Results for 'strength of punishment'

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  1.  13
    Effect of strength of punishment for "correct" or "incorrect" responses on visual discrimination performance.George J. Wischner, Harry Fowler & Stephen A. Kushnick - 1963 - Journal of Experimental Psychology 65 (2):131.
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  2.  12
    Further experiments in the strength of connections where the connection is punished or rewarded or neither punished nor rewarded.Irving Lorge, Jack Eisonson & Bertram Epstein - 1934 - Journal of Experimental Psychology 17 (3):412.
  3.  98
    The Practice of Punishment: Towards a Theory of Restorative Justice.Wesley Cragg - 1992 - New York: Routledge.
    This study focuses on the practice of punishment, as it is inflicted by the state. The author's first-hand experience with penal reform, combined with philosophical reflection, has led him to develop a theory of punishment that identifies the principles of sentencing and corrections on which modern correctional systems should be built. This new theory of punishment is built on the view that the central function of the law is to reduce the need to use force in the (...)
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  4.  19
    Hume on Self-Government and Strength of Mind.Albert Cotugno - 2024 - Hume Studies 49 (1):53-75.
    Throughout his writings, Hume extols the benefits of an attribute he calls “Strength of Mind,” which he defines as the “prevalence of the calm passions over the violent” (T 2.3.3.10). But there is some question as to how he thought a person could attain this important trait. Contemporary scholars have committed Hume to the view that only indirect and social methods, such as state punishment or sympathetic pressure, could effectively cultivate it. Yet a closer examination of Hume’s corpus (...)
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  5.  17
    Pharmaceutical Promotion in Bangladesh: Assessing the Strength of Regulatory Documents.Fatema Johora & Md Sayedur Rahman - 2020 - Bangladesh Journal of Bioethics 9 (3):1-10.
    Pharmaceutical promotion is a negative influencing force for prescribing. However, very few regulatory initiatives are taken to overcome this unwarranted influence. The present research was conducted in such context with an attempt to review the regulatory documents related to pharmaceutical promotion in Bangladesh including Code of Pharmaceutical Marketing Practices (CPMP), and to compare CPMP with different global guidelines. The studied guidelines demonstrate effort to regulate promotion, though that varies to a great extent, particularly in enforcement aspects. Clearly defined ethical and (...)
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  6.  32
    A Theory of Legal Punishment: Deterrence, Retribution, and the Aims of the State.Matthew C. Altman - 2021 - New York, NY: Routledge.
    "This book argues for a mixed view of punishment that balances consequentialism and retributivism. He has published extensively on philosophy and applied ethics. A central question in the philosophy of law is why the state's punishment of its own citizens is justified. Traditionally, two theories of punishment have dominated the field: consequentialism and retributivism. According to consequentialism, punishment is justified when it maximizes positive outcomes. According to retributivism, criminals should be punished because they deserve it. This (...)
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  7.  18
    Three Capuchin missionaries in the Kingdom of Congo at the end of the 17th century: Cavazzi, Merolla and Zucchelli. Strength and prose in the stories of punitive spectacles and exemplary punishments.José Sarzi Amade - 2018 - Veritas: Revista de Filosofía y Teología 39:137-160.
    Résumé L’article traite de littérature de voyage et plus particuliérement de récits de missionnaires italiens de l’ordre des Capucins, ayant ceuvré à 1’évangélisation du Royaume du Congo vers la fin du XVIIe siécle. Giovanm Antonio Cavazzi da Montecuccolo, Girolamo Merolla da Sorrento et Antonio Zucchelli da Gradisca ont un point commun, celuí d’avoir reporté dans leurs livres respectifs, des mamfestations d’aprionsmes, de violences à l’encontre des us et coutumes congolais. L’étude en offre les détails littéraires traduisant ees répressions et leurs (...)
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  8.  43
    In a Weakly Dominated Strategy Is Strength: Evolution of Optimality in Stag Hunt Augmented with a Punishment Option.Peter Vanderschraaf - 2016 - Philosophy of Science 83 (1):29-59.
    I explore the evolution of strategies in an Augmented Stag Hunt game that adds a punishing strategy to the ordinary Stag Hunt strategies of cooperating, which aims for optimality, and defecting, which “plays it safe.” Cooperating weakly dominates punishing and defecting is the unique evolutionarily stable strategy. Nevertheless, for a wide class of Augmented Stag Hunts, polymorphic strategies combining punishing and cooperating collectively have greater attracting power for replicator dynamics than that of the ESS. The analysis here lends theoretical support (...)
