BackgroundOne of the next frontiers in HIV research is focused on finding a cure. A new priority includes people with HIV (PWH) with non-AIDS terminal illnesses who are willing to donate their bodies at the end-of-life (EOL) to advance the search towards an HIV cure. We endeavored to understand perceptions of this research and to identify ethical and practical considerations relevant to implementing it.MethodsWe conducted 20 in-depth interviews and 3 virtual focus groups among four types of key stakeholders in the (...) United States (PWH, biomedical HIV cure researchers, HIV clinicians, and bioethicists) to obtain triangulated viewpoints because little was known about the ethics of this topic. Each group was queried as to ethical considerations, safeguards, and protections for conducting HIV cure-related research at the EOL to ensure this research remains acceptable.ResultsAll four key stakeholder groups generally supported HIV cure-related research conducted at the EOL because of the history of altruism within the PWH community and the potential for substantial scientific knowledge to be gained. Our informants expressed that: (1) Strong stakeholder and community involvement are integral to the ethical and effective implementation, as well as the social acceptability of this research; (2) PWH approaching the EOL should not inherently be considered a vulnerable class and their autonomy must be respected when choosing to participate in HIV cure-related research at the EOL; (3) Greater diversity among study participants, as well as multi-disciplinary research teams, is necessitated by HIV cure-related research at the EOL; (4) The sensitive nature of this research warrants robust oversight to ensure a favorable risk/benefit balance and to minimize the possibility of therapeutic misconception or undue influence; and (5) Research protocols should remain flexible to accommodate participants’ comfort and needs at the EOL.ConclusionBecause of the ethical issues presented by HIV cure-related research at the EOL, robust ethical safeguards are of utmost importance. The proposed ethical and practical considerations presented herein is a first step in determining the best way to maximize this research’s impact and social value. More much inquiry will need to be directed towards understanding context-specific and cultural considerations for implementing EOL HIV cure research in diverse settings. (shrink)

The U.S. National Institute of Allergies and Infectious Diseases and the National Institute of Mental Health have a new research priority: inclusion of terminally ill persons living with HIV in HIV cure-related research. For example, the Last Gift is a clinical research study at the University of California San Diego for PLWHIV who have a terminal illness, with a prognosis of less than 6 months. As end-of-life HIV cure research is relatively new, the scientific community has a timely opportunity to (...) examine the related ethical challenges. Following an extensive review of the EOL and HIV cure research ethics literature, combined with deliberation from various stakeholders and our experience with the Last Gift study to date, we outline considerations to ensure that such research with terminally ill PLWHIV remains ethical, focusing on five topics: 1) protecting autonomy through informed consent, 2) avoiding exploitation and fostering altruism, 3) maintaining a favorable benefits/risks balance, 4) safeguarding against vulnerability through patient-participant centeredness, and 5) ensuring the acceptance of next-of-kin/loved ones and community stakeholders. EOL HIV cure-related research can be performed ethically and effectively by anticipating key issues that may arise. While not unique to the fields of EOL or HIV cure-related research, the considerations highlighted can help us support a new research approach. We must honor the lives of PLWHIV whose involvement in research can provide the knowledge needed to achieve the dream of making HIV infection curable. (shrink)

The objective of the study was to investigate the relationship between childhood IQ of parents and characteristics of their adult offspring. It was a prospective family cohort study linked to a mental ability survey of the parents and set in Renfrew and Paisley in Scotland. Participants were 1921-born men and women who took part in the Scottish Mental Survey in 1932 and the Renfrew/Paisley study in the 1970s, and whose offspring took part in the Midspan Family study in 1996. There (...) were 286 offspring from 179 families. Parental IQ was related to some, but not all characteristics of offspring. Greater parental IQ was associated with taller offspring. Parental IQ was inversely related to number of cigarettes smoked by offspring. Higher parental IQ was associated with better education, offspring social class and offspring deprivation category. There were no significant relationships between parental IQ and offspring systolic blood pressure, diastolic blood pressure, cholesterol, glucose, lung function, weight, body mass index, waist hip ratio, housing, alcohol consumption, marital status, car use and exercise. Structural equation modelling showed parental IQ associated with offspring education directly and mediated via parental social class. Offspring education was associated with offspring smoking and social class. The smoking finding may have implications for targeting of health education. (shrink)

