A tese é de que a concepção de Duhem da ciência antecipa, entre outros elementos, o modelo de escolha de teorias científicas associado com as concepções de Popper, Lakatos e Kuhn. No contexto do seu debate com Poincaré, Duhem propõe um modelo metodológico de escolha racional de teorias formado, também, de componentes extralógicos. O modelo substitui a metodologia bipartida, teoria e natureza, por uma tripartida, confrontação entre duas teorias e natureza. Tal metodologia verifica-se adequada para descrever o processo de escolha (...) de teoria formado das etapas da refutação e rejeição. Ambas as propostas revelam seu enfoque histórico-crítico cuja tese é a interdependência entre história e teoria da ciência. A interdependência configura-se num laboratório para a elaboração, a avaliação e teste das propostas metafísicas e metodológicas para a construção de uma teoria da ciência. (shrink)

O objetivo é propor uma reconstrução racional da concepção da ciência de Duhem, por meio do recurso da metodologia da teoria da ciência, como uma teoria normativa da dinâmica do conhecimento. Essa reconstrução ajuda a estabelecer que Duhem não pode ser classificado como um convencionalista/pragmatista, como sugere a interpretação-padrão, e, além disso, que Duhem almeja construir uma concepção que seja um termo médio entre a concepção metafísica clássica e a concepção do convencionalismo/pragmatismo. A estratégia metodológica para construir esse termo médio (...) é a proposta de um realismo estrutural e convergente. Duhem substitui o sujeito transcendental dos clássicos por uma teoria transcendental a ser alcançada por um processo dinâmico. Using the resources of the methodology of theory of science we propose a rational reconstruction of Duhem's conception of science, interpreting it as a normative theory of the dynamics of knowledge. Such a reconstruction helps to establish that Duhem cannot be classified as a conventionalist/pragmatist as proposed in the standard interpretation, and, furthermore, that Duhem proposes to construct a conception of science as a middle way between a classical metaphysical conception and a conventionalist/pragmatist conception. The methodological strategy for this middle way is the proposal of a structural and convergent realism. Duhem replaces the transcendental subject of the classics with a transcendental theory to be reached by a dynamic process. (shrink)

A reconstrução racional do programa de pesquisa do racionalismo clássico sob a perspectiva da abordagem de solução de problemas.

The present work sets out to discuss in three main steps the roots of the indeterministic paradigm for quantum mechanics as against a causal explanation of reality. The first step is to present the fundamental role played by non-local Fourier analysis in the Copenhagen paradigm. The second is to present wavelet local analysis, a recent formalism that will perhaps allow the development of a new causal paradigm for physics. The third is to present the Heisenberg-Bohr uncertainty relations as a direct (...) mathematical consequence of Fourier non-local analysis. Finally, experimental evidence violating these relations is presented. These results imply that the indeterministic approach has reached its limits. However, they can be explained within a causal framework allowing a more general mathematical formulation for uncertainty relations. (shrink)

The present work sets out to discuss in three main steps the roots of the indeterministic paradigm for quantum mechanics as against a causal explanation of reality. The first step is to present the fundamental role played by non-local Fourier analysis in the Copenhagen paradigm. The second is to present wavelet local analysis, a recent formalism that will perhaps allow the development of a new causal paradigm for physics. The third is to present the Heisenberg-Bohr uncertainty relations as a direct (...) mathematical consequence of Fourier non-local analysis. Finally, experimental evidence violating these relations is presented. These results imply that the indeterministic approach has reached its limits. However, they can be explained within a causal framework allowing a more general mathematical formulation for uncertainty relations. (shrink)

The nature of quantum waves, whether they are real physical waves or, on the contrary, mere probability waves, has been a very controversial theme since the beginning of quantum theory. Here we present some possible experiments that may clarify the problem.

The aim of this paper is to provide a conceptual framework that will help in understanding and evaluating, along social and ethical lines, the issue of killing day-old male chicks and two alternative directions of responsible innovations to solve this issue. The following research questions are addressed: Why is the killing of day-old chicks morally problematic? Are the proposed alternatives morally sound? To what extent do the alternatives lead to responsible innovation? The conceptual framework demonstrates clearly that there is a (...) moral “lock-in”, and why the killing of day-old chicks is indeed an issue. Furthermore, it is shown that both alternative directions address some important objections with regard to the killing of day-old chicks, but that they also raise new dilemmas. It also becomes clear that the framework enables and secures anticipation, reflection, deliberation with and responsiveness to stakeholders, the four dimensions of responsible innovation, in a structured way. (shrink)

The literature on public perceptions of, and attitudes towards, nanotechnology used in the agrifood sector is reviewed. Research into consumer perceptions and attitudes has focused on general applications of nanotechnology, rather than within the agrifood sector. Perceptions of risk and benefit associated with different applications of nanotechnology, including agrifood applications, shape consumer attitudes, and acceptance, together with ethical concerns related to environmental impact or animal welfare. Attitudes are currently moderately positive across all areas of application. The occurrence of a negative (...) or positive incident in the agri-food sector may crystallise consumer views regarding acceptance or rejection of nanotechnology products. •Acceptance of agrifood nanotechnology based on perceptions of risk, benefit and ethics.•Attitudes towards nanotechnology in general are currently moderately positive.•Occurrence of a major nanotechnology-related "event" may crystallise consumer attitude. (shrink)

