accident that happens to public art, it is one that is always waiting to happen. The principal media and materials of public art are stone and metal sculpture (...) not so much by choice as by necessity. “A public sculpture,” says Lawrence Alloway, “should be invulnerable or inaccessible. It should have the material strength to resist attack or be easily cleanable, but it also needs a formal structure that is not wrecked by alterations.”12 The violence that surrounds public art is more, however, than simply the ever-present possibility of an accident—the natural disaster or random act of vandalism. Much of the world’s public art—memorials, monuments, triumphal arches, obelisks, columns, and statues—has a rather direct reference to violence in the form of war or conquest. From Ozymandias to Caesar to Napoleon to Hitler, public art has served as a kind of monumentalizing of violence, and never more powerfully than when it presents the conqueror as a man of peace, imposing a Napoleonic code or a pax Romana on the world. Public sculpture that is too frank or explicit about this monumentalizing of violence, whether the Assyrian palace reliefs of the ninth century b.c., or Morris’s bomb sculpture proposal of 1981, is likely to offend the sensibilities of a public committed to the repression of its own complicity in violence.13 The very notion of public art as we receive it is inseparable from what Jürgen Habermas has called “the liberal model of the public sphere,” a dimension distinct from the economic, the private, and the political. This ideal realm provides the space in which disinterested citizens may contemplate a transparent emblem of their own inclusiveness and solidarity, and deliberate on the general good, free of coercion, violence, or private interests.14 12. Lawrence Alloway, “The Public Sculpture Problem,” Studio International 184 : 124.13. See Leo Bersani and Ulysse Dutoit, “The Forms of Violence,” October, no. 8 : 17-29, for an important critique of the “narrativization” of violence in Western art and an examination of the alternative suggested by the Assyrian palace reliefs.14. Habermas first introduced this concept in The Structural Transformation of the Public Sphere: An Inquiry into a Category of Bourgeois Society, trans. Thomas Burger and Frederick Lawrence . First published in 1962, it has since become the focus of an extensive literature. See also Habermas’s short encyclopedia article, “The Public Sphere,” trans. Sara Lennox and Frank Lennox, New German Critique 1 : 49-55, and the introduction to it by Peter Hohendahl in the same issue, pp. 45-48. I owe much to the guidance of Miriam Hansen and Lauren Berlant on this complex and crucial topic. W. J. T. Mitchell, editor of Critical Inquiry, is Gaylord Donnelly Distinguished Service Professor of English and art at the University of Chicago. His recent book is Iconology: Image, Text, Ideology. (shrink)

In this essay I’d like to help readers prepare to learn from Gilles Deleuze’s Difference and Repetition.1 Such an essay is needed, as truer words were never spoken than when Deleuze said of it in his "Letter to a Harsh Critic": "it's still full of academic elements, it's heavy going"2 Now part of the “academic” aspect of the work comes from Deleuze having submitted Difference and Repetition to his jury as the primary thesis for the doctorat d'Etat in 1968.3 But (...) that doesn’t lessen the need for help when first approaching the book. The context of Deleuze’s remarks in his “Letter” should be noted: he has just been noting that "the history of philosophy plays a patently repressive role in philosophy, it's philosophy's own version of the Oedipus complex."4 Deleuze continues that he tried to subvert this repressive function by various means. First, by writing on authors such as Lucretius, Hume, Spinoza and Nietzsche who contested the rationalist tradition by the "critique of negativity, the cultivation of joy, the hatred of interiority, the externality of forces and relations, the denunciation of power [pouvoir]." Second, and quite notoriously, by “a sort of buggery [enculage] or (it comes to the same thing) immaculate conception.” That is, by making the author say something in their own words that would be “monstrous.”5 These are famous lines, and the last is certainly amusing in an épater les bourgeois sort of way. But what's really important in my view comes next, when Deleuze explains what it means to finally write "in your own name," as he claims he first did in Difference and Repetition. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Problem with BreathÉglantine Colon (bio)On day 1, when my comrades and I talked about it, we couldn't quite figure out how it happened. It just seemed as though we had suddenly been incited not to communicate or enact our love for each other. This time, no policy had been formulated, no law had been issued. It was harder than usual to locate where, to which parts of the (...) apparatus, we should direct our attention.On day 2, we were at a loss. We had gotten so good at reading the apparatus. We had developed wonderfully efficient techniques of resistance. Each and every one of us had become most brilliant at crafting discrete gestures of love. On day 3 onwards, we were misfiring on a regular basis, falling in and out of love with the same wrong comrades, over and over again, and always out of sync. The loving gestures we composed were barely legible and when