The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell. Besides coding for ubiquitous structures, minimal genomes encode a wealth of functions that dissipate energy in an unanticipated way. Analysis of these functions shows that they are meant to manage information under conditions when discrimination of substrates in a noisy background is preferred over a simple recognition process. We show here that many of these functions, including transporters and (...) the ribosome construction machinery, behave as would behave a material implementation of the informationmanaging agent theorized by Maxwell almost 150 years ago and commonly known as Maxwell’s demon (MxD). A core gene set encoding these functions belongs to the minimal genome required to allow the construction of an autonomous cell. These MxDs allow the cell to perform computations in an energy-efficient way that is vastly better than our contemporary computers. (shrink)

The emphasis of systems and synthetic biology on quantitative understanding of biological objects and their eventual re-design has raised the question of whether description and construction standards that are commonplace in electric and mechanical engineering are applicable to live systems. The tuning of genetic devices to deliver a given activity is generally context-dependent, thereby undermining the re-usability of parts, and predictability of function, necessary for manufacturing new biological objects. Tolerance and allowance are key aspects of standardization that need to be (...) brought to biological design. These should endow functional building blocks with a pre-specified level of confidence for bespoke biosystems engineering. However, in the absence of more fundamental knowledge, fine-tuning necessarily relies on evolutionary/combinatorial gravitation toward a fixed objective. (shrink)

Synthetic biology (SynBio) covers two main areas: application engineering, exemplified by metabolic engi- neering, and the design of life from artificial building blocks. As the general public is often reluctant to embrace synthetic approaches, preferring nature to artifice, its immediate future will depend very much on the public’s reaction to the unmet needs created by the pervasive demands of sustainability. On the other hand, this reluctance should not have a negative impact on research that will now take into account the (...) existence of the multiple transitions that cells face over time. The ages of life—birth, development, maturation, senescence and death—reflect specific key transitions and have, until now, rarely been taken into account in SynBio designs. This results in a mismatch between novelty and the very long evolutionary time that led to the existing chassis [remember that this is the common term used to describe the cellular framework as seen by synthetic biologists (de Lorenzo & Danchin, 2008)]. It also implies that, in general, transitions between growth stages will be taken into account with the appro- priate embodiment of highly specific processes. This is particularly important when adapting new models to their host, whether natural or artificial. Adaptation fol- lows two stages, short-term accommodation of new entities and long-term assimilation into the cell as a whole. This requires discrimination between classes of entities. We suggest that proteins playing the essential role of Maxwell’ demons, here named Maxwell’s dis- criminators (MxDs) to refer to their original function, will permit the assimilation and accommodation of artificial constructs. As a consequence, we can foresee that class discrimination, beyond mere recognition, will be implemented in SynBio 2.0, leading to an authentic par- adigm shift (Kuhn, 1996), based on conceptions that embody information as a genuine currency of reality. (shrink)

The standard representation of the Central Dogma (CD) of Molecular Biology conspicuously ignores metabolism. However, both the metabolites and the biochemical fluxes behind any biological phenomenon are encrypted in the DNA sequence. Metabolism constrains and even changes the information flow when the DNA‐encoded instructions conflict with the homeostasis of the biochemical network. Inspection of adaptive virulence programs and emergence of xenobiotic‐biodegradation pathways in environmental bacteria suggest that their main evolutionary drive is the expansion of their metabolic networks towards new chemical (...) landscapes rather than perpetuation and spreading of their DNA sequences. Faulty enzymatic reactions on suboptimal substrates often produce reactive oxygen species (ROS), a process that fosters DNA diversification and ultimately couples catabolism of the new chemicals to growth. All this calls for a revision of the CD in which metabolism (rather than DNA) has the leading role. (shrink)

