Deep brain stimulation — a novel surgical procedure — is emerging as a treatment of last resort for people diagnosed with neuropsychiatric disorders such as severe obsessive-compulsive disorder. The US Food and Drug Administration granted a so-called humanitarian device exemption to allow patients to access this intervention, thereby removing the requirement for a clinical trial of the appropriate size and statistical power. Bypassing the rigors of such trials puts patients at risk, limits opportunities for scientific discovery, and gives device manufacturers (...) unique marketing opportunities. We argue that Congress and federal regulators should revisit the humanitarian device exemption to ensure that it is not used to sidestep careful research that can offer valuable data with appropriate patient safeguards. (shrink)

Nucleation and motion of kink pairs on partial dislocations are examined by elasticity theory for materials with a high Peierls stress. Two approaches are used: one considers the change in average stacking-fault energy due to alloying elements and the other considers the change in local SFE due to a nearby solute atom. Both approaches highlight the role of SFE on kink nucleation, propagation and annihilation and both furnish strain rate as a function of stress, temperature and SFE. Model predictions are (...) compared with yield stress data for two systems: firstly, an intermetallic, MoSi 2 , which softens for alloying elements that decrease the SFE and hardens for Re additions that increase the SFE; secondly, a ceramic oxide, MgO-Al 2 O 3 spinel, which softens with increasing addition of excess alumina and at the same time exhibits a decrease in SFE. The average SFE approach agrees qualitatively with the data while quantitative agreement is obtained with the local SFE approach. The possibility is considered that the model applies to other materials, such as TiAl, HfV 2 and Fe 3 Al, which show softening with certain alloying additions. One requirement is that the dislocations are dissociated more than a few atomic distances; otherwise kink nucleation occurs on the perfect dislocation . Hence the model does not apply to materials such as bcc metals which only have a core dissociation. Normal hardening effects of solutes from size and modulus misfits are additive with any softening effects from a decrease in SFE and so may mask the latter, as occurs for W additions to MoSi 2. (shrink)

Brodtkorb's "phenomenological reading" discusses the conceptually resistant realities, "World," "Body," "Others," and "Time," as they are interpreted in Moby Dick, and are focused by Melville in the inscrutable meaning of the white whale. "Mediation" is the key to interpretation, and, thus, the hero of the novel is Ishmael, who understands that the whale's meaning is constituted anew by each perceiver; Ishmael's mental life is a succession of attitudes—a series of "incantations"—which matches existence as process. From this phenomenological point of view, (...) Ahab's rigid interpretation of the whale as an allegory of divine malevolence is doomed, since allegory is a static mediated category, untrue to process. Yet this processional epistemology is itself in doubt if, as Brodtkorb admits, the uncertainty of the inscrutable is itself in question; and this doubt allows for the potential correctness of even Ahab's reductive allegorization. Thus, while Brodtkorb's phenomenology is a very sensitive instrument for indicating the shifting meanings of Melville's world, the final relation of potentially correct and incantatory concepts to this world is weakly conceived, due to the weakness of the instrument itself.—E. S. T. (shrink)

The introductory revised essay, "Horses of Wrath: Recent Critical Lessons," followed by nine reprinted essays, pits the Christian Rationalist, Wimsatt, an aroused Horse of Instruction, against the Tigers of Wrath, Blakean Myth critics led by Northrop Frye. Their battleground is the relation of poetry to life: what for the Blakeans is the fearful symmetry of poetry as the apocalypse of life is for Wimsatt the hateful siege of contraries, both an anarchy of life and a confusion of poetic limits. Wimsatt (...) supports the classical and Christian notion that harmony comes "in spite of" the conflict of good and evil, not "because of" that conflict, as the Blakeans would claim. For Wimsatt, poetry's unique kind of cognition is the analogous perspective it establishes toward contraries, namely the perspective of drama and metaphor in which is created a mock substance of the human condition. But after Wimsatt's analysis, we are left with a dualism which can be itself a hateful contrary: the more poetry performs its perspective function, the more it destroys its subject matter. It is also to the credit of Wimsatt's theoretic hesitancy that he will not let us forget these contraries.—E. S. T. (shrink)

Brodtkorb's "phenomenological reading" discusses the conceptually resistant realities, "World," "Body," "Others," and "Time," as they are interpreted in Moby Dick, and are focused by Melville in the inscrutable meaning of the white whale. "Mediation" is the key to interpretation, and, thus, the hero of the novel is Ishmael, who understands that the whale's meaning is constituted anew by each perceiver; Ishmael's mental life is a succession of attitudes—a series of "incantations"—which matches existence as process. From this phenomenological point of view, (...) Ahab's rigid interpretation of the whale as an allegory of divine malevolence is doomed, since allegory is a static mediated category, untrue to process. Yet this processional epistemology is itself in doubt if, as Brodtkorb admits, the uncertainty of the inscrutable is itself in question; and this doubt allows for the potential correctness of even Ahab's reductive allegorization. Thus, while Brodtkorb's phenomenology is a very sensitive instrument for indicating the shifting meanings of Melville's world, the final relation of potentially correct and incantatory concepts to this world is weakly conceived, due to the weakness of the instrument itself.—E. S. T. (shrink)

