Results for 'Nadia Blackshaw'

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  1.  29
    Everettian Branching in the World and of the World.Nadia Blackshaw, Nick Huggett & James Ladyman - manuscript
    This paper investigates the formation and propagation of wavefunction `branches' through the process of entanglement with the environment. While this process is a consequence of unitary dynamics, and hence significant to many if not all approaches to quantum theory, it plays a central role in many recent articulations of the Everett or `many worlds' interpretation. A highly idealized model of a locally interacting system and environment is described, and investigated in several situations in which branching occurs, including those involving Bell (...)
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  2.  27
    Inconsistency arguments still do not matter.Bruce P. Blackshaw, Nicholas Colgrove & Daniel Rodger - 2021 - Journal of Medical Ethics 1:1-4.
    William Simkulet has recently criticised Colgrove et al’s defence against what they have called inconsistency arguments—arguments that claim opponents of abortion (OAs) act in ways inconsistent with their underlying beliefs about human fetuses (eg, that human fetuses are persons at conception). Colgrove et al presented three objections to inconsistency arguments, which Simkulet argues are unconvincing. Further, he maintains that OAs who hold that the fetus is a person at conception fail to act on important issues such as the plight of (...)
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  3. Solitudine e conversazione: i moralisti classici e David Hume / Nadia Boccara.Nadia Boccara - 1994 - Roma: Università degli studi della Tuscia, Istituto di scienze umane e delle arti, Facoltà di lingue e letterature straniere moderne.
     
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  4. Prolife Hypocrisy: Why Inconsistency Arguments Do Not Matter.Nicholas Colgrove, Bruce Philip Blackshaw & Daniel Rodger - 2020 - Journal of Medical Ethics (Online First):1-6.
    Opponents of abortion are often described as ‘inconsistent’ (hypocrites) in terms of their beliefs, actions and/or priorities. They are alleged to do too little to combat spontaneous abortion, they should be adopting cryopreserved embryos with greater frequency and so on. These types of arguments—which we call ‘inconsistency arguments’—conform to a common pattern. Each specifies what consistent opponents of abortion would do (or believe), asserts that they fail to act (or believe) accordingly and concludes that they are inconsistent. Here, we show (...)
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  5.  35
    Strengthened impairment argument does not restate Marquis.Bruce Philip Blackshaw - 2021 - Journal of Medical Ethics 47 (12):841-842.
    With Perry Hendricks, I recently outlined a strengthened version of the impairment argument for the immorality of abortion. Alex Gillham has argued that our use of Don Marquis’ deprivation of a ‘future-like ours’ account entails we were merely restating Marquis’ argument for the immorality of abortion. Here, I explain why SIA is more than just a reframing of Marquis.
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  6. The Problem of Spontaneous Abortion: Is the Pro-Life Position Morally Monstrous?Bruce P. Blackshaw & Daniel Rodger - 2019 - The New Bioethics 25 (2):103-120.
    A substantial proportion of human embryos spontaneously abort soon after conception, and ethicists have argued this is problematic for the pro-life view that a human embryo has the same moral status as an adult from conception. Firstly, if human embryos are our moral equals, this entails spontaneous abortion is one of humanity’s most important problems, and it is claimed this is absurd, and a reductio of the moral status claim. Secondly, it is claimed that pro-life advocates do not act as (...)
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  7. Fine-Tuning the Impairment Argument.Bruce Blackshaw & Perry Hendricks - 2021 - Journal of Medical Ethics 47 (9):641-642.
    Perry Hendricks’ original impairment argument for the immorality of abortion is based on the impairment principle (TIP): if impairing an organism to some degree is immoral, then ceteris paribus, impairing it to a higher degree is also immoral. Since abortion impairs a fetus to a higher degree than fetal alcohol syndrome (FAS) and giving a fetus FAS is immoral, it follows that abortion is immoral. Critics have argued that the ceteris paribus is not met for FAS and abortion, and so (...)
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  8.  8
    Filosofia e letteratura tra Seicento e Settecento: atti del convegno internazionale, Viterbo, 3-5 febbraio 1997.Nadia Boccara (ed.) - 1999 - Roma: Archivio Guido Izzi.
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  9.  29
    The self as a moral agent: Preschoolers behave morally but believe in the freedom to do otherwise.Nadia Chernyak & Tamar Kushnir - 2014 - Journal of Cognition and Development 15 (3):453-464.
