An amendment to this paper has been published and can be accessed via the original article.

The accurate annotation of an unknown protein sequence depends on extant data of template sequences. This could be empirical or sets of reference sequences, and provides an exhaustive pool of probable functions. Individual methods of predicting dominant function possess shortcomings such as varying degrees of inter-sequence redundancy, arbitrary domain inclusion thresholds, heterogeneous parameterization protocols, and ill-conditioned input channels. Here, I present a rigorous theoretical derivation of various steps of a generic algorithm that integrates and utilizes several statistical methods to predict (...) the dominant function in unknown protein sequences. The accompanying mathematical proofs, interval definitions, analysis, and numerical computations presented are meant to offer insights not only into the specificity and accuracy of predictions, but also provide details of the operatic mechanisms involved in the integration and its ensuing rigor. The algorithm uses numerically modified raw hidden markov model scores of well defined sets of training sequences and clusters them on the basis of known function. The results are then fed into an artificial neural network, the predictions of which can be refined using the available data. This pipeline is trained recursively and can be used to discern the dominant principal function, and thereby, annotate an unknown protein sequence. Whilst, the approach is complex, the specificity of the final predictions can benefit laboratory workers design their experiments with greater confidence. -/- . (shrink)

One of the world's premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine--and how understanding these principles can empower everyone.

Articles on spirituality, personality development and politics chiefly Karnataka, India.

This study explores the impact of both individual ethics (IE) and organizational ethics (OE) on ethical intention (EI). Ethical intention, or the individual's intention to engage in ethical behavior, is useful as a dependent variable because it relates to behavior which can be an expression of values, but also is influenced by organizational and societal variables. The focus is on EI in international business decision-making, since the international context provides great latitude in making ethical decisions. Results demonstrate that both IE (...) and OE influence EL Ethical congruence is also discussed as a positive influence. Younger managers are more influenced by OE than older managers. The findings call for creating governance mechanisms to enhance ethical congruence, thereby increasing the likelihood of managers making ethical choices in organizational decision-making. (shrink)

Karl Raimund Popper, (1902-1994) a leading apostle of antiinductivism, holds that the main problem of philosophy of science is the problem of demarcation. Accordingly, the demarcation principle distinguishes science from non-science. To Popper, logic, metaphysics and psychoanalysis are likely to fall into the non-science group. Principle of induction has been accepted even though resentfully as the chief tool of scientific investigation by the positivists as well as the scientists in general. Popper rejects the positivistic approach and on the contrary proposes (...) falsifiablity to furnish his iconoclastic project. This paper intends to indentify the problem of his very approaches in order to hold that in spite of some difficulties in the problem of induction itself, as the identifier of science, we do not have any alternative to save science from metaphysics. Finally, Popper’s so-called demarcation criterion is extensively examined here with a view to defend material aspect of inductive generalization. Philosophy and Progress, Vol#67-68; No#1-2; Jan-Dec 2020 P 33-48. (shrink)

On the characteristic features of Indian philosophy; vol. 1: interpretation of the Vedas and Upanishads.

Introduction: Intimate Partner Violence (IPV) has unfavorable consequences for women as well as for newborn babies, which is very serious and preventable public health problem. It is believed to have an excessive occurrence in lives of women in South Asia. The objective of this study is to describe the prevalence, risk factors and consequences of IPV in Bangladesh. Methods: A scoping review was carried out based on the past 12 years of posted and gray literature about IPV in Bangladesh using (...) Arksey and O’Malley’s framework. Only the literature addressing abuses or violence in households or outside including physical, sexual or mental violence on the married woman in Bangladesh were taken into consideration for the study. Results: The overall prevalence of IPV in Bangladesh, the latest reviews of rates ranging from 15.5-82.7%.Most of the IPV in Bangladesh was based totally on the experience of legally married women. The main risk factors of IPV in Bangladesh were women being younger, from lower socioeconomic reputation, from lower academic attainment and lower education of husband, dowry, child marriage, perceived disobedience of wives, family conflict, children had recently been ill, and incapability of to furnish sexual satisfaction. Maternal depressive symptoms, signs of stress, anxiety and constraint to the better health of young children are the main consequences of IPV in Bangladesh. Besides, IPV causes unwanted pregnancy, pregnancy loss in the form of miscarriage, induced abortion, or stillbirth and termination of pregnancy in Bangladesh. Conclusions: Woman’s empowerment may reduce IPV and understanding attitudes towards IPV in cultural context could be crucial for developing interventions to reduce IPV and its consequences. (shrink)

Although initiation of DNA replication is considered to be highly coordinated through multiple protein–DNA and protein–protein interactions, it is poorly understood how particular locations within the eukaryotic chromosome are selected as origins of DNA replication. Here, we discuss recent reports that present structural information on the interaction characteristics of the archaeal orthologues of the eukaryotic origin recognition complex with their cognate binding sequences.1,2 Since the archaeal replication system is postulated as a simplified version of the one in eukaryotes, by analogy, (...) these works provide insights into the functions of the eukaryotic initiator proteins. BioEssays 30:208–211, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