In this book, internationally recognized scholars in philosophical hermeneutics discuss various aspects of language and linguisticality. The translations of Hans-Georg Gadamer's two recent essays provoke a preliminary discussion on the philosopher's polemic claim in Truth and Method—"Being that can be understood is language." Topics addressed by the contributors include the relationship of rituals to tradition and the immemorial; the unity of the word; conversation; translation and conceptuality; and the interrelationship between the art of writing and linguisticality. This work is of (...) critical importance to anyone interested in Gadamer's claims regarding the boundaries of language, the transition from the prelinguistic to linguistic realms, and the role of rituals in this transition. (shrink)

When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

The Last Gift is an observational HIV cure-related research study conducted with people with HIV at the end of life (EOL) at the University of California San Diego. Participants agree to voluntarily donate blood and other biospecimens while living and their bodies for a rapid research autopsy postmortem to better understand HIV reservoir dynamics throughout the entire body. The Last Gift study was initiated in 2017. Since then, 30 volunteers were enrolled who are either (1) terminally ill with a concomitant (...) condition and have a prognosis of 6 months or less or (2) chronically ill with multiple comorbidities and nearing the EOL.Multiple ethical and logistical challenges have been revealed during this time; here, we share our lessons learnt and ethical analysis. Issues relevant to healthcare research include surrogate informed consent, personal and professional boundaries, challenges posed conducting research in a pandemic, and clinician burnout and emotional support. Issues more specific to EOL and postmortem research include dual roles of clinical care and research teams, communication between research personnel and clinical teams, legally required versus rapid research autopsy, identification of next of kin/loved ones and issues of inclusion. Issues specific to the Last Gift include logistics of body donation and rapid research autopsy, and disposition of the body as a study benefit.We recommend EOL research teams to have clear provisions around surrogate informed consent, rotate personnel to maintain boundaries, limit direct contact with staff associated with clinical care and have a clear plan for legally required versus research autopsies, among other recommendations. (shrink)

The conflicting positions of the two early eleventh century Yogācāra scholars, Ratnākaraśānti and his critic Jñānaśrīmitra, concerning whether or not consciousness can exist without content are inseparable from their respective understandings of enlightenment. Ratnākaraśānti argues that consciousness can be contentless —and that, for a buddha, it must be. Mental content can be defeated by reasoning and made to disappear by meditative cultivation, and so it is fundamentally distinct from the nature of consciousness, which is never defeated and never ceases. That (...) mental content is thus separable from the nature of consciousness is unimaginable to Jñānaśrīmitra, who argues that all mental content cannot be so defeated, nor can it disappear completely, and who concludes that Ratnākaraśānti’s commitment to this idea can be based on nothing but faith. Contra Jñānaśrīmitra, I will suggest that Ratnākaraśānti’s view is based not only on faith, but is also driven by a certain theory of buddhahood, the implications of which he is committed to working out. Because Ratnākaraśānti’s theory of buddhahood is developed in part in his tantric work, our understanding of his position benefits from our reading it in this context, wherein buddhahood and the most effective techniques for attaining it are explored. (shrink)