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  9.  59
    Punishing with Care: treating offenders as equal persons in criminal punishment.Helen Brown Coverdale - 2013 - Dissertation, The London School of Economics and Political Science
    Most punishment theories acknowledge neither the full extent of the harms which punishment risks, nor the caring practices which punishment entails. Consequently, I shall argue, punishment in most of its current conceptualizations is inconsistent with treating offenders as equals qua persons. The nature of criminal punishment, and of our interactions with offenders in punishment decision-making and delivery, risks causing harm to offenders. Harm is normalized when central to definitions of punishment, desensitizing us to (...)
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  10.  93
    Punishment and Autonomous Shame in Confucian Thought.Justin Tiwald - 2017 - Criminal Justice Ethics 36 (1):45-60.
    As recorded in the Analects, Kongzi (Confucius) held that using punishment to influence ordinary citizens will do little to develop a sense of shame (chi 恥) in them. This term is usually taken to refer to a sense of shame described here as “ autonomous,” understood as a predisposition to feel ashamed when one does something wrong because it seems wrong to oneself, and not because others regard it as wrong or shameful. Historically, Confucian philosophers have thought a great (...)
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  11.  27
    Nicomachean Ethics.Terence Irwin & Aristotle of Stagira - 1999 - Indianapolis: Hackett Publishing.
    Building on the strengths of the first edition, the second edition of the Irwin Nicomachean Ethics features a revised translation (with little editorial intervention), expanded notes (including a summary of the argument of each chapter), an expanded Introduction, and a revised glossary.
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  12. Legal Punishment.Thaddeus Metz - 2004 - In Christopher Roederer & Darrel Moellendorf (eds.), Jurisprudence. Juta. pp. 555-87.
    We seek to outline philosophical answers to the questions of why punish, whom to punish and how much to punish, with illustrations from the South African legal system. We begin by examining the differences between forward- and backward-looking moral theories of legal punishment, their strengths and also their weaknesses. Then, we ascertain to which theory, if any, contemporary South Africa largely conforms. Finally, we discuss several matters of controversy in South Africa in the context of forward- and backward-looking theories, (...)
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  13. "My Place in the Sun": Reflections on the Thought of Emmanuel Levinas.Committee of Public Safety - 1996 - Diacritics 26 (1):3-10.
    In lieu of an abstract, here is a brief excerpt of the content:Martin Heidegger and OntologyEmmanuel Levinas (bio)The prestige of Martin Heidegger 1 and the influence of his thought on German philosophy marks both a new phase and one of the high points of the phenomenological movement. Caught unawares, the traditional establishment is obliged to clarify its position on this new teaching which casts a spell over youth and which, overstepping the bounds of permissibility, is already in vogue. For once, (...)
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  14.  68
    Victor’s Justice: The Next Best Moral Theory of Criminal Punishment[REVIEW]François Tanguay-Renaud - 2013 - Law and Philosophy 32 (1):129-157.
    In this essay, I address one methodological aspect of Victor Tadros's The Ends of Harm-­-­namely, the moral character of the theory of criminal punishment it defends. First, I offer a brief reconstruction of this dimension of the argument, highlighting some of its distinctive strengths while drawing attention to particular inconsistencies. I then argue that Tadros ought to refrain from developing this approach in terms of an overly narrow understanding of the morality of harming as fully unified and reconciled under (...)
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  15. Why Retributivists Should Endorse Leniency in Punishment.Göran Duus-Otterström - 2013 - Law and Philosophy 32 (4):459-483.
    This paper develops a retributivist argument for leniency in punishment. It argues that even retributivists who defend desert-based punishment have a reason, internal to their view, to prefer more lenient over more severe punishments when there are doubts concerning how much punishment an offender deserves. This is because retributivists should take an asymmetrical view to underpunishment and overpunishment, and because the likelihood of overpunishment goes up with the severity of punishment. The radicalness of the ensuing leniency (...)
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  16.  9
    Can an Action Be Its Own Punishment?Margaret Paton - 1979 - Philosophy 54 (210):534 - 540.
    An attempt to vindicate Retributivism as a moral theory has been made by Professor Winch in the context of a discussion of punishment and reward as non-institutional concepts. His method is to divorce the concepts from the institutions of punishment and reward by considering them as they feature in the recipient's consciousness. It is in the area of the agent's awareness of his relation to his past actions that Retributivism can be made to flourish again and its moral (...)
