Pax genes are a family of development control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA‐binding activity. Originally, paired‐box‐containing genes were detected in Drosophila malenogaster, where they exert multiple functions during embryogenesis. In vertebrates, Pax genes are also involved in embryogenesis. Mutations in four out of nine characterized Pax genes have been associated with either congenital human diseases such as Waardenburg syndrome (PAX3), Aniridia (PAX6), Peter's (...) anomaly (PAX6), renal coloboma syndrome (PAX2), Small eye (Pax6), (Pax21Neu), which all show defects in development. Recently, analysis of spontaneous and transgenic mouse mutants has revealed that vertebrate Pax genes are key regulators during organogenesis of kidney, eye, ear, nose, limb muscles, vertebral column and brain. Like their Drosophila counterparts, vertebrate Pax genes are involved in pattern formation during embryogenesis, possibly by determiing the time and place of organ initiation of morphogenesis. For most tissues, however, the nature of the primary development action of Pax transcription factors remains to be elucidated. One predominant theme is signal transduction during tissue interactions, which may lead to a position‐specific regulation of cell proliferation. (shrink)

This article proposes a more culturalist and variegated conception of the individual than that presented by individualization theorists. Inspired by the approach of the individual advocated by Émile Durkheim, Talcott Parsons and John Meyers, it first outlines the general script of the individual-as-actor that informs modern individualism as well as the generic characteristics that are routinely attributed to persons such as agency and free will. It subsequently reconstructs three predominant interpretations of this general script, i.e. utilitarian, moral and expressive individualism. (...) For each variant, the intellectual genesis and overall definition of the institutionalization in specific societal domains and the dominant articulations in social theory are briefly presented. With this threefold distinction, the aim is to synthesize the extensive literature on individualism and to show the sociological strengths of approaching subjectivity in terms of institutionalized scripts. (shrink)

The paper offers a critical appreciation of sand in the Japanese tradition of karesansui 枯山水gardens. At first, sand is approached from a phenomenological standpoint, then described in relation to the Daoist ideals of “blandness” (dan 淡) and its original function in Shinto shrines. The following sections draw an East-West comparison between the sand garden at Ginkaku-ji 銀閣寺 and the sand sculptures by the Basque artist Andoni Bastarrika, and between the sand garden at Shisen-dō 詩仙堂 and the Renaissance garden at Villa (...) di Castello. The main purpose is to illustrate the philosophical significance of sand in respect to the aesthetic expression of such Buddhist-influenced notions as ku 空 (“emptiness”), yuge 遊戲(“play”), kire-tsuzuki 切れ続き(“cut-continuance” or “dis/continuity”) and the dialectic of conventional and ultimate reality. (shrink)

This study examined video game–playing aggression among graduate and undergraduate students at Rochester Institute of Technology in upstate New York. The following three research questions were posed: In the context of video game playing, what differences are there in levels of aggression in relation to sex? What differences are there in levels of aggression and type of video games played? Are aggression and length of video game playing related? A nonprobability sample of students (N = 175) was selected and electronically (...) surveyed. The Buss–Perry Aggression Questionnaire, a widely used self-reported measure, was used to assess aggression. No significant difference was found between men and women with regard to levels of aggression, and no statistically significant relationship was found between aggression and length of video game playing (r = −.05, p =.52). However, significant differences were found in levels of aggression between playing and nonplaying respondents of action role-playing (t = −1.48, df = 175, p =.01) and role-playing video games (t = −1.24, df = 175, p =.02). Players of role-playing games had lower levels of aggression than nonplayers. Since role-playing requires one to take the part of another person, empathy might play a role in reduced levels of aggression. Although exposure to violent video games has been related to decreased empathy, role-playing games show just the opposite. It is suggested that controversies regarding violent video games might best be explained by moral panic theory and that competitive games may attract more aggressive players. (shrink)