Since Piaget (1936), the concept of development has concerned the forms of adaptation deployed by the subject within his environment. Inspired by this constructivist perspective, many approaches, such as professional didactics (Pastré, 2011), problematization (Fabre, 2009, 2011) and investigation approaches (Grangeat, 2011, 2013) have advanced the idea of training through situations. As part of the socio-constructivist expectations of the latest teaching programs, we analyze teacher activity during a “débriefing after observation” (Villeret, 2008) about Moon phases conducted in primary school classes (...) (Munoz & Villeret, 2012). In this article we examine whether “débriefing after observation” is a situation that allows for the development of teachers and pupils. We show that this activity allows pupils to learn, “problematize”, conceptualize and develop epistemologically based knowledge. It also allows the teacher to develop his skills to «do problematize» the pupils. These results allow us to discuss further the notion of «potential development situation» (Mayen, 1999) to complement it with the notions of “reactive and effective development situations”. (shrink)

We give the precise correspondence between polarized linear logic and polarized classical logic. The properties of focalization and reversion of linear proofs are at the heart of our analysis: we show that the tq-protocol of normalization for the classical systems and perfectly fits normalization of polarized proof-nets. Some more semantical considerations allow us to recover LC as a refinement of multiplicative.

Dans un monde dominé par les conflits, il arrive qu’il faille se défendre. L’invention des armes a évolué en parallèle avec le savoir technique, puis scientifique, et il est même arrivé que la recherche d’applications militaires ait joué un rôle moteur dans la découverte scientifique. Lorsque les armes ne servent pas à attaquer d’autres nations, leur fabrication et leur commerce se justifient morale- ment. Il faut cependant qu’elles ne puissent échapper à ceux qui les construisent et doivent en contrôler la (...) diffusion. Facilement mise en œuvre, la guerre utilisant des organismes vivants ou ce qu’ils pro- duisent comme armes est très ancienne. Or l’originalité des êtres vivants est qu’ils se multiplient, qu’un seul individu suffit à recouvrir la Terre de ses descendants. La biologie ne se prête jamais à un usage militaire moralement défendable parce que le confinement au champ de bataille est impossible. De ce fait, les applications de la biologie ont été vite écartées du domaine de la Défense permise par les traités internationaux. La Convention de 1972 sur l’Interdiction des Armes Biologiques et à Toxines (CIABT), entrée en vigueur en 1975, est aujourd’hui signée par 183 pays (ratifiée par 175) sur un total de 193, sans compter Taïwan qui l’a ratifiée mais n’est pas reconnu par l’ONU. Elle interdit la mise au point, la fabrication, l’acquisition, le transfert, la conservation, le stockage et l’utilisation des armes bio- logiques et à toxines. Elle constitue un élément essentiel de la lutte contre la prolifération des armes de destruction massive. (shrink)

Anticiper les épidémies est le souhait le plus vif de toutes les institutions qui veillent sur la santé publique. Un raisonnement naïf permet de penser qu’il suffit de faire évoluer en laboratoire un organisme potentiellement pathogène pour savoir comment sa descendance pourra devenir plus virulente pour l’homme. Il est alors facile de faire croître cet organisme sur des cellules humaines, qu’il infecte mal pour commencer, puis de retenir ses descendants au fur et à mesure qu’ils deviennent plus infectieux. La vision (...) optimiste affirme alors que les caractériser permettra de construire des défenses appropriées. Bien des variations sur ce thème sont possibles, y compris avec l’aide de la synthèse artificielle de variants dont on saurait imaginer la pathogénicité pour l’homme. Depuis plus de deux décennies, des chercheurs développent des expériences de ce type, dite de « gain de fonction » (GdF). Leur interprétation repose sur l’illusion que nous savons prévoir l’évolution des êtres vivants. En réalité, ceux que nous observons aujourd’hui ont été sélectionnés au cours du temps précisément parce qu’ils conduisent toujours à des comportements imprévisibles. Une règle clé de l’évolution est que la vie, pour durer dans des circonstances qui ne peuvent être prévues, doit sans cesse faire émerger des formes innovantes. À ce caractère propre à la vie s’ajoute un imprévisible lié à l’impéritie humaine, cause de l’omniprésence des accidents de laboratoire. Or, en virologie spécialement, l’accident est la règle et non l’exception. Il faut ajouter que le caractère public de ces expériences les rend utilisables par toutes les structures malveillantes qui sont hélas répandues dans le monde. Il n’est pas difficile alors d’imaginer les conséquences catastrophiques des expériences de GdF. Nous proposons donc qu’elles soient purement et simplement interdites et que toute transgression soit sévèrement punie, en frappant d’abord au porte-monnaie, ce qui semble être la meilleure façon de faire dans nos sociétés devenues universellement vénales. (shrink)

