Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

A paper about cross-cultural and cross-racial loving that emphasizes the need to understand and affirm the plurality in and among women as central to feminist ontology and epistemology. Love is seen not as fusion and erasure of difference but as incompatible with them. Love reveals plurality. Unity–not to be confused with solidarity–is understood as conceptually tied to domination.

Sir George Etherege, William Wycherley and William Congreve introduce into their play-worlds major female characters who demand independence and equality from their male counterparts. This book focuses on each major female character who demands independence and equality of her gallant-libertine before she will commit to marriage or courtship with him. This demand for equality is a contrast to the social and marital relationships found in the real world of 17th century English Restoration society where marriage was a bargaining (...) process for property and where the woman was treated as the man's property. Each of the three playwrights develops his virtuous women in a different way. Wycherley's approach to his characters, for instance, is quite different from that of Etherege and Congreve. But in each case, the playwrights present major female characters who prove themselves superior in wit and wisdom and thoroughly modern in their outlook. (shrink)

Eugen Fink is considered one of the clearest interpreters of phenomenology and was the preferred conversational partner of Edmund Husserl and Martin Heidegger. In Play as Symbol of the World, Fink offers an original phenomenology of play as he attempts to understand the world through the experience of play. He affirms the philosophical significance of play, why it is more than idle amusement, and reflects on the movement from "child's play" to "cosmic (...) class='Hi'>play." Well-known for its non-technical, literary style, this skillful translation by Ian Alexander Moore and Christopher Turner invites engagement with Fink's philosophy of play and related writings on sports, festivals, and ancient cult practices. (shrink)

Play The concept of play has received considerable attention in the past, yet one can generally conclude from modern work on the subject that its stature ...

Eugen Fink is considered one of the clearest interpreters of phenomenology and was the preferred conversational partner of Edmund Husserl and Martin Heidegger. In Play as Symbol of the World, Fink offers an original phenomenology of play as he attempts to understand the world through the experience of play. He affirms the philosophical significance of play, why it is more than idle amusement, and reflects on the movement from "child's play" to "cosmic (...) class='Hi'>play." Well-known for its non-technical, literary style, this skillful translation by Ian Alexander Moore and Christopher Turner invites engagement with Fink's philosophy of play and related writings on sports, festivals, and ancient cult practices. (shrink)

Both in his earliest debates with thinkers such as Foucault and Levinas, and in later critiques of political immediacy, Derrida invoked the inescapable burden of a necessary but impossible universalism. By raising the stakes so high it would seem that deconstruction generates hyperbolic conceptions of ethics and justice, but also precludes any form of day to day political positivity. In this essay I pursue the seemingly less ‘ethical’ conception of play in Derrida's work to argue for a multiple universalism.

The idea of creation as the free, spontaneous, and joyous play (līlā) of the gods has been a pervasive motif in Indian thought since Vedic times. In the tradition of Advaita Vedānta, however, where the sole Reality is Brahman alone, divine playfulness is given an illusionistic interpretation and līlā becomes an expression of the deceptive power of māyā.

How kids play in virtual worlds, how it matters for their offline lives, and what this means for designing educational opportunities.

This study examines the socio-cultural significance of dolls as Roman girls' toys. It focuses on a sample of ivory, bone, and cloth dolls, many of which have ornate hairstyles, molded breasts and, in some cases, delineated genitalia. As the only explicitly gendered toys from the Roman world, these constitute unique bodies of evidence for exploring questions of socialization and identity formation, and assessing ancient ideals. Often treated as relatively straightforward objects that prepared girls for futures as wives and mothers, (...) this study argues instead that they were more complex and conveyed mixed messages to their young owners. By isolating three specific features of the dolls , situating these in their historical and ideological milieux, and linking them with expectations for girls known from literary sources, the dolls' multivalence as artifacts of gender and status is revealed. (shrink)

