The concept of predisposition in medicine is ancient, and the term diathesis was used to express it since the days of Hippocrates and, especially, of Galen.The concept of diathesis was enormously popular throughout the nineteenth century, despite the vagueness of its actual meaning. It was clarified only in the early years of the twentieth century (1902), when it was however losing its clinical relevance, by a replacement of the concept ofchemical individuality by A.E. Garrod, followed thirty years later by the (...) concept ofinborn factors in disease (1931). (shrink)

Aggressive therapies and the manipulation of life are now commonly applied to children, often including neonates and children who cannot express their consent. This text discusses a range of bioethical dilemmas concerning children and medicine.

The ability to feel pain is a property of human beings that seems to be based entirely in our biological natures and to place us squarely within the animal kingdom. Yet the experience of pain is often used as an example of a mental attribute with qualitative properties that defeat attempts to identify mental events with physiological mechanisms. I will argue that neurophysiology and psychology help to explain the interwoven biological and subjective features of pain and recommend a view of (...) pain which differs in important respects from the one most commonly accepted. (shrink)

This Companion provides a fresh and comprehensive account of this outstanding work, which remains among the most frequently read works of Greek philosophy, indeed of Classical antiquity in general. The sixteen essays, by authors who represent various academic disciplines, bring a spectrum of interpretive approaches to bear in order to aid the understanding of a wide-ranging audience, from first-time readers of the Republic who require guidance, to more experienced readers who wish to explore contemporary currents in the work’s interpretation. The (...) three initial chapters address aspects of the work as a whole. They are followed by essays that match closely the sequence in which topics are presented in the ten books of the Republic. Since the Republic returns frequently to the same topics by different routes, so do the authors of this volume, who provide the readers with divergent yet complementary perspectives by which to appreciate the Republic’s principal concerns. (shrink)

Tracing a central theme of Plato's Republic , G. R. F. Ferrari reconsiders in this study the nature and purpose of the comparison between the structure of society and that of the individual soul. In four chapters, Ferrari examines the personalities and social status of the brothers Glaucon and Adeimantus, Plato's notion of justice, coherence in Plato's description of the decline of states, and the tyrant and the philosopher king—a pair who, in their different ways, break with the terms of (...) the city-soul analogy. In addition to acknowledging familiar themes in the interpretation of the Republic —the sincerity of its utopianism, the justice of the philosopher's return to the Cave—Ferrari provocatively engages secondary literature by Leo Strauss, Bernard Williams, and Jonathan Lear. With admirable clarity and insight, Ferrari conveys the relation between the city and the soul and the choice between tyranny and philosophy. City and Soul in Plato's Republic will be of value to students of classics, philosophy, and political theory alike. (shrink)

This full-length study of Plato's dialogue Phaedrus, now in paperback, is written in the belief that such concerted scrutiny of a single dialogue is an important part of the project of understanding Plato so far as possible 'from the inside' - of gaining a feel for the man's philosophy. The focus of this account is on how the resources both of persuasive myth and of formal argument, for all that Plato sets them in strong contrast, nevertheless complement and reinforce each (...) other in his philosophy. Not only is the dialogue in its formal structure a dovetail of myth and argument, but the philosophic life that it praises is also shaped by an acknowledgement of the limitations of argument and the importance of mythical understanding. By means of this correlation of form and content Plato invites his readers, through the very act of reading, to take a first step along the path of the philosophical life. (shrink)

First published in 2000, this translation of one of the great works of Western political thought is based on the assumption that when Plato chose the dialogue form for his writing, he intended these dialogues to sound like conversations - although conversations of a philosophical sort. In addition to a vivid, dignified and accurate rendition of Plato's text, the student and general reader will find many aids to comprehension in this volume: an introduction that assesses the cultural background to the (...) Republic, its place within political philosophy, and its general argument; succinct notes in the body of the text; an analytical summary of the work's content; a full glossary of proper names; a chronology of important events; and a guide to further reading. The result is an accomplished and accessible edition of this seminal work, suitable for philosophers and classicists as well as historians of political thought at all levels. (shrink)

Quel bon vent, quel joli vent, ma vie m’appelle, ma vie m’attend French folk song 1. Presentists and Growing Block theorists appeal to ‘powerful intuitions’ when they defend their respective conceptions of time . Eternalists are prepared to go some length towards ‘reconciling’ the view from nowhen with at least some of these intuitions, or try to explain them away . Unaided intuitions may in fact underdetermine any particular metaphysical choice. One set of intuitions about time seems to have been (...) neglected, though, in spite of its power. These intuitions are the mirror image of those supporting the Growing Block theory , and they are modelled on a pre-reflective understanding of our own life. According to the intuitions, only the future and the present are real; the past isn’t. The present is the constantly eroding edge of the future, which thus shrinks incessantly. There is less and less future as the present proceeds. The obvious intuitive model of this view of time is our life; from which every day eats up a little bit. Smaller scale models are available in everyday life. As you are reading this text, you have less and less to read. You know it. You know that at some point you’ll finish, or stop, reading it. But a model is not enough to make a grand philosophical claim, and indeed the very existence of the model is the ground for a negative claim: a picture, it may be said, is holding you captive. The Future Shrinker has two tasks. The first is to show that the intuitive picture supporting the claim is robust and does not make implausible epistemological claims. The second task is to show that her theory is at least compatible with scientific lore, and at best a good way …. (shrink)