Ignorance usually excuses from responsibility, unless the person is culpable for the ignorance itself. Since a lot of wrongdoing occurs in ignorance, the question of what makes ignorance culpable is central for a theory of moral responsibility. In this article I examine a prominent answer, which I call the ‘volitionalist tracing account,’ and criticize it on the grounds that it relies on an overly restrictive conception of responsibility‐relevant control. I then propose an alternative, which I call the ‘capacitarian conception of (...) control,’ and on the basis of it I advance an account of culpable ignorance that avoids the skeptical upshots of the volitionalist proposal. If correct, my account establishes three important truths: agents can be directly in control of their ignorance, they can be directly responsible for more than actions and omissions, and their moral obligations extend beyond the performance of intentional actions and omissions. (shrink)

In Infinity and the Mind, Rudy Rucker leads an excursion to that stretch of the universe he calls the "Mindscape," where he explores infinity in all its forms: potential and actual, mathematical and physical, theological and mundane. Here Rucker acquaints us with Gödel's rotating universe, in which it is theoretically possible to travel into the past, and explains an interpretation of quantum mechanics in which billions of parallel worlds are produced every microsecond. It is in the realm of infinity, he (...) maintains, that mathematics, science, and logic merge with the fantastic. By closely examining the paradoxes that arise from this merging, we can learn a great deal about the human mind, its powers, and its limitations. Using cartoons, puzzles, and quotations to enliven his text, Rucker guides us through such topics as the paradoxes of set theory, the possibilities of physical infinities, and the results of Gödel's incompleteness theorems. His personal encounters with Gödel the mathematician and philosopher provide a rare glimpse at genius and reveal what very few mathematicians have dared to admit: the transcendent implications of Platonic realism. (shrink)

In this article I discuss David Shoemaker’s recently published piece “Responsibility: The State of the Question. Fault Lines in the Foundations.” While agreeing with Shoemaker on many points, I argue for a more unified diagnosis of the seemingly intractable debates that plague (what I call) “responsibility studies.” I claim that, of the five fault lines Shoemaker identifies, the most basic one is about the role that the notion of deserved harm should play in the theory of moral responsibility. I argue (...) that the deep divide between those theorists who affirm and those who deny that moral responsibility is essentially about the justification of desert thus understood can be traced to the disagreement about whether the focus on the reactive attitudes by itself entails that moral responsibility has nothing to do with traditional questions about desert and free will. I then show that the seeming intractableness of the other four fault lines Shoemaker identifies is expectable and explicable in light of this more basic disagreement. After this diagnostic work, I conclude by suggesting a solution to the “morass” that has taken over responsibility studies: theorists working in the field should acknowledge that it has effectively bifurcated into two discrete subareas, which I suggest calling “retribution studies” and “interpersonal studies.” -/- . (shrink)

The United Nations Convention on the Rights of the Child (UNCRC) is presented and understood as the primary reference point regarding questions of children’s rights. However, the UNCRC is not a neutral instrument deployed to meet the rights of children: it embodies a specific perception of the child, childhood and citizenship. The interpretation of the UNCRC from the point of view of children’s legal status emphasises the autonomy of children; the focus is on the rights that children possess. Conversely, the (...) social-political interpretation of the UNCRC addresses the question of how the rights of children can be realised. It is suggested that distinguishing between these interpretations is essential with regard to questions of pedagogy and education. (shrink)

In public communication contexts, such as when a company announces the proposal for an important organizational change, argumentation typically involves multiple audiences, rather than a single and homogenous group, let alone an individual interlocutor. In such cases, an exhaustive and precise characterization of the audience structure is crucial both for the arguer, who needs to design an effective argumentative strategy, and for the external analyst, who aims at reconstructing such a strategic discourse. While the peculiar relevance of multiple audience is (...) often emphasized in the argumentation literature and in rhetorical studies, proposals for modelling multi-audience argumentative situations remain scarce and unsystematic. To address this gap, we propose an analytical framework which integrates three conceptual constructs: Rigotti and Rocci’s notion of communicative activity type, understood as the implementation of an interaction scheme into a piece of institutional reality, named interaction field; the stakeholder concept, originally developed in strategic management and public relations studies to refer to any actor who affects and/or is affected by the organizational actions and who, accordingly, carries an interest in them; the concept of participant role as it emerges from Goffman’s theory of conversation analysis and related linguistic and media studies. From this integration, we derive the notion of text stakeholder for referring to any organizational actor whose interest becomes an argumentative issue which the organizational text must account for in order to effectively achieve its communicative aim. The text stakeholder notion enables a more comprehensive reconstruction and characterization of multiple audience by eliciting the relevant participants staged in a text and identifying, for each of them, the interactional role they have, the peculiar interest they bear and the related argumentative issue they create. Considering as an illustrative case the defense document issued by a corporation against a hostile takeover attempt made by another corporation, we show how this framework can support the analysis of strategic maneuvering by better defining the audience demand and, so, better explaining how real arguers design and adapt their topical and presentational choices. (shrink)

