We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad’s classic discussion of emergence, we distinguish two conditions sufficient for emergence. Emergence in biology must be compatible with the thought that all explanations of systemic properties are mechanistic explanations and with their sufficiency. Explanations of systemic properties are always in terms of the properties of the parts within the system. Nonetheless, systemic properties can still be emergent. If the properties of the components (...) within the system cannot be predicted, even in principle, from the behavior of the system’s parts within simpler wholes then there also will be systemic properties which cannot be predicted, even in principle, on basis of the behavior of these parts. We show in an explicit case study drawn from molecular cell physiology that biochemical networks display this kind of emergence, even though they deploy only mechanistic explanations. This illustrates emergence and its place in nature. (shrink)

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...

Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression. They can be either simulated numerically or analyzed analytically. Systems biology integrates quantitative molecular data acquisition with mathematical models to design new experiments, discriminate between alternative mechanisms and explain the molecular basis of cellular properties. At the heart of this approach are mechanistic models of molecular networks. We focus on the articulation and development of mechanistic (...) models, identifying five constraints which guide the articulation of models in molecular systems biology. These constraints are not independent of one another, with the result that modeling becomes an iterative process. We illustrate the use of these constraints in the modeling of the mechanism for bistability in the lac operon. (shrink)

Investigations into inter-level relations in computer science, biology and psychology call for an *empirical* turn in the philosophy of mind. Rather than concentrate on *a priori* discussions of inter-level relations between 'completed' sciences, a case is made for the actual study of the way inter-level relations grow out of the developing sciences. Thus, philosophical inquiries will be made more relevant to the sciences, and, more importantly, philosophical accounts of inter-level relations will be testable by confronting them with what really happens (...) in science. Hence, close observation of the ever-changing reduction relations in the developing sciences, and revision of philosophical positions based on these empirical observations, may, in the long run, be more conducive to an adequate understanding of inter-level relations than a traditional *a priori* approach. (shrink)

Biochemistry and molecular biology have been focusing on the structural, catalytic, and regulatory proper- ties of individual macromolecules from the perspective of clarifying the mechanisms of metabolism and gene expression. Complete genomes of ‘primitive’ living organisms seem to be substantially larger than necessary for metabolism and gene expression alone. This is in line with the findings of silent phenotypes for supposedly important genes, apparent redundancy of functions, and variegated networks of signal transduction and transcription factors. Here we propose that evolutionary (...) optimization has been much more intensive than to lead to the bare minima necessary for autonomous life. Much more complex organisms prevail. Much of this complexity arises in the nonlinear interactions between cellular macromolecules and in subtle differences between paralogs (isoenzymes). The complexity can only be understood when analyzed quantitatively, for which quantitative experimentation is needed in living systems that are as simple and manipulatable as possible, yet complex in the above sense. We illustrate this for the glutamine synthetase cascade in Escherichia coli. By reviewing recent molecular findings, we show that this cascade is much more complex than necessary for simple regulation of ammonia assimilation. Simulations suggest that the function of this complexity may lie in quasi-intelligent behavior, including conditioning and learning. (shrink)

In recent years, many philosophers of science have attempted to articulate a theory of non-epistemic emergence that is compatible with mechanistic explanation and incompatible with reductionism. The 2005 account of Fred C. Boogerd et al. has been particularly influential. They argued that a systemic property was emergent if it could not be predicted from the behaviour of less complex systems. Here, I argue that Boogerd et al.'s attempt to ground emergence in complexity guarantees that we will see (...) emergence, but at the cost of rendering it either trivial or epistemic. There are three basic problems. First, neither the measures of complexity explicitly mentioned by Boogerd et al. nor the most popular measures in the literature can do the practical and theoretical work that they assign to complexity. Second, I argue that while the success of their view depends on restricting the base of information available to the reductionist, this cannot be done in a way that is metaphysically neutral with respect to emer.. (shrink)