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

The purpose of this article is to provide a critical examination of two aspects of culture and biomedicine that have helped to shape the meaning and practice of genetic testing for breast cancer. These are: (1) the cultural construction of fear of breast cancer, which has been fuelled in part by (2) the predominance of a ‘risk’ paradigm in contemporary biomedicine. The increasing elaboration and delineation of risk factors and risk numbers are in part intended to help women to contend (...) with their fear of breast cancer. However, because there is no known cure or foolproof prevention for breast cancer, risk designations bring with them recommendations for vigilant surveillance strategies and screening guidelines. We argue that these in effect exacerbate women’s fears of breast cancer itself. The volatile combination of discourses of fear, risk and surveillance have significant ethical and social consequences for women’s lives and well-being. Genetic testing decisions are made within this context; if nurses understand this context they can play an important role in helping women to cope with the anxiety and fear of breast cancer risk. (shrink)

Objectives To evaluate whether the requirement of “minimal risk and burden” for paediatric research without direct benefit to the subjects compromises the ability to obtain data necessary for improving paediatric care. To provide evidence-based reflections on the EU recommendation that allows for a higher level of risk. Design and setting Systematic analysis of the approval/rejection decisions made by the Dutch Central Committee on Research involving Human Subjects (CCMO). Review methods The analysis included 165 proposals for paediatric research without direct benefit (...) that were reviewed by the CCMO between January, 2000, and July, 2007. A separate, in-depth analysis of all drug studies included 18 early phase drug studies and nine other drug studies without direct benefit. Results 11 out of 165 studies were definitively rejected because the CCMO did not regard the risk and/or burden to be minimal. In three of these 11 cases (including two early phase drug studies) the requirement of minimal risk and burden was cited as the only reason for rejection. Four other early phase drug studies also involved risks and/or burdens that were not regarded to be minimal but were nevertheless approved. Conclusions The requirement of minimal risk and burden, aiming to protect research subjects, occasionally leads to rejection of protocols. Early phase drug studies relatively often do not comply with the requirement. Committees may find ways to approve important studies that formally should be rejected, but that is not a desirable solution. The regulatory framework should be revised to make such occasional exceptions to the requirement legitimate and transparent. (shrink)

The purpose of this article is to provide a critical examination of two aspects of culture and biomedicine that have helped to shape the meaning and practice of genetic testing for breast cancer. These are: the cultural construction of fear of breast cancer, which has been fuelled in part by the predominance of a ‘risk’ paradigm in contemporary biomedicine. The increasing elaboration and delineation of risk factors and risk numbers are in part intended to help women to contend with their (...) fear of breast cancer. However, because there is no known cure or foolproof prevention for breast cancer, risk designations bring with them recommendations for vigilant surveillance strategies and screening guidelines. We argue that these in effect exacerbate women’s fears of breast cancer itself. The volatile combination of discourses of fear, risk and surveillance have significant ethical and social consequences for women’s lives and well-being. Genetic testing decisions are made within this context; if nurses understand this context they can play an important role in helping women to cope with the anxiety and fear of breast cancer risk. (shrink)

Kushner and Thomasma have assembled a distinguished group of contributors who are almost all practising clinicians with an interest in medical ethics. The book is well laid out and is divided into two main parts: part one “On caring for patients” and part two “On becoming a `team player’: searching for esprit de corps and conflicts of socialization”. This is a convenient way to think about medical ethics. Part one covers the ethical dilemmas of doctors caring for patients and the (...) many practical problems that arise; this area of medical ethics is what most doctors would consider to be “true” medical ethics. Many doctors would not consider part two to be medical ethics at …. (shrink)

Most donated organs in the United States come from brain dead donors, while a small percentage come from patients who die in “controlled,” or expected, circumstances, typically after the family or surrogate makes a decision to withdraw life support. The number of organs available for transplant could be substantially if donations were permitted in “uncontrolled” circumstances–that is, from people who die unexpectedly, often outside the hospital. According to projections from the Institute of Medicine, establishing programs permitting “uncontrolled donation after circulatory (...) determination of death,” or uDCDD, throughout the United States has the potential to provide 22,000 more donation opportunities annually. In contrast, U.S. controlled donation after circulatory determination of death, or cDCDD, cases have increased progressively over the past decade from 87 to 848 donors, but currently account for only 10.6 percent of all deceased donors. Following the IOM recommendations, several projects exploring the feasibility of uDCDD were funded by the federal government, including a grant from the Health Resources and Services Administration that supported a pilot project in New York City in which the authors of this article participated.A key feature of our protocol, and indeed of many uDCDD protocols, is the initiation of preservation methods such as chest compressions and extracorporeal membrane oxygenation shortly after death in order to perfuse and preserve the donor's organs. Critics of uDCDD argue that the means of determining death deviates from generally ascribed principles. They assert that reinstituting circulation in order to preserve organs has the effect of “undoing” the prior determination of death. The result is that cDCDD is widely accepted and practiced routinely even though it only marginally increases the number of organs available for transplantation, and uDCDD is widely considered unacceptable despite being ethically embraced and proven to significantly increase organ donation opportunities in other countries. This article explores the evolution of this counterintuitive state of affairs and calls for a policy that, in line with the IOM report, allows for both cDCDD and uDCDD protocols. (shrink)