In this paper I investigate which of the main conditions proposed in the moral responsibility literature are the ones that spell trouble for the idea that Artificial Intelligence Systems could ever be full-fledged responsible agents. After arguing that the standard construals of the control and epistemic conditions don’t impose any in-principle barrier to AISs being responsible agents, I identify the requirement that responsible agents must be aware of their own actions as the main locus of resistance to attribute that kind (...) of agency to AISs. This is because this type of awareness is thought to involve first-person or de se representations, which, in turn, are usually assumed to involve some form of consciousness. I clarify what this widespread assumption involves and conclude that the possibility of AISs’ moral responsibility hinges on what the correct theory of de se representations ultimately turns out to be. (shrink)

What does it mean to drive a Cadillac? What does 'cuckoo' suggest about the bird? -- two examples explored in this investigation of the history of language signs and of what philosophers, linguists, and others have had to say about them. Rudi Keller shows how signs emerge, function, and develop in the permanent process of language change. He recombines thoughts and ideas from Plato to the present day to create a new theory of the meaning and evolution of icons (...) and symbols. By assuming no prior knowledge and by developing his argument from first principles, Rudi Keller has written a basic text which includes all the necessary features: easy style, good organization, original scholarship, and historical depth. This is a non-technical book which will interest linguists, philosophers, students of communications and cultural studies, semioticians/semanticists, sociologists, and anthropologists. (shrink)

Machine generated contents note: ContentsIntroduction: A Change of Heart1. What's behind Animal Advocacy? -- 2. The Love of a Dog: Of Pets and Puppy Mills, Mixed-Breeds and Shelters -- 3. The Animal on Your Plate: Farmers, Vegans, and Locavores -- 4. Where the Wild Things Ought to Be: Sanctuaries, Zoos, and Exotic Pets -- 5. From Object to Subject: Animals in Scientific Research -- 6. Clothing Ourselves in Stories of Love: Affect and Animal AdvocacyConclusion: Trouble in the PackAcknowledgments -- Notes (...) -- Bibliography -- Index. (shrink)

Recently it has become clear that integrins and other adhesive receptors play an important role in the control of cell growth and differentiation. In various cell types, anchorage to the extracellular matrix via integrins strongly influences the ability of the cell to respond to soluble mitogens or to differentiation factors. Thus adhesive receptors must generate signals that influence cell behavior. Some of the pathways of adhesion receptor signaling are now beginning to be worked out, but there is still much to (...) learn. In particular, the mechanistic basis for the cooperation between anchorage signals and signals from soluble growth and differentiation factors remains ill‐defined. This review will examine some of the current information linking adhesion receptors to control of mitogenesis and differentiation. (shrink)

Metaphors “highlight and hide” different aspects of phenomena. A behavioral economic metaphor for excessive consumption highlights the contextual features of behavioral-environment relations. Can the behavioral momentum metaphor generate a representation of context that is at least as useful as that generated by behavioral economics? Maybe, maybe not; or maybe a mixed metaphor will do a better job than either alone.

Catholic social teaching is the Church’s “best-kept secret,” as the saying goes, but is it becoming literally true? This paper tests the proposition that the US bishops are developing a pattern of obscuring or, in effect, hiding particular social teachings of the popes. The instances examined include the ideological error of single-issue advocacy; the meaning of the right to form labor unions; and the intrinsic value of nonhuman species and ecosystems. It would be true irony if the “best-kept secret” were (...) that the bishops were actually keeping a secret. The paper contends that this expression, now more than a metaphor, has acquired a double meaning to which one ought to attend, for papal social teaching should be openly embraced and handed on to the faithful. (shrink)