This paper considers Jñānaśrīmitra’s defense of manifestation as the criterion of ultimate existence. In the first section, "Asatkhyāti and Adhyavasāya: making sense of manifestation as the criterion of the real", I show the way that, in response to Ratnākaraśānti’s Nirākāravāda, Jñānaśrīmitra argues for a sharp distinction between manifestation and determination in an effort to establish that the manifestation of something unreal is incoherent. The unreal, he thinks, is only ever determined; it is never manifest to consciousness, properly speaking. In the (...) second section, “To be manifest is to be locked away in a single awareness-event”, I turn to one of the consequences of this view that Jñānaśrīmitra embraces: what manifests is only what appears in a single moment of conscious awareness. In the third section, “The scope of neither-one-nor-many: Jñānaśrīmitra’s Interpretation of PV 3.220–221”, I consider one of the problems this raises: how is it that an appearance with mutually opposed parts manifests in one and the same unitary moment of awareness? Jñānaśrīmitra solves this problem by appealing to the nature of manifestation and its distinction from determination: what is manifest, even if it is variegated, is nondual and indivisible; distinctions arise only on the basis of determination. I trace the details of this solution in the context of his discussion of an important pair of verses from Dharmakīrti. Finally, in the last section, “The marvelous nonduality of variegated awareness-events”, I turn to the surprising buddhological consequences of this solution. (shrink)

Abstract:Ratnākaraśānti (ca. 970–1040) holds three conflicting positions: luminosity (prakāśa) is the ultimately real nature of consciousness; luminosity and appearances (ākāras) are identical; and appearances are false (alīka) because they are targeted by the neither-one-nor-many argument. But why is luminosity not false, too, given its identity with appearances? In response to this worry, Ratnākaraśānti develops a notion of identity (tādātmya) that lets him claim that, although luminosity and appearance are composed of the same stuff, they are not identical in every respect. (...) On the basis of this, he limits the scope of the neither-one-nor-many argument such that it targets appearances but not luminosity. Other philosophers (and possibly Ratnākaraśānti himself) then further limit the argument's scope, showing that it also does not target experiences of pleasure (sukha) and, crucially for their buddhology, the innate bliss (sahajānanda) that characterizes the experience of buddhahood. (shrink)

This book explores Dostoevsky as a political thinker from his religious and philosophical foundation to nineteenth-century European politics and how themes that he had examined are still relevant for us today.

The present book is true to its title. A collection of articles that stems from a symposium of the same name at the University of Hamburg in 2017, the authors here bring different perspectives to bear on the philosophical and historical relations between Buddhism and scepticism. Though this is relatively well-trodden ground, the insightful studies here shed new light on the matter. We find historical studies of the possible links between Pyrrhonism and Buddhism ; a defense of Nāgārjuna's philosophical scepticism (...) as of the Pyrrhonian variety ; considerations of the role of sceptical doubt in less expected places, such as in Dharmakīrti's and Vasubandhu's... (shrink)

Recent studies of spider phobia have indicated thatfearof spiders is closely associated with the disease-avoidance response of disgust. It is argued that the disgust-relevant status of the spider resulted from its association with disease and illness in European cultures from the tenth century onward. The development of the association between spiders and illness appears to be linked to the many devastating and inexplicable epidemics that struck Europe from the Middle Ages onwards, when the spider was a suitable displaced target for (...) the anxieties caused by these epidemics. Such factors suggest that the pervasive fear of spiders that is commonly found in many Western societies may have cultural rather than biological origins, and may be restricted to Europeans and their descendants. (shrink)

This new edition of Introduction to Lattices and Order presents a radical reorganization and updating, though its primary aim is unchanged. The explosive development of theoretical computer science in recent years has, in particular, influenced the book's evolution: a fresh treatment of fixpoints testifies to this and Galois connections now feature prominently. An early presentation of concept analysis gives both a concrete foundation for the subsequent theory of complete lattices and a glimpse of a methodology for data analysis that is (...) of commercial value in social science. Classroom experience has led to numerous pedagogical improvements and many new exercises have been added. As before, exposure to elementary abstract algebra and the notation of set theory are the only prerequisites, making the book suitable for advanced undergraduates and beginning graduate students. It will also be a valuable resource for anyone who meets ordered structures. (shrink)

Rapid Ethical Assessment (REA) is a form of rapid ethnographic assessment conducted at the beginning of research project to guide the consent process with the objective of reconciling universal ethical guidance with specific research contexts. The current study is conducted to assess the perceived relevance of introducing REA as a mainstream tool in Ethiopia.