In the eighteenth-century England, the aesthetic vision of most contemporary writers of the time was closely related to the social, political and religious system of belief. Augustan writers, satirists particularly, sought to reclaim for literature the morally privileged status, they thought, it supposedly held in the context of the Latitudinarian system of thought; the very rationale behind the ethic of good nature that distinguishes major writings of the time, namely the dramatic, journalistic and fictional works of the major eighteenth century (...) novelist and satirist Henry Fielding. His major dramatic works not only display the influence of the Latitudinarian philosophy but mainly Shaftesbury’s moral theory of innate goodness, which Fielding revokes, offering then a representation of a more universal moral frame which rather reflects and criticizes the society of the author’s time. The providential pattern that Fielding creates in his plays valorizes indeed the principle of good-nature and the triumph of virtue against all apparent social evils. Most significantly, it has positioned Henry Fielding himself in a “comedic” tradition in which characters are not ultimately responsible for themselves. In the present paper, and with reference to Earl of Shaftesbury’s assumptions about the ideal good-natured man, I intend to evince that Fielding uses the value of good-nature and virtue not as pure moral abstractions, but rather as nodal points around which he organizes, and through which he presents a broad cultural and historical vision. With reference to his major regular comedies, and a through a close study of his most representative characters, I will attempt to evince that this underlying moral vision is more than an abstract rumination of the relative power of good and evil. When we view and consider such concepts as virtue, good-nature and ill-nature in the immediate contexts of his plays, we conceive a picture of a broad cultural landscape in which ethical values become nodal points of meaning, in which Fielding represents both the most basic, traditional values and the most sordid everyday events and attitudes of his society. (shrink)

Dr.Beitchman has created a variety, a plethora of interconnections and links and lines that connect many seemingly unconnectable literary elements and forms. Take for example the two political chapters...the first Shakespeare's King John and the last Jean Baudrillard's vision of 9/11; both deal with periods of crisis and loss of confidence/credibility of and in society conjuring a derangement that has become a syndrome. Drugs and literature connect Coleridge and Burroughs/ Kublai Khan and Naked Lunch and they in turn connect with (...) Platonism and the Russian Symbolist Theatre of the 20th century; Cabala obtrudes on the French writers discussed and the otherworldly ambiance of Villier's play Axel. And so the component essays and approaches play of against each other and enrich our view of a literature that transcends rather than merely compares. (shrink)

Drama, at least according to the Aristotelian view, is effective inasmuch as it successfully mirrors real aspects of human behavior. This leads to the hypothesis that successful dramas will portray fictional social networks that have the same properties as those typical of human beings across ages and cultures. We outline a methodology for investigating this hypothesis and use it to examine ten of Shakespeare’s plays. The cliques and groups portrayed in the plays correspond closely to those which have been observed (...) in spontaneous human interaction, including in hunter-gatherer societies, and the networks of the plays exhibit “small world” properties of the type which have been observed in many human-made and natural systems. (shrink)

Science has made a mighty advance since it originated in ancient Greece more than 2500 years ago. Yet we still live in Plato's cave today; we think everything around us moves continuously, but continuous motion is merely a shadow of real motion. This book will lead you to walk out the cave along a logical and comprehensible road. After passing Zeno's arrow, Newton's inertia, Einstein's light, and Schrodinger's cat, you will reach the real world, where every thing in the (...) universe, whether it is an atom or a ball or even a star, ceaselessly jumps in a random and discontinuous way. In a famous metaphor, God does play dice with the universe. Discovering motion is not continuous but discontinuous and random is like finding the Earth is not at rest but moving. The new discovery may finally solve Zeno's paradoxes and the quantum puzzle, and it will lead to a profound shift in our world view. (shrink)

Many of Mike Myers’ characters, both on Saturday Night Live (SNL) and in movies, take things either too seriously or too lightly. This chapter focuses on the pop‐cultural significance of “Wayne's World” by taking it broadly to include not just the SNL sketches but also the movies and various special appearances. In their way, Wayne Campbell and Garth (Dana Carvey) symbolize the importance of play, leisure, and fun in our lives, and in this respect touch on certain important (...) aspects of applied philosophy, specifically the philosophy of play. Activities that are playful or leisurely have intrinsic value, and are intrinsically motivated, which means that they are done for fun, or, “for their own sake.” One of the great twentieth‐century philosophers who champions the lazier, more leisurely side of life is Bertrand Russell. In their grasshopperly way, Wayne and Garth illustrate nicely John Huizinga's theory of play. (shrink)

This chapter contains sections titled: “Is this man cheating on his wife?” “Just a game” Play and Dating A Ludic Understanding of Dating The Wizards of Dating and Their Hangers‐on The Moral Significance of a Ludic Conception of Dating.