    Recent work suggests a strong connection between intuitions regarding our own free will and our moral behavior. We investigate the origins of this link by asking whether preschool-aged children construe their own moral actions as freely chosen. We gave children the option to make three moral/social choices (avoiding harm to another, following a rule, and following peer behavior) and then asked them to retrospect as to whether they were free to have done otherwise. When given the choice to act (either (...)
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  10.  24
    An initial accuracy focus prevents illusory truth.Nadia M. Brashier, Emmaline Drew Eliseev & Elizabeth J. Marsh - 2020 - Cognition 194 (C):104054.
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  11. Strengthening the impairment argument against abortion.Bruce Blackshaw & Perry Hendricks - 2020 - Journal of Medical Ethics 47 (7):515-518.
    Perry Hendricks’ impairment argument for the immorality of abortion is based on two premises: first, impairing a fetus with fetal alcohol syndrome is immoral, and second, if impairing an organism to some degree is immoral, then ceteris paribus, impairing it to a higher degree is also immoral. He calls this the impairment principle. Since abortion impairs a fetus to a higher degree than FAS, it follows from these two premises that abortion is immoral. Critics have focussed on the ceteris paribus (...)
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  12. Questionable benefits and unavoidable personal beliefs: defending conscientious objection for abortion.Bruce Philip Blackshaw & Daniel Rodger - 2020 - Journal of Medical Ethics 3 (46):178-182.
    Conscientious objection in healthcare has come under heavy criticism on two grounds recently, particularly regarding abortion provision. First, critics claim conscientious objection involves a refusal to provide a legal and beneficial procedure requested by a patient, denying them access to healthcare. Second, they argue the exercise of conscientious objection is based on unverifiable personal beliefs. These characteristics, it is claimed, disqualify conscientious objection in healthcare. Here, we defend conscientious objection in the context of abortion provision. We show that abortion has (...)
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  13. Abortion policies at the bedside: a response.Bruce Philip Blackshaw - 2023 - Journal of Medical Ethics 1 (12):852-853.
    Hersey et al have outlined a proposed ethical framework for assessing abortion policies that locates the effect of government legislation between the provider and the patient, emphasising its influence on interactions between them. They claim that their framework offers an alternative to the personal moral claims that lie behind legislation restricting abortion access. However, they fail to observe that their own understanding of reproductive justice and the principles of medical ethics are similarly predicated on their individual moral beliefs. Consequently, the (...)
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  14.  61
    A Comparison of American and Nepalese Children's Concepts of Freedom of Choice and Social Constraint.Nadia Chernyak, Tamar Kushnir, Katherine M. Sullivan & Qi Wang - 2013 - Cognitive Science 37 (7):1343-1355.
    Recent work has shown that preschool-aged children and adults understand freedom of choice regardless of culture, but that adults across cultures differ in perceiving social obligations as constraints on action. To investigate the development of these cultural differences and universalities, we interviewed school-aged children (4–11) in Nepal and the United States regarding beliefs about people's freedom of choice and constraint to follow preferences, perform impossible acts, and break social obligations. Children across cultures and ages universally endorsed the choice to follow (...)
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  15. Frozen Embryos and The Obligation to Adopt.Bruce P. Blackshaw & Nicholas Colgrove - 2020 - Bioethics (8):1-5.
    Rob Lovering has developed an interesting new critique of views that regard embryos as equally valuable as other human beings: the moral argument for frozen human embryo adoption. The argument is aimed at those who believe that the death of a frozen embryo is a very bad thing, and Lovering concludes that some who hold this view ought to prevent one of these deaths by adopting and gestating a frozen embryo. Contra Lovering, we show that there are far more effective (...)
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  16. Writing Australians all: A history of growing up from the ice age to the apology.Nadia Wheatley - 2013 - Agora (History Teachers' Association of Victoria) 48 (3):12.
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  17.  77
    Ectogenesis and the case against the right to the death of the foetus.Bruce P. Blackshaw & Daniel Rodger - 2018 - Bioethics 33 (1):76-81.
    Ectogenesis, or the use of an artificial womb to allow a foetus to develop, will likely become a reality within a few decades, and could significantly affect the abortion debate. We first examine the implications for Judith Jarvis Thomson’s violinist analogy, which argues for a woman’s right to withdraw life support from the foetus and so terminate her pregnancy, even if the foetus is granted full moral status. We show that on Thomson’s reasoning, there is no right to the death (...)