Pasteur’s originality in the way he developed pure research is to have understood the importance, for society, of the underlying motivation. Curiosity, of course, is a strong motivation, which explains why we seek to understand the origin of life. But, in front of the immensity of the possible choices, why not, also, choose to start from questions of economic interest (diseases of beer and wine, diseases aVecting the silk industry . . . ) Finally, of course, health is a constant (...) preoccupation, but the diseases, which have no borders, often come from tropical countries and Asia especially. It is therefore necessary to settle there, but not to come and impose one’s point of view, but on the contrary to use the knowledge coming from the local culture in order to open new ways of understanding the reality of the world. (shrink)

Une nouvelle inscription digraphe a été découverte dans le sanctuaire d'Aphrodite à Amathonte de Chypre : c'est la consécration par le roi Androklès, dans les années 330-310 av. J.-C, des statues de ses deux fils, Orestheus et Andragoras, à « l'Aphrodite chypriote ». La partie écrite en syllabaire chypriote malheureusement très mutilée, paraît transcrire la langue indigène, dite « étéochypriote ».

La partie supérieure d'une grande amphore Bichrome découverte en 1987 dans le sanctuaire d'Aphrodite à Amathonte est décorée sur une face de deux taureaux respirant une fleur qui encadrent une inscription syllabique, sur l'autre d'un taureau marchant vers un «arbre de vie» et un arbre. Ce décor exceptionnel s'inspire étroitement des ivoires du type de Nimroud et des coupes en argent chypro-phéniciennes, ce qui situe probablement le vase dans.

In the last two decades, some authors in the philosophy for children movement have theorized that the community of philosophical inquiry can be a form of spiritual practice, of the care of the self, or a wisdom practice (De Marzio, 2009; Gregory, 2009, 2013, 2014;Gregory & Laverty, 2009). Yet, it is unclear if philosophy for children is, by itself, a form of spiritual education, or if it requires some sorts of modification to be one. And, if it is (...) or can be a form of spiritual education, we can interrogate in what ways and to what extent is it one. It is these questions that this text aims to explore. To do so, we will first clarify the meaning of spiritual education through the presentation of two authors who have explicitly written on that topic. The first is Parker J. Palmer, who has developed a perspective on what it means to reclaim the spiritual roots of education, derived from his study and practice of Quaker spirituality. The second is Pierre Hadot, who has explored how the practice of philosophy in Western antiquity was a form of spiritual exercise. From our presentation of these two authors will emerge a particular perspective of what spiritual education means. In the last section of the text we will use this presentation to examine in what ways philosophy for children can be a form of spiritual education and if requires adaptations to be one. (shrink)

The anticipated social capabilities of robots may allow them to serve in authority roles as part of human-machine teams. To date, it is unclear if, and to what extent, human team members will comply with requests from their robotic teammates, and how such compliance compares to requests from human teammates. This research examined how the human-likeness and physical embodiment of a robot affect compliance to a robot's request to perseverate utilizing a novel task paradigm. Across a set of two studies, (...) participants performed a visual search task while receiving ambiguous performance feedback. Compliance was evaluated when the participant requested to stop the task and the coach urged the participant to keep practicing multiple times. In the first study, the coach was either physically co-located with the participant or located remotely via a live-video. Coach type varied in human-likeness and included either a real human, a Nao robot, or a modified Roomba robot. The second study expanded on the first by including a Baxter robot as a coach and replicated the findings in a different sample population with a strict chain of command culture. Results from both studies showed that participants comply with the requests of a robot for up to 11 min. Compliance is less than to a human and embodiment and human-likeness on had weak effects on compliance. (shrink)

