With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something 'genetic'? This is the fundamental question that Sahotra Sarkar's book addresses. The author analyses the nature of reductionism in classical and molecular genetics. He shows that there are two radically different kinds of reductionist explanation: genetic reduction (as found in classical genetics) and physical reduction (...) (found in molecular genetics). This important book clarifies the meaning of the term 'genetic', shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology. (shrink)

Polygenic score (PGS) computations assume an additive model of gene action because associations between phenotypes and alleles at different loci are compounded, ignoring interactions between alleles or loci let alone between genotype and environment. Consequently, PGSs are subject to the same objections that invalidated traditional heritability analyses in the 1970s. Thus, PGSs should not be used in the social sciences.

This paper attempts a critical reappraisal of Nagel's (1961, 1970) model of reduction taking into account both traditional criticisms and recent defenses. This model treats reduction as a type of explanation in which a reduced theory is explained by a reducing theory after their relevant representational items have been suitably connected. In accordance with the deductive-nomological model, the explanation is supposed to consist of a logical deduction. Nagel was a pluralist about both the logical form of the connections between the (...) reduced and reducing theories (which could be conditionals or biconditionals) and their epistemological status (as analytic connections, conventions, or synthetic claims). This paper defends Nagel's pluralism on both counts and, in the process, argues that the multiple realizability objection to reductionism is misplaced. It also argues that the Nagel model correctly characterizes reduction as a type of explanation. However, it notes that logical deduction must be replaced by a broader class of inferential techniques that allow for different types of approximation. Whereas Nagel (1970), in contrast to his earlier position (1961), recognized the relevance of approximation, he did not realize its full import for the model. Throughout the paper two case studies are used to illustrate the arguments: the putative reduction of classical thermodynamics to the kinetic theory of matter and that of classical genetics to molecular biology. (shrink)

Derek Parfit's On What Mattersis widely recognized as elegant, profound, and destined to change the landscape of moral philosophy. In Volume One, Parfit argues that the distinct--indeed, powerfully conflicting--theories of deontology and contractualism can be woven together in a way so as to yield utilitarian conclusions. Husain Sarkar in this book calls this, The Ultimate Derivation. Sarkar argues, however, that this derivation is untenable. To underwrite this conclusion, this book traverses considerable Parfitian terrain. Sarkar shows why Parfit (...) hasn't quite solved what Sidgwick had called "the profoundest problem in ethics"; he offers a reading of Kant, Rawls, and Scanlon that reveals Parfit's keen utilitarian bias; and he demonstrates why Parfit's Triple Theorydoes not succeed in its task of unifying conflicting moral theories. The final chapter of the book is about meta-ethics. It shows that Parfit's Convergence Principleis mistaken even though it unveils Parfit's utterly humane concerns: Moral philosophers are not, as Parfit thinks, climbing the same mountain. But for all that, Sarkar maintains, Parfit's book is arguably the greatest consequential tract in the history of moral philosophy. shows that Parfit's Convergence Principleis mistaken even though it unveils Parfit's utterly humane concerns: Moral philosophers are not, as Parfit thinks, climbing the same mountain. But for all that, Sarkar maintains, Parfit's book is arguably the greatest consequential tract in the history of moral philosophy. (shrink)

Ludwig Wittgenstein's interest in the writings of Rabindranath Tagore, is recognized among scholars worldwide though little has been written on his fascination with Tagore's poetry and symbolic plays. In Language, Limits, and Beyond, Priyambada Sarkar explores Tagore and Wittgenstein's philosophical arguments on the concept of 'threshold of language and meaning', highlighting the systematic connections between Tagore's canon and Wittgenstein's early works. Situatingher study in the early 1900s, when Tagore's poetry had just become available in Europe, Sarkar finds similarities (...) between Tagore's and Wittgenstein's exploration of the limits of language. She argues that Wittgenstein's early philosophy can be better understood when juxtaposed with Tagore.Drawing parallels between the worlds of philosophy and poetry, Sarkar identifies the point of convergence of their two philosophies in the realm of language, tracing how they reach surprisingly similar conclusions through entirely different paths of inquiry. Sarkar finally claims that such important points of contact will help one to arrange the pieces of the Tractarian jigsaw puzzle in a manner where all the pieces of logic, language, world, and the mystical will fall into place and form acoherent picture. (shrink)

