Despite a library full of literature on miRNA biology, core issues relating to miRNA target detection, biological effect, and mode of action remain controversial. This essay proposes that the predominant mechanism of direct miRNA action is translational inhibition, whereas the bulk of miRNA effects are mRNA based. It explores several issues confounding miRNA target detection, and discusses their impact on the dominance of “miRNA seed” dogma and the exploration of non‐canonical binding sites. Finally, it makes comparisons between miRNA target prediction (...) and transcription factor binding prediction, and questions the value of characterizing miRNA binding sites based on which miRNA nucleotides are paired with an mRNA. (shrink)

Hermeneutical injustice, as a species of epistemic injustice, is when members of marginalized groups are unable to make their experiences communicatively intelligible due to a deficiency in collective hermeneutical resources, where this deficiency is traditionally interpreted as a lack of concepts. Against this understanding, this paper argues that even if adequate concepts that describe marginalized groups’ experiences are available within the collective hermeneutical resources, hermeneutical injustice can persist. This paper offers an analysis of how this can happen by introducing the (...) notion of hermeneutical excess: the introduction of additional concepts into collective hermeneutical resources that function to obscure agents’ understanding of the lived experiences of marginalized groups. The injustice of hermeneutical excesses happens not due to hermeneutical marginalization (the exclusion of members of marginalized groups from the construction of hermeneutical resources), but rather hermeneutical domination: when members of dominant groups have been inappropriately included in the construction of hermeneutical resources. By taking as exemplary cases the concepts of “reverse racism” and “non-consensual sex” this paper shows how such excesses are introduced as a kind of defensive strategy used by dominant ideologies precisely when progress with social justice is made. (shrink)

The concern of this article is to establish the difference between physiognomy and expression as it may be understood phenomenologically. The work of Merleau-Ponty founds the phenomenological appreciation of physiognomy, and Gestalt psychological studies on perceptual organization elaborate the specifics of physiognomic structure despite the naturalist assumptions of that school of psychology. Physiognomy is the organized structural specification of expression in the phenomenon that presents itself. This view is an alternative to conventional topical but nonthematic considerations on physiognomy . Art (...) therapy with its use of various media is a venue in which the physiognomy of clients' art products is a display of integralness or pathology. It is an immediate access to the world of the patient. The work of the Gestalt psychologist Rudolf Arnheim and of the art therapist Mala Betensky are associated with the phenomenology of Merleau-Ponty in order to advance understanding of the significance of physiognomy in experience, in behavior, and in art therapy. (shrink)

This article on the early history of phenomenological psychological research in the academic context in America focuses on the four approaches of the following respective psychologists: 1) Donald Snygg, Arthur W. Combs, and Anne C. Richards and Fred Richards; 2) Robert B. MacLeod; 3) Adrian L. van Kaam; and 4) Amedeo P. Giorgi. It begins by first addressing the "context" for this early history namely, the European origin of philosophical phenomenology and the connection of it with the psychology of its (...) times in Europe, and then the American background for the development of a sensibility for phenomenology and an eventual connection of phenomenology with psychology. Each of the four positions was examined in terms of basic approach to the study of human experience and behavior. That is, examination was directed toward whether the respective position was under the aegis of psychology as a human science or as a natural science. Also examined were the research postures and the methodologies of the four positions in terms of their respective degrees of reflecting either the human science or the natural science approach, and in terms of their approximation to a phenomenological psychology. It was found that syncretism characterized the approaches of the first three positions, and that there was either an absence of phenomenological psychological method in the psychologies of those positions or, in the case of MacLeod, an undeveloped and non-worked-out method. Only the work of Amedeo Giorgi presented 1) a human science approach that was radical and not compromised by natural science syncretions, and 2) an articulated phenomenological psychological method based on Husserl's concept of intentionality and on mediation of Merleau-Ponty's philosophical phenomenological method. (shrink)

The concern of this study is the consequences of art education information on the experiencing of a painting that has already been experienced in a condition naïve to such information. It is believed that experiential data of viewers with respect to such consequences can be accessed by way of the phenomenological approach. The phenomenological psychology and methodology that are representative of this approach are that of Amedeo P. Giorgi. The employment of Giorgi’s phenomenological psychological method in this study is in (...) the service of education and pedagogy. Giorgi’s history of research on a phenomenological psychology and the method specific to it goes back a number of decades. Four major presentations by Giorgi are the sources for designing the study here in the use of his method. Giorgi’s book is the major source for the understanding of his development and use of the method. (shrink)

