This chapter extends biogenetic structural theory to a consideration of the biopsychological principles underlying higher phases of consciousness, particularly those attained by the systematic exploration of consciousness called contemplation. The concepts of psychic energy, flow, centeredness, energy circulation, and dreambody are explored as presented in various mystical traditions, and a model of the underlying neurophysiology is presented in terms of ergotropic-trophotropic tuning. The psychophysiology of various forms of meditation together with emergent peak experiences is examined and integrated into the ergotropic-trophotropic (...) tuning model. Structural invariance of ergotropic-trophotropic tuning as well as invariant aspects of contemplation across different cultures and associated with different symbol systems is considered. Finally the nature and implications of Void Consciousness, God Consciousness, or Abssolute Unitary Being are examined. (shrink)

A biogenetic structural explanation is offered for the cross‐culturally common mystical experience called portalling, the experience of moving from one reality to another via a tunnel, door, aperture, hole, or the like. The experience may be evoked in shamanistic and meditative practice by concentration upon a portalling device (mirror, mandala, labyrinth, skrying bowl, pool of water, etc.). Realization of the portalling experience is shown to be fundamental to the phenomenology underlying multiple reality cosmologies in traditional cultures and is explained in (...) terms of radical re‐entrainment of the neurological systems mediating experience in the brain. Phenomenological experiments with mirror portalling devices from both the Tibetan and the Tsimshian religious traditions are reported. (shrink)

Recent reports of CRISPR/Cas9 genome editing in parasitic helminths open up new avenues for research on these dangerous pathogens. However, the complex morphology and life cycles inherent to these parasites present obstacles for the efficient application of CRISPR/Cas9‐targeted mutagenesis. This is especially true with the trematode flukes where only modest levels of gene mutation efficiency have been achieved. Current major challenges in the application of CRISPR/Cas9 for study of parasitic worms thus lie in enhancing gene mutation efficiency and overcoming issues (...) involved in host passage so that mutated parasites survive. Strategies developed for CRISPR/Cas9 studies on Caenorhabditis elegans, protozoa and mammalian cells, including novel delivery methods, the choice of selectable markers, and refining mutation precision represent novel tactics whereby these impediments can be overcome. Furthermore, employing CRISPR/Cas9‐mediated gene drive to interfere with vector transmission represents a novel approach for the control of parasitic worms that is worthy of further exploration. (shrink)

'Conditions of Possibility and Impossibility': Wittgenstein, Heidegger and Derrida Derrida’s writings expose ways in which philosophical texts presuppose distinctions that they are also determined to ignore. Such a dependency might be thought to undermine those texts, replacing what they take to be fundamental with deeper, unacknowledged foundations. Yet Derrida maintains that there is no simple undermining in the offing and that the structures he identifies are not to be understood as ‘supra-transcendentals’ to philosophy's ‘transcendentals’. This paper identifies a context within (...) which Derrida might be seen as operating and, on that basis, articulates two possible readings of his work. The first takes Derrida to be engaging in a powerfully tempting line of thought whose roots lie in Heidegger and of which the work of Wittgenstein provides a critique. The second takes Derrida to be engaging instead in a form of reflection akin to that of Wittgenstein, revealing confused analogies that provide philosophical texts with the illusion of content and their distinctive pseudo-logic. I take as an illustrative case Derrida‘s early discussion of Aristotle on time; I compare Derrida’s analysis of how Aristotle comes to formulate what appears to be an essential truth about time with the early Wittgenstein’s reflections on how superficial analogies between different forms of discourse suggest that we have a grasp of what we come to see as ‘ontological categories’. The strengths and weaknesses of the two readings are evaluated. (shrink)

The aim of UK-REACH (“The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers”) is to understand if, how, and why healthcare workers (HCWs) in the United Kingdom (UK) from ethnic minority groups are at increased risk of poor outcomes from COVID-19. In this article, we present findings from the ethical and legal stream of the study, which undertook qualitative research seeking to understand and address legal, ethical, and social acceptability issues around data protection, privacy, and information (...) governance associated with the linkage of HCWs’ registration data and healthcare data. We interviewed 22 key opinion leaders in healthcare and health research from across the UK in two-to-one semi-structured interviews. Transcripts were coded using qualitative thematic analysis. Participants told us that a significant aspect of Big Data research in public health is varying drivers of mistrust—of the research itself, research staff and funders, and broader concerns of mistrust within participant communities, particularly in the context of COVID-19 and those situated in more marginalised community settings. However, despite the challenges, participants also identified ways in which legally compliant and ethically informed approaches to research can be crafted to mitigate or overcome mistrust and establish greater confidence in Big Data public health research. Overall, our research indicates that a “Big Data Ethics by Design” approach to research in this area can help assure (1) that meaningful community and participant engagement is taking place and that extant challenges are addressed, and (2) that any new challenges or hitherto unknown unknowns can be rapidly and properly considered to ensure potential (but material) harms are identified and minimised where necessary. Our findings indicate such an approach, in turn, will help drive better scientific breakthroughs that translate into medical innovations and effective public health interventions, which benefit the publics studied, including those who are often marginalised in research. (shrink)