Newman objects to human germ-line editingGerm-line editing on both philosophical and practical grounds. While the philosophical grounds are compelling, I argue that they are not sufficiently strong to exclude all germ-line editingGerm-line editing to eliminate genetic diseasesGenetic disease. However, the practical reasons he offers preclude germ-line editing except in very limited circumstances. I argue that my requirement of gene specificityGene specificity in Cut-and-Paste Genetics can address his concerns. Meanwhile Baxter argues that my criteria are so restrictive that they would exclude (...) all presently plausible candidate genes from being edited in the human germ-line editingGerm-line editing. I agree that this may be the case but that it is an acceptable policy situation because it behooves us to be very careful when editing of the human germ-line is at stake. (shrink)

By now it has become commonplace to note that the early Carnap was strongly influenced by Kant and the neo-Kantianism of his day.1 As early as 1977 Haack noted some striking similarities between the Aufbau and the first Critique; since then, Haack’s observation has been underscored by documenting the explicit role of the neo-Kantians in Carnap’s early education and intellectual development.2 Whether or not Carnap in the Aufbau was at all interested in traditional empiricism, or even strongly influenced by Russell, (...) remains debatable.3 However, a decisive early influence of Kant cannot be persuasively denied. Nevertheless, Kant and the neo-Kantians do not comprise the whole story. An equally important influence on Carnap in Der Raum, though perhaps slightly less so in the Aufbau, was Husserl.4 This paper begins the project of tracing the precise extent and nature of that influence.KeywordsPhysical SpaceFormal SpaceLogical EmpiricismVienna CircleLogical SyntaxThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. (shrink)

A classification of models of reduction into three categories — theory reductionism, explanatory reductionism, and constitutive reductionism — is presented. It is shown that this classification helps clarify the relations between various explications of reduction that have been offered in the past, especially if a distinction is maintained between the various epistemological and ontological issues that arise. A relatively new model of explanatory reduction, one that emphasizes that reduction is the explanation of a whole in terms of its parts is (...) also presented in detail. Finally, the classification is used to clarify the debate over reductionism in molecular biology. It is argued there that while no model from the category of theory reduction might be applicable in that case, models of explanatory reduction might yet capture the structure of the relevant explanations. (shrink)

We study a multilateral bargaining problem, where the buyer intends to purchase a subset of available items, each owned by a seller. The subset purchased must satisfy a notion of contiguity, which is modeled using graphs. The graph theoretic approach allows us to study different degrees of complementarity and substitutability between items. It also allows us to examine how degrees of complementarity and substitutability affect the share of surplus obtained by the buyer in the equilibrium of the bargaining game. We (...) characterize necessary and sufficient conditions on the graphs for the buyer to extract full surplus in subgame perfect equilibrium. When the conditions are not met, we provide upper bounds on the equilibrium surplus share of the buyer. (shrink)

It is shown that, for technical reasons, the additivity of variance criterion employed by Lloyd (1988) to define a unit of selection is, in almost all models of selection, inconsistent with the possibility that genes are sometimes not the unit of selection. A case when the latter view is particularly attractive is that of heterosis, and the additivity criterion is inadequate in even such an extreme case. The connection between that criterion and the so-called "fundamental theorem of natural selection" is (...) briefly explored. Skepticism is expressed about the value of measures such as variance in efforts to resolve any of the disputes about the "units of selection.". (shrink)

This article is a systematic critical survey of work done in the philosophy of biology within the logical empiricist tradition, beginning in the 1930s and until the end of the 1950s. It challenges a popular view that the logical empiricists either ignored biology altogether or produced analyses of little value. The earliest work on the philosophy of biology within the logical empiricist corpus was that of Philipp Frank, Ludwig von Bertalanffy, and Felix Mainx. Mainx, in particular, provided a detailed analysis (...) of biology in the 1930s and 1940s in his contribution to the logical empiricists’ Encyclopedia of Unified Science. However, the most important contributions to the philosophy of biology were those of Joseph Henry Woodger and Ernest Nagel. Woodger is primarily remembered for deploying the axiomatic method in biology but he also used semiformal methods for the analysis of many biological problems. While Woodger’s axiomatic work was often derided by some later philosophers of biology (e.g., David Hull and Michael Ruse), this article defends both the biological and the philosophical significance of some of that work, for instance, those aspects that led to the recognition of the conceptual complexity of mereology and temporal identity in biological systems. Woodger’s semiformal analyses were even more important, for instance, his explication of the concepts of the Bauplan and of innateness. Nagel’s importance lies in his analyses of reduction and emergence in the context of all empirical sciences and his use of these analyses in a careful exploration of biological problems. While Nagel’s model of reduction was generally rejected by philosophers of science in the 1970s and 1980s, particularly for biological contexts, it has recently been sympathetically reconstructed by many commentators; this article defends its continued relevance for the philosophy of biology. (shrink)

