In addition to double‐ and single‐strand DNA breaks and isolated base modifications, ionizing radiation induces clustered DNA damage, which contains two or more lesions closely spaced within about two helical turns on opposite DNA strands. Post‐irradiation repair of single‐base lesions is routinely performed by base excision repair and a DNA strand break is involved as an intermediate. Simultaneous processing of lesions on opposite DNA strands may generate double‐strand DNA breaks and enhance nonhomologous end joining, which frequently results in the formation (...) of deletions. Recent studies support the possibility that the mechanism of base excision repair contributes to genome stability by diminishing the formation of double‐strand DNA breaks during processing of clustered lesions. BioEssays 23:745–749, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

In a long question, "Whether there is motion to quality," which became part of his Oxford Expositio omnium librorum Physicorum cum questionibus optime disputatis, composed before 1310, Walter Burley supported the succession-of-forms theory of qualitative change. After commenting on Peter Lombard's Sentences at Paris, Burley took part in disputations on controversial questions in the early 1320s, resulting in his De primo et ultimo instanti and his Tractatus Primus and Tractatus Secundus de intensione et remissione formarum. In these independent controversial (...) works, Burley advanced and defended the succession-of-forms theory with greater detail and precision. This paper examines the treatment of the mathematics of alteration in Burley's final Parisian Expositio in libros octo de physico auditu in light of this earlier controversial work. (shrink)

As its modern edition appears in the Synthese Historical Library, Adam Wodeham’s Tractatus de indivisibilibus does not appear to belong to any one discipline. With regard to its intended audience, the notice of the book appearing on the back cover states that “This book is an important contribution to the history of philosophy.” But it continues, “It will be of interest to all medievalists, particularly to those concerned with medieval science, philosophy, and logic. Theologians and historians of mathematics will also (...) find it useful.”Adam de Wodeham, Tractatus de indivisibilibus. A Critical Edition with Introduction, Translation, and Textual Notes, ed. Rega Wood (Dordrecht: Kluwer Academic Publishers, 1988). In its medieval context as well, Tractatus de indivisibilibus had ambiguous disciplinary status. It begins with the question, “Whether charity or [any] other incorruptible form is composed of indivisible forms.”Wodeham, Tractatus de indivisibilibus, p. 33. Such a reference to charity signals a connection to the Sentences of Peter Lombard, Book I, dist. 17. In introducing his answer to this question, however, Wodeham states, “Because this difficulty is the same for all composite divisible things, whether intensive or extensive, which are of one and the same species or homogeneous, therefore I will briefly inquire indifferently concerning the former and the latter.”Wodeham, Tractatus de indivisibilibus, pp. 34–35. Here and elsewhere, I occasionally modify Rega Wood’s translation in the interests of exactness. The solutions Wodeham then proposes to the questions he asks rely nearly always on logic. (shrink)

As its modern edition appears in the Synthese Historical Library, Adam Wodeham’s Tractatus de indivisibilibus does not appear to belong to any one discipline. With regard to its intended audience, the notice of the book appearing on the back cover states that “This book is an important contribution to the history of philosophy.” But it continues, “It will be of interest to all medievalists, particularly to those concerned with medieval science, philosophy, and logic. Theologians and historians of mathematics will also (...) find it useful.”Adam de Wodeham, Tractatus de indivisibilibus. A Critical Edition with Introduction, Translation, and Textual Notes, ed. Rega Wood (Dordrecht: Kluwer Academic Publishers, 1988). In its medieval context as well, Tractatus de indivisibilibus had ambiguous disciplinary status. It begins with the question, “Whether charity or [any] other incorruptible form is composed of indivisible forms.”Wodeham, Tractatus de indivisibilibus, p. 33. Such a reference to charity signals a connection to the Sentences of Peter Lombard, Book I, dist. 17. In introducing his answer to this question, however, Wodeham states, “Because this difficulty is the same for all composite divisible things, whether intensive or extensive, which are of one and the same species or homogeneous, therefore I will briefly inquire indifferently concerning the former and the latter.”Wodeham, Tractatus de indivisibilibus, pp. 34–35. Here and elsewhere, I occasionally modify Rega Wood’s translation in the interests of exactness. The solutions Wodeham then proposes to the questions he asks rely nearly always on logic. (shrink)

Psychology and Buddhism. From Individual to Global Community. Edited by Kathleen H. Dockett, Rita Dudley-Grant and C. Peter Bankart. Kluwer Academic/Plenum Publishers, New York 2003. xv, 308 pp. £47.00. ISBN 0-306-47412-3.