Etrange personnage que Pierre Nicole. La postérité l'a rangé parmi les deuxièmes rôles de Port-Royal, une sorte de permanent du parti janséniste. Il a secondé le grand Arnauld, instruit Racine dans les Petites Ecoles, aidé Pascal et traduit en latin ses Provinciales. Fidèle entre les fidèles, et en même temps mal à l'aise dans cette atmosphère de fronde et de résistance que représente le milieu de Port-Royal, au sein de la France du XVII e siècle, ce latiniste timoré ne (...) songeait qu'aux Moyens de conserver la paix avec les hommes - titre de l'un de ses essais les plus célèbres. Dès que les tensions semblent s'apaiser, pendant la trêve appelée "la Paix de l'Eglise", Nicole peut enfin laisser libre cours à sa vocation de moraliste et de psychologue. Il publie, volume après volume ses Essais de morale : le succès sera tel que le libraire, après la mort de Pierre Nicole, s'ingéniera à en augmenter la série jusqu'à atteindre vingt-cinq volumes. Depuis la fin du XVIII e siècle, ce classique de la littérature morale était devenu pour ainsi dire inaccessible. On en publie parfois quelques pages choisies, défigurées par les coupures et les corrections. Il est proposé ici au lecteur moderne de redécouvrir dix essais de Nicole, donnés dans leur intégralité. Certains nous replongent dans les principes moraux d'un autre âge (et tirent de cet exotisme une part de leur valeur). D'autres présentent les qualités de finesse, le piquant, le goût du paradoxe qui ont longtemps fait juger Nicole comme un des grands représentants, à côté de Pascal et de La Rochefoucauld, de la littérature morale classique. L'oeuvre morale de Nicole s'avère ainsi demeurer passionnante pour un lecteur moderne, au moins à trois égards : 1/ ses considérations sur l'amour-propre, qui constituent les premiers jalons d'un utilitarisme économique ; 2/ ses réflexions sur la sociabilité et une approche originale de la civilité ; 3/ ses observations pédagogiques, émanant d'un des principaux maîtres des Petites Ecoles de Port-Royal. (shrink)

Nicole Shukin pursues a resolutely materialist engagement with the "question of the animal," challenging the philosophical idealism that has dogged the question by tracing how the politics of capital and of animal life impinge on one ...

There is a growing realisation that the current upward trend in levels of disclosure of social, ethical and environmental performance by corporations and other organisations is not being accompanied by simultaneous greater levels of public trust. Low levels of confidence in the information communicated in public reporting is probably undermining the impetus for this disclosure. This article suggests that this credibility gap can be narrowed through the use of third party independent assurance. However, this is not an unqualified panacea. Much (...) verification and assurance practice itself has to date been of questionable robustness, reliability and consistency, and has been framed by financial assurance models that are inadequate for the broader, qualitative dimensions of social, ethical and environmental performance. The paper argues that there is need for a universal standard for the provision of assurance of social, ethical and environmental reporting, and indeed for the credibility of the assurance providers themselves. The new AA1000S Assurance Standard, developed by the Institute of Social and Ethical AccountAbility, offers an approach and a tool for addressing these gaps. (shrink)

“Dumpster diving” is a term generally used for obtaining items, in this case food for consumption, from dumpsters. This study evaluates the prevalence of dumpster diving in two low-income urban communities in Minneapolis, Minnesota. Additionally, attitudes and beliefs of adults who engage in this behavior are reported. Surveys (n=396) were used to collect data including individual dumpster diving behavior, food security, health, and demographic data. Nearly one-fifth of those surveyed had used dumpster diving as a means to obtain food. Focus (...) groups (n=17) were conducted to further evaluate dumpster divers’ attitudes and beliefs about dumpster diving, use of food assistance programs including benefits and barriers, and other strategies used to obtain food such as stealing. Focus group participants were primarily homeless and most were high school educated. Ways to improve delivery of food assistance are suggested. In conclusion, more research on the use of dumpsters as a source of food is needed. Utilizing more of the 96 billion pounds of food wasted each year in the US through food recovery and donation programs could help to provide socially acceptable means for low-income urban dwellers to obtain food. (shrink)

The role of research ethics committees, and research ethics issues more broadly are often not viewed in the context of the development of scientific methods and the academic community. This topic piece seeks to redress this gap. I begin with a brief outline of the changes we experience within the social sciences before exploring in more detail their impact on research ethics and the practices of research ethics committees. I conclude with recommendations for how the existing research ethics processes may (...) be made more future-proof. (shrink)