This paper forms an introduction to this issue, the contents of which arose directly or indirectly from a conference in May 2001 on Corruption of scientific integrity? — The commercialisation of academic science. The introduction, in recent decades, of business culture and values into universities and research institutions is incompatible with the openness which scientific and all academic pursuit traditionally require. It has given rise to a web of problems over intellectual property and conflict of interest which has even led (...) to corporate sponsors’ suppressing unfavourable results of clinical trials, to the detriment of patients’ health. Although there are those who see the norms of science developing to recognise the importance of instrumental science aiming at specific goals and of knowledge judged by its value in a context of application, none justifies the covert manipulation of results by vested interest. Public awareness of these problems is growing and creating a climate of opinion where they may be addressed. We suggest a way forward by the introduction of nationally and internationally-accepted guidelines for industrial collaboration which contain proper protections of the core purposes of universities and of the independence of their research. Some codes suggested for this purpose are discussed. We note that some universities are moving to adopt such codes of conduct, but argue the need for strong support from the government through its funding bodies. (shrink)

In order to study early human development while avoiding the burdens associated with human embryo research, scientists are redirecting their efforts towards so-called human embryo-like structures (hELS). hELS are created from clusters of human pluripotent stem cells and seem capable of mimicking early human development with increasing accuracy. Notwithstanding, hELS research finds itself at the intersection of historically controversial fields, and the expectation that it might be received as similarly sensitive is prompting proactive law reform in many jurisdictions, including the (...) Netherlands. However, studies on the public perception of hELS research remain scarce. To help guide policymakers and fill this gap in the literature, we conducted an explorative qualitative study aimed at mapping the range of perspectives in the Netherlands on the creation and research use of hELS. This article reports on a subset of our findings, namely those pertaining to (the degrees of and requirements for) confidence in research with hELS and its regulation. Despite commonly found disparities in confidence on emerging biotechnologies, we also found wide consensus regarding the requirements for having (more) confidence in hELS research. We conclude by reflecting on how these findings could be relevant to researchers and (Dutch) policymakers when interpreted within the context of their limitations. (shrink)

This book aims to provide an introduction to Aristotle's Politics, highlighting the major themes and arguments offered in the scholar's work. It begins with a discussion on what Aristotle perceives as human good, which he had described as the ethical purpose of political science, and how he views the political community, or the polis, as a community of persons formed with a view to some good purpose and a supreme entity in the sense that it is not just one aspect (...) of city-state society but is the whole of that society. The book also discusses Aristotle's arguments against the abolition of the household for the ruling class and the communism of families and property, which Plato advocates, and highlights certain inconsistencies and vulnerabilities in his arguments supporting natural slavery and on how the husband should rule over his wife and children. The book presents Aristotle's account of the relative merits of six different types of constitution and his views on the best possible constitution that will help in the realization of the polis' true purpose of achieving the good life. It ends with a discussion on Aristotle's view of political science in relation to the protection of particular constitutions against constitutional change and political disorder. (shrink)

In this talk I consider a body of my more recent work in order to isolate the shared approach that it takes to reading Platonic dialogue, an approach which had been absent from my writing on Plato up to that point and is largely absent from any of the traditions that influence how most of us read Plato. Its key feature is a refusal to treat the character Socrates as operating as if he were Plato’s secret agent within the dialogue—as (...) if one should attribute to Socrates all of the cunning and the control with which one might credit instead the author who scripted Socrates’s habitual triumphs. The focus of this new approach is rather on Plato’s “writerly” philosophizing: on how Plato exploits the distinction between what he and his character Socrates are up to as philosophers in order to guide our sense of his own activity and aims as a philosophic writer. (shrink)

This paper discusses the surprising resurgence in the fortunes of the British eugenics movement in the 1930s. It is argued that although mass unemployment may in the long run have discredited that version of eugenics in which social dependence and destitution were attributed to genetic defect, in the short run the Depression was often perceived as a vindication of the eugenical creed. In particular, the attempt to reduce the fertility of the unemployed by popularising birth control techniques, and the voluntary (...) sterilization campaign aimed at preventing the propagation of defectives from the so-called Social Problem Group, satisfied the urge felt by many conservative members from the professional classes to respond creatively to the country's crisis, without endangering existing social and economic institutions. It is also shown that not until 1938 did events in Germany cause substantial damage to the cause of eugenics in Britain. In fact, the ‘German experiment’ was actually greeted with approval by certain British eugenists of an authoritarian cast of mind. However, the Society as a whole never identified with these right-wing extremists, thanks in part to the moderating influence exercised by its General Secretary, Dr. C. P. Blacker, whose prime concern was with psycho-medical problems likely to concern people of all party persuasions. (shrink)

It is rarely, if at all, thought that Socrates committed suicide; but such was the case, or so I want to suggest. My suggestion turns not upon any new interpretation of ancient sources but rather upon seeking a determination of the concept of suicide itself.

Decompressive craniectomy is a technically straightforward procedure whereby a large section of the cranium is temporarily removed in cases where the intracranial pressure is dangerously high. While its use has been described for a number of conditions, it is increasingly used in the context of severe head injury. As the use of the procedure increases, a significant number of patients may survive a severe head injury who otherwise would have died. Unfortunately some of these patients will be left severely disabled; (...) a condition likened to the RUB, an acronym for the Risk of Unacceptable Badness. Until recently it has been difficult to predict this outcome, however an accurate prediction model has been developed and this has been applied to a large cohort of patients in Western Australia. It is possible to compare the predicted outcome with the observed outcome at 18 months within this cohort. By using predicted and observed outcome data this paper considers the ethical implications in three cases of differing severity of head injury in view of the fact that it is possible to calculate the RUB for each case. (shrink)