When do two sentences say the same thing, that is, express the same content? We defend two-component (2C) semantics: the view that propositional contents comprise (at least) two irreducibly distinct constituents, (1) truth-conditions, and (2) subject-matter. We contrast 2C with one-component (1C) semantics, focusing on the view that subject-matter is reducible to truth- conditions. We identify exponents of this view and argue in favor of 2C. An appendix proposes a general formal template for propositional 2C semantics.

This essay argues that Mark C. Murphy's original contribution to natural law ethics succeeds in finding a way between older metaphysical and newer purely practical approaches in this genre. Murphy's reconstruction of the function argument, critique of subjectivist theories of well-being, and rigorous formulation of a flexible welfarist theory of value deserve careful attention. I defend Kant against Murphy's critique and argue that Murphy faces the problem of showing that all his basic goods are morally inviolable. Although I endorse Murphy's (...) critique of radical virtue ethics, I raise objections to the basic moral norms he derives from his list of goods, and to the analysis of peace of mind and happiness as basic goods. (shrink)

For some, ‘transformation’ is the new non-reductive and non-normative ‘development’, attracting attention from interdisciplinary array, but of particular theoretical and practical interest to Spirituality scholars. In philosophical context, transformation theory has suffered greatly from ’agency-structure’ dualism and suspension of ontology in body-mind dualism and rationalist virtue controversy. Drawing on the work of Bhaskar, Segal and Slote, a renegotiated and more meaningful sense of transformation emerges from their cumulative analytical and conceptual enrichment. In the complexity of possible relations between self, self-concept (...) and society, lies the traditionally neglected transformative middle of sui-generis human depth. In redress, arguably, Bhaskar’s meta-philosophy accommodates Segal’s experiential depth analysis and Slote’s understanding of empathy and receptivity as valuable insights for ’awakening’ to transformative process. (shrink)

Berkeley’s likeness principle is the claim that “an idea can be like nothing but an idea”. The likeness principle is intended to undermine representationalism: the view (that Berkeley attributes to thinkers like Descartes and Locke) that all human knowledge is mediated by ideas in the mind which represent material objects. Yet, Berkeley appears to leave the likeness principle unargued for. This has led to several attempts to explain why Berkeley accepts it. In contrast to ‘metaphysical’ and ‘epistemological’ interpretations available in (...) the literature, in this paper I defend a ‘conceptual’ interpretation. I argue that Berkeley accepts the likeness principle on the basis of (i) his commitment to the transparency of ideas, and (ii) his account of resemblance which he sets out in his works on vision. Thus, I provide an explanation for Berkeley’s reasons for accepting the likeness principle which, appropriately, focuses on his views concerning ideas and likeness. (shrink)

Margaret Macdonald was at the institutional heart of analytic philosophy in Britain in the mid-twentieth century. Yet, her views on the nature of philosophical theories diverge quite considerably from those of many of her contemporaries. In this paper, I focus on her 1953 article ‘Linguistic Philosophy and Perception’, a provocative paper in which Macdonald argues that the value of philosophical theories is more akin to that of poetry or art than science or mathematics. I do so for two reasons. First, (...) because it reveals just how far Macdonald’s meta- philosophical views diverged from those of many of her contemporaries. Second, because the discussion in LPP pre-empts recent literature on the nature of philosophical inquiry and the efficacy of philosophical arguments. Indeed, Macdonald’s paper is just as likely to provoke discussion today as it was in the 1950s. (shrink)