The introductory revised essay, "Horses of Wrath: Recent Critical Lessons," followed by nine reprinted essays, pits the Christian Rationalist, Wimsatt, an aroused Horse of Instruction, against the Tigers of Wrath, Blakean Myth critics led by Northrop Frye. Their battleground is the relation of poetry to life: what for the Blakeans is the fearful symmetry of poetry as the apocalypse of life is for Wimsatt the hateful siege of contraries, both an anarchy of life and a confusion of poetic limits. Wimsatt (...) supports the classical and Christian notion that harmony comes "in spite of" the conflict of good and evil, not "because of" that conflict, as the Blakeans would claim. For Wimsatt, poetry's unique kind of cognition is the analogous perspective it establishes toward contraries, namely the perspective of drama and metaphor in which is created a mock substance of the human condition. But after Wimsatt's analysis, we are left with a dualism which can be itself a hateful contrary: the more poetry performs its perspective function, the more it destroys its subject matter. It is also to the credit of Wimsatt's theoretic hesitancy that he will not let us forget these contraries.—E. S. T. (shrink)

Warning research participants and patients about potential risks associated with participation/treatment is a fundamental part of consent. However, such risk warnings might cause negative expectations and subsequent nocebo effects (i.e., negative expectations cause negative outcomes) in participants. Because no existing review documents how past research has quantitatively examined nocebo effects – and negative expectations – arising from consent risk warnings, we conducted a pre-registered scoping review (N = 9). We identified several methodological issues across these studies, which in addition to (...) mixed findings, limit conclusions about whether risk warnings cause nocebo effects. (shrink)

In recent years, we have seen a new concern with ethics training for research and development professionals. Although ethics training has become more common, the effectiveness of the training being provided is open to question. In the present effort, a new ethics training course was developed that stresses the importance of the strategies people apply to make sense of ethical problems. The effectiveness of this training was assessed in a sample of 59 doctoral students working in the biological and social (...) sciences using a pre–post design with follow-up and a series of ethical decision-making measures serving as the outcome variable. Results showed not only that this training led to sizable gains in ethical decision making but also that these gains were maintained over time. The implications of these findings for ethics training in the sciences are discussed. (shrink)

One of the most important theoretical and ideological tasks of Marxist philosophy is the critical study of the philosophical thought of the West. In the second half of the 1970s and beginning of the 1980s, the ideological struggle on the international arena entered a new stage. It was characterized by the turn of the forces of imperialist reaction away from the politics of detente to the politics of the "cold war," to the active opposition to the forces of peace, democracy, (...) and socialism. The struggle of ideas has swung back and forth in the context of, on the one hand, a resurgence of reactionary anticommunist tendencies, and the stimulation and expansion of antimilitary movements and the struggles of the peoples for peace and socialism on the other. (shrink)

Using covariant derivatives and the operator definitions of quantum mechanics, gauge invariant Proca and Lehnert equations are derived and the Lorenz condition is eliminated in U(1) invariant electrodynamics. It is shown that the structure of the gauge invariant Lehnert equation is the same in an O(3) invariant theory of electrodynamics.

To properly understand behavior, we must obtain both ultimate and proximate explanations. Put briefly, ultimate explanations are concerned with why a behavior exists, and proximate explanations are concerned with how it works. These two types of explanation are complementary and the distinction is critical to evolutionary explanation. We are concerned that they have become conflated in some areas of the evolutionary literature on human behavior. This article brings attention to these issues. We focus on three specific areas: the evolution of (...) cooperation, transmitted culture, and epigenetics. We do this to avoid confusion and wasted effort—dangers that are particularly acute in interdisciplinary research. Throughout this article, we suggest ways in which misunderstanding may be avoided in the future. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

In contemporary discussion of the philosophy of religion, or for that matter of any branch of philosophy, the names of Whitehead and Wittgenstein are not often linked. Whitehead's later work is, for the most part, treated as a rather specialized interest, an attractively under-cultivated field for the enterprising thesis-writer perhaps, but well away from the main centres of current philosophical activity. And what he has to say about specifically religious or theological issues 1 becomes simply one ramification of an ingenious (...) but somewhat eccentric system. Nonetheless, there is at least this much justification for considering it in relation to the much more influential and widely discussed views of Wittgenstein. Whitehead has some original things to say about God, Wittgenstein some original reasons for thinking that Whitehead's brand of originality is here radically misplaced. And the possibility or otherwise of such theological originality is an issue of very considerable importance for the philosophy of religion. (shrink)

‘… and he arranged it all. It's done me the world of good, I can tell you. And that's why I said that yesterday was both yesterday and two years ago.’‘Well, it still sounds nonsense to me. I told you H. G. Wells would do you no good.’.