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  18. Artificial Consciousness Is Morally Irrelevant.Bruce P. Blackshaw - 2023 - American Journal of Bioethics Neuroscience 14 (2):72-74.
    It is widely agreed that possession of consciousness contributes to an entity’s moral status, even if it is not necessary for moral status (Levy and Savulescu 2009). An entity is considered to have...
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  19.  40
    Conceptualizing Corporate Accountability in International Law: Models for a Business and Human Rights Treaty.Nadia Bernaz - 2020 - Human Rights Review 22 (1):45-64.
    This article conceptualizes corporate accountability under international law and introduces an analytical framework translating corporate accountability into seven core elements. Using this analytical framework, it then systematically assesses four models that could be used in a future business and human rights treaty: the United Nations Guiding Principles on Business and Human Rights model, the Universal Declaration of Human Rights model, the progressive model, and the transformative model. It aims to contribute to the BHR treaty negotiation process by clarifying different options (...)
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  20.  25
    Disentangling Conscience Protections.Nadia N. Sawicki - 2018 - Hastings Center Report 48 (5):14-22.
    Earlier this year, the U.S. Department of Health and Human Services announced its intent to strengthen enforcement of legal protections for health care providers' conscience rights. It proposed regulations that would give the DHHS Office of Civil Rights greater authority to ensure that recipients of federal funding comply with federal conscience laws. This recent development creates an opportunity for scholars and policy‐makers to revisit the perennial debate about whether and how law should protect health care providers' rights of conscience. Arguments (...)
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  21.  28
    Telling the Stories of Others.Nadia Mehdi - 2022 - Ergo: An Open Access Journal of Philosophy 9.
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  22.  98
    Agency, Pregnancy and Persons: Essays in Defense of Human Life.Nicholas Colgrove, Bruce P. Blackshaw & Daniel Rodger (eds.) - 2022 - Oxford, UK: Routledge.
    This book provides extensive and critical engagement with some of the most recent and compelling arguments favoring abortion choice. It features original essays from leading and emerging philosophers, bioethicists and medical professionals that present philosophically sophisticated and novel arguments against abortion choice. The chapters in this book are divided into three thematic sections. The first set of essays focuses primarily on unborn human individuals--zygotes, embryos and fetuses. In these chapters it is argued, for example, that human organisms begin to exist (...)
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  23.  17
    La comprensión lectora como contribución a la autonomía bioética.Nadia Micaela Álvarez Pelaez & Edgar Mateo Guaman Barros - 2021 - Revista Ethika+ 3:183-198.
    Se realizó un diagnóstico de la autonomía biótica en pacientes oncológicos, evidenciando que la mayoría no conocen, y no comprenden la carta de CI afectando la autonomía bioética. Ante esta problemática este proyecto crea dos cuadernillos uno para niños y uno para adultos. Estos cuadernillos parten y responden al reconocimiento de la condición del paciente, sus afectaciones cognitivas y emocionales, su nivel de escolaridad y su nivel de comprensión lectora. Los cuadernillos centrados en estrategias de comprensión lectora, incluyen actividades dialógicas (...)
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  24.  82
    Inconsistency arguments still do not matter.Bruce Philip Blackshaw, Nicholas Colgrove & Daniel Rodger - 2022 - Journal of Medical Ethics 48 (7):485-487.
    William Simkulet has recently criticised Colgrove et al ’s defence against what they have called inconsistency arguments—arguments that claim opponents of abortion act in ways inconsistent with their underlying beliefs about human fetuses. Colgrove et al presented three objections to inconsistency arguments, which Simkulet argues are unconvincing. Further, he maintains that OAs who hold that the fetus is a person at conception fail to act on important issues such as the plight of frozen embryos, poverty and spontaneous abortion. Thus, they (...)
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  25.  55
    Micro-foundations and Methodology: A Complexity-Based Reconceptualization of the Debate.Nadia Ruiz & Armin W. Schulz - 2023 - British Journal for the Philosophy of Science 74 (2):359-379.
    In a number of very influential publications, Epstein and Hoover (among other authors) have recently argued that a thoroughly micro-foundationalist approach towards economics is unconvincing for metaphysical reasons. However, as we show in this article, this metaphysical/social ontological approach to the debate fails to resolve the status of micro-foundations in the practice of economic modelling. To overcome this, we argue that endogenizing a model—that is, providing micro-foundations for it—correlates with making that model more complex. Specifically, we show that models with (...)
