Clonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCR‐ABL, characteristic of chronic myeloid leukemia; mutations of the PIG‐A gene, characteristic of paroxysmal nocturnal hemoglobinuria; the V617F mutation in the JAK2 gene, characteristic of myeloproliferative diseases. The population frequencies of these three blood (...) disorders fit well with a hierarchical model of hematopoiesis. The fate of any mutant clone will depend on the target cell and on the fitness advantage, if any, that the mutation confers on the cell. In general, we can expect that only a mutation in a hematopoietic stem cell will give long‐term disease; the same mutation taking place in a cell located more downstream may produce just a ripple in the hematopoietic ocean. (shrink)

The evolution and maintenance of cooperation in human and animal societies challenge various disciplines ranging from evolutionary biology to anthropology, social sciences, and economics. In social interactions, cooperators increase the welfare of the group at some cost to themselves whereas defectors attempt to free ride and neither provide benefits nor incur costs. The problem of cooperation becomes even more pronounced when increasing the number of interacting individuals. Punishment and voluntary participation have been identified as possible factors to support cooperation and (...) prevent cheating. Typically, punishment behavior is unable to gain a foothold in a population, while volunteering alone can efficiently prevent deadlocks in states of mutual defection but is unable to stabilize cooperation. The combined effects of the two mechanisms have surprisingly different consequences in finite and infinite populations. Here we provide a detailed comparison of the two scenarios and demonstrate that driven by the inherent stochasticity of finite populations, the possibility to abstain from social interactions plays a pivotal role, which paves the way for the establishment of cooperation and punishment. (shrink)

Contrary to assumptions that changes in brain networks are possible only during crucial periods of development, research in the past decade has supported the idea of a permanently plastic brain. Novel experience, altered afferent input due to environmental changes and learning new skills are now recognized as modulators of brain function and underlying neuroanatomic circuitry. Given findings in experiments with animals and the recent discovery of increases in gray and white matter in the adult human brain as a result of (...) learning, the old concept of cognitive reserve, that is the ability to reinforce brain volume in crucial areas and thus provide a greater threshold for age-dependent deficits, has been reinforced. The challenge we face is to unravel the exact nature of the dynamic structural alterations and, ultimately, to be able to use this knowledge for disease management. Understanding normative changes in brain structure that occur as a result of environmental changes and demands is pivotal to understanding the characteristic ability of the brain to adapt. (shrink)

Many consumers implicitly associate sustainability with lower product strength. This so-called ethical = less strong intuition (ELSI) poses a major threat for the success of sustainable products. This article explores this pervasive lay theory and examines whether it is a key barrier for sustainable consumption patterns. Even more importantly, little is known about the underlying mechanisms that might operate differently at the implicit and explicit levels of the consumer’s decision-making. To fill this gap, three studies examine how the implicit judgments (...) that consumers activate automatically shape their consumption behaviors, in concert with their more controlled explicit beliefs about sustainable products. The Main Study investigates the ELSI’s imprint on actual shopping patterns and disentangles the implicit and explicit mechanisms of the lay theory. This paper also asks how this negative influence can be attenuated by examining whether the consumer’s interest in sustainable consumption reduces reliance on the ELSI. Two follow-up studies confirm the robustness from different methodological and practical perspectives. Implications for companies and policy makers are derived. (shrink)

When the social relevance of robotic applications is addressed today, the use of assistive technology in care settings is almost always the first example. So-called care robots are presented as a solution to the nursing crisis, despite doubts about their technological readiness and the lack of concrete usage scenarios in everyday nursing practice. We inquire into this interconnection of social robotics and care. We show how both are made available for each other in three arenas: innovation policy, care organization, and (...) robotic engineering. First, we analyze the discursive “logics” of care robotics within European innovation policy, second, we disclose how care robotics is encountering a historically grown conflict within health care organization, and third we show how care scenarios are being used in robotic engineering. From this diagnosis, we derive a threefold critique of robotics in healthcare, which calls attention to the politics, historicity, and social situatedness of care robotics in elderly care. (shrink)