Le manuscrit decouvert a la Bibliotheque de la Sorbonne est la seule source en francais du cours d'esthetique de Hegel. Le cahier ne mentionne aucun nom, mais les traces de l'ecriture de Victor Cousin atteste que celui-ci en etait le possesseur et le destinataire. La comparaison avec les autres sources manuscrites montre que se texte se rapporte au cours donne a Berlin pendant le semestre d'ete 1823, prenant la forme d'un abrege. L'accent est mis sur la structuration du discours (...) et la dimension systematique, distinguant cette version condensee de l'edition traditionnelle de l'Esthetique. Le texte constitue egalement l'exemple exceptionnel d'une traduction hegelienne realisee du vivant du philosophe. L'enseignement de Hegel, inedit en son temps, se trouve ainsi restitue pour la premiere fois au public francophone sous sa forme originale. (shrink)

Este trabajo presenta una lección impartida por tres maestros de la primera mitad del siglo XII: Honorio de Autún, Hugo de San Víctor, y Guillermo de Conches. Los tres fueron ilustres magistri y destacados escritores. La lección versa sobre la importancia de los estudios y la formación intelectual. Está dividida en tres partes, impartida cada una de ellas por uno de los maestros citados.

Analyser les origines de l'apparition du concept de zoonite comme unité d'organisation segmentaire en zoologie demande de se placer dans le contexte de la première moitié du dix-neuvième siècle, plus spécifiquement vers 1826-1839. Si les origines de la problématique remontent à Goethe, d'une part, à des botanistes tels que de Candolle d'autre part, la thèse de Moquin-Tandon sur les dédoublements chez les végétaux (1826) est une étape essentielle. Les hypothèses de multiplication et de diversification des organes arrangés selon une symétrie, (...) préside aussi à ses recherches sur les Hirusinées (1827). Le zoonite est une unité organique élémentaire pouvant se démultiplier et il est structuré symétriquement. Mais, ce qui le caractérise est sa composition lui conférant une autonomie. En 1832, Dugès regardera le rapport entre zoonite et organisme total sous l'angle de la conformité organique. Il déduit de ses observations les lois de multiplicité des organismes, de disposition, de modification et de coalescence. Cette dernière loi deviendra primordiale chez Dugès en 1838 pour expliquer l'évolution de l'être composé ainsi que la croissance embryonnaire. Mais, le zoonitisme des années 1830 ne constitue pas une théorie scientifique, même s'il servira ultérieurement de référence, en particulier dans la physiologie animale d'Edwards. To analyse the origins of the appearance of the zoonite concept as a unit of segmentary organisation in zoology requires positioning oneself in the context of the first half of the nineteenth century, more specifically in the years 1826-1839. If the origins of the problem go back to Goethe, on the one hand, and to botanists such as de Candolle on the other, the thesis of Moquin-Tandon on the splitting of plants (1826) is an essential step. The hypotheses of multiplication and diversification of organs arranged according to a symmetry, also presides over his research on the Hirudinées (1827). The zoonite is an elementary organic unit which can multiple itself and is structured symmetrically. But what characterises it is that its composition confers on it a certain autonomy. In 1832, Dugès regarded the connection between zoonite and total organism from the angle of organic conformity. He deduced from his observations the laws of multiplicity of organisms, of disposition, of modification and of coalescence. This last law would become vital to Dugès in 1838 for explaining the evolution of the composed being as well as embryonic development. But zoonitism in the 1830s did not constitute a scientific theory, even if it would ultimately serve as a reference, in particular for the animal physiology of Edwards. (shrink)

This chapter contains sections titled: Acosta, José de (1539–1600) Alberdi, Juan Bautista (1810–84) Bello, Andrés (1781–1865) Bilbao, Francisco (1823–65) Bolkvar, Simón (1783–1830) Casas, Bartolomé de las (1484–1566) Caso, Antonio (1883–1946) Cruz, Sor Juana Inés de la (1651–95) da Costa, Newton Carneiro Affonso (b. 1929) Dussel, Enrique (b. 1934) Frondizi, Risieri (1910–83) Gaos, José (1900–69) González Prada, Manuel (1848–1918) Gracia, Jorge J. E. (b. 1942) Haya de la Torre, Victor Raúl (1895–1979) Hostos, Eugenio Marka de (1839–1903) Ingenieros, José (1877–1925) Korn, (...) Alejandro (1860–1936) Lastarria, José Victorino (1817–88) Lemos, Miguel (1854–1917) Mariátegui, José Carlos (1895–1930) Martk, José (1853–95) Méndez Sierra, Justo (1848–1912) Mora, José Maria Luis (1794–1850) Miró Quesada, Francisco (b. 1918) Rabossi, Eduardo (1930–2005) Ramos, Samuel (1897–1959) Rodó, José Enrique (1872–1917) Romero, Francisco (1891–1962) Sahagún, Fray Bernardino de (1499–1590) Salazar Bondy, Augusto (1925–74) Sarmiento, Domingo Faustino (1811–88) Ofelia Schutte (b. 1945) Sepslveda, Juan Ginés de (ca. 1494–1573) Torretti, Roberto (b. 1930) Vasconcelos, José (1882–1959) Vaz Ferreira, Carlos (1872–1958) Villoro, Luis (b. 1922) Vitoria, Francisco de (ca. 1483–1546) Zea Aguilar, Leopoldo (1912–2004) Acknowledgment Further Reading. (shrink)

