Results for 'base editing'

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  1.  9
    Case Report: Feasibility of a Novel Virtual Reality-Based Intervention for Patients With Schizophrenia.Edit Vass, Viktória Simon, Zita Fekete, Balázs Kis & Lajos Simon - 2021 - Frontiers in Psychology 12.
    Schizophrenia is a severe and disabling mental illness, associated with persistent difficulties in social functioning. While gaining and retaining a job or staying socially integrated can be very difficult for the patients, the treatment of poor functionality remains challenging with limited options in pharmacotherapy. To address the limitations of medical treatment, several interesting and innovative approaches have been introduced in the field of psychotherapy. Recent approaches incorporate modern technology as well, such as virtual reality. A potential therapeutic benefit of virtual (...)
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  2.  19
    Guidelines for open peer review implementation.Edit Görögh & Tony Ross-Hellauer - 2019 - Research Integrity and Peer Review 4 (1).
    Open peer review (OPR) is moving into the mainstream, but it is often poorly understood and surveys of researcher attitudes show important barriers to implementation. As more journals move to implement and experiment with the myriad of innovations covered by this term, there is a clear need for best practice guidelines to guide implementation. This brief article aims to address this knowledge gap, reporting work based on an interactive stakeholder workshop to create best-practice guidelines for editors and journals who wish (...)
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  3.  9
    A concept drift-tolerant case-base editing technique.Ning Lu, Jie Lu, Guangquan Zhang & Ramon Lopez de Mantaras - 2016 - Artificial Intelligence 230 (C):108-133.
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  4.  7
    Is Therapeutic Germline Editing Value-based Healthcare? An Early Health Technology Assessment.Federico Pennestrì - 2020 - Phenomenology and Mind 19 (19):194.
    Innovative healthcare technologies may raise ethical concerns which prevent their implementation for fear of unexpected or undesirable outcomes, even before they are introduced into usual clinical practice. Essential to innovation is therefore to analyze benefits and drawbacks from a multidisciplinary point of view (i.e., biomedical, social, financial). Value-based healthcare is currently the most comprehensive theoretical framework to evaluate the benefits of healthcare technologies on patients and society in the longer term. Technically, “the systematic evaluation of properties, effects and/or impacts of (...)
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  5.  22
    Kenyon Cell Subtypes/Populations in the Honeybee Mushroom Bodies: Possible Function Based on Their Gene Expression Profiles, Differentiation, Possible Evolution, and Application of Genome Editing.Shota Suenami, Satoyo Oya, Hiroki Kohno & Takeo Kubo - 2018 - Frontiers in Psychology 9.
    Honey bees are eusocial insects and the workers inform their nestmates of information regarding the location of food source using symbolic communication, called ‘dance communication’, that are based on their highly advanced learning abilities. Mushroom bodies (MBs), a higher-order center in the honey bee brain, comprise some subtypes/populations of interneurons termed Kenyon cells (KCs) that are distinguished by their cell body size and location in the MBs, as well as their gene expression profiles. Although the role of MBs in learning (...)
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  6. Improving the justice‐based argument for conducting human gene editing research to cure sickle cell disease.Berman Chan - 2019 - Bioethics 34 (2):200-202.
    In a recent article, Marilyn Baffoe-Bonnie offers three arguments for conducting CRISPR/Cas9 biotechnology research to cure sickle-cell disease (SCD) based on addressing historical and current injustices in SCD research and care. I show that her second and third arguments suffer from roughly the same defect, which is that they really argue for something else rather than for conducting CRISPR/Cas9 research in particular. For instance, the second argument argues that conducting this gene therapy research would improve the relationship between SCD sufferers (...)
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  7.  22
    Biosocial Bases of Criminal Behaviour. Edited by Sarnoff A. Mednick and Karl O. Christiansen. Pp. 298 + index. (Gardner Press, New York, 1977.) Price £16.20. [REVIEW]D. J. West - 1978 - Journal of Biosocial Science 10 (4):445-446.