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  17. Crime and Humane Ethics.Carl Heath & National Council for the Abolition of the Death Penalty - 1934 - Allenson & Co..
     
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  18. Understanding Strength of Will.Michael Brent - 2014 - In Fabio Bacchini Massimo Dell'Utri & Stefano Caputo (eds.), New Advances in Causation, Agency, and Moral Responsibility. Cambridge Scholars Press. pp. 165-178.
    Richard Holton has presented an important criticism of two prominent accounts of action, a criticism that employs a notion of strength of will. Holton claims that these well-known accounts of action cannot explain cases in which an agent adheres to the dictates of a previous resolution in spite of a persistent desire to the contrary. In this chapter, I present an explanation and defense of Holton’s criticism of these accounts of action, and then I argue that while Holton highlights (...)
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  19. How is strength of will possible?Richard Holton - 2003 - In Sarah Stroud & Christine Tappolet (eds.), Weakness of will and practical irrationality. New York: Oxford University Press. pp. 39-67.
    Most recent accounts of will-power have tried to explain it as reducible to the operation of beliefs and desires. In opposition to such accounts, this paper argues for a distinct faculty of will-power. Considerations from philosophy and from social psychology are used in support.
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  20.  3
    Parliamentary Party Cohesion and the Scarcity of Sanctions in the Belgian Chamber of Representatives.Sam Depauw - 1999 - Res Publica 41 (1):15-39.
    Party cohesion is crucial in parliamentary proceedings, for the strength of parties is determined by it. However high levels of party unanimity, parliamentary party cohesion is under no circumstances to be taken for granted. It is the outcome of a persistent struggle. From a rational choice point of view, the monitoring and sanctioning of recalcitrant MPs by the parliamentary party leadership is the condition sine qua non for party cohesion. Yet, rewards and punishments do not seem the cement that (...)
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  21. Strength of early visual adaptation depends on visual awareness.Randolph Blake, Duje Tadin, Kenith V. Sobel, Tony A. Raissian & Sang Chul Chong - 2006 - Pnas Proceedings of the National Academy of Sciences of the United States of America 103 (12):4783-4788.
  22.  80
    The Problem of Punishment.David Boonin - 2008 - Cambridge University Press.
    In this book, David Boonin examines the problem of punishment, and particularly the problem of explaining why it is morally permissible for the state to treat those who break the law in ways that would be wrong to treat those who do not? Boonin argues that there is no satisfactory solution to this problem and that the practice of legal punishment should therefore be abolished. Providing a detailed account of the nature of punishment and the problems that (...)
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  23. The strength of weak ties: A network theory revisited.Mark Granovetter - 1983 - Sociological Theory 1 (1983):201-233.
    In this chapter I review empirical studies directly testing the hypotheses of my 1973 paper "The Strength of Weak Ties" (hereafter "SWT") and work that elaborates those hypotheses theoretically or uses them to suggest new empirical research not discussed in my original formulation. Along the way, I will reconsider various aspects of the theoretical argument, attempt to plug some holes, and broaden its base.
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  24. Consequentialist Theories of Punishment.Hsin-Wen Lee - 2022 - In Matthew C. Altman (ed.), The Palgrave Handbook on the Philosophy of Punishment. Palgrave-Macmillan. pp. 149-169.
    In this chapter, I consider contemporary consequentialist theories of punishment. Consequentialist theories of punishment look to the consequences of punishment to justify the institution of punishment. Two types of theories fall into this category—teleology and aggregationism. I argue that teleology is implausible as it is based on a problematic assumption about the fundamental value of criminal punishment, and that aggregationism provides a more reasonable alternative. Aggregationism holds that punishment is morally justified because it is (...)
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  25.  74
    In Defense of “Pure” Legal Moralism.Danny Scoccia - 2013 - Criminal Law and Philosophy 7 (3):513-530.
    In this paper I argue that Joel Feinberg was wrong to suppose that liberals must oppose any criminalization of “harmless immorality”. The problem with a theory that permits criminalization only on the basis of his harm and offense principles is that it is underinclusive, ruling out laws that most liberals believe are justified. One objection (Arthur Ripstein’s) is that Feinberg’s theory is unable to account for the criminalization of harmless personal grievances. Another (Larry Alexander’s and Robert George’s) is that it (...)