According to a standard view of the second law of thermodynamics, our belief in the second law can be justified by pointing out that low-entropy macrostates are less probable than high-entropy macrostates, and then noting that a system in an improbable state will tend to evolve toward a more probable state. I would like to argue that this justification of the second law is unhelpful at best and wrong at worst, and will argue that certain puzzles sometimes associated with the (...) second law are merely artifacts of this questionable justification. *Received October 2006; revised October 2007. †To contact the author, please write to: Department of Philosophy, University of Chicago, 1115 E. 58th St., Chicago, IL 60637; e-mail: [email protected]. (shrink)

This paper reports the results of three studies using mood induction procedures (MIPs) designed to investigate the relationship between anxiety and disgust. Study 1 used guided imagery vignettes (i.e., asking participants to imagine themselves in a series of described situations) and music (Mayer, Allen, & Beauregard, 1995). Study 2 used video clips (Gross & Levenson, 1995). Study 3 used autobiographical recall and music (Blagden & Craske, 1996). In order to be as sure as possible that target moods were being induced, (...) and that manipulation checks provided good evidence of mood induction, Studies 1 and 2 measured six moods (anxiety, sadness, happiness, anger, disgust, and contempt) on visual analogue scales. In addition, Study 3 included two further mood measures: a 30-adjective rating scale measuring 10 emotions, the Differential Emotion Scale (DES; Izard, 1972) and a free label questionnaire, allowing participants to record how they feel without any prior imposed structure. Results from all three studies demonstrated that induced anxiety will produce increases in reported disgust, but there was no evidence for an effect of induced disgust on reported anxiety. These findings were independent of the type of MIP (guided imagery vignette and music, video clips, and autobiographical recall and music), and the type of dependent mood measure used (visual analogue scale, differential emotion scale or a free label questionnaire). The findings have important implications for the putative role of disgust in anxious psychopathologies, and suggest that if disgust does have a causal influence in some anxious psychopathologies, this influence is not mediated simply by experienced disgust facilitating experienced anxiety. (shrink)

Ambitious targets to reduce greenhouse gas emissions from agriculture have been set by both national governments and their respective livestock sectors. We hypothesize that farmer self-identity influences their assessment of climate change and their willingness to implement measures which address the issue. Perceptions of climate change were determined from 286 beef/sheep farmers and evaluated using principal component analysis. The analysis elicits two components which evaluate identity, and two components which evaluate behavioral capacity to adopt mitigation and adaptation measures. Subsequent Cluster (...) Analyses reveal four farmer types based on the PCA scores. ‘The Productivist’ and ‘The Countryside Steward’ portray low levels of awareness of climate change, but differ in their motivation to adopt pro-environmental behavior. Conversely, both ‘The Environmentalist’ and ‘The Dejected’ score higher in their awareness of the issue. In addition, ‘The Dejected’ holds a high sense of perceived risk; however, their awareness is not conflated with an explicit understanding of agricultural GHG sources. With the exception of ‘The Environmentalist’, there is an evident disconnect between perceptions of agricultural emission sources and their contribution towards GHG emissions amongst all types. If such linkages are not conceptualized, it is unlikely that behavioral capacities will be realized. Effective communication channels which encourage action should target farmers based on the groupings depicted. Therefore, understanding farmer types through the constructs used in this study can facilitate effective and tailored policy development and implementation. (shrink)

Most phobias are focussed on a small number of fear-inducing stimuli (e.g., snakes, spiders). A review of the evidence supporting biological and cognitive explanations of this uneven distribution of phobias suggests that the readiness with which such stimuli become associated with aversive outcomes arises from biases in the processing of information about threatening stimuli rather than from phylogenetically based associative predispositions or “biological preparedness.” This cognitive bias, consisting of a heightened expectation of aversive outcomes following fear-relevant stimuli, generates and maintains (...) robust learned associations between them. Some of the features of such stimuli which determine this expectancy bias are estimates of how dangerous they are, the semiotic similarity between them and their aversive outcomes, and the degree of prior fear they elicit. Ontogenetic and cultural factors influence these features of fear-relevant stimuli and are hence important in determining expectancy bias. The available evidence does not exclude the possibility that both expectancy biases and specific evolved predispositions coexist, but the former can explain a number of important findings that the latter cannot. (shrink)