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  8.  22
    Evidence‐based Education Policy: What evidence? What basis? Whose policy? – Edited by D. Bridges, P. Smeyers and R. Smith. [REVIEW]Jim Mackenzie - 2012 - Educational Philosophy and Theory 44 (1):117-119.
  9.  28
    Act-Based Conceptions of Propositional Content, edited by Friederike Moltmann and Mark Textor. [REVIEW]Sébastien Richard - 2019 - Grazer Philosophische Studien 96 (4):639-645.
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  10.  16
    The Mahavadanasutra: A New Edition Based on Manuscripts Discovered in Northern Turkestan.Richard Salomon & Takamichi Fukita - 2004 - Journal of the American Oriental Society 124 (4):816.
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  11. The object-based and process-based regulation of genome editing.Michal Koščík & Eliška Vladíková - 2023 - In Santa Slokenberga, Timo Minssen & Ana Nordberg (eds.), Governing, protecting, and regulating the future of genome editing: the significance of ELSPI perspectives. Boston: Brill/Nijhoff.
     
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  12.  17
    The Psychology of Reasoning, based on Experimental Researches in Hypnotism. Edited by A.G. White.A. Binet - 1900 - Philosophical Review 9:111.
  13.  26
    Springer Handbook of Model-based Science: edited by Lorenzo Magnani and Tommaso Bertolotti, Cham, Springer, 2017, xl + 1179 pp., ISBN 9783319305257, €298.Daniele Chiffi - 2019 - International Studies in the Philosophy of Science 32 (1):65-67.
    Volume 32, Issue 1, March 2019, Page 65-67.
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  14.  19
    Prime editing in plants and mammalian cells: Mechanism, achievements, limitations, and future prospects.V. Edwin Hillary & S. Antony Ceasar - 2022 - Bioessays 44 (9):2200032.
    Clustered, regularly interspaced, short palindromic repeat (CRISPR)/CRISPR‐associated protein (CRISPR/Cas) system has revolutionized genetic research in the life sciences. Four classes of CRISPR/Cas‐derived genome editing agents, such as nuclease, base editor, recombinase, and prime editor have been introduced for engineering the genomes of diverse organisms. The recently introduced prime editing system offers precise editing without many off‐target effects than traditional CRISPR‐based systems. Many researchers have successfully applied this gene‐editing toolbox in diverse systems for various genome‐editing (...)
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  15.  14
    Aristotle’s metaphysics Lambda: Annotated Critical Edition Based Upon a Systematic Investigation of Greek, Latin, Arabic and Hebrew Sources.Stefan Alexandru - 2011 - Boston: Brill. Edited by Aristotle.
    In this annotated critical edition of Aristotle’s _Metaphysics_ Lambda Stefan Alexandru draws upon many hitherto unexplored sources of the direct and indirect tradition, _inter alia_ upon an independent Greek manuscript he has discovered in the Vatican Library.
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  16.  12
    Editorial Special Edition on Evidence-Based Approaches and Practises in Phenomenology.Christopher R. Stones - 2012 - Indo-Pacific Journal of Phenomenology 12 (sup1).
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  17.  4
    Aristotle's Metaphysics Lambda: annotated critical edition based upon systematic investigation of Greek, Latin, Arabic and Hebrew sources.Stefan Alexandru - 2011 - Athens: Ekdoseis To Palimpsēston. Edited by Aristotle.
    In this annotated critical edition of Aristotle’s Metaphysics Lambda Stefan Alexandru draws upon many hitherto unexplored sources of the direct and indirect tradition, inter alia upon an independent Greek manuscript he has discovered in the Vatican Library.
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  18.  14
    Visions of Development: Faith-Based Initiatives. Edited by Wendy R. Tyndale.Alexander Lucie-Smith - 2010 - Heythrop Journal 51 (4):708-708.
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  19.  8
    The English Faust Book: A Critical Edition Based on the Text of 1592.John Henry Jones (ed.) - 2011 - Cambridge University Press.