While prior ecolabel research suggests that consumers’ trust of ecolabel sponsors is associated with their purchase of ecolabeled products, we know little about how third-party certification might relate to consumer purchases when trust varies. Drawing on cognitive theory and a stratified random sample of more than 1200 consumers, we assess how third-party certification relates to consumers’ use of ecolabels across different program sponsors. We find that consumers’ trust of government and environmental NGOs to provide credible environmental information encourages consumers’ use (...) of ecolabels sponsored by these entities, and consumers do not differentiate between certified versus uncertified ecolabels in the presence of trust. By contrast, consumers’ distrust of private business to provide credible environmental information discourages their use of business association-sponsored ecolabels. However, these ecolabels may be able to overcome consumer distrust if their sponsors certify the ecolabels using third-party auditors. These findings are important to sponsors who wish develop ecolabels that are more credible to consumers, and thus encourage more widespread ecolabel use. (shrink)

L'expression de nos émotions est-elle la même d'une langue à l'autre? À partir d'un large éventail de langues présentes continents, cet ouvrage témoigne de la grande variété des modalités d'expression des émotions, en fonction des codes culturels de différentes sociétés à tradition écrite ou orale. Les situations envisagées ici vont de la communication orale spontanée dans des contextes divers aux récits en passant par la création théâtrale et la poésie. S'appuyant sur ces sources multiples, l'ouvrage expose les procédés lexicaux grammaticaux, (...) métaphoriques et discursifs ou encore les représentations graphiques mis en oeuvre pour exprimer les émotions. (shrink)

Self-esteem can influence educational success, and educational success can also be influenced by self-esteem. Hence, high self-esteem has been recognized as a key predictor of academic success in students. Thus, this study investigates the relationship between self-esteem and anxiety of senior high school students. Employing descriptive-correlational design with 194 senior high school students enrolled in private schools during the school year 2021-2022. Based on the statistical analysis, there is a correlation between self-esteem and anxiety (r.=.125).

The 'ethics of deconstruction'? -- Ethical (im)possibilities -- Ethics under erasure -- Ethical experience : a cinematic example.

We demonstrate in two experiments that real and imagined body movements appropriate to metaphorical phrases facilitate people's immediate comprehension of these phrases. Participants first learned to make different body movements given specific cues. In two reading time studies, people were faster to understand a metaphorical phrase, such as push the argument, when they had previously just made an appropriate body action (e.g., a push movement) (Experiment 1), or imagined making a specific body movement (Experiment 2), than when they first made (...) a mismatching body action (e.g., a chewing movement) or no movement. These findings support the idea that appropriate body action, or even imagined action, enhances people's embodied, metaphorical construal of abstract concepts that are referred to in metaphorical phrases. (shrink)

Various authors debate the question of whether neuroscience is relevant to criminal responsibility. However, a plethora of different techniques and technologies, each with their own abilities and drawbacks, lurks beneath the label “neuroscience”; and in criminal law responsibility is not a single, unitary and generic concept, but it is rather a syndrome of at least six different concepts. Consequently, there are at least six different responsibility questions that the criminal law asks—at least one for each responsibility concept—and, I will suggest, (...) a multitude of ways in which the techniques and technologies that comprise neuroscience might help us to address those diverse questions. In a way, on my account neuroscience is relevant to criminal responsibility in many ways, but I hesitate to state my position like this because doing so obscures two points which I would rather highlight: one, neither neuroscience nor criminal responsibility are as unified as that; and two, the criminal law asks many different responsibility questions and not just one generic question. (shrink)

A heterogeneous survey sample of for-profit, non-profit and government employees revealed that organizational factors but not personal characteristics were significant antecedents of misconduct and job satisfaction. Formal organizational compliance practices and ethical climate were independent predictors of misconduct, and compliance practices also moderated the relationship between ethical climate and misconduct, as well as between pressure to compromise ethical standards and misconduct. Misconduct was not predicted by level of moral reasoning, age, sex, ethnicity, job status, or size and type of organization. (...) Demographic variables predicted job satisfaction and organizational variables added significant incremental variance. Results suggest the importance of promoting a moral organization through the words and actions of senior managers and supervisors, independent of formal mechanisms such as codes of conduct. (shrink)

Deliberative democracy is an embattled political project. It is accused of political naiveté for it only talks about power without taking power. Others, meanwhile, take issue with deliberative democracy’s dominance in the field of democratic theory and practice. An industry of consultants, facilitators, and experts of deliberative forums has grown over the past decades, suggesting that the field has benefited from a broken political system. This book is inspired by these accusations. It argues that deliberative democracy’s tense relationship with power (...) is not a pathology but constitutive of deliberative practice. Deliberative democracy gains relevance when it navigates complex relations of power in modern societies, learns from its mistakes, remains epistemically humble but not politically meek. These arguments are situated in three facets of deliberative democracy—norms, forums, and systems—and concludes by applying these ideas to three of the most pressing issues in contemporary times—post-truth politics, populism, and illiberalism. (shrink)