Anders, Rudi Sometimes it is nice to do something totally unconnected to the usual bustle of life, such as a walk in the park. This time I visit a German Lutheran church in Melbourne; I have never entered it before. The exterior and interior consistently retain the traditional design. The bluestone gives it a sense of permanence - timelessness. I rarely like modern churches; mixing modern and traditional never works for me. This church is not large and has an (...) intimate feel to it. The people are all smiles. I like people, regardless of their beliefs. Family groups look like they feel at home, and visitors like me are made welcome. I sit and admire the skill of the craftsmen who attended to every detail in the church. They didn't have the modern machines we take for granted. (shrink)

Les pages que Husserl a consacrées à l'art et à la conscience esthétique sont rares et éparses. Il n'en reste pas moins que la théorie qui y voit le jour fait preuve d'une grande systématicité. L'oeuvre d'art, comme elle le sera plus tard chez Sartre, y est invariablement désignée au titre d'objet irréel. Non qu'elle ne possède une effectivité matérielle qui en assure la présence dans le champ de la perception et en constitue le soubassement physique, mais, bien plutôt, qu'elle (...) soit illocalisable dans ce champ et irréductible à ce soubassement. La raison en étant que l'objet d'art est un objet imaginaire qui ne trouve dans la réalité dont il est fait que le moyen de s'y objectiver et non celui de s'y individualiser. Son irréalité, il la reçoit du regard "désintéressé", au sens kantien du terme, qu'il appelle, de la visée intentionnelle particulière qui lui donne d'apparaître en tant que "néant" ou "rien", comme se plaît à le répéter Husserl. C'est à retracer la genèse de cette conception dématérialisée de l'oeuvre artistique et du type de conscience qui l'appréhende que s'attache ce livre, non moins qu'à en cerner les enjeux théoriques. Deux voies d'investigation ont été privilégiées à cet égard. L'une, interne, s'efforce d'en dégager la provenance et d'en saisir le statut au sein même de la phénoménologie husserlienne. L'autre, externe, la confronte à des théories esthétiques rivales et à la production artistique dont elle a à rendre compte afin, par contraste, d'en faire jaillir et d'en apprécier la véritable portée heuristique. Le résultat est que les catégories conceptuelles élaborées par Husserl pour fonder son approche du phénomène de l'art et de l'intention qui en prend acte s'avèrent, en définitive, sujettes à la critique. (shrink)

Non‐reflectivist real self views claim that people are morally responsible for all and only those bits of conduct that express their true values and cares, regardless of whether they have endorsed them or not. A phenomenon that is widely cited in support of these views is inverse akrasia, that is, cases in which a person is praiseworthy for having done the right thing for the right reasons despite her considered judgment that what she did was wrong. In this paper I (...) show that non‐reflectivist real self views are problematic by focusing on the related but neglected phenomenon of inverse enkrasia, which occurs when an agent commits wrongdoing by following a mistaken evaluative judgment that, unbeknownst to her, runs contrary to her true values and cares. Intuitively, inverse enkratics are blameworthy for their actions although the latter don't express their real selves; therefore, non‐reflectivist real self views are false. I assess the implications of this result for the viability of the quality of will paradigm and conclude that the latter survives unscathed to the problems besetting real self views. The lesson is that defenders of the quality of will paradigm should stop talking about real selves altogether. (shrink)

In this essay, I draw the discourses around bestiality/zoophilia into the realm of queer theory in order to point to a new form of animal advocacy, something that might be called, in shorthand, loving animals. My argument is quite simple: if all interdicts against bestiality depend on a firm notion of exactly what sex is (and they do), and if queer theory disrupts that firm foundation by arguing that sexuality is impossible to define beforehand and pervades many different kinds of (...) relations (and it does), then viewing bestiality in the frame of queer theory can give us another way to conceptualize the limitations of human exceptionalism. By focusing on transformative connections between humans and animals, a new form of animal advocacy emerges through the revolutionary power of love. (shrink)