we would intuitively find a genre in which to communicate our love, something would inevitably break down. Voices, generally. Sometimes the entire figurative system. Bodies, always. We would lose sleep and appetite over love and get useless for weeks.And then, the problem with love became a problem with breath. On day 6, the air got hot and busy with ashes and all sunsets turned red. At every breath, for all we knew, we could be inhaling particles of carbonized pine sap, debris of melted trailer parts, or burnt baby birds in bits. I quit smoking. I bought boxes of white masks at the construction store. The dominant smell during these days was a cagey mix of ghost paint, polymer fibers, and dry chemistry.On day 17, the air got cold and saturated with drops of viral poison. The city shut down. An incredibly sad number of lungs, too. The perspective to live in pods and die alone, disconnected from each other's breath, hyper-connected to life-support machines, plunged many of us, myself included, into brand new strands of historical despair. For those of us whose lungs had been weakened by bad inner-city fumes, evil chemicals, or entire centuries of racialized exposure to horrendous air quality, the problem with breath became plain lethal.Our neighborhoods were saturated with wildfire smoke and unnecessary death. Elsewhere, the streets were not empty. And when I say not empty, I mean they were just not. Or not yet. Usual metallic densities on the bridge. Geometrical glows of digital light in the underground. [End Page 237]Abnormally, no bodies of any ancestries were being captured, or hanged, or tortured, or kneeled upon. Nothing tangible, nothing blatantly repressive this time. No gas, no gag, no name, no whip, no rope. No strangulating remnant of sovereignty within no softness of biopower. A racist and classist brand of distributive pneumocracy is what it was, or at least this is how it initially appeared.On day 25, "Critical Pandemic Studies" became a thing, and "Pod Theory" a subgenre in post-social anthropology. Denounced as a "white fantasy of networked individualism," (in one of its purest forms) as "domestic fascism dressed as elective affinity," the pod appeared to us, from the get-go, as a thoroughly ratchet social formation. On day 29, the "podtag" emerged as a timely intervention in existing forms of street art. Equational in its form, efficient in its power of evocation, and satirical in its poetic economy, the podtag proliferated on the privatized walls of neighborhoods where the biggest challenges presented to breathing were unreasonably difficult Pilates classes on Zoom. Click for larger view View full resolutionOn day 35, the air got complex and full of knots, so striated that we could no longer count on our capacity to share the same air. A meal was being cooked, an instrument was being played, a child was given birth to, and suddenly the rhythm of all breaths would break. Sometimes a pair of lungs would refuse, stubbornly, to take in any oxygen until someone else's pair of lungs had released its own dose of carbon dioxide. At other times, the quantity of air available to each one of us would decrease with... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Two Cheers for Blueprints, or, Negative Reasons for Positive UtopianismAntonis Balasopoulos (bio)It is well known that the decline of programmatic or so-called blueprint utopias and utopianism came on the heels of a widespread and concerted attack against them during the first two decades of the Cold War. In the writings of thinkers like Hayek, Popper, Talmon, Kolakowski, and many others, program became synonymous with hubris.1 It was construed as (...) a dangerous effort to regulate the diversity of human subjectivity and the complexity of the social organism, a repressive will-to-order and predictability that tainted utopias by associating them with Totalitarianism. In Popper’s exemplary exposition:The Utopian attempt to realize an ideal state, using a blueprint for society as a whole, is one which demands a strong centralized rule of a few, and which therefore is likely to lead to a dictatorship. [...] [Utopia] claims to plan rationally for the whole of society, although we do not possess anything like the factual knowledge which would be necessary to make good such an ambitious claim.2 [End Page 489]Yet, though this view of how Utopia, to recall Robert C. Elliott, became “a bad word,” is accurate in itself, it also reflects only the negative or destructive side of Cold War anti-utopianism, a trend whose logical inconsistencies and ideological biases have already been ably dissected in the work of Russell Jacoby, Marc Olssen, and Darren Webb, to name but a few.3What one could term the “positive” or “productive” side of anti-utopian denunciations of the dogmatically programmatic character allegedly inherent in utopias went well beyond the exigencies of generating a geopolitical and ideological enemy image. It involved an effort to reconcile western subjects to seismic and highly consequential shifts within postwar, late-capitalist societies themselves. If, as I have argued elsewhere, utopian fictions (and, indeed, nonfictions) before the Cold War period can be read as fictions of organization—of everything from architecture and urban planning, to production, sexuality and biological reproduction, clothing, or diet—it is also the case that in them, “organization” is a response, a reaction