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  26.  40
    Strength of perceptual experience predicts word processing performance better than concreteness or imageability.Louise Connell & Dermot Lynott - 2012 - Cognition 125 (3):452-465.
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  27.  59
    The Significance of Transferred Intent.Peter Westen - 2013 - Criminal Law and Philosophy 7 (2):321-350.
    The doctrine of transferred intent (or transferred “malice” in England) generally provides that if A attempts to harm B but, because of bad aim, misses and accidentally causes the same harm to befall C, A’s harmful intent vis-à-vis B is transferred to C, thus rendering A guilty of intentionally harming C. Commentators acknowledge the doctrine to be a legal fiction, but they differ regarding whether the fiction produces just results, some believing it does, others believing that A is guilty at (...)
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  28. The Government of Civil Society and the Self: Adam Smith's Political and Moral Thought.Jeffrey Lomonaco - 1999 - Dissertation, The Johns Hopkins University
    The dissertation seeks to characterize the style of government embodied in Adam Smith's vision of civil society. It is composed of two parts. The first, preparatory part develops a framework for offering a historically sensitive interpretation of Smith's works by drawing on and criticizing the treatment of the eighteenth century in the work of several contemporary political theorists and historians of political thought. Part II gives the full-fledged interpretation of Smith's thought, based on both detailed textual interpretation and broad contextual (...)
     
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  29.  62
    The strength of Martin-Löf type theory with a superuniverse. Part I.Michael Rathjen - 2000 - Archive for Mathematical Logic 39 (1):1-39.
    Universes of types were introduced into constructive type theory by Martin-Löf [12]. The idea of forming universes in type theory is to introduce a universe as a set closed under a certain specified ensemble of set constructors, say $\mathcal{C}$ . The universe then “reflects” $\mathcal{C}$ .This is the first part of a paper which addresses the exact logical strength of a particular such universe construction, the so-called superuniverse due to Palmgren (cf. [16, 18, 19]).It is proved that Martin-Löf type (...)
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  30. The Strength of Hume's "Weak" Sympathy.Andrew S. Cunningham - 2004 - Hume Studies 30 (2):237-256.
    Hume’s understanding of sympathy in section 2.1.11 of the Treatise—that it is a mental mechanism by means of which one sentient being can come to share the psychological states of another—has a particularly interesting implication. What the sympathizer receives, according to this definition, is the passing psychological “affection” that the object of his sympathy was experiencing at the moment of observation. Thus the psychological connection produced by Humean sympathy is not between the sympathizer and the “other” as a “whole person” (...)
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  31.  19
    Of punishment.Mitchell N. Berman - 2012 - In Marmor Andrei (ed.), The Routledge Companion to Philosophy of Law. Routledge. pp. 141.
  32. Moral Responsibility and the Strike Back Emotion: Comments on Bruce Waller’s The Stubborn System of Moral Responsibility.Gregg Caruso - forthcoming - Syndicate Philosophy 1 (1).
    In The Stubborn System of Moral Responsibility (2015), Bruce Waller sets out to explain why the belief in individual moral responsibility is so strong. He begins by pointing out that there is a strange disconnect between the strength of philosophical arguments in support of moral responsibility and the strength of philosophical belief in moral responsibility. While the many arguments in favor of moral responsibility are inventive, subtle, and fascinating, Waller points out that even the most ardent supporters of (...)
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  33.  11
    Bodies and Disciplines: Intersections of Literature and History in Fifteenth-Century England.Barbara Hanawalt & David Wallace - 1996 - Univ of Minnesota Press.
    Centered on practices of the body - human bodies, the "body politic", this book considers a fascinating and largely uncanonical group of texts, as well as public dramas, rituals, and spectacles, from multidisciplinary perspectives. These essays consider the way the human body is subjected to educational discipline, to corporate celebration, and to the production of gendered identity through the experiences of marriage and childbirth. Among the topics explored are the "theatrics of punishment", including legal mutilation; the representation of the (...)
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  34.  56
    The strength of some Martin-Löf type theories.Edward Griffor & Michael Rathjen - 1994 - Archive for Mathematical Logic 33 (5):347-385.