In this article, I argue that queer women – especially cis and trans lesbians – have more in common than contemporary fissures either allow for or acknowledge. Lesbians who recognised their queer sexuality in the 1970s have in common with trans women the shared condition of being, in the words of the 1970s radical feminist Marilyn Frye, ‘spat summarily out of reality’. We also share the experience of refusing to accept this condition. I make this argument by manoeuvring away from (...) questions of gender identity and focusing instead on gender’s ontoformativity: the astonishing, welcome and transformative fact that new social realities are brought into being by new social practices. I turn to experimental writing to explore this matter. Through this medium, the cis lesbian poet Nicole Brossard and the trans lesbian poet Trace Peterson wrote themselves into worlds, languages and social orders that refused to acknowledge their existence. Brossard was writing in 1970s Montreal, Peterson in early twenty-first-century New York, but what they have in common, indeed what radical lesbian theory from the 1970s shares with contemporary theorising by trans women, is the insight that identifying with men is expected. It is in identifying with women that we are most at risk. (shrink)

Anders, Rudi To solve a problem such as wars between nations and civil wars it is necessary to discover what causes the problem.

The article explores similarities between the philosophies of Zhuangzi and Aristippus, focusing in particular on play and eudaimonism. The main thesis is that both authors encourage the cultivation of a playful mindset, defined in the paper as the “ludic self”, which operates as a strategy for leading a flourishing life. By shaping a fluid, unstructured identity, the ludic self promotes negative subtraction from the structuring power of social nexus and proactive adaptation to shifting circumstances. Furthermore, some aspects of these philosophies (...) present an inter-disciplinary convergence with scientific findings from the psycho-biology of play, concerned with the mobilization of cathected energies and the prevention, or resolution, of addictive states. These promising connections with the fields of psychology and biology also represent an original contribution in respect to the existing debates within Zhuangzi studies, and scholarship on the Cyrenaics. From a methodological point of view, the article pursues what Rorty defines as a “rational reconstruction”, which involves a re-interpretation of past philosophies in light of present debates, ideas and vocabularies with the aim of engaging a trans-cultural, trans-historical dialogue. The value of this operation relies upon the universality of human experience, which always allows re-interpretation and re-actualization of past philosophies as a dialogical exercise of questioning otherness within a hermeneutic framework. (shrink)

v. I. Cycles, causality, ecology -- v. II. Evolution & appendices.

Renewable energy technology is often seen as a positive expression of technology, meeting energy needs with minimal environmental impact. But, by integrating nature with the ordering of the electric grid, renewables silently convert that nature into what Martin Heidegger referred to as standing reserve—resources of the technological commodity chain to be ordered, controlled, converted, and consumed on demand. However, it may be possible to mitigate the downsides of this process through a transition to more decentralized, local sources of renewable energy (...) operations and management that maintain awareness of the ways in which energy is generated and distributed. (shrink)

'The infinite! No other question has ever moved so profoundly the spirit of man; no other idea has so fruitfully stimulated his intellect; yet no other concept stands in greater need of clarification than that of the infinite.' David Hilbert (1862-1943). This interdisciplinary study of infinity explores the concept through the prism of mathematics and then offers more expansive investigations in areas beyond mathematical boundaries to reflect the broader, deeper implications of infinity for human intellectual thought. More than a dozen (...) world-renowned researchers in the fields of mathematics, physics, cosmology, philosophy, and theology offer a rich intellectual exchange among various current viewpoints, rather than a static picture of accepted views on infinity. The book starts with a historical examination of the transformation of infinity from a philosophical and theological study to one dominated by mathematics. It then offers technical discussions on the understanding of mathematical infinity. Following this, the book considers the perspectives of physics and cosmology: Can infinity be found in the real universe? Finally, the book returns to questions of philosophical and theological aspects of infinity"--Provided by publisher. (shrink)