Paul Boghossian has pointed out a ’circularity problem’ for dispositionalist theories of meaning: as a result of the holistic character of belief fixation, one cannot identify someone’s meaning such and such with facts of the form S is disposed to utter P under conditions C, without C involving the semantic and intentional notions that such a theory was to explain. Alex Miller has recently suggested an ’ultra‐sophisticated dispositionalism’ (modelled on David Lewis’s well known version of functionlism) and has argued that (...) this version of dispositionalism escapes Boghossian’s ’circularity problem’. Miller argues, nonetheless, that another of Boghossian’s criticisms of dispositionalism, ’the infinity problem’ still applies to this ’ultra‐sophisticated dispositionalism’: C will still draw upon a potential infinity of mediating background clusters of belief. The present paper argues that the feature that ’the infinity problem’ presents as problematic is a feature of a host of familiar explanations. Our fundamental difficulty in this area is not our inability to understand how a more general model can be applied to a particular domain (the intentional understood as dispositional) but our failure to understand that general model itself (dispositional explanation). (shrink)

A substantial guide providing an overview of both physicalism and metaphysical naturalism, reviewing both questions of formulation and justification for both doctrines. Includes a diagnostic strategy for understanding talk of naturalism as a metaphysical thesis.

Recently the attempt has been made to demonstrate Heidegger's relevance to the concerns of analytic philosophers. A focus for this effort has been the criticism in his early work of Cartesian ontology. While a number of important works have mapped out this area of Heidegger's thought, a crucial task has not been carried out, namely that of assessing how Heidegger can accommodate those phenomena which motivate the Cartesian to adopt his highly counter-intuitive ontology. As long as we fail to examine (...) how Heidegger's early ontology copes with the possibilities of error and of hallucination, the suspicion will remain that Heidegger is simply insensitive to those phenomena on which the Cartesian focuses. Neither Heidegger nor the Cartesian have been done any favours by commentators showing little inclination to bring the opponents into closer combat. This paper attempts to correct that omission. (shrink)

Inside What Would Plato Do?, you'll find the basics of philosophy, written in an easy, digestible way we can all understand, along with questions to help you apply these important theories to your own life. So, after you've learned about a philosophical concept, you'll then be challenged to test yourself and see how the results can impact your daily life. For instance, after learning about Kant's theory of morality and the importance of intention you're challenged with questions like: Can good (...) people do bad things? Was there a time when you intended to do something helpful that ended up being hurtful? Does that make you a good person (because you intended to do good) or a bad person (because the results were bad)? What Would Plato Do? will not only help you better understand some of the greatest thinkers ever but will also help you think of the world around you in a whole new way! (shrink)

For the newly trained Cognitive Behavioural Therapist, there are a wealth of challenges and difficulties faced as they try and apply their new found skills in the outside world. These might include the stresses of working in isolation, and finding it difficult to widen their scope or bounce ideas of other CBT therapists; or the need for practical advice on setting up group therapy; the possible conflicts betweens ethical practice and theory; trying to retain ones integrity as a therapist, while (...) maintaing a viable business practice.The Oxford Guide to Surviving CBT Practice is the one-stop resource for the newly trained therapist. It offers practical guidance on a range of issues and challenges faced by the therapist. Written by people with vast experience of training and practising CBT, it draws on real life situations to help the reader hone and develop their skills, adjust to life as a therapist, and maintain a successful and satisfying career whilst helping others.With thousands of new CBT therapists due to be trained over the coming years, this book will be a well thumbed and constant companion for all those starting life as a therapist - one they will want to have to hand at all times. (shrink)