According to Eugen Fink, a thorough elucidation of the meaning of play has the capacity to lead us towards an understanding of the world as a totality. In order to go beyond Plato’s understanding of play as an inferior copy of serious action, Fink provides an analysis of the cultic game. This form of playing cannot be said to be the origin of all play, but it enables us to demonstrate how the act of playing transcends (...) circumscribed beings inside the world and provides a relationship with a higher whole, in which the community participating in the play is encompassed. A masked shaman does not represent a particular god, but brings to presence the action of gods upon humans as such. Thus, the cultic game is a symbol of a more important reality, not an inferior representation of an individual reality. This, however, is still not a sufficiently radical interpretation of the ontological dimension of play: the whole is only understood as an action of gods, i.e. mediately. Fink strives to demonstrate on the cont... (shrink)

Theatrical characters’ dual existence on stage and in text presents a unique, challenging case for the analytical philosopher. -/- Analytic Philosophy and the World of the Play re-examines the ontological status of theatre and its fictional objects through the "possible worlds" thesis, arguing that theatre is not a mirror of our world, but a re-creation of it. Taking a fresh look at theatre’s key elements, including the hotly contested relationships between character and actor; onstage and offstage "worlds"; (...) and the play-text and performance, Michael Y. Bennett presents a radical new way of understanding the world of the play. (shrink)

In the wake of the Corrupted Blood incident, which afflicted the massively multiplayer online computer role-playing game World of Warcraft in 2005, it has been suggested that both, the incident itself and massively multiplayer online computer role-playing games in general, can be utilised to inform and assist real-world epidemic and public health research. In this paper, I engage critically with these claims.

The term “social world” is increasingly familiar in philosophy and political theory. Rawls uses it quite often, especially in his later works. But there has been little explicit discussion of the term and the idea of social worlds. My aim in this paper is to show that political philosophers, Rawlsian or not, should think seriously about social worlds and the roles these things play and ought to play in their work. The idea of social worlds can help (...) political philosophers think about what they do in new and fruitful ways and enrich debates about the roles, aims, and methodology of political philosophy. I begin by analyzing Rawls’s uses of “social world.” I then propose a broadly Rawlsian conception of social worlds as logically possible closed networks of social relations between agents. Next, I put this conception to work, arguing that the idea of navigating the landscape of social worlds can help us better understand the four apparently disparate roles of political philosophy that Rawls presents. Moving beyond Rawls interpretation, I use the idea of social worlds to develop an analogy and distinction between world-oriented and principle-oriented approaches to political philosophy. While principle-oriented approaches grant centrality and importance to engagement with principles of justice, legitimacy, or other political concepts, world-oriented approaches grant centrality and importance to engagement with social worlds. I propose two examples of world-oriented approaches, political philosophy as navigation and political philosophy as world-building, and argue that they are viable and worthy of further consideration. (shrink)

"All life upon the stage"; the Theatrum Mundi. In this volume, a seventeenth century metaphor is revisited and is seen as applying to all art in all times. In the "magic mirror of art" the human being discerns the hidden spheres of human life and commemorates and celebrates its glorious victories and mourns its ignominious defeats. Let us rediscover Art as a witness to the human predicament as well as a celebrant of humanity's most sublime moments. This is the invitation (...) of this collection of studies by A-T. Tymieniecka, Hanna Scolnicov, Muella Erkilic, Matt Landrus, Patricia Trutty-Coohill, Monika Bakke, David Brubaker, Tammy Knipp, Howard Pearce, Ellen J. Burns, G. Backhaus, Ethan J. Leib, Lawrence Kimmel, Ingrid Scheibler, Gottfried Scholz, L.F. Werth, A. Carillo, M. Statkiewicz, K. O'Rourke, B. Meyler, H. Meltzer, Jiuan Heng, W.V. Davies. Art as mirror of life, human life as participating in a stage play, corresponds to the fervent search human being of the causes, reasons, puzzles of our existence which elude us in the concrete life. This XVII c. conception of Theatrum Mundi opens as this volume shows a fascinating field of investigation for our times. (shrink)

In this essay, I focus on Lugones’s relatively lesser explored notion of playfulness. I weigh in on the debate about whether playfulness is necessary for what Lugones calls “world-traveling,” which enables one to recognize another person as a full subject. I argue that although the attribute of playfulness may not be necessary for world-traveling, it is necessary for collaborative world-making––creating a new, shared world that is opened through the activity of play.