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  26.  95
    The impairment argument for the immorality of abortion: A reply.Bruce P. Blackshaw - 2019 - Bioethics 33 (6):723-724.
    In his recent article Perry Hendricks presents what he calls the impairment argument to show that abortion is immoral. To do so, he argues that to give a fetus fetal alcohol syndrome is immoral. Because killing the fetus impairs it more than giving it fetal alcohol syndrome, Hendricks concludes that killing the fetus must also be immoral. Here, I claim that killing a fetus does not impair it in the way that giving it fetal alcohol syndrome does. By examining the (...)
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  27.  71
    The impairment argument for the immorality of abortion revisited.Bruce P. Blackshaw - 2019 - Bioethics (Online):211-213.
    Perry Hendricks has recently presented the impairment argument for the immorality of abortion, to which I responded and he has now replied. The argument is based on the premise that impairing a fetus with fetal alcohol syndrome is immoral, and on the principle that if impairing an organism is immoral, impairing it to a higher degree is also—the impairment principle. If abortion impairs a fetus to a higher degree, then this principle entails abortion is immoral. In my reply, I argued (...)
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  28.  48
    Categorization of Whistleblowers Using the Whistleblowing Triangle.Nadia Smaili & Paulina Arroyo - 2019 - Journal of Business Ethics 157 (1):95-117.
    In view of recent studies that identified certain interest groups as potential whistleblowers, we propose an integrative conceptual framework to examine whistleblower behavior by whistleblower type. The framework, dubbed the whistleblowing triangle, is modeled on the fraud triangle and is comprised of three factors that condition the act of whistleblowing: pressure, opportunity, and rationalization. For a rich examination, we use a qualitative research framework to analyze 11 whistleblowing cases of corporate financial statement fraud in Canada that were publicly denounced between (...)
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  29.  21
    Zooming in on Justice: The Case for Virtual Bioethics Conferencing.Bruce P. Blackshaw, Daniel Rodger & Daniel J. Hurst - 2024 - American Journal of Bioethics 24 (4):60-62.
    In their target article, “Proposed Principles for International Bioethics Conferencing: Anti-Discriminatory, Global, and Inclusive,” Jecker et al. (2024) highlight the growing international scope o...
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  30. Psychological Impact of the Lockdown in Italy Due to the COVID-19 Outbreak: Are There Gender Differences?Nadia Rania & Ilaria Coppola - 2021 - Frontiers in Psychology 12.
    The COVID-19 emergency has hit the whole world, finding all countries unprepared to face it. The first studies focused on the medical aspects, neglecting the psychological dimension of the populations that were forced to face changes in everyday life and in some cases to stay forcedly at home in order to reduce contagion. The present research was carried out in Italy, one of the countries hardest hit by the pandemic. The aim was to analyze the perception of happiness, mental health, (...)
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  31. Parental responsibilities and moral status.Bruce Philip Blackshaw & Daniel Rodger - 2020 - Journal of Medical Ethics 47 (3):187-188.
    Prabhpal Singh has recently defended a relational account of the difference in moral status between fetuses and newborns as a way of explaining why abortion is permissible and infanticide is not. He claims that only a newborn can stand in a parent–child relation, not a fetus, and this relation has a moral dimension that bestows moral value. We challenge Singh’s reasoning, arguing that the case he presents is unconvincing. We suggest that the parent–child relation is better understood as an extension (...)
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  32. Meeting the Epicurean challenge: a reply to Christensen.Bruce P. Blackshaw & Daniel Rodger - 2019 - Journal of Medical Ethics 45 (7):478-479.
    In ’Abortion and deprivation: a reply to Marquis’, Anna Christensen contends that Don Marquis’ influential ’future like ours’ argument for the immorality of abortion faces a significant challenge from the Epicurean claim that human beings cannot be harmed by their death. If deprivation requires a subject, then abortion cannot deprive a fetus of a future of value, as no individual exists to be deprived once death has occurred. However, the Epicurean account also implies that the wrongness of murder is also (...)
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  33.  9
    Génome humain, espèce humaine et droit.Nadia Belrhomari - 2013 - Paris: L'Harmattan.
