The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

This book moves toward building a new and more comprehensive theory of literature, philosophy, psychology, and art. The extremely popular work of Ken Wilber, unites the best of both western and eastern thought and affirms that the stages of consciousness, more refined than that of the reasoning mind, do exist.

Investigations into the relationship between attention and awareness appear to agree on one thing; the former is neither necessary nor sufficient for the latter. I argue that this might be a mistake. I look at a series of blindsight experiments, which conclude that attention occurs in the absence of awareness. By combining these cases with a widely accepted neurophysiological model of attention, I claim that the experiments are not nearly as compelling as they initially appear. I conclude by showing that (...) this position potentially generalizes to cover other purported, non- pathological cases of dissociation between attention and awareness. This leaves rational space for the possibility that attention is both necessary and sufficient for consciousness, and thus of a ‘free explanatory trade-up' from a theory of the first to a theory of the second. This would constitute a significant step in solving the ‘easy' problem of consciousness. (shrink)

Löwe and von Hartel have drawn attention to the striking similarity between R's contents and those of a lost manuscript bequeathed by Philippe d' Harcourt to the library at Bee. This manuscript is described in a twelfth-century catalogue as follows:7 ‘in alio Seneca de naturalibus questionibus et Adelermus Batensis [Adhelardus Bathonensis Becker), Proba vates, Aurea Capra, et liber Hildeberti Turonensis archiepiscopi de dissensione interioris et exterioris hominis, et sermones eius et uita ipsius.’.

Löwe and von Hartel have drawn attention to the striking similarity between R's contents and those of a lost manuscript bequeathed by Philippe d' Harcourt to the library at Bee. This manuscript is described in a twelfth-century catalogue as follows:7 ‘in alio Seneca de naturalibus questionibus et Adelermus Batensis [Adhelardus Bathonensis Becker), Proba vates, Aurea Capra, et liber Hildeberti Turonensis archiepiscopi de dissensione interioris et exterioris hominis, et sermones eius et uita ipsius.’.

BLWith new text and full apparatus criticus The Eudemian Ethics was one of two ethical treatises which Aristotle wrote on the subject of ethica or `matters to do with character'. Although the two works cover much the same ground, the Nicomachean Ethics is better known; the poor manuscript tradition of the Eudemian Ethics has made correct translation and interpretation of the text extremely difficult. The subject of the work is the choice of a certain means of conduct, made by a (...) `man of practical wisdom', between two extremes of behaviour: asceticism and yielding to uncontrolled impulses. Aristotle also stresses the notion of moral intention and the importance of virtue of character. This new Oxford Classical Text of the Eudemian Ethics is the result of many years of work. After Sir David Ross's death, his original text was substantially reworked and revised by his friend and colleague R. R. Walzer, who was aided in the revision by his former pupil Mrs Jean Mingay, who continued his work after his death in 1974. Mrs Mingay was fortunate in being able to make use of previously unpublished contributions from D. J. Allan after his death in the late seventies, and more recently has been helped in her work by the suggestions of Professor D. A. Russell, David Robinson, and Christopher Rowe. (shrink)

Among psychologists and vision scientists,binocular rivalry has enjoyed sustainedinterest for decades dating back to the 19thcentury. In recent years, however, rivalry''saudience has expanded to includeneuroscientists who envision rivalry as a tool for exploring the neural concomitants ofconscious visual awareness and perceptualorganization. For rivalry''s potential to berealized, workers using this tool need toknow details of this fascinating phenomenon,and providing those details is the purpose ofthis article. After placing rivalry in ahistorical context, I summarize major findingsconcerning the spatial characteristics and thetemporal dynamics (...) of rivalry, discuss two majortheoretical accounts of rivalry ( eye vs stimulus rivalry) and speculate on possibleneural concomitants of binocular rivalry. (shrink)

This book presents the results of these thinkers in a newly unified manner and displays their significance for the philosophy of mathematics.

This book presents the results of these thinkers in a newly unified manner and displays their significance for the philosophy of mathematics.

This invaluable resource is the first one-volume, in-depth, comprehensive history of modern science ever published.

This article addresses the issue of moral compunction among a sample of senior managers set against the background of their routine organizational participation. In considering what factors influence their moral sensibilities these managers were interviewed using an approach designed to elicit their perceptions concerning both the ethical and commercially imperative dimensions of their working lives. The qualitative data resulting from this inquiry, while tentative, indicates the primacy of the normative appeal of shareholder value, conditioned by the exigencies of engagement in (...) corporate bureaucracies, including the maintenance of career and livelihood responsibilities. These conclusions indicate the magnitude of the obstacle that the normative business ethics project requires to overcome in order to fulfil its promise. (shrink)

This article addresses the issue of moral compunction among a sample of senior managers set against the background of their routine organizational participation. In considering what factors influence their moral sensibilities these managers were interviewed using an approach designed to elicit their perceptions concerning both the ethical and commercially imperative dimensions of their working lives. The qualitative data resulting from this inquiry, while tentative, indicates the primacy of the normative appeal of shareholder value, conditioned by the exigencies of engagement in (...) corporate bureaucracies, including the maintenance of career and livelihood responsibilities. These conclusions indicate the magnitude of the obstacle that the normative business ethics project requires to overcome in order to fulfil its promise. (shrink)

What is xenophobia? Why is xenophobia immoral? How is xenophobia's conceptual and moral meaning diminished? Investigations of these questions would invigorate xenophobia as a topic in public morality and discourage the public's acquiescing to xenophobia's new prominence. This paper focuses on the third question, the diminishment of xenophobia. In the first section, I outline a general conception of xenophobia. In the second, I explain how theories of membership in liberal democratic societies relegate xenophobia to a minor moral concern. And, in (...) the third, that the conflation of xenophobia with racism disadvantages the former. How liberal Democratic nations imagine membership and how those nations imagine racism shelters xenophobia. (shrink)

Now and in the foreseeable future the human race is and will be divided into societies that we call states and that are separated by strictly defined borders and regimes that are often in opposition to one another. If not all states are multinational, all of them are multicultural. Whenever a state is formed we can be sure that differences have already emerged and will soon declare themselves with a strong voice.

Almost all ethical guidelines and legislative policies concerning biomedical research involving human subjects contain provisions about relevance of research for the participating populations, informed consent, adequate care for research induced injuries and several other safeguards but the poor continue to suffer. Globalization has further aggravated poor people’s vulnerability by exposing them to international markets. Since the developing countries are abode of higher population of the poor they have become the unholy mines of this human ore for researchers. In this paper (...) I examine various dimensions of poverty and analyze the international ethical responses in the area of biomedical research involving human subjects in order to determine their adequacy to protect the poor against exploitation and misuse and conclude that in view of the poor’s inherent and extreme vulnerability and the failure of ethical pronouncements to protect them from misuse and exploitation, they should be excluded from being enrolled as research subjects. (shrink)