Fred Feldman's fascinating new book sets out to defend hedonism as a theory about the Good Life. He tries to show that, when carefully and charitably interpreted, certain forms of hedonism yield plausible evaluations of human lives. Feldman begins by explaining the question about the Good Life. As he understands it, the question is not about the morally good life or about the beneficial life. Rather, the question concerns the general features of the life that is good in itself (...) for the one who lives it. Hedonism says (roughly) that the Good Life is the pleasant life. After showing that received formulations of hedonism are often confused or incoherent, Feldman presents a simple, clear, coherent form of sensory hedonism that provides a starting point for discussion. He then presents a catalogue of classic objections to hedonism, coming from sources as diverse as Plato, Aristotle, Brentano, Ross, Moore, Rawls, Kagan, Nozick, Brandt, and others. One of Feldman's central themes is that there is an important distinction between the forms of hedonism that emphasize sensory pleasure and those that emphasize attitudinal pleasure. Feldman formulates several kinds of hedonism based on the idea that attitudinal pleasure is the Good. He claims that attitudinal forms of hedonism - which have often been ignored in the literature -- are worthy of more careful attention. Another main theme of the book is the plasticity of hedonism. Hedonism comes in many forms. Attitudinal hedonism is especially receptive to variations and modifications. Feldman illustrates this plasticity by formulating several variants of attitudinal hedonism and showing how they evade some of the objections. He also shows how it is possible to develop forms of hedonism that are equivalent to the allegedly anti-hedonistic theory of G. E. Moore and the Aristotelian theory according to which the Good Life is the life of virtue, or flourishing. He also formulates hedonisms relevantly like the ones defended by Aristippus and Mill. Feldman argues that a carefully developed form of attitudinal hedonism is not refuted by objections concerning 'the shape of a life'. He also defends the claim that all of the alleged forms of hedonism discussed in the book genuinely deserve to be called 'hedonism'. Finally, after dealing with the last of the objections, he gives a sketch of his hedonistic vision of the Good Life. (shrink)

This book provides an introduction to measurement theory for non-specialists and puts measurement in the social and behavioural sciences on a firm mathematical foundation. Results are applied to such topics as measurement of utility, psychophysical scaling and decision-making about pollution, energy, transportation and health. The results and questions presented should be of interest to both students and practising mathematicians since the author sets forth an area of mathematics unfamiliar to most mathematicians, but which has many potentially significant applications.

1. Philosophers tend to talk of belief as a ‘propositional attitude.’ As Fodor says:" The standard story about believing is that it's a two place relation, viz., a relation between a person and a proposition. My story is that believing is never an unmediated relation between a person and a proposition. In particular nobody grasps a proposition except insofar as he is appropriately related to some vehicle that expresses the proposition. " Fodor's story – that belief is a three-place relation (...) between a person, a proposition and a vehicle – is hardly non-standard; by assigning to propositions an essential place in acts of belief, he too is a ‘propositionalist’. My own view is that believing is primarily a relation between a believer and the world . While a great many human beliefs are propositional, many, perhaps most, are mondial and propositionless. As for animals who lack language, it may be that all their beliefs are mondial. In the present article, I show that distinguishing these two very different kinds of belief – de mundo as well as de dicto – enables one to explain phenomena of doxastic dissonance that standard propositionalist accounts cannot adequately explain .The next two sections, §1.1 and §1.2, are about ‘the world’ that is the doxastic object in the primary belief relation, providing needed background for the thesis that mondial belief is more primitive and basic than propositional belief.1.1. The world does not contain itself. Things in the world are …. (shrink)