to traumatic historical experiences of disorganization, from the decline of the ancient city-state in the case of Platonic utopianism; to the impoverishment and dislocation of rural communities in the era of Thomas More; to the experience of the fracturing of religious community during the religious, civil, and international wars that marked the seventeenth century; to the dramatic impact of early nineteenth-century industrialization on artisanal and agrarian communities, on family cohesion and on the rhythms of the premodern working day.4My argument is, then, that the anti-utopian denunciation of blueprint and program was not simply motivated by the liberal capitalist attack against the planned and highly regulated character of economy and society in the countries of so-called actually existing socialism. It was also motivated by the ideological need to normalize and legitimize the transition, within western capitalist societies themselves, to what Scott Lash and John Urry called “disorganized capitalism.” Lash and Urry’s book, originally published during the decade of the triumphant rise of neoliberalism, in 1987, launches its investigation by tellingly quoting the passage of Marx and Engels’s Communist Manifesto that focuses on the creatively destructive aspects of capitalist social transformation: the bourgeoisie, Lash and Urry observe, is a class “with vested interest in change, crisis and chaos”; the social world over which it presides is one “which swings wildly out of control, menacing and destructive.”5 In their introduction, the authors outline the basic features of the postwar shift from the organized capitalism of the mid-nineteenth and early twentieth centuries to its disarticulated successor formation during the rise of [End Page 490] neoliberal governance. Under the rubric of “disorganization” (which is to say, of a mutation within the western capitalist economic and social order), they include de-industrialization and the decline in the absolute and relative size of the working class in the core capitalist economies; the rise of flexible forms of labor organization in the place of defunct Taylorist principles; the weakening of trade unionist organization; the increasing decoupling of large monopolies from the control and regulation... (shrink)

This article is concerned with the problem of the relation between the genetic information contained in the DNA and the emergence of visible structure in multicellular animals. The answer is sought in a reappraisal of the data of experimental embryology, considering molecular, cellular and organismal aspects. The presence of specific molecules only confers a tissue identity on the cells when their concentration exceeds the threshold of differentiation. When this condition is not fulfilled the activity of the genes that code for (...) the specific molecules in question only confers on them a histogenetic potency, i.e. the capacity to form the corresponding tissue in further development (or to transdifferentiate to that tissue). The progressive restriction of histogenetic potencies during development reflects the irreversible repression of more and more genes. The establishment of a given tissue identity under the influence of an inducing tissue (or a morphogenetic hormone) is only possible when the cells have acquired the competence to respond. Tissue differentiation proceeds progressively during development thanks to the cytoplasmic memory that cells retain collectively (or sometimes individually) of the items of information successively registered by their ancestors cells. The increasing complexity of visible structure emerging during development results only from the progression of tissue differentiation. This involves continual exchange of information among the cells and leads to (1) cell displacements and rearrangements, particularly during organogenesis and (2) extreme diversification of cell individualities within tissues, particularly during postembryonic growth. A mutation (just as a teratogenic factor) evokes an anomaly that is localized in both space and time because it alters a certain aspect of cell behaviour (particularly cell surface adhesiveness or mitotic activity) at the time when this is involved in the establishment of a particular structural trait. Neither the organization of the adult nor the modalities of development are encoded in the DNA. The automatic concatenation of cell interactions in the embryo and the structural amplification it entails is conditioned by the specific biochemical composition of the cytoplasm of the egg and by the heterogeneous distribution of its inclusions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Ad Infinitum: The Ghost in Turing’s Machine: Taking God Out of Mathematics and Putting the Body Back InTony E. JacksonAd Infinitum: The Ghost in Turing’s Machine: Taking God Out of Mathematics and Putting the Body Back In, by Brian Rotman; xii & 203 pp. Stanford: Stanford University Press, 1993, $39.50 cloth, $12.95 paper.Brian Rotman’s book attempts to pull mathematics—the last, most solid home of metaphysical thought—off its absolutist (...) foundations and into the roiling current of postmodernism. His argument works in what has by now become a rather standard manner. He shows how the grounding ideas of mathematics rest upon the insupportable assumption of a realm of absolute truth, “truth perfect, truth outside time, outside space, outside the material