Explicit, quantitative procedures for identifying biodiversity priority areas are replacing the often ad hoc procedures used in the past to design networks of reserves to conserve biodiversity. This change facilitates more informed choices by policy makers, and thereby makes possible greater satisfaction of conservation goals with increased efficiency. A key feature of these procedures is the use of the principle of complementarity, which ensures that areas chosen for inclusion in a reserve network complement those already selected. This paper sketches the (...) historical development of the principle of complementarity and its applications in practical policy decisions. In the first section a brief account is given of the circumstances out of which concerns for more explicit systematic methods for the assessment of the conservation value of different areas arose. The second section details the emergence of the principle of complementarity in four independent contexts. The third section consists of case studies of the use of the principle of complementarity to make practical policy decisions in Australasia, Africa, and America. In the last section, an assessment is made of the extent to which the principle of complementarity transformed the practice of conservation biology by introducing new standards of rigor and explicitness. (shrink)

Abstract:Contemporary painting is a complex practice, and artists regularly incorporate elements from different media such as photography, textile, and performance. Despite its status being diminished by different conceptual art movements, painting still has a critically important place in the artworld. This importance is largely due to painting’s ability to stretch across media and make a direct appeal to the senses. In this article, an attempt is made to theorize the facility of painting to incorporate different media and its resulting reflexivity. (...) Maurice Merleau-Ponty’s theory of embodiment and phenomenological theory of metaphor provide the theoretical means to articulate reflexivity in painting. Curatorial writing about contemporary painting and case studies of young painters from India form a backdrop for the analysis of examples from the painting practice of one of the authors to demonstrate the material dynamism of painting. It is shown that this reflexivity is intimately related to the sensuous texture of materials used in the creation of the paintings under discussion. The first-person narrative of artistic process and production provides insight into the embodied process of making and manipulating media and evidence that painters can create new insights about the ontology of painting. (shrink)

Maynard Smith notes that he provides a natural history and not a philosophical analysis of the use of concepts of information in contemporary biology. Just a natural history, however rich, would do little to resolve the ongoing controversy about the role of these concepts in biology. None of the disputants deny that the biological use of these concepts is pervasive. The dispute is about whether these concepts—and the framework in which they are embedded—continue to be of explanatory value in contemporary (...) biology. Fortunately, Maynard Smith does much more than provide a natural history: his contribution is also a sustained attempt to justify many of the uses of information in biology. (shrink)

In 1990 the Human Genome Project (HGP) was initiated with much fanfare as biology’s new Big Science project.

This chapter contains section titled: Introduction Classical Molecular Biology Genomics and Post‐Genomics Proteomics Towards a Systems Biology? Philosophical Implications Conclusions: An Invitation References.

Over the last eighteen years Manfred Eigen and his co-workers have postulated a new theory about the origin of life on earth that has presented a detailed account of how many of the features of extant living organisms (such as a universal genetic code and protein-nucleic acid interdependence) might have arisen from purely physical interactions.2 This theory is critically based on the special dynamical properties of certain chemical cycles called “hypercycles” which cause some of them to exhibit hyperbolic growth over (...) time while undergoing selection. The purpose of this paper is to separate two aspects of this theory and then to study the first one in greater detail. The first aspect consists of a physical account of evolution by natural selection at the molecular level that depends only on the kinetics of certain chemical systems and can be applied to a variety of such systems. The second consists of the special dynamical properties that are exhibited when this account is applied, specifically, to hypercycles. (shrink)