    First published in 1994, this scholarly edition of a major Renaissance text is edited and introduced by John Henry Jones, a leading expert on the Faust legend. The English translation of the best-selling German Faust Book of 1587 has long been known as Marlowe's principal source for Dr Faustus. The earliest surviving edition of this translation, published in 1592, is here presented complete, in modern spelling and with a line register for reference, together with full details of all alterations and (...)
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  20.  7
    Druma-kinnara-ra ja-pariprccha-sutra: A critical edition of the Tibetan text (Recension A) based on eight editions of the Kanjur and the Dunhuang Manuscript Fragment. Paul Harrison.Paul Williams - 1994 - Buddhist Studies Review 11 (1):73-75.
    Druma-kinnara-ra ja-pariprccha-sutra: A critical edition of the Tibetan text based on eight editions of the Kanjur and the Dunhuang Manuscript Fragment. Paul Harrison., The International Institute for Buddhist Studies, 5-3-23 Toranomon, Minato-ku, Tokyo 105, 1992. lvii, 360 pp.
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  21.  8
    Epigenetic editing: Dissecting chromatin function in context.Cristina Policarpi, Juliette Dabin & Jamie A. Hackett - 2021 - Bioessays 43 (5):2000316.
    How epigenetic mechanisms regulate genome output and response to stimuli is a fundamental question in development and disease. Past decades have made tremendous progress in deciphering the regulatory relationships involved by correlating aggregated (epi)genomics profiles with global perturbations. However, the recent development of epigenetic editing technologies now enables researchers to move beyond inferred conclusions, towards explicit causal reasoning, through 'programing’ precise chromatin perturbations in single cells. Here, we first discuss the major unresolved questions in the epigenetics field that can (...)
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  22.  59
    Should human germ line editing be allowed? Some suggestions on the basis of the existing regulatory framework.Iñigo de Miguel Beriain - 2018 - Bioethics 33 (1):105-111.
    The application of genetic editing techniques for the prevention or cure of disease is a highly promising tool for the future of humanity. However, its implementation contains a number of ethical and legal challenges that should not be underestimated. On this basis, some sectors have already asked for a veto on any intervention that modifies the human germ line, while supporting somatic line editing. In this paper, I will support that this suggestion makes no sense at all, because (...)
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  23. Reference and Essence, expanded edition (2nd edition).Nathan U. Salmon - 2005 - Amherst, NY: Prometheus Books.
    This is the second edition of an award-winning 1981 book (Princeton University Press and Basil Blackwell, based on the author’s doctoral dissertation) considered to be a classic in the philosophy of language movement known variously as the New Theory of Reference or the Direct-Reference Theory, as well as in the metaphysics of modal essentialism that is related to this philosophy of language.
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  24. CRISPR/Cas9 genome editing – new and old ethical issues arising from a revolutionary technology.Martina Baumann - 2016 - NanoEthics 10 (2):139-159.
    Although germline editing has been the subject of debate ever since the 1980s, it tended to be based rather on speculative assumptions until April 2015, when CRISPR/Cas9 technology was used to modify human embryos for the first time. This article combines knowledge about the technical and scientific state of the art, economic considerations, the legal framework and aspects of clinical reality. A scenario will be elaborated as a means of identifying key ethical implications of CRISPR/Cas9 genome editing in (...)
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  25. Scientific Explanation Papers Based on Herbert Spencer Lectures Given in the University of Oxford /Edited by A.F. Heath. --. --.A. F. Heath - 1981 - Clarendon, 1981.
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  26.  15
    The Editing Density of Moving Images Influences Viewers’ Time Perception: The Mediating Role of Eye Movements.Stefania Balzarotti, Federica Cavaletti, Adriano D'Aloia, Barbara Colombo, Elisa Cardani, Maria Rita Ciceri, Alessandro Antonietti & Ruggero Eugeni - 2021 - Cognitive Science 45 (4):e12969.
