This book identifies the organizing concepts of physical and biological phenomena by an analysis of the foundations of mathematics and physics.

La cognition humaine paraît étroitement liée à la structure de l'espace et du temps relativement auxquels le corps, le geste, l'intelligibilité semblent devoir se déterminer. Pourtant, ce qui, après les approches physico-mathématiques de Galilée et de Newton, fut caractérisé par Kant comme formes de l'intuition sensible, n'a cessé au cours des siècles qui suivirent de se trouver remis en cause dans leur saisie première par les développements théoriques. En mathématiques d'abord, avec les géométries non-euclidiennes, en physique ensuite, où relativité générale (...) puis théories quantiques et critiques ont dû remanier profondément l'objectivité de ces concepts pour en faire des catégories, certes toujours aussi essentielles, mais de plus en plus contre-intuitives, et maintenant en biologie où la temporalité, notamment, et la causalité se révèlent largement différentes de celles de la physique. C'est ce que nous tentons de présenter et de discuter dans ce texte en vue d'en dégager la pertinence pour la cognition elle-même. (shrink)

In this paper we define two types of formal biological entities corresponding to biological levels of organization, thebiolons and theorgons, the properties of which are phenomenologically analyzed and discussed.We examine then, in a rather speculative manner, how some characteristics of these entities may suggest analogies between properties of biological systems and some special features of quantum systems.

This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of life, such as rhythms, both physical (circadian, seasonal …) and properly biological (heart beating, respiration, metabolic …). In particular, the role of biological rhythms do not seem to have any counterpart in mathematical formalization of physical clocks, which are based on frequencies along the usual (...) (possibly thermodynamical, thus oriented) time. We then suggest a functional representation of biological time by a 2-dimensional manifold as a mathematical frame for accommodating autonomous biological rhythms. The “visual” representation of rhythms so obtained, in particular heart beatings, will provide, by a few examples, hints towards possible applications of our approach to the understanding of interspecific differences or intraspecific pathologies. The 3- dimensional embedding space, needed for purely mathematical reasons, allows to introduce a suitable extra-dimension for “representation time”, with a cognitive significance. (shrink)

"Réfléchir sur la science, mais aussi sur les relations humaines et sur des engagements politiques et militants, tout en faisant référence à des textes anciens et à des enseignements "traditionnaires", n'est-ce pas un peu provocateur? Pourtant, la présente évocation aspire à surmonter les parcellisations et l'éclatement de la pensée - telle, en particulier, que l'Occident la conçoit trop souvent - en traitant aussi bien du raisonnable que de l'affectif, du cognitif que du ressenti et de l'intime, du communautaire que du (...) politique. Il s'agit donc de trouver les voies, les canaux, d'une correspondance des singularités personnelles, visant les relations qu'elles peuvent et doivent élaborer et entretenir, afin de signifier le dégagement d'un sens : le projet d'une humanité. Expression d'une nécessité, d'une rationalité en quelque sorte et aussi, au moins, d'une expérience. Je trouve précieux et émouvant que tradition ésotérique juive et expérience militante gauchiste puissent s'apporter, s'échanger, s'entendre pour une perspective de mise en oeuvre envisageant de devenir commune, sans pour autant mélanger abusivement ce qui doit demeurer séparé, jusqu'à ce que l'alliance conclue entre des protagonistes dûment identifiés et authentifiés soit en mesure de reprendre en termes de compatibilités et de convergence ce qui s'est présenté trop souvent dans l'histoire en termes d'irréductibilités et d'aléatoire." Extrait et adapté de Francis Bailly, Avant-Propos. (shrink)

First Published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

This practical guide explores professional values in nursing, helping you to develop safe, compassionate, person-centred and evidence-based practice. The fundamental values of equality, anti-discriminatory practice and caring are discussed throughout. Chapters explore person-centred and holistic nursing care. They discuss working in partnership with people and families and working in partnership within the interprofessional team. The book explores vulnerability and safeguarding, challenging poor practice and promoting best practice. Chapters are mapped to NMC Standards for Pre-registration Nursing Education. Strong evidence base to (...) ensure best practice. Accessible style with features including learning outcomes, key points, summary boxes, case studies, reflection points and questions. Relevant to all fields of nursing, with case studies representing patients across the lifespan and with different healthcare needs. Free online resources include PowerPoints, additional scenarios and questions. Professional Values in Nursing is a valuable resource for all nursing students, helping to embed professional values in your everyday practice. (shrink)