_In Perception, Empathy, and Judgment_ Arne Johan Vetlesen focuses on the indispensable role of emotion, especially the faculty of empathy, in morality. He contends that moral conduct is severely threatened once empathy is prevented from taking part in an interplay with cognitive faculties in acts of moral perception and judgment. Drawing on developmental psychology, especially British "object relations" theory, to illuminate the nature and functioning of empathy, Vetlesen shows how moral performance is constituted by a sequence involving perception, judgment, (...) and action, with an interplay between the agent's emotional and cognitive faculties occurring at each stage. In the powerful tradition from Kant to present-day theorists such as Kohlberg, Rawls, and Habermas, reason is privileged over feeling and judgment over perception, in such a way that basic philosophical questions remain unasked. Vetlesen focuses our attention on these questions and challenges the long-standing assertion that emotions are damaging to moral response. In the final chapter he relates his argument to recent feminist critiques that have also castigated moral theorists in the Kantian tradition for their refusal to recognize a role for emotion in morality. While the book's argument is philosophical, its method and scope are interdisciplinary. In addition to critiques of such philosophers as Arendt, MacIntyre, and Habermas, it contains discussions of specific historical, ideological, and sociological factors that may cause "numbing"—selective or broad-ranging, pathological insensitivity—in humans. The Nazis' mass killing of Jews is studied to illuminate these and other relevant empirical aspects of large-scale immoral action. (shrink)

Ecologically responsible policies are concerned only in part with pollution and resource depletion. There are deeper concerns which touch upon principles of diversity, complexity, autonomy, decentralization, symbiosis, egalitarianism, and classlessness.

Recent theoretical and empirical work in cognitive science and neuroscience is brought into contact with the concept of the flow experience. After a brief exposition of brain function, the explicit–implicit distinction is applied to the effortless information processing that is so characteristic of the flow state. The explicit system is associated with the higher cognitive functions of the frontal lobe and medial temporal lobe structures and has evolved to increase cognitive flexibility. In contrast, the implicit system is associated with the (...) skill-based knowledge supported primarily by the basal ganglia and has the advantage of being more efficient. From the analysis of this flexibility/efficiency trade-off emerges a thesis that identifies the flow state as a period during which a highly practiced skill that is represented in the implicit system’s knowledge base is implemented without interference from the explicit system. It is proposed that a necessary prerequisite to the experience of flow is a state of transient hypofrontality that enables the temporary suppression of the analytical and meta-conscious capacities of the explicit system. Examining sensory-motor integration skills that seem to typify flow such as athletic performance, writing, and free-jazz improvisation, the new framework clarifies how this concept relates to creativity and opens new avenues of research. (shrink)

Covering a period from the Middle Ages through the 1990s, and addressing phenomena overlooked by Rokkan such as statebuilding and nationalism, this book demonstrates that Rokkan's models continue to be relevant to modern political science and sociology. Kommisrud's study is a valuable contribution to Rokkanian approaches and the understanding of Eastern European development within the historical and geographic context of Europe as a whole.

Excessive fear generalisation is a feature characteristic of clinical anxiety and has been linked to its aetiology. Previous animal studies have shown that the mere passage of time increases fear generalisation and that brief exposure to training cues prior to long-term testing reverses this effect. The current study examined these phenomena in humans. Healthy participants learned the relationship between the presentation of a picture of a neutral male face and the delivery of a mild shock. One group was immediately tested (...) with a novel picture of a somewhat different male face (generalisation test). Another group was tested one week later. A third group was also tested one week later and was additionally exposed to the training picture prior to testing. During picture presentations, shock-expectancy ratings were obtained as a measure of fear. Fear generalisation increased from the immediate test to the 1-week follow-up test. This result could not be attributed to level of neuroticism or a general increase in fear (incubation). Furthermore, the time-dependent increase in fear generalisation vanished following brief exposure to the training picture. Results indicate that human fear generalisation is a temporally dynamic process and that memory for stimulus details can be re-established following a reminder treatment. (shrink)

Evil is a poorly understood phenomenon. In this provocative 2005 book, Professor Vetlesen argues that to do evil is to intentionally inflict pain on another human being, against his or her will, and causing serious and foreseeable harm. Vetlesen investigates why and in what sort of circumstances such a desire arises, and how it is channeled, or exploited, into collective evildoing. He argues that such evildoing, pitting whole groups against each other, springs from a combination of character, situation, and social (...) structure. By combining a philosophical approach inspired by Hannah Arendt, a psychological approach inspired by C. Fred Alford and a sociological approach inspired by Zygmunt Bauman, and bringing these to bear on the Holocaust and ethnic cleansing in the former Yugoslavia, Vetlesen shows how closely perpetrators, victims, and bystanders interact, and how aspects of human agency are recognized, denied, and projected by different agents. (shrink)