Structural realism holds that ontological commitments induced by successful scientific theories should focus on the structures rather than the objects posited by the theories. Thus structural realism goes beyond the empirical adequacy criterion of traditional (or constructive) empiricism. It also attempts to avoid the problems scientific realism faces in contexts of radical theory change accompanied by discordant shifts in posited theoretical objects. Structural realism emerged in the context of attempts to interpret developments in twentieth-century physics. In a biological context, Stanford (...) (2006) provided pre-emptive criticism. French (2011, 2012) has since attempted to answer those criticisms and extend structural realism to the biological realm. This paper argues that, though Stanford’s criticism may be misplaced, and structural realism fares much better than traditional scientific realism in biological contexts, it remains a promissory note. The promise is based on shifting the focus of the debate from the status of biological laws to that of biological organization, an issue that remains a live debate within biology. (shrink)

The idea with which Rabindranath Tagore established Visva-Bharati is different from that of the grounding of Immanuel Kant's "university with condition" or that of Jacques Derrida's "university without condition." The thinking that finally materialized into Visva-Bharati, or rather the "fore-thinking," is an uncanny complex of aesthetics, politics, topolitics, pedagogy, and Tagorean philosophy of the "home" and the "world." There is neither the "conflict" of Kant's essay _The Conflict of the Faculties_ nor Derrida's absolute radicality and radical absoluteness: there is neither (...) Kant's "freedom of the Enlightenment" nor Derrida's "freedom from the Enlightenment." Ranjan Ghosh captures this so-called dichotomy engrossingly in his book _Aesthetics, Politics, Pedagogy and Tagore_. In Tagore's idea of university, we find a "traffic," an exchange of some sort, between nativism and cosmopolitanism, colonial and postcolonial, singularity and plurality, root and rootlessness. Ghosh not only controls the "traffic" in his work but also gives his close reading of the institution and, most importantly, the underlying principle that led to the establishment of the institution. Visva-Bharati was not built upon the principles of a modern university. It did not have the moral responsibility of following the already established norms and regulations or the society at large but had what Ghosh calls a sense of "no-responsibility." Tagore's idea of university was thus built upon the "no-responsibility" toward the old Eurocentric model of pedagogy and the "responsibility" toward creating a new and more reflective model. He employed one set of responsibilities to "counter" another set of responsibilities. This article in a way is a reimagining, a commentary on Ghosh's work on the pedagogical aspects of Visva-Bharati. (shrink)

BackgroundStudies on different methods to supplement the traditional informed consent process have generated conflicting results. This study was designed to evaluate whether participants who received group counseling prior to administration of informed consent understood the key components of the study and the consent better than those who received individual counseling, based on the hypothesis that group counseling would foster discussion among potential participants and enhance their understanding of the informed consent.MethodsParents of children participating in a trial of nutritional supplementation were (...) randomized to receive either group counseling or individual counseling prior to administration of the informed consent. To assess the participant's comprehension, a structured questionnaire was administered approximately 48-72 hours afterwards by interviewers who were blinded to the allocation group of the respondents.ResultsA total of 128 parents were recruited and follow up was established with 118 (90.2%) for the study. All respondents were aware of their child's participation in a research study and the details of sample collection. However, their understanding of study purpose, randomization and withdrawal was poor. There was no difference in comprehension of key elements of the informed consent between the intervention and control arm.ConclusionsThe results suggest that the group counseling might not influence the overall comprehension of the informed consent process. Further research is required to devise better ways of improving participants' understanding of randomization in clinical trials.Trial RegistrationClinical Trial Registry - India (CTRI): CTRI/2009/091/000612. (shrink)

This chapter contains sections titled: Space The constructionist phase Viennese positivism The syntactic phase Semantics Inductive logic The legacy.

Reductionism concerns a set of ontological and epistemological claims, and methodological strictures based on them, about the relationship between two different scientific domains. The critical assumption is that one of these domains is privileged over the other in the sense that the concepts, rules, laws, and other elements of the privileged domain can be used to specify, constitute, or account for those of the other “reduced” domain. This specification often consists of explanation, such that the “reducing” domain is epistemically privileged (...) over the reduced one. Explanations of this type are “reductionist” (or, are “reductions”) and reductionism is then the thesis that such explanations will always be forthcoming or at least are possible in principle. Reductionism is most plausible if the entities of the reduced domain can be interpreted as arising from (e.g., as aggregates of) entities of the reduced domain. This ontological claim is controversial but motivates many reductionist theses and associated scientific research programs. Thus, epistemological and ontological claims about reductionism have the methodological implication that they should govern and guide scientific research. When such research proves to be fruitless over a period of time, the associated reductionist claims themselves become suspect. Although issues connected with reductionism arise in the physical and social sciences, most attention to reductionism in philosophy of science over the last few decades has focused on the biological sciences, especially after the advent of molecular biology made it plausible to believe that biological phenomena can be uniformly explained (in detail) from their physical basis. However, the program of finding such explanations has a long philosophical history often couched in terms of seeking “mechanical,” “mechanistic,” or “materialistic” explanations. The contrast here is with traditional vitalism and various forms of teleology and holism. (shrink)