    Le décryptage du génome humain autorise désormais une manipulation du vivant humain. Mû par un souci de perfection, l'homme exploite aujourd'hui ce qui participe à son essence même, son génome. La diversité intraspécifique humaine s'en trouve perturbée, la vulnérabilité génétique augmentée. Le droit se trouve donc investi d'un rôle : préserver la nature humaine. Dès lors, faut-il penser d'autres voies pour prémunir notre humanité contre les risques d'une manipulation irréfléchie de notre génome.
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  34.  12
    Meaning of Education and Wellbeing: Understanding and Preventing the Risk of Loss of Meaning in Students.Nadia Baatouche, Paul de Maricourt & Jean-Luc Bernaud - 2022 - Frontiers in Psychology 13:796107.
    The phenomenon of malaise is on the rise at universities, reflecting a deteriorating psychological state that is a combination of anxiety and stress factors. This psychological and emotional upheaval within students is indicative of a fundamental existential issue. In fact, hidden behind the choice of an educational program is the significance given by the student to their life goals. It is this dimension of attributing meaning to one’s education and, more broadly, to one’s life (the existential dimension) that we have (...)
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  35.  17
    Post COVID-19 workplace ostracism and counterproductive behaviors: Moral leadership.Nadia Hassan Ali Awad & Boshra Karem Mohamed El Sayed - 2023 - Nursing Ethics 30 (7-8):990-1002.
    Background The wide proliferation of Covid-19 has impacted billions of people all over the world. This catastrophic pandemic outbreak and ostracism at work have posed challenges for all healthcare professionals, especially for nurses, and have led to a significant increase in the workload, several physical and mental problems, and a change in behavior that is more negative and counterproductive. Therefore, leadership behaviors that are moral in nature serve as a trigger and lessen the adverse workplace effects on nurses’ conduct. Aim (...)
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  36.  12
    D’un désert à l’autre.Nadia Tazi - 2024 - Cités 97 (1):57-66.
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  37.  25
    Ethics of sleep tracking: techno-ethical particularities of consumer-led sleep-tracking with a focus on medicalization, vulnerability, and relationality.Nadia Primc, Jonathan Hunger, Robert Ranisch, Eva Kuhn & Regina Müller - 2023 - Ethics and Information Technology 25 (1):1-12.
    Consumer-targeted sleep tracking applications (STA) that run on mobile devices (e.g., smartphones) promise to be useful tools for the individual user. Assisted by built-in and/or external sensors, these apps can analyze sleep data and generate assessment reports for the user on their sleep duration and quality. However, STA also raise ethical questions, for example, on the autonomy of the sleeping person, or potential effects on third parties. Nevertheless, a specific ethical analysis of the use of these technologies is still missing (...)
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  38.  41
    Is pregnancy really a good Samaritan act?Bruce P. Blackshaw - 2021 - Christian Bioethics 27 (2):158–168.
    One of the most influential philosophical arguments in favour of the permissibility of abortion is Judith Jarvis Thomson’s violinist analogy, presented in ‘A Defense of Abortion’. Its appeal for pro-choice advocates lies in Thomson’s granting that the fetus is a person with equivalent moral status to any other human being, and yet demonstrating—to those who accept her reasoning—that abortion is still permissible. In her argument, Thomson draws heavily on the parable of the Good Samaritan, arguing that gestating a fetus in (...)
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  39. If fetuses are persons, abortion is a public health crisis.Bruce Blackshaw & Daniel Rodger - 2021 - Bioethics 35 (5):465-472.
    Pro-life advocates commonly argue that fetuses have the moral status of persons, and an accompanying right to life, a view most pro-choice advocates deny. A difficulty for this pro-life position has been Judith Jarvis Thomson’s violinist analogy, in which she argues that even if the fetus is a person, abortion is often permissible because a pregnant woman is not obliged to continue to offer her body as life support. Here, we outline the moral theories underlying public health ethics, and examine (...)
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  40.  90
    Community of Philosophical Inquiry as a Discursive Structure, and its Role in School Curriculum Design.Nadia Kennedy & David Kennedy - 2011 - Journal of Philosophy of Education 45 (2):265-283.
    This article traces the development of the theory and practice of what is known as ‘community of inquiry’ as an ideal of classroom praxis. The concept has ancient and uncertain origins, but was seized upon as a form of pedagogy by the originators of the Philosophy for Children program in the 1970s. Its location at the intersection of the discourses of argumentation theory, communications theory, semiotics, systems theory, dialogue theory, learning theory and group psychodynamics makes of it a rich site (...)