Francis Bacon, lawyer, statesman, and philosopher, remains one of the most effectual thinkers in European intellectual history. We can trace his influence from Kant in the 1700s to Darwin a century later. The Advancement of Learning , first published in 1605, contains an unprecedented and thorough systematization of the whole range of human knowledge. Bacon’s argument that the sciences should move away from divine philosophy and embrace empirical observation would forever change the way philosophers and natural scientists interpret their (...) world. (shrink)

F. H. Bradley was the foremost philosopher of the British Idealist school, which came to prominence in the second half of the nineteenth century. Bradley, who was a life fellow of Merton College, Oxford, was influenced by Hegel, and also reacted against utilitarianism. He was recognised during his lifetime as one of the greatest intellectuals of his generation and was the first philosopher to receive the Order of Merit, in 1924. His work is considered to have been important to the (...) formation of analytic philosophy. In metaphysics, he rejected pluralism and realism, and believed that English philosophy needed to deal systematically with first principles. This work, first published in 1893, is divided into two parts: 'Appearance' deals with exposing the contradictions that Bradley believed are hidden in our everyday conceptions of the world; and in 'Reality', he builds his positive account of reality and considers possible objections to it. (shrink)

This self-contained anthology collects some of the most influential primary source contributions to contemporary analytic philosophy, together with introductions and commentaries for each selection. It traces the development of a few central themes in analytic philosophy, in sufficient detail—from philosophy of mind and language, metaphysics, epistemology, and philosophical logic. Frege, Russell, Moore. Wittgenstein. Logical Empiricism. Ordinary Language Philosophy. Quine. Truth, Meaning, and Interpretation. Reference and Essence. For anyone interested in Analytic Philosophy.

This is the first critical edition since the nineteenth century of Bacon's principal philosophical work in English, The Twoo Bookes of Francis Bacon. Of the proficience and advancement of Learning, divine and humane - traditionally known as The Advancement of Learning.

This volume belongs to the first new critical edition of the works of Francis Bacon (1561-1626) to have been produced since the nineteenth century. The edition presents the works in broadly chronological order and according to the best principles of modern textual scholarship. The seven works in the present volume belong to the final completed stages (Parts III-V) of Bacon's hugely ambitious six-part sequence of philosophical works, collectively entitled Instauratio magna (1620-6). All are presented in the original Latin with (...) new facing-page translations. Three of the seven texts (substantial works in two cases, and all sharing a startlingly improbable textual history) are published and translated here for the first time: these are an early version of the Historia densi, the 'lost' Abecedarium, and the Historia de animato & inanimato. Another--the Prodromi sive anticipationes philosphiae secundae--has likewise never been translated before. Together with their commentaries and the introduction they open the way to important new understandings of Bacon's mature philosophical thought. (shrink)

[opening paragraph] -- Clark: The `astonishing hypothesis' which you put forward in your book, and which you obviously feel is very controversial, is that `You, your joys and sorrows, your memories and ambitions, your sense of personal identity and free will are, in fact, no more than the behaviour of a vast assembly of nerve cells. As Lewis Carroll's Alice might have phrased it: `You're nothing but a pack of neurons'.' But it seems to me that this is not so (...) astonishing a statement for a scientist to make. Isn't this what reductionist science has always believed? (shrink)

I describe a distinctive kind of fear that is generated by a vivid recognition of one’s mortal nature. I name it ‘existential shock’. This special fear does not take our future annihilation as any kind of harm, whether intrinsic or extrinsic. One puzzling feature of existential shock is that it is experienced as disclosing an important truth, yet attempts to specify this revelatory content bring us back to familiar facts about one’s inevitable death. But how can I discover something that (...) I already knew? I argue that in our everyday lives, we are in the grip of deeply entrenched patterns of thought and feeling that prevent the knowledge of our mortality from being fully assimilated. Rather, we merely ‘pay lip service’ to the facts of our mortality. I propose that existential shock involves a distinctive mode of presentation of oneself as a mortal being, in a way that cuts through subtle layers of denial that govern our lives. I develop this thesis by utilizing and synthesizing ideas from several traditions, including the work of Samuel Scheffler, Mark Johnston, Martin Heidegger, and Jay L. Garfield. (shrink)

Cleaning occupations, which in recent years have accounted for a not inconsiderable share of employment and job creation in France, are characterised by particularly bad working conditions and low pay. Is this situation inevitable? Are there not in fact mechanisms that might lead employers in the cleaning sector to adopt socially more responsible behaviours towards their employees? After all, the literature on corporate social responsibility suggests that the actions of consumers could be one of these mechanisms. The aim of our (...) paper is to test the impact on job quality of contact between cleaning workers and service recipients. To this end, we analyse data from a survey carried out by the French Ministry of Labour and supplemented by interviews. Our results indicate that contact with service recipients does indeed have an influence. (shrink)

Bradley's metaphysical views, akin to those of Hegel, with a special emphasis on the internal relations of the Absolute are developed at length in Appearance ...