Through a study of a sophisticated contemporary scientific experiment, it is shown how and why use of the term 'observation' in reference to that experiment departs from ordinary and philosophical usages which associate observation epistemically with perception. The role of "background information" is examined, and general conclusions are arrived at regarding the use of descriptive language in and in talking about science. These conclusions bring out the reasoning by which science builds on what it has learned, and, further, how that (...) process of building consists not only in adding to our substantive knowledge, but also in increasing our ability to learn about nature, by extending our ability to observe it in new ways. The argument of this paper is thus a step toward understanding how it is that all our knowledge of nature rests on observation. (shrink)

This paper provides a philosophical evaluation of the concept of handedness prevalent but largely unspoken in the scientific literature. This literature defines handedness as the preference or ability to use one hand rather than the other across a range of common activities. Using the philosophical discipline of phenomenology, I articulate and critique this conceptualization of handedness. Phenomenology shows defining a concept of handedness by focusing on hand use leads to a right hand biased concept. I argue further that a phenomenological (...) model based in spatial orientation rather than hand use provides a more inclusive concept of handedness. (shrink)

Preface: The target of film theory -- Camera searching in the world -- Is a camera essential? -- Cahiers axiom -- Tracing Bazin's trace -- Images contested today -- Editor's discovery of form -- Bazin's forerunners -- Documentaries in the cauldron of history -- Cahiers line -- Pursuing cinema in the twenty-first century -- Projector as spectator's searchlight -- Power of projection -- Opening the screen's dimensions -- Frame as threshold -- Writing out of the frame -- Evolution of the (...) subjects of cinema -- Modern film: Between classic and avant-garde -- Ontogeny of cinema -- Credits and auteurs: An ecology of adaptation -- Fidelity: The economy of adaptation. (shrink)

Since its original publication in 1975, this groundbreaking work has awakened millions of people to the existence of "speciesism"—our systematic disregard of nonhuman animals—inspiring a worldwide movement to transform our attitudes to animals and eliminate the cruelty we inflict on them. In Animal Liberation, author Peter Singer exposes the chilling realities of today’s "factory farms" and product-testing procedures—destroying the spurious justifications behind them, and offering alternatives to what has become a profound environmental and social as well as moral issue. (...) An important and persuasive appeal to conscience, fairness, decency, and justice, it is essential reading for the supporter and the skeptic alike. (shrink)

An examination of Galileo's thought and work that focuses on his contributions to modern science.

Concepts in Film Theory is a continuation of Dudley Andrew's classic, The Major Film Theories. In writing now about contemporary theory, Andrew focuses on the key concepts in film study -- perception, representation, signification, narrative structure, adaptation, evaluation, identification, figuration, and interpretation. Beginning with an introductory chapter on the current state of film theory, Andrew goes on to build an overall view of film, presenting his own ideas on each concept, and giving a sense of the interdependence of these (...) concepts. Andrew provides lucid explanations of theories which involve perceptual psychology and structuralism; semiotics and psychoanalysis; hermeneutics and genre study. His clear approach to these often obscure theories enables students to acquire the background they need to enrich their understanding of film -- and of art. (shrink)

It is argued that causal understanding originates in experiences of acting on objects. Such experiences have consistent features that can be used as clues to causal identification and judgment. These are singular clues, meaning that they can be detected in single instances. A catalog of 14 singular clues is proposed. The clues function as heuristics for generating causal judgments under uncertainty and are a pervasive source of bias in causal judgment. More sophisticated clues such as mechanism clues and repeated interventions (...) are derived from the 14. Research on the use of empirical information and conditional probabilities to identify causes has used scenarios in which several of the clues are present, and the use of empirical association information for causal judgment depends on the presence of singular clues. It is the singular clues and their origin that are basic to causal understanding, not multiple instance clues such as empirical association, contingency, and conditional probabilities. (shrink)

In this important new book in the IPPP series, a group of leading thinkers in psychiatry, psychology, and philosophy offer alternative perspectives that address both the scientific and clinical aspects of psychiatric validation, emphasizing throughout their philosophical and historical considerations.