Heart rate variability (HRV), the change in the time intervals between adjacent heartbeats, is an emergent property of interdependent regulatory systems that operate on different time scales to adapt to challenges and achieve optimal performance. This article briefly reviews neural regulation of the heart, and its basic anatomy, the cardiac cycle, and the sinoatrial and atrioventricular pacemakers. The cardiovascular regulation center in the medulla integrates sensory information and input from higher brain centers, and afferent cardiovascular system inputs to adjust heart (...) rate and blood pressure via sympathetic and parasympathetic efferent pathways. This article reviews sympathetic and parasympathetic influences on the heart, and examines the interpretation of HRV and the association between reduced HRV, risk of disease and mortality, and the loss of regulatory capacity. This article also discusses the intrinsic cardiac nervous system and the heart-brain connection, through which afferent information can influence activity in the subcortical and frontocortical areas, and motor cortex. It also considers new perspectives on the putative underlying physiological mechanisms and properties of the ultra-low-frequency (ULF), very-low-frequency (VLF), low-frequency (LF), and high-frequency (HF) bands. Additionally, it reviews the most common time and frequency domain measurements as well as standardized data collection protocols. In its final section, this article integrates Porges' polyvagal theory, Thayer and colleagues' neurovisceral integration model, Lehrer et al.'s resonance frequency model, and the Institute of HeartMath's coherence model. The authors conclude that a coherent heart is not a metronome because its rhythms are characterized by both complexity and stability over longer time scales. Future research should expand understanding of how the heart and its intrinsic nervous system influence the brain. (shrink)

Critical Theory constitutes one of the major intellectual traditions of the twentieth century, and is centrally important for philosophy, political theory, aesthetics and theory of art, the study of modern European literatures and music, the history of ideas, sociology, psychology, and cultural studies. In this volume an international team of distinguished contributors examines the major figures in Critical Theory, including Horkheimer, Adorno, Marcuse, Benjamin, and Habermas, as well as lesser known but important thinkers such as Pollock and Neumann. The volume (...) surveys the shared philosophical concerns that have given impetus to Critical Theory throughout its history, while at the same time showing the diversity among its proponents that contributes so much to its richness as a philosophical school. The result is an illuminating overview of the entire history of Critical Theory in the twentieth century, an examination of its central conceptual concerns, and an in-depth discussion of its future prospects. (shrink)

By contributing a few hundred dollars to a charity like UNICEF, a prosperous person can ensure that fewer poor children die, and that more will live reasonably long, worthwhile lives. Even when knowing this, however, most people send nothing, and almost all of the rest send little. What is the moral status of this behavior? To such common cases of letting die, our untutored response is that, while it is not very good, neither is the conduct wrong. What is the (...) source of this lenient assessment? In this contentious new book, one of our leading philosophers argues that our intuitions about ethical cases are generated not by basic moral values, but by certain distracting psychological dispositions that all too often prevent us from reacting in accord with our commitments. Through a detailed look at how these tendencies operate, Unger shows that, on the good morality that we already accept, the fatally unhelpful behavior is monstrously wrong. By uncovering the eminently sensible ethics that we've already embraced fully, and by confronting us with empirical facts and with easily followed instructions for lessening serious suffering appropriately and effectively, Unger's book points the way to a compassionate new moral philosophy. (shrink)

The primary task confronting an examination of the claimed connection between Kant's general theory of cognition and his account of aesthetic judgment requires clarifying perhaps the most obscure component of that account, the doctrine of the harmony of the faculties. Kant's presentation of this doctrine makes it notoriously difficult to penetrate. Much of what Kant says about the harmony of the faculties – perhaps the very phrase “the harmony of the faculties” – is rather imprecise and metaphorical. Yet, the importance (...) of a correct understanding of the harmony of the faculties to assessing both the merits of Kant's aesthetic theory and his claims for the epistemological significance of reflection is difficult to overstate, for it is precisely this state of harmony that ultimately grounds the validity of judgments of taste and does so in virtue of being a state in which the most general prerequisites to conceptual judgment are present. (shrink)

The purpose Tarski speaks of is "to do justice to our intuitions which adhere to the classical Aristotelian conception of truth." Tarski takes this to be some form of correspondence theory. He has earlier considered and rejected an even less satisfactory formula of this sort: 'a sentence is true if it corresponds to reality'. His own semantic conception of truth is meant to be a more precise variant doing justice to the correspondence standpoint. In this spirit I shall presently suggest (...) a revised version of. (shrink)