First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

BackgroundConcurrent with efforts to establish national and regional biorepositories in Africa is widespread endorsement of ethics committees as stewards of the interests of individual donors and their communities. To date, ethics training programs for IRB members in Botswana have focused on ethical principles and international guidelines rather than on the ethical dimensions of specific medical technologies and research methodologies. Little is known about the knowledge and concerns of current and prospective IRB members in Botswana with respect to export, reuse, storage, (...) and benefit-sharing of biospecimens.MethodsThis qualitative study examined perspectives of IRB members in Botswana about the collection and use of biospecimens in research. Forty-one IRB members representing five committees in Botswana participated in discussions groups in March 2013. Transcriptions of audiotapes and field notes were analyzed to identify issues of concern that might be alleviated through education and capacity-building, and areas that required ongoing discussion or additional regulatory guidance.ResultsAreas of concern included lack of understanding among patients and providers about the use of biospecimens in clinical care and research; reuse of biospecimens, particularly issues of consent, ownership and decision-making; export of specimens and loss of control over reuse and potential benefits; and felt need for regulatory guidance and IRB-member training. Local belief systems about bodily integrity and strong national identity in the construct of benefits may be at odds with initiatives that involve foreign biorepositories or consider such collections to be global public goods.ConclusionEducation is needed to strengthen IRB-member capacity to review and monitor protocols calling for the collection and use of biospecimens, guided by clear national policy on priority-setting, partnerships, review, and oversight. Engagement with local stakeholders is needed to harmonize fundamentally different ways of understanding the human body and community identity with the aims of contemporary biomedicine. (shrink)

This article presents a review of the literature, summarizes current initiatives, and provides a heuristic for assessing the effectiveness of a range of institutional review board collaborative strategies that can reduce the regulatory burden of ethics review while ensuring protection of human subjects, with a particular focus on international research. Broad adoption of IRB collaborative strategies will reduce regulatory burdens posed by overlapping oversight mechanisms and has the potential to enhance human subjects protections.

BackgroundEthical and regulatory guidance on the collection and use of human biospecimens for research forms an essential component of national health systems in Sub-Saharan Africa, where rapid advances in genetic- and genomic-based technologies are fueling clinical trials involving HBS and the establishment of large-scale biobanks.MethodsAn extensive multi-level search for publicly available ethics regulatory guidance was conducted for each SSA country. A second review documented active trials listed in the WHO International Clinical Trials Registry Platform as of January 2015 in which (...) HBS collection was specified in the protocol. Findings were combined to determine the extent to which countries that are study sites for HBS-related research are supported by regulatory guidance language on the collection, use, ownership and storage of biospecimens.ResultsOf the 49 SSA countries, 29 had some form of national ethics guidance, yet only 17 provided language relating to HBS-related research, with specific guidance on consent, ownership, reuse, storage, and export/import/transfer. Ten countries accounted for 84 % of the active clinical trials involving the collection of HBS in SSA. All except one of these countries were found to have some national guidance in the form of regulations, codes of ethics, and/or standard operating procedures; however, only seven of the ten offered any language specific to HBS.ConclusionsDespite the fact that the bulk of registered clinical trials in SSA involving HBS, as well as existing and proposed sites for biorepositories under the H3Africa Initiative, are currently situated in countries with the most complete ethics and regulatory guidance, variability in the regulations themselves may create challenges for planned and future pan-African collaborations and may require legislative action at the national level to revise. Countries in SSA that still lack regulatory guidance on HBS will require extensive health system strengthening in ethics governance before they can be full participants in the modern research enterprise. (shrink)

First published in 1876, this forceful and vigorous classic of English moral philosophy, written in opposition to Utilitarianism by one of England's most eminent philosophers, is now available for the first time since 1977.

[opening paragraph] -- Clark: The `astonishing hypothesis' which you put forward in your book, and which you obviously feel is very controversial, is that `You, your joys and sorrows, your memories and ambitions, your sense of personal identity and free will are, in fact, no more than the behaviour of a vast assembly of nerve cells. As Lewis Carroll's Alice might have phrased it: `You're nothing but a pack of neurons'.' But it seems to me that this is not so (...) astonishing a statement for a scientist to make. Isn't this what reductionist science has always believed? (shrink)