    One objective of this paper is the determination of the proof-theoretic strength of Martin-Löf's type theory with a universe and the type of well-founded trees. It is shown that this type system comprehends the consistency of a rather strong classical subsystem of second order arithmetic, namely the one with Δ 2 1 comprehension and bar induction. As Martin-Löf intended to formulate a system of constructive (intuitionistic) mathematics that has a sound philosophical basis, this yields a constructive consistency proof of (...)
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  35. Strength of Mind and the Calm and Violent Passions.Elizabeth S. Radcliffe - 2015 - Res Philosophica 92 (3):1-21.
    Hume’s distinction between the calm and violent passions is one whose boundaries are not entirely clear. However, it is crucial to understanding his motivational theory and to identifying an unusual virtue he calls “strength of mind,” the motivational prevalence of the calm passions over the violent. In this paper, I investigate the boundaries of the calm passions and consider the constitution of strength of mind and why Hume regards it as an admirable trait. These are provocative issues for (...)
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  36.  16
    The strength of choiceless patterns of singular and weakly compact cardinals.Daniel Busche & Ralf Schindler - 2009 - Annals of Pure and Applied Logic 159 (1-2):198-248.
    We extend the core model induction technique to a choiceless context, and we exploit it to show that each one of the following two hypotheses individually implies that , the Axiom of Determinacy, holds in the of a generic extension of : every uncountable cardinal is singular, and every infinite successor cardinal is weakly compact and every uncountable limit cardinal is singular.
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  37.  49
    The strength of infinitary Ramseyan principles can be accessed by their densities.Andrey Bovykin & Andreas Weiermann - 2017 - Annals of Pure and Applied Logic 168 (9):1700-1709.
  38.  81
    The strength of sharply bounded induction requires M S P.Sedki Boughattas & Leszek Aleksander Kołodziejczyk - 2010 - Annals of Pure and Applied Logic 161 (4):504-510.
    We show that the arithmetical theory -INDx5, formalized in the language of Buss, i.e. with x/2 but without the MSP function x/2y, does not prove that every nontrivial divisor of a power of 2 is even. It follows that this theory proves neither NP=coNP nor.
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  39.  6
    The effects of induced positive and negative affect on Pavlovian-instrumental interactions.Isla Weber, Sam Zorowitz, Yael Niv & Daniel Bennett - 2022 - Cognition and Emotion 36 (7):1343-1360.
    Across species, animals have an intrinsic drive to approach appetitive stimuli and to withdraw from aversive stimuli. In affective science, influential theories of emotion link positive affect with strengthened behavioural approach and negative affect with avoidance. Based on these theories, we predicted that individuals’ positive and negative affect levels should particularly influence their behaviour when innate Pavlovian approach/avoidance tendencies conflict with learned instrumental behaviours. Here, across two experiments – exploratory Experiment 1 (N = 91) and a preregistered confirmatory Experiment 2 (...)
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  40.  52
    The strength of Mac Lane set theory.A. R. D. Mathias - 2001 - Annals of Pure and Applied Logic 110 (1-3):107-234.
    Saunders Mac Lane has drawn attention many times, particularly in his book Mathematics: Form and Function, to the system of set theory of which the axioms are Extensionality, Null Set, Pairing, Union, Infinity, Power Set, Restricted Separation, Foundation, and Choice, to which system, afforced by the principle, , of Transitive Containment, we shall refer as . His system is naturally related to systems derived from topos-theoretic notions concerning the category of sets, and is, as Mac Lane emphasises, one that is (...)
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  41.  17
    Strength of Religious Faith in the Portuguese Catholic Elderly.Nuno Amado & António M. Diniz - 2017 - Archive for the Psychology of Religion 39 (1):82-98.
    This study aimed to adapt the Santa Clara Strength of Religious Faith Questionnaire -Brief Version to the Portuguese elderly, and to investigate the effect of relevant and easy to assess predictors on the strength of religious faith. Participants were 778 non-institutionalized Catholic elderly, with a majority of women, young-olds, with four years or less of education, and practicing Catholics. The sample was randomly split in two to study the invariance and the structural validity of the SCSRFQ-Brief Version across (...)
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  42. The Rationale of Punishment.Jeremy Bentham - 2009 - Amherst, N.Y.: Prometheus Books. Edited by James T. McHugh.
    Definitions and distinctions -- Classification -- Of the ends of punishment -- Cases unmeet for punishment -- Expense of punishment -- Measure of punishment -- Of the properties to be given to a lot of punishment -- Of analogy between crimes and punishment -- Of retaliation -- Popularity -- Simple afflictive punishments -- Of complex afflictive punishments -- Of restrictive punishments--territorial confinement -- Imprisonment -- Imprisonment--fees -- Imprisonment examined -- General scheme of imprisonment -- (...)