This book is a collection of papers which reflect the recent trends in the philosophy and history of molecular biology. It brings together historians, philosophers, and molecular biologists who reflect on the discipline's emergence in the 1950's, its explosive growth, and the directions in which it is going. Questions addressed include: (i) what are the limits of molecular biology? (ii) What is the relation of molecular biology to older subdisciplines of biology, especially biochemistry? (iii) Are there theories in molecular biology? (...) (iv) If so, how are these theories structured? (v) What role did information theory play in the rise of molecular biology? The book will open the way for many future researchers. (shrink)

The emergence of CRISPR/Cas9 technology has revolutionized gene editing and made both gene therapy and eugenic control of future human evolution plausible. This accessible book puts these developments in their historical and scientific contexts and analyzes the policy and ethical challenges they raise. It presents the case for altering the human germ-line to eliminate a large number of genetic diseases controlled by a single or few genes, while pointing out that gene therapy is likely to ineffective for diseases with more (...) complex causation. In parallel it explores the possibility of genetic enhancement in a similarly subscribed set of cases. But it also argues that, in general, genetic enhancement is ethically problematic and should be approached with caution. Given the success of CRISPR/Cas9 gene editing, and the explosion of related techniques, in practice it would be virtually impossible to ban germ-line editing for the future. A more useful goal is to regulate it with oversight that represents all stakeholders. That, in turn, requires an informed public discussion of these issues which this book aims to foster. (shrink)

A recent set of experiments by Cairnset al.(1988) purport to show that some mutations in a strain ofE. colibacteria are directed in the sense that they are induced, somehow, in an environment that is suited for them. If this claim is true it would limit the validity of the neo-Darwinian assumption that evolution proceeds by “random variation and natural selection” which requires that there be no correlation between the genesis of a particular mutation and the fitness of the corresponding phenotype (...) in the environment in which the mutation occurs. Instead, it would argue for the occurrence of some “neo-Lamarckian” processes in evolution in the sense that the genesis of some mutations would have a positive correlation with the fitness of the resultant phenotype in that environment. Thus, one of the most fundamental tenets of the neo-Darwinian interpretation of evolution would be brought into question. (shrink)

This article focuses on ‘Love Jihad,’ the neologism that Hindutva, or Hindu Extremism, has invented to incite suspicion and violence against Indian Muslims. I begin with a brief discussion of several characteristics of the Hindutva organisational and ideological apparatus. Then I discuss anti-Love Jihad campaigns as a strategy to assert Hindu extremism in interpersonal relations. I go on to highlight specific episodes of ‘Love Jihad’ attacks by the Hindu Right that have targeted and made a political spectacle of love and (...) marriage across community boundaries. I suggest that Love Jihad campaigns become a mode of producing docile, submissive subjects who will not question regimes of power, be it neoliberalism, religious majoritarianism or social hierarchies and injustice. (shrink)

This paper presents an integralist approach to Jaina logic. This is built around an analysis of the pivotal notion of antarvyāpti in Jaina logic. It is shown in this connection why antarvyāpti needs to be considered the ‘Core Perspective/problem’ of Jaina logic. Next, it is shown how all the salient features of Jaina logic (as viewed from its language-oriented perspective and the epistemic perspective respectively) stand intimately related to the so-called core perspective. In the remaining sections of the paper topics (...) like relationship of the core perspective i) to various non-standard systems of logic [DL, FL, NMR etc.,], ii) to the four pillars and to the eight MPC’s of Jaina philosophy, iii) to some bluntly unimaginative ways of looking at Jaina logic [e.g., Ducko-Rabbitism], iv) to the scheme of classification of propositions in Jaina logic, v) to the resulting conceptual economies related to methodology, and especially to a unified theory of Hetvābhāsa and, finally, vi) to a re-assessment of Frege-Husserl discord in the light of the significance of Jñānātmakatā vs Vākyātmakatā in Jaina logic, etc., have been discussed. (shrink)