According to a recent newspaper article, 40 million people in the European Union live in anxiety every single day . Apparently only 6% of the population can summon the courage to talk about their anxiety with their doctor. It would seem that doctors have too little time to recognize the signs of what the article calls the “new illness”. Nor are they encouraged to do so by the renowned scientific journals, where the focus is solely on a purely medical treatment (...) for anxiety, or by the pharmaceutical industry, where anxiety is equated with “long-term easy money”. The title of the article immediately struck me, especially since it seemed to be in flat contradiction to its subtitle: “Anxiety as the other side of affluence. Being afraid without knowing why”. Let me first of all try to explain why this contradiction did not really surprise me.It is well known that `anxiety' is traditionally opposed to `fear', where the difference is said to be that fear has a clear object but anxiety does not. One is afraid of something determinate, whereas with anxiety one appears to be afraid without knowing precisely why or what one fears. Yet this distinction is not so straightforward: merely mentioning it is not the same as maintaining it, as can be seen in this frequently cited passage from Freud: “anxiety [Angst] has an unmistakable relation to expectation: it is anxiety about something. It has a quality of indefiniteness and lack of object. In precise speech we use the word `fear' [Furcht] rather than `anxiety' [Angst] if it has found an object”.Freud appears to waver between two possibilities: either anxiety is essentially characterized by indeterminacy and a lack of object, in which case it is literally anxiety for nothing, or anxiety is temporarily undetermined, in which case it is anxiety for something that cannot immediately be named but that could be named and determined with the proper technique or therapy. In this second case — the one Freud clearly prefers — anxiety would be a fear whose object is provisionally undetermined. And indeed, hardly a paragraph further Freud no longer concerns himself with the distinction he just drew and with seeming carelessness sets aside the rules of correct usage which he brought to his readers' attention: “a real danger is a danger that is known, and realistic anxiety is anxiety about a known danger of this sort. Neurotic anxiety is anxiety about an unknown danger. Neurotic danger is thus a danger that has still to be discovered.Analysis has shown that it is a pulsional danger [Triebgefahr]. By bringing this danger which is not known into consciousness, the analyst makes neurotic anxiety no different from realistic anxiety, so that it can be dealt with in the same way”. Neurotic anxiety, then, is only anxiety as long as the danger causing the anxiety is unknown. And Freud's treatment for revealing that danger essentially boils down to turning the neurotic anxiety into a realistic anxiety, or more precisely: to show that the danger, although different in each case, is knowable in principle and so does not betray anxiety but fear! Realistic anxiety already has an object and is therefore fear. Neurotic anxiety has a hidden object which can and must be disclosed: “where there is anxiety there must be something that one is afraid of”.Evidently, “anxiety is not so simple a matter”, as Freud himself wrote and, one could add, experienced in the text from which I have just quoted at length. (shrink)

An encyclopedia article on the epistemic or knowledge condition for moral responsibility, written for the SEP.

Anders, Rudi When I see a colourful sunset, my mind goes to a spectacular purple sunset I saw near the Mexican border many years ago. That memory stops me from being fully aware of the scene in front of me. No two sunsets are the same and my memory is stopping me from fully appreciating the spectacle before my eyes. Famous and spectacular places don't work for me because expectations and memories get in the way, but when I walk (...) alone in nature I find my mind stops chattering and I begin to effortlessly notice the shades of green in the foliage, the patterns in the bark on the trees and the sounds and fragrances. It sometimes feels as if am absorbed by the surroundings. When this happens I don't bother with the names of birds or flowers because even that distracts from direct experience. (shrink)

Anders, Rudi A Melbourne suburb A short speech Congratulations..

Anders, Rudi The articles in AH I like best are the ones with which I disagree to a greater or lesser degree, because they force me to re-think and clarify my position. One such article was by John Perkins, titled 'Let's admit that Islam is a problem'. Although the article is very well-written, and I admire John's fact-finding regarding Islam, I think he misses the elephant in the room. Namely, Christian Europe and North America killed far more people than (...) Islam ever did. Buddhist and Shinto Japan did shocking things in the last world war. Jews in Israel ignore the rights of Palestinians. The atheist communist Soviet Union was as bad as Christian Czarist Russia. There is gross injustice in Hindu India. I don't think Islam should be singled out as a problem. I agree that religion can be a problem but the many atheist dictators, for example: Napoleon Bonaparte, Mussolini and Stalin, are also a problem, so atheism as such is not a guarantee of justice. (shrink)

Anders, Rudi I enjoy mixing with people who hold different beliefs from mine. Belief is a very complex and rather odd thing. I am particularly interested in the psychology of belief. Sometimes belief is the cause of terrible conflict and suffering.

Anders, Rudi Mental conditioning is like gravity; it feels so normal and ever-present that it often goes unnoticed, but it influences much human behaviour. I am not free when I am not aware how my ideas and attitudes are absorbed from my culture, family, the media and peers. It takes courage to stand alone.