The distinction between the body schema and the body image has become the stock in trade of much recent work in cognitive neuroscience and philosophy. Yet little is known about the interactions between these two types of body representations. We need to account not only for their dissociations in rare cases, but also for their convergence most of the time. Indeed in our everyday life the body we perceive does not conflict with the body we act with. Are the body (...) image and the body schema then somehow reshaping each other or are they relatively independent and do they only happen to be congruent? On the basis of the study of bodily hallucinations, we consider which model can best account for the body schema/body image interactions. (shrink)

Obras escogidas/M. Sánchez-Mazas. - v.1.

Woodward’s interventionist theory of causation is beset by a problem of circularity: the analysis of causes is in terms of interventions, and the analysis of interventions is in terms of causes. This is not in itself an argument against the correctness of the analysis. But by requiring us to have causal knowledge prior to making any judgements about causation, Woodward’s theory does make it mysterious how we can ever start acquiring causal knowledge. We present a solution to this problem by (...) showing how the interventionist notion of causation can be rationally generated from a more primitive agency notion of causation. The agency notion is easily and non-circularly applicable, but fails when we attempt to capture causal relations between non-actions. We show that the interventionist notion of causation serves as an appropriate generalisation of the agency notion. Furthermore, the causal judgements based on the latter generally remain true when rephrased in terms of the former, which allows one to use the causal knowledge gained by applying the agency notion as a basis for applying Woodward’s interventionist theory. We then present an overview of relevant empirical evidence from developmental psychology which shows that our proposed rational reconstruction lines up neatly with the actual development of causal reasoning in children. This gives additional plausibility to our proposal. The article thus provides a solution to one of the main problems of interventionism while keeping Woodward’s analysis intact. (shrink)

Este trabalho é um breve estudo sobre a análise literária de textos cristãos elaborada por Erich Auerbach. O objetivo é destacar como, a partir do sermão 256 de Santo Agostinho e da Bíblia, Auerbach ilumina a articulação do sublime cristão com o sermo humilis , ou seja, incorpora a linguagem ordinária e temas prosaicos cotidianos para transmitir a mensagem religiosa. Do ponto de vista teórico-conceitual, faremos uma breve exposição sobre teoria da literatura, mais especificamente, sobre mimesis e literatura, como forma (...) de pensar a abordagem de textos cristãos. Segundo Auerbach, o texto cristão, num mundo bastante conturbado, incorporou a vida e a linguagem simples das pessoas para, então, configurar uma nova forma do sublime. Concluímos que o texto cristão, visando a uma formulação religiosa (normativa), para isso trouxe para seu interior aquilo que definimos como dinâmica histórica, para trabalhá-la numa proposta de sentido. Palavras-chave : Erich Auerbach. Sermo humilis. S ublime. Literatura. Mímesis. (shrink)

The dream of Leibniz and that of Frege, to create a lingua characteristica in order to demonstrate conceptual thought, incorporates in a wider process, the division and tension between the distinct Spheres which the human sub-species have been creating. Spheres which remain hidden by natural language, essentially spoken language. For the creation and demonstration of the Conceptual Sphere the establishing of a language of characteres has become indispensable, essentially written language. Is a consequence a tension is established between Natural language-Formal (...) language with their corresponding reductionist tendences. (shrink)