Ne vers 1180 a Aurillac, mort le 30 mars 1249, Guillaume d'Auvergne est nomme eveque de Paris des 1228. Son oeuvre est contemporaine de la querelle de l'aristotelisme qui gagne la faculte de theologie, et du bouleversement de l'histoire theorique qui l'accompagne. Quelle est la cause efficiente de la pensee? D'ou vient l'intelligible necessairement present dans l'ame qui pense? C'est a cela que repondent les neuf premieres parties du chapitre sept du De anima, ecrit vers 1240. La noetique de Guillaume (...) d'Auvergne, complexe, s'y deploie et sensiblement se demarque de l' augustinisme avicennisant qui traditionnellement la caracterise. L'ame, dans son rapport au sensible, est principium agens, lectrice, en tant qu'elle pense, d'un livre dont elle-meme est l'auteur, et dont la verite se passe en partie de l'illumination divine. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

We perceive smells as perduring complex entities within a distal array that might be conceived of as smellscapes. However, the philosophical orthodoxy of Odor Theories has been to deny that smells are perceived as having a distal location. Recent challenges have been mounted to Odor Theories’ veracity in handling the timescale of olfactory perception, how it individuates odors as a distal entities, and their claim that olfactory perception is not spatial. The paper does not aim to dispute these criticisms. Rather, (...) what will be shown is that Molecular Structure Theory, a refinement of Odor Theory, can be further developed to handle these challenges. The theory is further refined by focusing on distal perception that requires considering the perceptual object as mereologically complex persisting odor against a background scene conceived of as a smellscape. What will be offered is an expansion of Molecular Structure Theory to account for distal smell perception within natural environments. (shrink)

Creating what sort of professional? Master's level nurse education as a professionalising strategy This paper reports on a detailed analysis of selected findings from a larger study of master's level nurse education. It locates some features of such education within the contemporary situation of nursing as a profession and interprets the role of master's level nurse education as a professionalising strategy. In‐depth interviews were undertaken with a purposive sample of 18 nurse lecturers drawn from eight universities in the United Kingdom. (...) The interview agenda explored participants’ perspectives of the characteristics of master's level performance in practice. Interview transcripts were interpreted by drawing upon hermeneutic methodology.The following themes emerged. (a) The credibility of the master's level nurse was of central importance. In terms of the literature of professionalisation, this may be interpreted as a factor in enhancing the legitimacy of nursing as an occupation. (b) The clinical capability attributed to the nurse is interpreted as leading to an increase in the authority commanded by the expert professional. Thus, the individual capability of the master's level nurse enhances the attribution of autonomous skill to the occupation as a whole. (c) The master's level nurse is seen to exercise influence and leadership and this strengthens the power and status of nursing.Nursing does not have the appearance of a ‘traditional’ profession, neither has it a clear stance as a ‘new profession’. Rather it appears to be especially responsive to the tide of public opinion manifest through government edicts. While nursing is employing rhetoric that espouses both positions, the direction of master's level education is anomalous. (shrink)

Development of a vaccine for schistosomiasis, a parasitic disease currently affecting over 200 million people worldwide, has been targeted as a priority by the World Health Organisation. Research demonstrating the ability of humans to acquire natural immunity to schistosome infection, together with the successful use of attenuated vaccines in animals both under laboratory and field conditions, suggest that development of a human vaccine is feasible. Attenuated vaccines for schistosomiasis are considered neither safe nor practicable for human use, however, and therefore (...) other approaches must be considered. This review examines progress currently being undertaken in a number of different areas towards achieving the goal of a safe and effective human vaccine for schistosomiasis. (shrink)

This is a book grounded in the real ethical challenges of modern business practice, with a world-religious perspective so necessary in an era of globalization.

Denis McManus presents a novel account of Martin Heidegger's early vision of our subjectivity and the world we inhabit. He explores key elements of Heidegger's philosophy, and argues that Heidegger's central claims identify genuine demands that must be met if we are to achieve the feat of thinking determinate thoughts about the world around us.

The ethical development of business graduates is a critical issue. Yet, little empirical evidence exists on the factors affecting business graduate ethical development and behaviour using an Islamic perspective. This study examines the effects of mentoring support, the perceived standard of ethical conduct of peers, and individual ethical attributes of National female business graduates from the United Arab Emirates. Research has shown that formal and informal mentoring relationships benefit new employees by enabling them to further learn and grow within an (...) organisation. On the other hand, some employees have also shown that these relationships can have a negative impact on a new employee’s ethical orientation. The aim of this study is to investigatethe ethical orientations of Emirati female business graduates as they move from the relative sanctity of home and university into a new multicultural, westernised business environment. The results suggest that the ethical evaluations and behavioural intentions of Emirati graduates are affected by a multiplicity of sources including professional bodies and both mentors and peers in the workplace. It may be prudent at such a significant time in the UAE’s development that educators consider introducing ethical education into tertiary curriculum. (shrink)

