Social studies of science and technology are dominated by action and macro approaches. This has led to a neglect of institutions and institutional arrangements at the meso level, which are important, in particular to the student of technology. The transfer of concepts and methods from social studies of science to technology studies has conserved this lack of concern with the meso level. This article suggests a more critical evaluation of this transfer, along with a review of the now popular assumption (...) of a high degree of similarity between science and technology. Two case studies show how meso-level considerations are important to an understanding of the nature of technological innovation and illustrate the lack of similarity between scientific and technological development. (shrink)

Oncogene activation leads to cellular transformation by deregulation of biological processes such as proliferation and metabolism. Paradoxically, this can also sensitize cells to nutrient deprivation, potentially representing an Achilles' heel in early stage tumors. The mechanisms underlying this phenotype include loss of energetic and redox homeostasis as a result of metabolic reprogramming, favoring synthesis of macromolecules. Moreover, an emerging mechanism involving the deregulation of mRNA translation elongation through inhibition of eukaryotic elongation factor 2 kinase (eEF2K) is presented. The potential consequences (...) of eEF2K deregulation leading to cell death under nutrient depletion are discussed. Finally, the relevance of eEF2K as a master regulator of the response to nutrient deprivation in vivo, and its potential exploitation for therapeutic targeting of cancers, are elaborated. Overall, a better understanding of the adaptive mechanisms allowing tumors to circumvent oncogene‐induced hypersensitivity to nutrient deprivation is a promising avenue for uncovering novel therapeutic targets in cancers. (shrink)

It is proposed that our memory is made up of individual, unconnected Records, to each of which is attached a Heading. Retrieval of a Record can only be accomplished by addressing the attached Heading, the contents of which cannot itself be retrieved. Each Heading is made up of a mixture of content in more or less literal form and context, the latter including specification of environment and of internal states (e.g. drug states and mood). This view of memory allows an (...) easy account of a number of natural memory phenomena as well as a variety of laboratory findings such as the differences between recall and recognition. The theory further proposes that Headed Records can neither be deleted nor modified. Data apparently against such a hypothesis can be accounted for in terms of the retrieval process. (shrink)

My thesis is that you can lie with ‘ P therefore Q ’ without P or Q being lies. For you can lie by virtue of not believing that P supports Q. My thesis is reconciled with the principle that all lies are assertions through H. P. Grice’s account of conventional implicatures. These semantic cousins of conversational implicatures are secondary assertions that clarify the speaker’s attitude toward his primary assertions. The meaning of ‘therefore’ commits the speaker to an entailment thesis (...) even though the speaker does not enter that commitment into the text. Insincere conventional implicatures are akin to insincerely asserted footnotes. An absence of lies in the text is compatible with the presence of lies in the meta-text. (shrink)

review of Mellor's *The Matter of Chance*.

Edward O. Wilson’s recent decision to abandon kin selection theory has sent shockwaves throughout the biological sciences. Over the past two years, more than a hundred biologists have signed letters protesting his reversal. Making sense of Wilson’s decision and the controversy it has spawned requires familiarity with the historical record. This entails not only examining the conditions under which kin selection theory first emerged, but also the organicist tradition against which it rebelled. In similar fashion, one must not only examine (...) Wilson’s long career, but also those thinkers who influenced him most, especially his intellectual grandfather, William Morton Wheeler (1865–1937). Wilson belongs to a long line of organicists, biologists whose research highlighted integration and coordination, many of whom struggled over the exact same biological riddles that have long defined Wilson’s career. Drawing inspiration (and sometimes ideas) from these intellectual forebears, Wilson is confident that he has finally identified the origin of the social impulse. (shrink)

Morton White proposes two patterns of expansion for sentences of the form "Possible (x is Q)" in "On What Could Have Happened" (Philosophical Review, 1968). His attempts in "Ands and Cans" (Mind, 1974) and in "Positive Freedom, Negative Freedom, and Possibility" (Journal of Philosophy, 1973) to simplify these two patterns and his argument for abandoning the first pattern are mistaken. Although I question a number of White's claims, my purpose is to improve his treatment of possibility rather than to (...) refute it. Our understanding of what constitutes "the same circumstances" largely determines whether a given condition is appropriately mentioned in a first-pattern expansion. This point helps support the form of compatibilism White advocates. (shrink)

The Challenger incident was a result of at least four kinds of difficulties: differing perceptions and priorities of the engineers and management at Thiokol and at NASA, a preoccupation with roles and role responsibilities on the part of engineers and managers, contrasting corporate cultures at Thiokol and its parent, Morton, and a failure both by engineers and by managers to exercise individual moral responsibility. I shall argue that in the Challenger case organizational structure, corporate culture, engineering and managerial habits, (...) and role responsibilites precipitated events contributing to the Challenger disaster. At the same time, a number of individuals at Morton Thiokol and NASA were responsible for the launch failure. Differing world views, conflicting priorities of the engineers and managers on this project, and the failure of either engineers or management to take personal moral responsibility for decision-making contributed significantly to the event. (shrink)