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  43. The Strength of Knowledge in Plato’s Protagoras.Justin Clark - 2012 - Ancient Philosophy 32 (2):237-255.
  44.  58
    The strength of weak artificial consciousness.Anil Seth - 2009 - International Journal of Machine Consciousness 1 (1):71-82.
  45.  64
    The Strength of the Rainbow Ramsey Theorem.Barbara F. Csima & Joseph R. Mileti - 2009 - Journal of Symbolic Logic 74 (4):1310 - 1324.
    The Rainbow Ramsey Theorem is essentially an "anti-Ramsey" theorem which states that certain types of colorings must be injective on a large subset (rather than constant on a large subset). Surprisingly, this version follows easily from Ramsey's Theorem, even in the weak system RCA₀ of reverse mathematics. We answer the question of the converse implication for pairs, showing that the Rainbow Ramsey Theorem for pairs is in fact strictly weaker than Ramsey's Theorem for pairs over RCA₀. The separation involves techniques (...)
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  46.  22
    Evidential Strength of Intonational Cues and Rational Adaptation to Reliable Intonation.Timo B. Roettger & Michael Franke - 2019 - Cognitive Science 43 (7):e12745.
    Intonation plays an integral role in comprehending spoken language. Listeners can rapidly integrate intonational information to predictively map a given pitch accent onto the speaker's likely referential intentions. We use mouse tracking to investigate two questions: (a) how listeners draw predictive inferences based on information from intonation? and (b) how listeners adapt their online interpretation of intonational cues when these are reliable or unreliable? We formulate a novel Bayesian model of rational predictive cue integration and explore predictions derived under a (...)
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  47.  9
    The “strength of the humbles”: memory and history of another Colombia in Vivan los compañeros.Antonio Becerra Bolaños & Nayra Pérez Hernández - 2018 - Alpha (Osorno) 47:105-120.
    Resumen Aunque Carlos Arturo Truque sigue siendo poco conocido, no podemos hablar de literatura afrocolombiana, ni colombiana, sin su aporte. Con una producción literaria dispersa en publicaciones periódicas, el chocoano apuesta por el cuento cuando este no era suficientemente valorado en su país. Vivan los compañeros recoge todos sus cuentos, en los que se acerca tanto a los personajes excluidos de la sociedad como a los episodios de la historia colombiana más “vergonzosos”, desde un lenguaje que se aleja de todo (...)
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  48.  40
    The strength of Martin-Löf type theory with a superuniverse. Part II.Michael Rathjen - 2001 - Archive for Mathematical Logic 40 (3):207-233.
    Universes of types were introduced into constructive type theory by Martin-Löf [3]. The idea of forming universes in type theory is to introduce a universe as a set closed under a certain specified ensemble of set constructors, say ?. The universe then “reflects”?.This is the second part of a paper which addresses the exact logical strength of a particular such universe construction, the so-called superuniverse due to Palmgren (cf.[4–6]).It is proved that Martin-Löf type theory with a superuniverse, termed MLS, (...)
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  49. Retribution and the theory of punishment.Hugo Adam Bedau - 1978 - Journal of Philosophy 75 (11):601-620.
    This paper examines hart's model (1967) of the retributive theory. section i criticizes the model for not answering all the main questions to which a theory of punishment should be addressed, as hart alleges it does. section ii criticizes the model for its omission of the concept of desert. section iii criticizes attempts by card (1973) and by von hirsch (1976) to provide new ways of proportioning punitive severity to criminal injury. section iv discusses the idea of retribution in (...)
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  50.  10
    Physical ‘strength’ of the multi‐protein chain connecting immune cells: Does the weakest link limit antibody affinity maturation?Rajat Desikan, Rustom Antia & Narendra M. Dixit - 2021 - Bioessays 43 (4):2000159.
    The affinities of antibodies (Abs) for their target antigens (Ags) gradually increase in vivo following an infection or vaccination, but reach saturation at values well below those realisable in vitro. This ‘affinity ceiling’ could in many cases restrict our ability to fight infections and compromise vaccines. What determines the affinity ceiling has been an unresolved question for decades. Here, we argue that it arises from the strength of the chain of protein complexes that is pulled by B cells during (...)
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