    The present study examined whether cinematographic editing density affects viewers’ perception of time. As a second aim, based on embodied models that conceive time perception as strictly connected to the movement, we tested the hypothesis that the editing density of moving images also affects viewers’ eye movements and that these later mediate the effect of editing density on viewers’ temporal judgments. Seventy participants watched nine video clips edited by manipulating the number of cuts (slow‐ and fast‐paced (...) against a master shot, unedited condition). For each editing density, multiple video clips were created, representing three different kinds of routine actions. The participants’ eye movements were recorded while watching the video, and the participants were asked to report duration judgments and subjective passage of time judgments after watching each clip. The results showed that participants subjectively perceived that time flew more while watching fast‐paced edited videos than slow‐paced or unedited videos; by contrast, concerning duration judgments, participants overestimated the duration of fast‐paced videos compared to the master‐shot videos. Both the slow‐ and the fast‐paced editing generated shorter fixations than the master shot, and the fast‐paced editing led to shorter fixations than the slow‐paced editing. Finally, compared to the unedited condition, editing led to an overestimation of durations through increased eye mobility. These findings suggest that the editing density of moving images by increasing the number of cuts effectively altered viewers’ experience of time and add further evidence to prior research showing that performed eye movement is associated with temporal judgments. (shrink)
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  27.  8
    King Horn: An Edition Based on Cambridge University Library MS Gg.4.27 with an Analysis of the Textual Transmission. [REVIEW]Ralph Iii - 1985 - Speculum 60 (4):936-939.
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  28.  38
    The complexity of the gene and the precision of CRISPR : What is the gene that is being edited?Esha Shah, David Ludwig & Phil Macnaghten - 2021 - Elementa: Science of Anthropocene 9 (1):00072.
    The rapid development of CRISPR-based gene editing has been accompanied by a polarized governance debate about the status of CRISPR-edited crops as genetically modified organisms. This article argues that the polarization around the governance of gene editing partly reflects a failure of public engagement with the current state of research in genomics and postgenomics. CRISPR-based gene-editing technology has become embedded in a narrow narrative about the ease and precision of the technique that presents the gene as a (...)
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  29.  37
    Editing the Reactive Genome: Towards a Postgenomic Ethics of Germline Editing.Stephan Guttinger - 2019 - Journal of Applied Philosophy 37 (1):58-72.
    The reported birth of genetically modified twins in late 2018 has given new fuel to debates about the ethics of germline genome editing (GGE). There is a broad consensus among stakeholders that clinical uses of GGE should be temporarily banned as the technology is not yet deemed safe for use in humans. However, the idea of a complete ban is dismissed by many based on the expectation that more research will eventually allow scientists to make the technology safe without (...)
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  30.  23
    Editing Newton in Geneva and Rome: The Annotated Edition of the Principia by Calandrini, Le Seur and Jacquier.Niccolò Guicciardini - 2015 - Annals of Science 72 (3):337-380.
    SummaryThis contribution examines the circumstances of composition of the annotated edition of Newton's Principia that was printed in Geneva in 1739–1742, which ran to several editions and was still in print in Britain in the mid-nineteenth century. This edition was the work of the Genevan Professor of Mathematics, Jean Louis Calandrini, and of two Minim friars based in Rome, Thomas Le Seur and François Jacquier. The study of the context in which this edition was conceived sheds light on the early (...)
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  31. Reasons to Genome Edit and Metaphysical Essentialism about Human Identity.Tomasz Żuradzki & Vilius Dranseika - 2022 - American Journal of Bioethics 22 (9):34-36.
    In this commentary paper, we are taking one step further in questioning the central assumptions in the bioethical debates about reproductive technologies. We argue that the very distinction between “person affecting” and “identity affecting” interventions is based on a questionable form of material-origin essentialism. Questioning of this form of essentialist approach to human identity allows treating genome editing and genetic selection as more similar than they are taken to be in the standard approaches. It would also challenge the idea (...)
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  32.  2
    Les bases de la morale evolutioniste.Herbert Spencer - 1885 - Good Press.