Although the canonical distribution is one of the central tools of statistical mechanics, the reason for its effectiveness is poorly understood. This is due in part to the fact that there is no clear consensus on what it means to use the canonical distribution to describe a system in equilibrium with a heat bath. I examine some traditional views as to what sort of thing we should take the canonical distribution to represent. I argue that a less explored alternative, according (...) to which the canonical distribution represents a time ensemble of sorts, has a number of advantages that rival interpretations lack. †To contact the author, please write to: Department of Philosophy, University of Chicago, 1115 E. 58th St., Chicago, IL 60637; e‐mail: [email protected]. (shrink)

This paper argues that the negativity of hermeneutic experience is revelatory for the following reasons. Hermeneutic failure is not the equivalent of making an erroneous step in a closed circuit of reasoning. Neither is it a refutation. It concerns becoming conscious of an omission, an oversight, an unjustifiable claim to completeness and even the displacement of one interpretation by another more suggestive. The negative dimension of hermeneutic failure is incontrovertibly connected with becoming progressively aware of how, contrary to expectations, a (...) different way of seeing is possible: something comes to light which displaces one’s former judgement. Consciousness of failure is, then, indissociable from an emergent awareness of overlooked and unremarked ways of thinking: “I should have been alert to this” or “I failed to take account of that”. Consciousness of failure is revelatory precisely because something else and something other than my expectation has shown itself to be decisive and in so doing has displaced my former understanding. This is the basis of the claim that the educative and spiritual importance of hermeneutics lies precisely in the practical pursuit of the impossible. It is a key contention of the paper that hermeneutic understanding expands and extends itself as a consequence of its impossible quest for completion. (shrink)

This article suggests evidence for and reasons why prior acquisition may either facilitate or inhibit acquisition of a new construction. It investigates acquisition of the German passive and future constructions which contain a lexical verb with either the auxiliary sein “to be” or werden “to become”, and are related through these to potential supporting constructions. We predicted that a supported construction should be acquired earlier, faster, and unusually rapidly. An inhibited construction should show an extended depressed usage. We analyzed a (...) dense corpus of a German boy between 2;0 and 5;0. He acquired the sein- before the werden-passive. The former was supported by his prior acquisition of the sein copula, whereas the werden-passive itself supported one werden copula construction. He acquired the werden-future extremely slowly due to the hindrance of a semantically identical construction. These results fit with an emergentist approach in which apparently “sudden” acquisition is still due to gradual learning mechanisms. (shrink)

Background Rapid Ethical Assessment is a form of rapid ethnographic assessment conducted at the beginning of research project to guide the consent process with the objective of reconciling universal ethical guidance with specific research contexts. The current study is conducted to assess the perceived relevance of introducing REA as a mainstream tool in Ethiopia. Methods Mixed methods research using a sequential explanatory approach was conducted from July to September 2012, including 241 cross-sectional, self-administered and 19 qualitative, in-depth interviews among health (...) researchers and regulators including ethics committee members in Ethiopian health research institutions and universities. Results In their evaluation of the consent process, only 40.2% thought that the consent process and information given were adequately understood by study participants; 84.6% claimed they were not satisfied with the current consent process and 85.5% thought the best interests of study participants were not adequately considered. Commonly mentioned consent-related problems included lack of clarity, inadequate information, language barriers, cultural differences, undue expectations and power imbalances. About 95.4% believed that consent should be contextualized to the study setting and 39.4% thought REA would be an appropriate approach to improve the perceived problems. Qualitative findings helped to further explore the gaps identified in the quantitative findings and to map-out concerns related to the current research consent process in Ethiopia. Suggestions included, conducting REA during the pre-test phase of studies when applicable. The need for clear guidance for researchers on issues such as when and how to apply the REA tools was stressed. Conclusion The study findings clearly indicated that there are perceived to be correctable gaps in the consent process of medical research in Ethiopia. REA is considered relevant by researchers and stakeholders to address these gaps. Exploring further the feasibility and applicability of REA is recommended. (shrink)