On the basis of distinctions between those properties of entities that can be defined without reference to other entities and those that (in different ways) cannot, this note argues that non-trivial forms of frequency-dependent selection of entities should be interpreted as selection occurring at a level higher than that of those entities. It points out that, except in degenerately simple cases, evolutionary game-theoretic models of selection are not models of individual selection. Similarly, models of genotypic selection such as heterosis cannot (...) be legitimately interpreted as models of genic selection. The analysis presented here supports the views that: (i) selection should be viewed as a multi-level process; (ii) upper-level selection is ubiquitous; (iii) kin selection should be viewed as a type of group selection rather than individual selection; and (iv) inclusive fitness is not an individual property. (shrink)

The first in-depth reference to the field that combines scientific knowledge with philosophical inquiry, this encyclopedia brings together a team of leading scholars to provide nearly 150 entries on the essential concepts in the philosophy of science. The areas covered include biology, chemistry, epistemology and metaphysics, physics, psychology and mind, the social sciences, and key figures in the combined studies of science and philosophy. (Midwest).

The emergence of CRISPR/Cas9 technology has revolutionized gene editing and made both gene therapy and eugenic control of future human evolution plausible. This accessible book puts these developments in their historical and scientific contexts and analyzes the policy and ethical challenges they raise. It presents the case for altering the human germ-line to eliminate a large number of genetic diseases controlled by a single or few genes, while pointing out that gene therapy is likely to ineffective for diseases with more (...) complex causation. In parallel it explores the possibility of genetic enhancement in a similarly subscribed set of cases. But it also argues that, in general, genetic enhancement is ethically problematic and should be approached with caution. Given the success of CRISPR/Cas9 gene editing, and the explosion of related techniques, in practice it would be virtually impossible to ban germ-line editing for the future. A more useful goal is to regulate it with oversight that represents all stakeholders. That, in turn, requires an informed public discussion of these issues which this book aims to foster. (shrink)

Foreward by Pramod K. Nayar -- Prologue -- Acknowledgments -- Introduction -- The dys-abled players of Samuel Beckett's Endgame -- The circumcised body of Franz Kafka's select letters -- 'Connoisseurship ... of disease' and Thomas Mann's Death in Venice -- 'Undiscovered countries' with Virginia Woolf's On being ill -- 'Connect nothing with nothing' in T.S. Eliot's The wasteland -- Epilogue -- Pathography -- Index.

Image segmentation in land cover regions which are overlapping in satellite imagery, is one crucial challenge. To detect true belonging of one pixel becomes a challenging problem while classifying mixed pixels in overlapping regions. In current work, we propose one new approach for image segmentation using a hybrid algorithm of K-Means and Cellular Automata algorithms. This newly implemented unsupervised model can detect cluster groups using hybrid 2-Dimensional Cellular-Automata model based on K-Means segmentation approach. This approach detects different land use land (...) cover areas in satellite imagery by existing K-Means algorithm. Since it is a discrete dynamical system, cellular automaton realizes uniform interconnecting cells containing states. In the second stage of current model, we experiment with a 2-dimensional cellular automata to rank allocations of pixels among different land-cover regions. The method is experimented on the watershed area of Ajoy river (India) and Salinas (California) data set with true class labels using two internal and four external validity indices. The segmented areas are then compared with existing FCM, DBSCAN and K-Means methods and verified with the ground truth. The statistical analysis results also show the superiority of the new method. (shrink)

Does religiosity help or hinder the exercise of agency? This article brings new evidence to bear on this long-standing debate, examining the life and work of the indigenous activist and follower of liberation theology, Rigoberta Menchú, in Guatemala, and the experiences of a millenarian community in Brazil, particularly one of its leaders, Dona Dodô. The two cases elucidate the dynamics of agency and piety, challenging the idea that pious individuals lack agency. In particular, the article interrogates the construction of pious (...) women as doubly oppressed by the forces of religion and patriarchy, and argues that, on the contrary, it was in the course of religious observance that Menchú and members of the millenarian community mounted challenges to ecclesiastical as well as political orders. Thus, the article underscores the possibilities for resistance and contention through piety rather than at odds with it. In studying these historical figures, the article looks beyond the Global North, which has inspired much of the theorising on religion and agency, to women and men marginalised by their ethnicity, poverty and rurality. In doing so, it demonstrates how religion can enable action among those far from traditional centres of power. (shrink)