    Les bases de la morale evolutionniste (8e ed.) / par Herbert SpencerDate de l'edition originale: 1905Sujet de l'ouvrage: Morale evolutionnisteCollection: Bibliotheque scientifique internationale; 35Ce livre est la reproduction fidele d'une oeuvre publiee avant 1920 et fait partie d'une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d'un partenariat avec la Bibliotheque nationale de France, offrant l'opportunite d'acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la BnF.Les oeuvres faisant partie de (...)
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  33.  31
    Aristotle’s Metaphysics Lambda: Annotated Critical Edition Based upon a Systematic Investigation of Greek, Latin, Arabic and Hebrew Sources by Stefan Alexandru.Pantelis Golitsis - 2016 - Journal of the History of Philosophy 54 (3):497-498.
    This is the second edition of Aristotle’s Metaphysics Lambda within two years, following Silvia Fazzo’s Il libro Lambda della Metafisica di Aristotele. Unlike Fazzo, Alexandru does not accompany the Greek text with a translation, but he should be thanked for providing a most valuable and exhaustive critical apparatus, which makes almost unnecessary any further work on the available sources. Alexandru has examined with great accuracy all forty-three Greek manuscripts that transmit Lambda and has fully collated the thirteen manuscripts that are (...)
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  34.  37
    A Newtonian tale details on notes and proofs in Geneva edition of Newton's Principia.Raffaele Pisano & Paolo Bussotti - 2016 - BSHM-Journal of the British Society for the History of Mathematics:1-19.
    Based on our research regarding the relationship between physics and mathematics in HPS, and recently on Geneva Edition of Newton's Philosophiae Naturalis Principia Mathematica (1739–42) by Thomas Le Seur (1703–70) and François Jacquier (1711–88), in this paper we present some aspects of such Edition: a combination of editorial features and scientific aims. The proof of Proposition XLIII is presented and commented as a case study.
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  35.  6
    Prolegomena to Any Future Metaphysics that Will be Able to Present Itself as a Science: A Translation from the German Based on the Original Editions.Immanuel Kant & Peter G. Lucas - 1966 - Manchester University Press.
  36.  19
    Review Symposium: Educational Research and Evidence‐based Practice ‐ Edited by Martyn Hammersley.Stephen Gorard, David Gough, Marilyn Osborn & Gillian Hampden-Thompson - 2008 - British Journal of Educational Studies 56 (3):340-348.
  37.  26
    James E. Baumgartner. Bases for Aronszajn trees. Tsukuba journal of mathematics, vol. 9 , pp. 31–40. - James E. Baumgartner. Polarized partition relations and almost-disjoint functions. Logic, methodology and philosophy of science VIII, Proceedings of the Eighth International Congress of Logic, Methodology and Philosophy of Science, Moscow, 1987, edited by Jens Erik Fenstad, Ivan T. Frolov, and Risto Hilpinen, Studies in logic and the foundations of mathematics, vol. 126, North-Holland, Amsterdam etc. 1989, pp. 213–222. [REVIEW]Stevo Todorcevic - 2000 - Bulletin of Symbolic Logic 6 (4):497-498.
  38.  88
    An essay concerning humane understanding, volume 1 MDCXC, based on the 2nd edition, books 1 and.John Locke - unknown
  39.  17
    An essay concerning humane understanding, volume 2 MDCXC, based on the 2nd edition, books 3 and.John Locke - unknown
  40.  23
    Human genome editing: how to prevent rogue actors.Beverley A. Townsend - 2020 - BMC Medical Ethics 21 (1):1-10.
    BackgroundHuman genome editing technologies offer much potential benefit. However, central to any conversation relating to the application of such technologies are certain ethical, legal, and social difficulties around their application. The recent misuse, or inappropriate use, by certain Chinese actors of the application of genome editing technologies has been, of late, well noted and described. Consequently, caution is expressed by various policy experts, scientists, bioethicists, and members of the public with regard to the appropriate use of human germline (...)