The ethical development of business graduates is a critical issue. Yet, little empirical evidence exists on the factors affecting business graduate ethical development and behaviour using an Islamic perspective. This study examines the effects of mentoring support, the perceived standard of ethical conduct of peers, and individual ethical attributes of National female (Emirati) business graduates from the United Arab Emirates. Research has shown that formal and informal mentoring relationships benefit new employees by enabling them to further learn and grow within (...) an organisation. On the other hand, some employees have also shown that these relationships can have a negative impact on a new employee’s ethical orientation. The aim of this study is to investigatethe ethical orientations of Emirati female business graduates as they move from the relative sanctity of home and university into a new multicultural, westernised business environment. The results suggest that the ethical evaluations and behavioural intentions of Emirati graduates are affected by a multiplicity of sources including professional bodies and both mentors and peers in the workplace. It may be prudent at such a significant time in the UAE’s development that educators consider introducing ethical education into tertiary curriculum. (shrink)

This article uncovers a hitherto underappreciated aspect of transatlantic cultural history: Moravian late humanism, and its relationship to contemporary intellectual currents in the Americas and the broader Republic of Letters in the age of Benjamin Franklin. To date, the Moravians have attracted the attention of scholars for their novel theological views on gender and sexuality, their unique approach to reconciling piety with profit, their missionary efforts among native populations, their musical culture and their rejection of slavery. Their interactions with the (...) world of transatlantic and global late humanism, however, have not been studied in any systematic way. The present analysis opens and closes with a remarkable but almost unknown Latin oration, delivered in Philadelphia in 1742 by Nicolaus Ludwig von Zinzendorf, to an audience provided with printed copies commissioned from the Franklin Press. A critical edition and an English translation of this work are provided in an appendix. In our article we examine the original European genesis and subsequent transatlantic context of Zinzendorf’s oration, tracing its development from a formal theological apologia into a quasi-legal statement of the count’s commitment to Moravian values, expressed in an erudite allusory language which left its listeners bemused. As our investigation shows, however, the confusion of the Philadelphia worthies who gathered to hear Zinzendorf ’s oration cannot be put down to a lack of cultural awareness among the leading missionaries and settlers from Germany and Denmark, many of whom partook fully in the contemporary culture of late humanism, both before and after they crossed the Atlantic. Through detailed reconstructions of their educations, correspondence networks, reading habits and note-taking practices, we show the richness of the Moravians’ transatlantic culture of late humanism, which ran the gamut from Ciceronian oratory to pious poetry in learned languages. Basing our argument on a little-known body of archival and printed sources in Latin, German, English and indigenous languages, we argue that Moravian late humanism had a significant impact on the development and expression of the Moravian church’s unique theology, its missionaries’ study of native languages and their interactions with other groups in the Atlantic world. In so doing, we also place the Moravians in the context of contemporary intellectual life in New England, the Caribbean, Europe and the Catholic world. (shrink)

Many business schools profess a commitment to ethics in their mission statements and focus a spotlight on the intersection between the university’s mission and attention to business ethics. To explore this trend, we analyze a sample of students’ values from two universities with an explicit religious foundation and recognized commitment to ethics against students from another university where this attention is not as explicit. This study identifies the personal values orientations (PVOs) for these students, born between 1980 and 2000, thus (...) millennials, and considers if differences can be attributed to the university’s culture and mission or business school curriculum. We utilize Social Identity Theory as a promising framework for illuminating these considerations. Our results confirm that a religious‐orientation characterizing a university’s mission may influence the business students’ (or millennials’) PVOs. Students at the two religious institutions manifested a stronger social, rather than personal, and moral, rather than competence, value orientation. Only marginal differences were discovered when assessing within group differences in the value orientations among our sample of business students. (shrink)

When it originated in the late 19th century, psychometrics was a field with both a scientific and a social mission: psychometrics provided new methods for research into individual differences, and at the same time, these psychometric instruments were considered a means to create a new social order. In contrast, contemporary psychometrics - due to its highly technical nature and its limited involvement in substantive psychological research - has created the impression of being a value-free discipline. In this article, we develop (...) a contrasting characterization of contemporary psychometrics as a value-laden discipline. We expose four such values: that individual differences are quantitative (rather than qualitative), that measurement should be objective in a specific sense, that test items should be fair, and that utility of a model is more important than its truth. Our goal is not to criticize psychometrics for employing these values, but rather to bring them into the open and to show that these values are not inevitable and are in need of systematic evaluation. (shrink)