There is no better time than the present to be studying the intersections of drama, theater, and philosophy. Since 2000, numerous monographs have been published on the interrelation between those subjects, and organizations such as the Performance Philosophy Network continue to promote innovative research by theater professionals and academics alike. However, a lacuna remains in this bustling scholarly enterprise. This scholarship, by and large, tends to draw from either ancient philosophy or from Continental European thought. As is often the case (...) in... (shrink)

The plays in this new volume were written early in Marcel’s career, and were published together under the title Le Seuil invisible (The Invisible Threshold) in 1913. The first play, Grace, explores the theme of religious conversion. The drama depicts a crisis between characters of genuine depth and sincerity, who are struggling with different interpretations of shared experiences. Similar themes are addressed but developed differently in the second play, The Sandcastle. This drama explores the confrontation between one’s beliefs (...) and their consequences when faced with challenging family and social circumstances. The play asks us to think about what happens when our beliefs and theories, especially about religion, morality and politics, come up against situations in life that can test them. Both plays illustrate one of the major themes of both Marcel’s dramatic and philosophical work: that life’s most profound, fulfilling experiences are compromised more than ever in what he describes as the modern, broken world (le monde cassé), one unfortunately characterized by alienation, loss of meaning and feelings of despair. (shrink)

Although Eugen Fink often reflected upon the role religion, these reflections are yet to be addressed in secondary literature in any substantive sense. For Fink, religion is to be understood in relation to “play,” which is a metaphor for how the world presents itself. Religion is a non-repetitive, and entirely creative endeavor or “symbol” that is not achieved through work and toil, or through evaluation or power, but rather, through his idea of play and “cult” as the (...) imaginative distanciation from a predictable lifeworld. This paper describes Fink’s understanding of religion and its most relevant aspects found in Spiel als Weltsymbol. The paper is organized into five sections—1: An introduction to his phenomenological approach in general, and description of the role of “play”; 2: investigations into the relation between play and world; 3: a description of his phenomenology of religion; 4: engagements in the idea of cult-play and the sacred sphere, and 5: reflection on his idea of the play of God. (shrink)

This late work of Frithjof Schuon represents a general survey of his metaphysical perspective, which is that of the Sophia perennis, or "perennial wisdom" at the heart of the world's religions. This new edition features a fully revised translation from the French original as well as over 50 pages of new material, including previously unpublished selections from the author's letters and other private writings.

Although every emerging infectious disease occurs in a unique context, the behaviour of previous pandemics offers an insight into the medium- and long-term outcomes of the current threat. Where an informative historical analogue exists, epidemiologists and policymakers should consider how the insights of the past can inform current forecasts and responses.

The convergence of human and artificial intelligence is currently receiving considerable scholarly attention. Much debate about the resulting _Hybrid Minds_ focuses on the integration of artificial intelligence into the human brain through intelligent brain-computer interfaces as they enter clinical use. In this contribution we discuss a complementary development: the integration of a functional in vitro network of human neurons into an _in silico_ computing environment. To do so, we draw on a recent experiment reporting the creation of silico-biological intelligence as (...) a case study (Kagan et al., 2022b ). In this experiment, multielectrode arrays were plated with stem cell-derived human neurons, creating a system which the authors call _DishBrain_. By embedding the system into a virtual game-world, neural clusters were able to receive electrical input signals from the game-world and to respond appropriately with output signals from pre-assigned motor regions. Using this design, the authors demonstrate how the _DishBrain_ self-organises and successfully learns to play the computer game ‘Pong’, exhibiting ‘sentient’ and intelligent behaviour in its virtual environment. The creation of such hybrid, silico-biological intelligence raises numerous ethical challenges. Following the neuroscientific framework embraced by the authors themselves, we discuss the arising ethical challenges in the context of Karl Friston’s Free Energy Principle, focusing on the risk of creating synthetic phenomenology. Following the _DishBrain’s_ creator’s neuroscientific assumptions, we highlight how DishBrain’s design may risk bringing about artificial suffering and argue for a congruently cautious approach to such synthetic biological intelligence. (shrink)

Schoolgirls writing short stories have surrendered themselves to some rules of a game, which, according to Ricoeur and Gadamer, delimits a field where everything ’is played’, and thereby, ’shatters the seriousness’ of ’the self-presence of a subject’. This article proposes that this field has a serious side of its own that reveals something true about the everyday reality of being a girl. The proposed worlds in the girls’ short stories are places from which research on women’s lives should begin is (...) a central argument, along with the contention that for the researcher to be able to take the seriousness of this playful writing into account, she also has to assume the position of a playful figure. The article suggests that the empirical data of schoolgirl writing invited the researcher to think Ricoeur and feminist epistemology together. Further, a suggestion is that the roles of reading given by the texts have consequences for a ’new’ process-oriented writing pedagogy and the teacher of writing as well. (shrink)