Solon's fragments 9–11 are preserved in three late authors: frr. 9 and 11 by Diodoros Sikelos , 9.20.2, Plutarch , Solon 3.6 and 30.3 respectively, and Diogenes Laertios , 1.50 and 1.51 respectively; and fr. 10 by Diogenes Laertios alone, 1.49. They are all quoted in the context of Solon's reaction to Peisistratos. Stories on this theme were circulating by the time of the Aristotelian Athenaion Politeia , and Rhodes' scepticism about them is well founded. Its author did not garnish (...) his version of events with these poems, nor indeed with any Solonian utterance, and he explicitly states that myth-making on this subject had already resulted in two stories about Solon and Peisistratos which were chronologically impossible. (shrink)

There is general acknowledgement that both the anterior cingulate and orbitofrontal cortex are implicated in reinforcement-guided decision making, and emotion and social behaviour. Despite the interest that these areas generate in both the cognitive neuroscience laboratory and the psychiatric clinic, ideas about the distinctive contributions made by each have only recently begun to emerge. This reflects an increasing understanding of the component processes that underlie reinforcement- guided decision making, such as the representation of reinforcement expectations, the exploration, updating and representation (...) of action values, and the appreciation that choices are guided not just by the prospect of reward but also by the costs that action entails. Evidence is emerging to suggest that the anterior cingulate and orbitofrontal cortex make distinct contributions to each of these aspects of decision making. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 265 concluding chapter (pp. 150-52), Dr. Clair deals with "Comment lire l'oeuvre du P. Thomassin," providing much guidance to anyone who wishes to avail himself of the rich resources in Thomassin's writings. From the point of view of the history of philosophy, the most interesting aspects of Thomassin's thought seem to be (1) his "Cartesianism," that is, the extent to which he early imbibed Descartes' new ideas, (...) and played a role in the fusion of the views of Augustine, B6rulle, and Descartes that developed in the Oratory, (2) his attempt to find a viable theory of the nature of Grace somewhere between Arnauld and Malebranche, and (3) his efforts to formulate a philosophy of history within an Augustinian theology; a philosophy of history that would make historical research and understanding of genuine philosophical and religious value to man. Dr. Clair's too brief discussions indicate that Thomassin was definitely influenced by reading Descartes, but also that Thomassin was much too eclectic to be a Cartesian. With regard to the problem of Grace, where the Cartesian Arnauld fought with the semi-Cartesian Malebranche, Thomassin tried deftly to maintain an Augustinian position that was not quite as rigid as that of the Jansenists, nor as moderate as that of Malebranche (though Arnauld tried to use Thomassin's erudition and authority in his battles with Malebranche). Unfortunately Dr. Clair does not try to evaluate whether Thomassin really found a coherent and theologically acceptable middle-ground between the two antagonists. On the subject of the philosophy of history, Thomassin's views seem most interesting (at least to this reviewer). The short text that Dr. Clair includes on the difference of history from science reveals Thomassin trying to show that the investigation and comprehension of temporal particulars can have significant value for man's understanding of man and that there can be genuine certainty about past facts. Thomassin was writing in the period when modern historical method and outlook were born, when historical study changed from chronicles and ammunition in theological and political disputes to a basic way of understanding human nature. Those concerned with the role of Bayle, Hume, Gibbon, and Vico in developing an historical methodology and a rationale for art historical approach to human problems might well profit from considering Thomassin's writings in this area, and the influence they had on modern historiography and philosophies of history. Dr. Clair's short work certainly helps in filling a lacuna in our picture of the seventeenth century. It also makes one wish he had done more, and had provided a "complete" study of Thomassin's thought and influence. That, perhaps, is one of the major purposes of this new series, in that it will lead scholars to looking into the more hidden portions of the period, and will lead them to filling out in more detail and depth the history of the rise and fall of modern philosophy. It is to be hoped that future volumes in this series will continue to whet our appetites for further investigations, and will transform more of the names we run across into figures about whom we have some information and from whom we can still learn something. RICHARD H. POPKIN University of California, San Diego Berkeley's Theory of Vision..4 Critical Examination of Bishop Berkeley's Essay towards a New Theory of Vision. By D. M. Armstrong. (Melbourne: University Press; London and N. Y.: Cambridge University Press, 1960. Pp. viii + 106. $4.50). Berkeley's brilliant though disconcerting Essay has been rather neglected for some time, except for the able studies of C. M. Turbayne of Rochester University (N. Y.). Armstrong's book is welcome for that reason, also for its freshness, clearness, and rich brevity. A1- 266 HISTORY OF PHILOSOPHY though a slim volume, it is packed with close yet lucid argumentation, conducted throughout with good manners, and throughout exploratory, clarifying problems, exposing logical and empirical difficulties, not grandly telling us what the truth is but leaving us in a better position to carry on the exploration ourselves. It is an exemplary piece of philosophical discussion. He clears his ground by noting that the Essay, so far as... (shrink)