Introduction: Expressions of dignity as a clinical phenomenon in nursing homes as expressed by caregivers were investigated. A coherence could be detected between the concepts and phenomena of existence and dignity in relationships and caring culture as a context. A caring culture is interpreted by caregivers as the meaning-making of what is accepted or not in the ward culture. Background: The rationale for the connection between existence and dignity in relationships and caring culture is that suffering is a part of (...) existence, as well as compassion in relieving suffering, and ontological interdependency. Aim: To describe different expressions of dignity in relationships and existence in context of caring cultures from the perspective of the caregivers. Research design: The methodology and method are hermeneutic. The method used was to merge the theoretical preunderstanding as one horizon of understanding with empirical data. Participants and research context: Focus group interviews with caregivers in nursing homes. Ethical considerations: The principles of the Helsinki Declaration have been followed to, for example, preserve self-determination, integrity, dignity, confidentiality and privacy of the research persons. Findings: Data interpretation resulted in four themes: Encountering existential needs that promote dignity in a caring culture; To amplify dignity in relationships by the creative art of caring in a caring culture; Violation of dignity by ignorance or neglect in a non-caring culture and The ethic of words and appropriated ground values in a caring culture. Discussion: Dignity-promoting acts of caring, or dignity-depriving acts of non-caring are adequate to see from the perspective of dignity in relationships and existence and the caring culture. Conclusions: Dignity in relationships seems to touch the innermost existential life, as the existential life is dependent on confirmation from others. (shrink)

The use of the concept of social history of science is sketched in the Anglo‐American and the German discussions from the mid 1970s up to recent work. By presenting a ‘social map’ of a selected scientific community it is argued that between the categories of discipline and single scientist there exists a wide ‘social space’ of groups within which science is pursued. In adopting a milieu theoretic approach an ecology of science is proposed as a suitable extension of the social (...) history of science. (shrink)

We are living in a time of acute vulnerability. From climate change to drone warfare, terrorist attacks to mass shootings, safe spaces to trigger warnings, not to mention the COVID-19 pandemic, homo vulnerabilis is once again coming to terms with the fact that it can be wounded, or even killed. Against such finitude, sovereignty is now reasserting itself as a political power that might save us from our ontological state. The irony is, of course, that such sovereignty – for example (...) through camps, walls, police violence, or drones – is also the underlying, historical cause of many of our most intense contemporary experiences of vulnerabilization. Interrupting the dialectic by which sovereignty manages to be both the cause of our vulnerabilization and the phantasmatic tool of its prevention, in Being Vulnerable Arne De Boever explores how today’s experiences of vulnerabilization can be translated into a collective human power that dismantles the form of sovereignty that is producing this state of affairs. Focused on theories, paradigms, and alternative formations of sovereignty, Being Vulnerable reconsiders the tradition of thinking through a political concept in order to approach it anew. (shrink)

In this paper we discuss an approach called grounded action cognition, which aims to provide a theory of the interdependencies between motor control and action-related cognitive processes, like perceiving an action or thinking about an action. The theory contrasts with traditional views in cognitive science in that it motivates an understanding of cognition as embodied, through application of Barsalou’s general idea of grounded cognition. To guide further research towards an appropriate theory of grounded action cognition we distinguish between grounding qua (...) acquisition and grounding qua constitution. On this basis, we distinguish three possible theoretical conceptions of grounded action cognition. In addition to these methodological and conceptual analyses, we draw on recent empirical evidence to motivate our inclination towards a particular theory. According to this theory certain representations are involved in action cognition and action perception that are not modality-specific as usually proposed by advocates of grounded cognition. Further, the evidence is in favor of our more specific theory stating that for some cognitive abilities, some motor abilites are constitutive. (shrink)

In a recent book onThe Publics of Science; Experts and Laymen Through History, Agustí Nieto-Galan introduced his subject of a (mostly Western) history of public science, covering the times from the Scientific Revolution to the twenty-first century, with reference to Sigmund Freud. In one of his essays of cultural critique, Freud had, so to speak, put culture itself on his couch, and this session also featured talk about science and technological application.Civilization and Its Discontentsidentified a factor of disillusionment in the (...) progress of science and technology, which gave rise to “The Uneasiness in Culture” (the literal translation of the title of Freud's German essayDas Unbehagen in der Kultur), and this uneasiness tainted a great deal of the happiness science and technology were intended to cultivate (Nieto-Galán 2011; Freud 1930). New technology and inventions like telephones, ocean liners, or drugs, Freud argued, were mostly remedies for negative developments technology had just created; for instance, without modern transportation people would stay close to each other and not need any telephone. (However, he did not address the issue of whether scientific knowledge itself may have provided some satisfaction.) The modern individual, as analyzed by Freud, was therefore constantly ill at ease with modern scientific and technological culture. (shrink)