Prospect Theory: For Risk and Ambiguity, provides a comprehensive and accessible textbook treatment of the way decisions are made both when we have the statistical probabilities associated with uncertain future events and when we lack them. The book presents models, primarily prospect theory, that are both tractable and psychologically realistic. A method of presentation is chosen that makes the empirical meaning of each theoretical model completely transparent. Prospect theory has many applications in a wide variety of disciplines. The material in (...) the book has been carefully organized to allow readers to select pathways through the book relevant to their own interests. With numerous exercises and worked examples, the book is ideally suited to the needs of students taking courses in decision theory in economics, mathematics, finance, psychology, management science, health, computer science, Bayesian statistics, and engineering. (shrink)

The alleged problem of "incommensurability" is examined, and attempts to explain scientific change in terms of concepts of meaning and reference are analyzed and rejected. A way of understanding scientific change through a properly developed concept of "reasons" is presented, and the issues of reasons, meaning, and reference are placed in the context of this broader interpretation of scientific change.

“What do you see when you look at your face in the mirror?” asks J. David Velleman in introducing his philosophical theory of action. He takes this simple act of self-scrutiny as a model for the reflective reasoning of rational agents: our efforts to understand our existence and conduct are aided by our efforts to make it intelligible. Reflective reasoning, Velleman argues, constitutes practical reasoning. By applying this conception, _Practical Reflection_ develops philosophical accounts of intention, free will, and the foundation (...) of morals. This new edition of _Practical Reflection_ contains the original 1989 text along with a new introduction and is the latest entry in The David Hume Series of Philosophy and Cognitive Science Reissues, which keeps in print previously published indispensable works in the area of cognitive science. _ _ _ _. (shrink)

William Molyneux was born in Dublin, studied in Trinity College Dublin, and was a founding member of the Dublin Philosophical Society (DPS), Ireland’s counterpart to the Royal Society in London. He was a central figure in the Irish intellectual milieu during the Early Modern period and – along with George Berkeley and Edmund Burke – is one of the best-known thinkers to have come out of that context and out of Irish thought more generally. In 1688, when Molyneux wrote the (...) letter to Locke in which he posed the now famous question about a man born blind made to see, he was an active member of the DPS and was on familiar terms with several other key figures in Irish philosophy at the time. For the most part, Irish thinkers in the seventeenth and eighteenth centuries answered “no” to Molyneux’s question of whether a blind man made to see could distinguish, by sight alone, between a cube and a sphere. (shrink)

This book examines the complex and varied ways in which fictions relate to the real world, and offers a precise account of how imaginative works of literature can use fictional content to explore matters of universal human interest. While rejecting the traditional view that literature is important for the truths that it imparts, the authors also reject attempts to cut literature off altogether from real human concerns. Their detailed account of fictionality, mimesis, and cognitive value, founded on the methods of (...) analytical philosophy, restores to literature its distinctive status among cultural practices. The authors also explore metaphysical and skeptical views, prevalent in modern thought, according to which the world itself is a kind of fiction, and truth no more than a social construct. They identify different conceptions of fiction in science, logic, epistemology, and make-believe, and thereby challenge the idea that discourse per se is fictional and that different modes of discourse are at root indistinguishable. They offer rigorous analyses of the roles of narrative, imagination, metaphor, and "making" in human thought processes. Both in their methods and in their conclusions, Lamarque and Olsen aim to restore rigor and clarity to debates about the values of literature, and to provide new, philosophically sound foundations for a genuine change of direction in literary theorizing. (shrink)

Based on a survey of 2,361 directors in 291 of the largest companies of the Southeast States, this study empirically examined boards of directors' stakeholder orientations. The results indicate that there exist distinct stakeholder groups perceived by directors, directors have high stakeholder orientations, directors view some stakeholders differently depending on their occupation and type.