Gadamer's aesthetics demonstrates that the experience of art is grounded in the objectivities of language, history and tradition. By treating words and images as transmittable placeholders for meanings and concepts, hermeneutics gives a persuasive account of how artworks communicate. Davey demonstrates how hermeneutics transforms aesthetic reflection into a poignant attentive practice that is open to the unexpected. This new "poetics" is relevant not only to the understanding of art but also to showing, explaining and defending the cognitive content of (...) the humanities. Hermeneutic aesthetics provides a sound basis for re-thinking humanities disciplines as critical-creative practices able to re-envision the future. (shrink)

Both syntactic and semantic solutions are given for the entailment problem of duality theory. The test algebra theorem provides both a syntactic solution to the entailment problem in terms of primitive positive formulae and a new derivation of the corresponding result in clone theory, viz. the syntactic description of $\operatorname{Inv(Pol}(R))$ for a given set R of finitary relations on a finite set. The semantic solution to the entailment problem follows from the syntactic one, or can be given in the form (...) of an algorithm. It shows, in the special case of a purely relational type, that duality-theoretic entailment is describable in terms of five constructs, namely trivial relations, intersection, repetition removal, product, and retractive projection. All except the last are concrete, in the sense that they are described by a quantifier-free formula. It is proved that if the finite algebra $\underline{M}$ generates a congruence-distributive variety and all subalgebras of $\underline{M}$ are subdirectly irreducible, then concrete constructs suffice to describe entailment. The concept of entailment appropriate to strong dualities is also introduced, and described in terms of coordinate projections, restriction of domains, and composition of partial functions. (shrink)

In Le différend Lyotard evocatively describes what remains to be heard as “the silence of feeling.” Setting Lyotard’s différend among a differentiated set of incommensurable family resemblances, including Rancière’s mésentente and Derrida’s différance, this paper argues that le différend même, far from coinciding with itself, points to the re-marks and differs from itself, silencing itself by putting itself under a conditional. This is what gives its particular affective quality that is bound up with address and listening. From this perspective, it (...) also becomes possible to develop a new analysis of the silencing said to constitute “cancel culture,” demonstrating that the marketplace-of-ideas model falsely presupposes a fictional equality of audibility and originary purity of speech. What Lyotard teaches us is that free speech cannot but silence itself. (shrink)

Some philosophers have recently argued that contrary to the traditional view, good scientific theories can in fact be logically inconsistent. The literature is now full of case-studies that are taken to support this claim. I will argue however that as of yet no-one has managed to articulate a philosophically interesting view about the role of logically inconsistent theories in science that genuinely goes against tradition, is plausibly true, and is supported by any of the case studies usually given.

Many arguments found in the physics literature involve concepts that are not well-defined by the usual standards of mathematics. I argue that physicists are entitled to employ such concepts without rigorously defining them so long as they restrict the sorts of mathematical arguments in which these concepts are involved. Restrictions of this sort allow the physicist to ignore calculations involving these concepts that might lead to contradictory results. I argue that such restrictions need not be ad hoc, but can sometimes (...) be justified by considering some of the metaphysical issues surrounding the question of the applicability of mathematics to physical reality. 1 Introduction 2 Rejecting inferential permissiveness 3 The agreement problem 4 Independent objections to the liberal view. (shrink)

This volume explores the place of aristocratic virtues and values in the modern democratic world. Essays examine aristocratic priorities and interpretations of historic and contemporary aristocratic assemblies as well as critiques of liberal or bourgeois virtues, democratic equality, and democratic institutions.