world of matter, energy, and entropy, truth somehow able to be discovered or apprehended but never invented” (p. 19). Rotman questions this Platonic grounding in a number of ways.First, with the help of linguistics (de Saussure, Benveniste, Wittgenstein, and Peirce) he provides a semiotic analysis of mathematical arguments as real-world linguistic events. Proof he looks at “not as a form of inference engaged in preserving eternal truths, but as an historically conditioned species of rhetoric” (p. 35). Secondly, Rotman argues that one idea has most secured the fortress-like solidity of mathematical Platonism: the idea of ad infinitum or infinite iteration. Mathematics takes off from the givenness of the natural numbers, our everyday 1, 2, 3 and so on to infinity. It is the “so on to infinity” that frames up the house of arithmetic as it has stood since Euclid. (Euclidean in this context is equivalent to Platonic in the context of philosophy.) But what is the referent of these numbers? Ultimately they are said to be the symbolic representation of the action of counting, which is the “mathematical ur-cognition” (p. 51). And yet we cannot imagine any material human situation in which counting could actually go on to infinity. Therefore, some impossible, supernatural agent (the ghost of the title) must be projected in order for this conception to exist. Similarly, Rotman argues against the assumption of “perfect repeatability” because this notion depends upon some purely imaginary, ideal identity of object or action that could possibly be repeated. Ad infinitum requires and assumes both a disembodied, metaphysical counter and a disembodied, metaphysical counted.So Rotman sets about putting the body back into this symbolic system by rejecting the idea of ad infinitum. Instead of assuming the existence of counting activities that run, in principle, out to infinity without changing their nature, Rotman posits what he calls “realizable iteration,” that is, counting that admits the necessary dissolution or change of whatever repetitive function you begin with. Put simply, he includes the fact that quantitative accumulation or repetition always eventually brings about a qualitative change: at some point in everyday life a difference of degree of the “same” thing or action inevitably becomes a difference of kind. The natural numbers and the ad infinitum [End Page 390] remain blissfully sheltered from this inescapable real world truth, but Rotman reformulates mathematics so as to include this truth in the very idea of numbering.In fact (and he acknowledges this) he theorizes counting after the model of chaos or complexity theory in the physical sciences. Realizable iteration, he says, will bring in the “qualitative differences” forgotten or repressed (the language of Nietzsche, Heidegger, and Freud runs throughout) in the metaphysical version of number, and “display [the qualitative differences] as the emergent effects of repetition” (p. 131). Even numerical addition, for instance, which had been the most linearly continuous of activities, now will be linear beginning from some initial point, but will become increasingly nonlinear as quantitative increase tends towards some point of qualitative discontinuity with what had come before. The point of discontinuity, though certain to appear, is by its nature not specifiable beyond a horizon of probability, and in this, Rotman aligns his arithmetic not only with chaos theory, but also with quantum mechanics. In an appendix, Rotman elaborates at least to a degree the “pre-elements” of his non-Euclidean arithmetic.As chaos theory does not destroy everyday cause... (shrink)

In my continuing efforts to build a bridge between psychoanalytic findings and biosemiotics here, as in previous works, ‘biosemiotic’ refers to the hierarchy of meaning-forms (from biological to semiotic-organizations) underlying an updated psychoanalytic model of mind. Within this framework I present a broad range of bio-semiotic phenomena, processes, dynamics, defenses, and universal and unique internalized interpersonal patterns, that in psychoanalysis all commonly fall under the broad heading of the “Unconscious.” Reconceptualized as interpretive data within the purview of a psychoanalytic discourse-semantic (...) this biosemiotic framework posits an epigenetic continuum of human meaning-organizations originating at basic organic levels, moving upward through biological, psycho-somatic and affective expression, proto-semiotic transmissions, represented forms, and finally to explicit linguistic signs and complex symbol systems. In addition to assuming an uninterrupted epigenetic continuum crystallizing in hierarchic organization, this framework accentuates the multilayered and increasingly condensed quality of higher more elaborate organizations of meaning in human communication, drawing attention to persisting biological undercurrents in implied sense, intent, and motivation, all of which impact on repressive/defensive mechanisms. Drawing from previous works (Aragno 1997, 2005, 2008a, b, Psychoanalytic Inquiry 29(1):30–47, 2009, Biosemiotics 3:57–77, 2010, 2011a, Signs 5:71–74, 2011b, Journal of the American Psychoanalytic Association, Centennial Paper, Special Centennial Issue 59(2):239–288, 2011b, Signs 5:29–70, 2011c) in which I labored to update and revise Freud’s first topographical theory of mind, this paper presents the phenomenology of unconscious ‘data’ for the purpose of introducing a diverse range of non-linguistic signifying forms from which psychoanalysts infer mental processes and ‘interpret’ meanings. An important underlying premise regarding psychoanalytic data and its relation to the basic biosemiotic ‘agenda’ is that until grounded in an updated developmental theory of mind inclusive of pre- and proto-semiotic-forms, that is evolutionarily plausible, epistemologically based, and correlates with contemporary neuroscience, the term “sign” is merely an abstract linguistic ‘label’ rather than a mental act with antecedent developmental stages manifesting meanings through different forms and modes of expression. Drawn from the yields of the psychoanalytic method and semantic this revised metatheoretical approach provides insights into the sensory-emotive, bodily origins of unconscious layers of non-linguistic signification thereby expanding our understanding of the formative stages of the ‘semiotic function’ in human evolution. This being the third in a series of papers integrating the yields of psychoanalytic methodology with the underlying premises of ‘Biosemiotics,’ some familiarity with the background knowledge provided in the previous two is strongly recommended. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dependent Co-Origination and Universal IntersubjectivityJoseph A. Bracken, SJTwo essays in a recent issue of Buddhist-Christian Studies dealt with the topic "Buddhist and Christian Views of Community." The first essay, by Rita Gross, was a careful analysis of the way in which the separation of home and workplace in contemporary Western society has tended to reduce effective community life to the nuclear family and thus pose significant disadvantages to everyone (...) involved (not only mothers, fathers, and their children but also non–family members, friends, and neighbors) within the broader civic community.1 A consumer-oriented culture catering to individual needs and desires has arisen to compensate for the pervasive feeling of loneliness and emptiness created by the relative lack of significant interpersonal relationships. In the second essay Donald Mitchell recounted the origin and unexpected growth of the International Focolare movment of which he is a longtime member.2 He noted how the founder of the movement, Chiara Lubich, and her women friends found inspiration for living together and working for the poor and the homeless around them in what they saw as the self-giving love of the three divine persons of the Christian doctrine of the Trinity both for one another and for all their creatures. This movement over time broadened to include first Protestant members, then Jews, Muslims, Buddhists, and Hindus, all drawn by the goal of richer life in community along with group efforts to assist the underprivileged of this world.My own contribution to the topic of Buddhist and Christian views of community will focus on the same communitarian model of the doctrine of the Trinity that originally inspired Lubich and her followers in the years during and after World War II, but my remarks will be more philosophically oriented. Following the lead of the late Colin Gunton in his book The One, the Three and the Many,3 I will analyze the communitarian model of the Trinity for its value in setting forth a new paradigm for the relationship of the One and the Many. As Gunton perceptively notes in the early chapters of his book, Western civilization seems to be still preoccupied with a basically Platonic understanding of the One and the Many in which the One enjoys primacy over the Many as their transcendent principle of order and intelligibility.4 As a result, even though freedom and individual self-expression are theoretically prized in Western societies, in point of [End Page 3] fact there is a great deal of uniformity and even repression of individual differences so as to conform to the cultural standards imposed by some dominant individual or minority group within each society. In the end people seem to fear the threat to personal security represented by wide diversity and plurality more than they value their individual liberty.Looking to the doctrine of the Trinity set forth by the Greek-speaking fathers of the Church, however, Gunton finds a new paradigm for the One and the Many whereby the One is emergent out of the interplay of the Many with one another rather than transcendent over the Many as their necessary principle of order and intelligibility.5 The Many are defined by their internal relations to one another rather than by their common relation to an external One. The community thus achieved is a differentiated unity, not only tolerating differences of the Many among themselves, but even fostering those differences so as to produce in the end a more complex form of community. The application to the Christian doctrine of the Trinity is obvious. The three divine persons are strictly defined with respect to one another; each of them has no self-identity apart from relation to the other two persons. Yet together they co-constitute the reality of the one God, a richly differentiated rather than blandly homogeneous unity.6The application to human beings and their membership in various communities, of course, is not so obvious. But Gunton believes that three principles or "transcendentals" for the understanding of the relation of human beings with one another and with God are at hand, given careful study of this communitarian model of the Trinity: namely, perichoresis, substantiality or... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“Above and Beneath Classification”: Bartleby, Life and Times of Michael K, and Syntagmatic ParticipationGert Buelens (bio) and Dominiek Hoens (bio)The history of the relation between the law, norm, or rule on the one hand and what forms an exception to that rule on the other is complex and multifaceted.1 In the most general terms, one could posit that the exception is that which escapes from the rule. Thus, (...) confronted with the strangeness of Michael K, his noncommunicativeness, his odd combination of meekness and intransigence, the medical officer in J. M. Coetzee’s Life and Times of Michael K assigns K a place “above and beneath classification” [Coetzee 151]. Michael K is at once too large and too small to fit into the administrative and humanitarian categories that pertain at the prisoner camp. He appears to the medical officer—whose good intentions and patient, selfless interest in K cannot be doubted—as a recalcitrant, nonidentifiable object that flirts with dehumanization. To put it in Bataille’s terms, Michael K is formless (informe), and his existence can, by mere virtue of that fact, be called scandalous.2Let us take a closer look at the expression “above and beneath classification.” We can note that (1) it names something that situates itself on the outside of any classification; (2) this something must have a paradoxical status, since it is at once above and beneath classification; (3) the nonclassifiable is regarded as such from a classifying perspective. Although the latter point may sound tautological, it nonetheless touches upon one of the most difficult dimensions of the exception: if the exception is always an exception to the rule, how can it exist otherwise than by virtue of that rule? how can it be more than just the rule’s negative? But if the exception radically breaks away from the rule, then how is it possible for that rule to identify the exception and recognize it as such? This crucial problem has formed the basis for reflection on the relation between rule and exception. Freud, for instance, saw the exception (crime) as constitutive of social ties and the social order. Lacan needed a special topology to show the extimate character of what is at once inside and outside the symbolic order [Lacan, Miller]. Religious ways of thinking could be said to have located the exception as transcendent to any human order. For Badiou, the secularization of the infinite cannot be thought apart from an immanent, rather than transcendent, event that is disruptive of all order. In Derrida’s subtle analyses, the originary supplement appears as both constitutive and deconstructive. Agamben regards the exception as having become the political rule. These interpretative frameworks, in spite of some deep distinctions, all show not only that the rule cannot do without the exception, but that the exception is just as dependent on the rule. Even when the exception is regarded as a kind of pure, ruleless being-as-such, the rule is at the very least conceptually [End Page 157] indispensable for this pure, mere being to be thinkable in the first place. In brief, however much one may want, for political or other reasons, to assign the exception a central place at the expense of the rule, that rule remains inescapable.Nonetheless, the inevitability of the rule should not lead us to conclude that it is also immutable, nor that we should adopt a conservatism that accepts the rule as a repressive normativity or as an inclusive and exclusive apparatus of judgment. That this is as impossible as it is undesirable is suggested by what we indicated under the second item: the exception is both above and beneath. The exception is the paradoxical given of that which at once escapes from existing categories and lacks all identity in that escape. The problem that Michael K and Bartleby, the second figure of exception we consider in this essay, present for the rule resides not just in the recalcitrance that allows them to show up the limits of the rule, but also in the doubling with which this goes hand in hand. Michael K and Bartleby are as pliant as they are obdurate, show great loyalty even... (shrink)

Micro RNAs (miRNAs) have been shown to control many cellular processes including developmental timing in different organisms. The prediction that miRNAs are involved in regulating hox genes of flies and mouse is quite a recent idea and is supported by the finding that mir‐196 represses Hoxb8 gene expression. The non‐coding regions that encode these miRNAs are also conserved across species in the same way as other mechanisms that regulate expression of hox genes. On the contrary, until now no homeotic phenotype, (...) a hallmark of any hox gene mutation, had been associated with any hox miRNA. Recent work on bithorax complex miRNA (miR–iab‐4–5p) shows, for the first time, that miRNAs can lead to homeotic transformation. This miRNA regulates Ultrabithorax (Ubx) and results in the transformation of haltere to wing.1 This study unveils a new complexity and finesse to the regulation of hox gene expression pattern that is needed for determining the anteroposterior body axis in all bilaterians. BioEssays 28: 445–448, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The theory of self-organization of complex systems studies