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  41.  97
    Why inconsistency arguments fail: a response to Shaw.Bruce P. Blackshaw, Nicholas Colgrove & Daniel Rodger - 2022 - The New Bioethics 28 (2):139-151.
    Opponents of abortion are commonly said to be inconsistent in their beliefs or actions, and to fail in their obligations to prevent the deaths of embryos and fetuses from causes other than induced...
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  42.  59
    The Ethics of Killing: Strengthening the Substance View with Time-relative Interests.Bruce P. Blackshaw - 2019 - The New Bioethics (Online):1-17.
    The substance view is an account of personhood that regards all human beings as possessing instrinsic value and moral status equivalent to that of an adult human being. Consequently, substance view proponents typically regard abortion as impermissible in most circumstances. The substance view, however, has difficulty accounting for certain intuitions regarding the badness of death for embryos and fetuses, and the wrongness of killing them. Jeff McMahan’s time-relative interest account is designed to cater for such intuitions, and so I present (...)
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  43.  28
    Autobiographical memory and survey methodology: Furthering the bridge between two disciplines.Nadia Auriat - 1992 - In Martin A. Conway, David C. Rubin, H. Spinnler & W. Wagenaar (eds.), Theoretical Perspectives on Autobiographical Memory. Kluwer Academic Publishers. pp. 295--312.
  44.  11
    Appropriation multisensorielle du rythme du français : codage rythmique visuel d’extraits filmiques au sein d’un dispositif hybride.Nadia Bacor - 2020 - Corela. Cognition, Représentation, Langage.
    Dans cette contribution, nous nous proposons d’aborder la perception multisensorielle du rythme du français par la réalisation d’un codage qui s’appuie sur un système de couleurs et de symboles d’extraits filmiques ayant pour objectif l’appropriation du rythme du français. Il s’agira donc d’apporter un éclairage théorique et pédagogique sur l’enseignement/apprentissage du rythme du Français Langue Étrangère en classes de langue pour des apprenants de FLE non-spécialistes de langues. Dans un premier temps, nous présenterons les fondements théoriques sur lesquels repose notre (...)
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  45. La société roumaine à la recherche de la normalité.Nadia Badrus - 1993 - Cahiers Internationaux de Sociologie 95:403-415.
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  46. Max Planck and the'Constants of Nature'.Nadia Robotti Massimiliano Badino & N. Robotti - 2001 - Annals of Science 58 (2):137-162.
     
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  47.  8
    Braucht es einen islamischen Luther?Nadia Baghdadi - 2018 - In Marcel Meier Kressig & Mathias Lindenau (eds.), Religion Und Vernunft - Ein Widerstreit?: Glauben in der Säkularen Gesellschaft. Vadian Lectures Band 4. Transcript Verlag. pp. 59-82.
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  48. Braucht es einen islamischen Luther?Nadia Baghdadi - 2018 - In Mathias Lindenau & Marcel Meier Kressig (eds.), Religion und Vernunft - Ein Widerstreit?: Glauben in der säkularen Gesellschaft. Bielefeld: Transcipt.
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  49. El género de la «muerte» en el Kitab al-'iqd al-Farid.Nadia María El Cheikh - 2010 - Al-Qantara 31 (2):411-436.
    Este artículo estudia la sección de la recopilación de adab del 'Iqd al-farid de Ibn 'Abd Rabbih llamada "El Libro de Lamentaciones, Condolencias y Elegías". Se analiza la función ideológica del 'Iqd, concretamente la manera en que se organiza el género con ocasión de la muerte. Localiza lo que parece haberse «reprimido» en el texto en un intento por determinar el material que fue pasado por alto, enterrado o alterado, y estudia la organización de sus prioridades. El artículo sostiene que (...)
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  50.  20
    Bistability of mitotic entry and exit switches during open mitosis in mammalian cells.Nadia Hégarat, Scott Rata & Helfrid Hochegger - 2016 - Bioessays 38 (7):627-643.
    Mitotic entry and exit are switch‐like transitions that are driven by the activation and inactivation of Cdk1 and mitotic cyclins. This simple on/off reaction turns out to be a complex interplay of various reversible reactions, feedback loops, and thresholds that involve both the direct regulators of Cdk1 and its counteracting phosphatases. In this review, we summarize the interplay of the major components of the system and discuss how they work together to generate robustness, bistability, and irreversibility. We propose that it (...)
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