Les pratiques et les discours philosophiques sous l'empire romain ont été largement inspirés par le langage des cultes à mystères. Depuis la période grecque classique, la pensée philosophique antique a assimilé et réélaboré la terminologie de ces cultes afin d'exprimer l'accès au savoir philosophique, le parcours de la connaissance et l'acquisition d'une 'révélation' réservée aux seuls initiés. Au fil des siècles, le langage platonicien, pétri de références aux cultes à mystères, devient le socle commun de la plupart des lettrés, quelle (...) que soit leur appartenance religieuse, païenne ou chrétienne. Dans une approche d'histoire des religions, la réflexion sur les catégories et leurs usages, tant dans les sources que dans l'historiographie, est inséparable de la construction de la discipline elle-même. Quel est dès lors l'impact de l'historiographie dans l'appréciation des rapports entre cultes à mystères et philosophie? Ensuite, dans quelle mesure les discours et pratiques philosophiques ont-ils été nourris par le lexique mystérique et par les rituels de ces cultes? Des textes réputés avoir partie liée avec les mystères, mais passablement négligés jusqu'ici, sont scrutés en détail--les fragments de Numénius, les Oracles Chaldaïques et plus généralement les expressions respectives des écoles philosophiques. Inversement, des pratiques rituelles mystériques sont susceptibles de révéler l'influence des réflexions philosophiques. Au fil des études, ce volume interroge la relation entre cultes à mystères et philosophies selon une double perspective, émique et étique, la seule qui puisse fournir des éclaircissements sur ce problème."--Page 4 of cover. (shrink)

Landscape and brandingexplores the way landscape is conceptualised, conceived, represented and designed by professionals in a brand-driven age. Landscape - incorporating tangible physical space as well as intangible concepts, narratives, images, and experiences of place - is constructed by a number of creative industries. This book tests the hypothesis that place branding, a powerful marketing and management practice, increasingly blurs the distinction between the promotionof landscape and its production in design terms. Place branding involves the strategic and systematic composition of (...) single-minded, experiential and market-friendly place identities which are consistently communicated across various media, including physical space. How does this implicate or transform notions of place, nature, landscape experience, and the qualitative value of landscape itself? How does this affect the role of landscape architecture? To answer these questions, place branding theory and practice is critically examined alongside an in depth case study of one specific landscape - the Blue Mountains (Australia). Projects undertaken between 1995 and 2015, including a branding strategy for the region, media campaigns, television, cinema, and several landscape architectural works in the public and private domain are comparatively analysed, focusing on the discourse, conventions and values informing their production, and the landscape narratives they convey. (shrink)

RÉSUMÉOn pense souvent qu'un changement significatif de notre caractère évaluatif pourrait saper notre responsabilité par rapport à nos méfaits passés. Dans cet article, j'explore cette intuition en analysant les concepts de responsabilité et de l'obligation de rendre des comptes, tels que présentés par Angela Smith. J'introduis une distinction entre « modification » et « remplacement » pour définir les limites de la responsabilité au fil du temps. Ces limites sont ensuite précisées en s'inspirant des travaux de Delia Graff sur les (...) arguments Sorites pour soutenir qu'une personne est responsable d'actes répréhensibles passés si elle demeure « manifestement similaire » à certains égards. (shrink)

This article aims at two objectives, the first is to prove the insufficiency of the Kantian ethics matrix to give an account of vulnerability and precarity that are part of human existence. We will show how the “losing” side of ethical theories of modernity, offer a richer frame to asses human interdependency. Our second objective is to pose the hypothesis about a relation between those discourses of freedom as autonomy and the negation of human vulnerability and hence of the relegation (...) or subalterization of the ethical arguments based on care. (shrink)

Passages from the writings of Immanuel Kant concerning how a person should treat her body are often cited in the present‐day debate about a market for human body parts. In this paper, I demonstrate that this has been a misuse of Kant because unlike those who cite him, Kant was not primarily concerned with prohibiting the sale of body parts. In the first section, I argue that once these particular passages are understood against the background of Kant’s moral philosophy, they (...) indicate he had much broader concerns relating to the correct moral relationship a rational person should have with her body. In the second section, I examine Stephen Munzer’s unusually detailed analysis of these passages, but conclude that like those who have provided less detailed analyses, he also fails fully to understand the rationale for Kant’s various prescriptions and prohibitions concerning the treatment of human body parts, and in doing so misrepresents Kant’s position. (shrink)