Corporate Reputation (CR) is essential to value generation and is co-created between a company and its stakeholders, including supply chain actors. Consequently, CR is a critical and valuable resource that should be managed carefully along supply chains. However, the current CR literature is fragmented, and a general definition of CR is elusive. Besides, the academic CR debate largely lacks a supply chain perspective. This is not surprising, as it is very difficult to collect reliable data along supply chains. When supply (...) chains span the globe, data collection is especially challenging, as the chain consists of multiple suppliers and subcontractors, positioned at different tier levels. Recognizing this, the paper examines firstly the current state of CR research through a systematic literature review from a business perspective. The review is combined with a bibliometric mapping approach to show the most influential research clusters, representative of CR research streams and their contributors. This process highlights that the connection between CR and supply chain issues represents a major research gap. Consequently, this paper introduces a research agenda connecting these the two traditionally separated research fields. (shrink)

In graphic novel format, explains the theories of various philosophers through humorous examples and anecdotes.

In graphic novel format, explains the theories of various philosophers through humorous examples and anecdotes.

Designed for courses in environmental ethics, this reader is also an attractive supplement to contemporary moral issues or any applied ethics courses. It features readings in environmental ethics, including Paul Taylor's seminal essay The Ethics of Respect for Nature and works by Vice Preseident Al Gore, Jr. and J. Baird Callicott. Features: * Includes only readings of highest quality, chosen to be accessible to students who do not have an extensive knowledge of philosophy. * Exposes students to all major areas (...) of environmental ethics, including wilderness, pollution and animals. * Ideal length is appropriate as a core text or supplement to a variety of contemporary ethics courses. * Extensive bibliography provides a unique resource for research materials in this growing field. * Essays contain philosohical arguments as well as critique. * Presents an agenda of protection and stewardship that involves students in the management of our planets ecosystem. (shrink)

The modern theory of computability is based on the works of Church, Markov and Turing who, starting from quite different models of computation, arrived at the same class of computable functions. The purpose of this paper is the show how the main results of the Church-Markov-Turing theory of computable functions may quickly be derived and understood without recourse to the largely irrelevant theories of recursive functions, Markov algorithms, or Turing machines. We do this by ignoring the problem of what constitutes (...) a computable function and concentrating on the central feature of the Church-Markov-Turing theory: that the set of computable partial functions can be effectively enumerated. In this manner we are led directly to the heart of the theory of computability without having to fuss about what a computable function is.The spirit of this approach is similar to that of [RGRS]. A major difference is that we operate in the context of constructive mathematics in the sense of Bishop [BSH1], so all functions are computable by definition, and the phrase “you can find” implies “by a finite calculation.” In particular ifPis some property, then the statement “for eachmthere isnsuch thatP” means that we can construct a functionθsuch thatP)for allm. Church's thesis has a different flavor in an environment like this where the notion of a computable function is primitive.One point of such a treatment of Church's thesis is to make available to Bishopstyle constructivists the Markovian counterexamples of Russian constructivism and recursive function theory. The lack of serious candidates for computable functions other than recursive functions makes it quite implausible that a Bishopstyle constructivist could refute Church's thesis, or any consequence of Church's thesis. Hence counterexamples such as Specker's bounded increasing sequence of rational numbers that is eventually bounded away from any given real number [SPEC] may be used, as Brouwerian counterexamples are, as evidence of the unprovability of certain assertions. (shrink)

We consider notions of boundedness of subsets of the natural numbers ℕ that occur when doing mathematics in the context of intuitionistic logic. We obtain a new characterization of the notion of a pseudobounded subset and we formulate the closely related notion of a detachably finite subset. We establish metric equivalents for a subset of ℕ to be detachably finite and to satisfy the ascending chain condition. Following Ishihara, we spell out the relationship between detachable finiteness and sequential continuity. Most (...) of the results do not require countable choice. (shrink)