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  41. Insolubilia, a logical study of the bases of set theory (edition of a previously unpublished dissertation).A. Koyre & P. Zambelli - 1999 - Giornale Critico Della Filosofia Italiana 19 (3):323-354.
     
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  42.  17
    Physics, Logic and History Based on the First International Colloquium Held at the University of Denver, May 16-20, 1966. Contributors: Hermann Bondi [and Others] Edited by Wolfgang Yourgrau and Allen D. Breck.Hermann Bondi, Wolfgang Yourgrau & Allen Dupont Breck (eds.) - 1970 - New York, NY, USA: Plenum Press.
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  43.  16
    Basic Rights: Subsistence, Affluence, and U.S. Foreign Policy: 40th Anniversary Edition.Henry Shue - 2020 - Princeton University Press.
    An expanded and updated edition of a classic work on human rights and global justice Since its original publication, Basic Rights has proven increasingly influential to those working in political philosophy, human rights, global justice, and the ethics of international relations and foreign policy, particularly in debates regarding foreign policy’s role in alleviating global poverty. Henry Shue asks: Which human rights ought to be the first honored and the last sacrificed? Shue argues that subsistence rights, along with security rights and (...)
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  44. 'Apologeticum Conventus S. Marci Florentiae'-Introduction about Savonarola and edition of the Latin text based on the Ambrosian Library MS-SP-II, 4-bis.A. F. Verde & E. Giaconi - 1997 - Rinascimento 37:67-154.
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  45.  7
    Diplomatic or eclectic critical editions of the Hebrew Bible? Considering a third alternative.Gert T. M. Prinsloo - 2022 - HTS Theological Studies 78 (1):7.
    Ever since the publication of the third edition of Rudolph Kittel’s Biblia Hebraica to the present gradual production of the Biblia Hebraica Quinta so-called editiones criticae minores of the Hebrew Bible are diplomatic editions. The Codex Leningradensis, dating from 1008/9 CE, is used as the base text, and the Biblia Hebraica text editors note significant variants in other Hebrew manuscripts and/or the ancient versions in eclectic fashion in a text-critical apparatus. The Hebrew University Bible Project also publishes a diplomatic (...)
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  46.  3
    The Science of Ethics as Based on the Science of Knowledge... Translated by A.E. Kroeger. Edited by... W.T. Harris.Johann Gottlieb Fichte, William Torrey Harris & Adolph Ernst Kroeger - 1897
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  47.  51
    Editing the Rhetorical Tradition.Patricia Bizzell - 2003 - Philosophy and Rhetoric 36 (2):109-118.
    In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.2 (2003) 109-118 [Access article in PDF] Editing the Rhetorical Tradition Patricia Bizzell The rhetorical tradition is always being edited. I know because I have edited it myself—that's a sort of pun, in which the words "the rhetorical tradition" refer both to a book and to the cultural phenomenon the book represents. Bruce Herzberg and I (2001) have co-edited an anthology entitled The Rhetorical Tradition: (...)
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  48.  5
    Emotion selectable end-to-end text-based speech editing.Tao Wang, Jiangyan Yi, Ruibo Fu, Jianhua Tao, Zhengqi Wen & Chu Yuan Zhang - 2024 - Artificial Intelligence 329 (C):104076.
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  49. The Editioning of Gardens.Gavin Keeney - manuscript
    Many of the following literary-critical texts (not all quite conventional “long-form” essays) originally appeared on the Landscape Agency New York website, LANY Archive-Grotto, on the web portal Geocities, between the years 1997 and 2008 – i.e., over a period of roughly ten years. Versions of some were published in various journals, academic or otherwise. In re-presenting them here, the intention is to trace a proverbial “red thread” that crosses the entirety of the work, arguably what might be denoted the works-based (...)
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  50.  8
    A Computer-Generated Concordance to the Syriac New Testament, According to the British and Foreign Bible Society's Edition, Based on the SEDRA Database.Michael Sokoloff & George Anton Kiraz - 1997 - Journal of the American Oriental Society 117 (4):727.
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