Die Gesundheitsreformen der vergangenen Jahrzehnte haben die Organisation Krankenhaus einem grundlegenden Wandel unterzogen. Neben offenkundig notwendigen und sinnvollen Veränderungen hat es aber auch solche gegeben, die die Frage aufwerfen, welchen gesellschaftlichen Aufgaben das Krankenhaus in Zukunft dienen soll. Pointiert gefragt: Welcher Effektivität soll die seit Jahren betriebene Effizienzsteigerung in der Organisation Krankenhaus dienen außer der Begrenzung eines allgemeinen Kostenanstiegs? Es ergibt sich ein paradoxer Befund: Der Wandel der Organisation Krankenhaus scheint sich maßgeblich der Ökonomisierung zu verdanken, die zugleich das Mittel (...) darstellt, mit dem der Wandel bewältigt werden soll. In diesem Beitrag werden organisations- und institutionstheoretische Entwicklungen auf den Prozess der Ökonomisierung abgebildet und aus einer ethischen Perspektive reflektiert. (shrink)

Big Data and biopolitics are two major issues currently attracting attention in public health discourse, but also in sociology of knowledge, STS Studies as well as in philosophy of science and bioethics. The paper considers big data to be a new form and instrument of biopolitics which addresses both the categories of body and space. It is expected to fundamentally transform health care systems, domestic environments and practices of self-observation and reflection. Accordingly the paper points out some problems and pitfalls (...) as well as open questions that have emerged in the field of AAL, which merit more attention in future public and academic debate. (shrink)

The Snowden leaks, first published in June 2013, provided unprecedented insights into the operations of state-corporate surveillance, highlighting the extent to which everyday communication is integrated into an extensive regime of control that relies on the ‘datafication’ of social life. Whilst such data-driven forms of governance have significant implications for citizenship and society, resistance to surveillance in the wake of the Snowden leaks has predominantly centred on techno-legal responses relating to the development and use of encryption and policy advocacy around (...) privacy and data protection. Based on in-depth interviews with a range of social justice activists, we argue that there is a significant level of ambiguity around this kind of anti-surveillance resistance in relation to broader activist practices, and critical responses to the Snowden leaks have been confined within particular expert communities. Introducing the notion of ‘data justice’, we therefore go on to make the case that resistance to surveillance needs to be conceptualized on terms that can address the implications of this data-driven form of governance in relation to broader social justice agendas. Such an approach is needed, we suggest, in light of a shift to surveillance capitalism in which the collection, use and analysis of our data increasingly comes to shape the opportunities and possibilities available to us and the kind of society we live in. (shrink)

“Living involves being exposed to pain every second—not necessarily as an insistent reality, but always as a possibility,” writes Arne Vetlesen in A Philosophy of Pain, a thought-provoking look at an inevitable and essential aspect of the human condition. Here, Vetlesen addresses pain in many forms, including the pain inflicted during torture; the pain suffered in disease; the pain accompanying anxiety, grief, and depression; and the pain brought by violence. He examines the dual nature of pain: how we attempt (...) to avoid it as much as possible in our daily lives, and yet conversely, we obtain a thrill from seeking it. Vetlesen’s analysis of pain is revealing, plumbing the very center of many of our most intense and complicated emotions. He looks at pain within different arenas of modern life such as family and work, and he specifically probes at a very common modern phenomenon, the idea of pushing oneself to the limit. Engaging throughout with the ideas of thinkers such as Søren Kierkegaard, Sigmund Freud, Martin Heidegger, Jean-Paul Sartre, Maurice Merleau-Ponty, Max Horkheimer, Theodor Adorno, Alice Miller, Susan Sontag, and Melanie Klein, A Philosophy of Pain asks which came first, thinking or feeling, and explores the concept and possibility of empathy. Vetlesen offers an original and insightful perspective on something that all of us suffer and endure—from a sprained ankle to a broken heart. Although pain is in itself unpleasant, our ability to feel it reminds us that we are alive. (shrink)