laws of sustainable co-evolutionary development of structures having different speeds of development as well as laws of assembling of a complex evolutionary whole from parts when some elements of “memory” must be included. The theory reveals general rules of nonlinear synthesis of complex evolutionary structures. The most important and paradoxical consequences of the holistic view, including an approach to solving the riddle of human personality, are as follows: 1) the (...) explanation why and under what conditions a part can be more complex than a whole ; 2) in order to reconstruct society it is necessary to change an individual but not by cutting off the supposed undesirable past, since a human being as a microcosm is the synthesis of all previous stages of evolution, and as a result of repression of, it would seem, the wild past one can extinguish a “divine spark” in his soul; 3) in the physical sense, singularity denotes a moment of instability, phase transition; one can talk about the human singularity of co-evolutionary processes, since in such a moment of instability individual actions of a human can play a key role in determining a channel of further development as well as in appearance of a new pattern of collective behavior in society; 4) as the models of nonlinear dynamics, elaborated at the Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences in Moscow, show, there is a possibility of a direct influence of the future and even a touch of an infinitely remote future in certain evolutionary regimes and under rigorously definite conditions, more over, it turns out that such a possibility exists only for a human but not for the human society. (shrink)

Cells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly (...) in vertebrates, indicating combinatorial and dynamic properties of Polycomb proteins, in some cases even overflowing outside the cell nucleus. Therefore, their function may not be limited to the imposition of rigid states of genetic programs, but on the ability to recognize signals and allow plastic transcriptional changes in response to different stimuli. Here, we discuss the most novel PcG mediated memory functions in facing and responding to the challenges posed by a fluctuating environment. Cellular microenvironment can regularly change, hence the need for a dynamic modulation of transcriptional programs by the epigenome. In the current review, we highlight novel emerging aspects of epigenetic memory controlled by PcG proteins and the evolution of specialized functions to convey plasticity and adaptability to environmental changes. (shrink)

For a fixed q  ℕ and a given Σ1 definition φ(d,x), where d is a parameter, we construct a model M of 1 Δ0 + ¬ exp and a non standard d  M such that in M either φ has no witness smaller than d or phgr; is equivalent to a formula ϕ(d,x) having no more than q alternations of blocks of quantifiers.

An infinite binary sequence is complex if the Kolmogorov complexity of its initial segments is bounded below by a computable function. We prove that a $\Pi _{1}^{0}$ class P contains a complex element if and only if it contains a wtt-cover for the Cantor set. That is, if and only if for every Y ⊆ ω there is an X in P such that X ⩾wtt Y. We show that this is also equivalent to the $\Pi _{1}^{0}$ class's (...) being large in some sense. We give an example of how this result can be used in the study of scattered linear orders. (shrink)

In this paper we continue the study of the theories IΔ n+1 (T), initiated in [7]. We focus on the quantifier complexity of these fragments and theirs (non)finite axiomatization. A characterization is obtained for the class of theories such that IΔ n+1 (T) is Π n+2 –axiomatizable. In particular, IΔ n+1 (IΔ n+1 ) gives an axiomatization of Th Π n+2 (IΔ n+1 ) and is not finitely axiomatizable. This fact relates the fragment IΔ n+1 (IΔ n+1 ) to induction (...) rule for Δ n+1 –formulas. Our arguments, involving a construction due to R. Kaye (see [9]), provide proofs of Parsons’ conservativeness theorem (see [16]) and (a weak version) of a result of L.D. Beklemishev on unnested applications of induction rules for Π n+2 and Δ n+1 formulas (see [2]). (shrink)

Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue‐specific expression of master genes during development. These highly sophisticated developmental transitions are dependent on the context‐ and tissue‐specific assembly of the different types of (...) Polycomb Group (PcG) complexes, which regulates their targeting and/or activities on chromatin. Here, an overview is provided of how PcG complexes function at multiple scales to regulate transcription, local chromatin environment, and higher order structures that support normal differentiation and are perturbed in tumorigenesis. (shrink)

The mechanisms used to establish embryonic polarity are still largely unknown. A recent paper(1) describes the expression pattern of the gene glp‐1, which is required for induction events during development of the nematode Caenorhabditis elegans. Although glp‐1 RNA is found throughout the early embryo, Glp‐1 protein is only expressed in anterior cells. This negative translational regulation in posterior cells is shown to be mediated through sequences in the glp‐1 3′ untranslated region (3′UTR). Thus in nematodes, as in Drosophila, translational repression (...) is one mechanism used to establish the embryonic anterior‐posterior axis. (shrink)