A novel piecewise water flow technique for text line extraction from multi-skewed document images of handwritten text of different scripts is presented here. The basic water flow technique assumes that the hypothetical water flows from both left and right sides of the image frame. This flow of water fills up the gaps between consecutive objects but faces obstruction if any object lies in the path of the flow. All unwetted regions in the document image are then labeled distinctly to extract (...) the text lines. However, the technique fails when two neighboring text lines touch each other, as water gets obstructed by the touching segment. To get rid of this difficulty, we have modified the basic water flow technique by iteratively applying the same over the vertically segmented document images. The main purpose of this vertical segmentation is to localize the text line segment where two text lines get joined. These segments are then horizontally fragmented, and each fragment is placed suitably to the text line in which it actually belongs to. This way, the probable data loss during isolation of the touching text line segment is minimized. Both the techniques have been tested on three different databases, viz., CMATERdb 1.1.1, CMATERdb 1.1.2, and ICDAR2009 handwritten segmentation contest pages, respectively. The test results show that the present technique outperforms the basic one for all three databases. (shrink)

In this paper, a novel approach for word extraction and character segmentation from the handwritten Bangla document images is reported. At first, a modified Run Length Smoothing Algorithm, called Spiral Run Length Smearing Algorithm, is applied for the extraction of words from the text lines of unconstrained handwritten Bangla document images. This technique has helped to overcome some of the drawbacks of standard horizontal and vertical RLSA techniques. SRLSA technique has been applied on the Bangla handwritten document image database CMATERdb1.1.1 (...) and the success rate of the word extraction is found to be 86.01%. In the second part of the work, we have presented a useful solution to the problem on how best word images of handwritten Bangla script can be segmented into constituent characters. Moreover, the technique can segment the words having discontinuity in Matra, a prominent feature of Bangla script. It also optimizes the trade-off between under/over segmentation as Matra region and segmentation points are estimated more precisely. As a result, better word segmentation accuracy is achieved with minimal data loss. Here, a success rate of 92.48% is observed on a dataset of 750 handwritten Bangla words which is 3.35% higher than that of our earlier techniques. (shrink)

Being inherently different from any other lifesaving organ transplant, uterine transplantation does not aim at saving lives but supporting the possibility to generate life. Unlike the kidneys or the liver, the uterus is not specifically a vital organ. Given the non-lifesaving nature of this procedure, questions have been raised about its feasibility. The ethical dilemma revolves around whether it is worth placing two lives at risk related to surgery and immunosuppression, amongst others, to enable a woman with absolute uterine factor (...) infertility to experience the presence of an organ enabling childbirth. In the year 2000, the first uterine transplantation, albeit unsuccessful, was performed in Saudi Arabia from where it has spread to the rest of the world including Sweden, the United States and now recently India. The procedure is, however, still in the preclinical stages and several ethical, legal, social and religious concerns are yet to be addressed before it can be integrated into the clinical setting as standard of care for women with absolute uterine factor infertility. (shrink)

The nature of the product to be discovered guides the reasoning to discover it. Biologists and medical researchers often search for mechanisms. The "new mechanistic philosophy of science" provides resources about the nature of biological mechanisms that aid the discovery of mechanisms. Here, we apply these resources to the discovery of mechanisms in medicine. A new diagrammatic representation of a disease mechanism chain indicates both what is known and, most significantly, what is not known at a given time, thereby guiding (...) the researcher and collaborators in discovery. Mechanisms of genetic diseases provide the examples. (shrink)

The phenomenological investigations of Siddhartha Gautama and Edmund Husserl arrive at the exact same conclusion concerning a fundamental and invariant structure of consciousness. Namely, that object-directed consciousness has a transcendental correlational intentional structure, and that this is fundamental -- in the sense of basic and necessary--to all object-directed experiences. This example of converging lines of evidence strongly suggests that phenomenology can indeed produce truths about consciousness, and thus that phenomenology has a rightful place in a science of consciousness. However, (...) Siddhartha challenges cognitive science's mainstream presuppositions concerning what the purpose of phenomenology is and what it means to study and understand consciousness. (shrink)

When The Emperor of All Maladies was published in late 2010, I knew it would be near the top of my stack of books to read. Since I am a PhD student in the History of Science and Medicine, reading a notable book on the history of cancer and its treatments is a must. Sadly, at the time of its publication, my mother had just died unexpectedly at age 82 of a disease for which she had never received a prior (...) diagnosis: cancer, or acute myelogenous leukemia, to be exact. From diagnosis to death took a mere six days. So I hesitated to take this in-depth look at cancer, a disease that left my family and me stunned and grieving from such a sudden loss. I reasoned, however, that the approach of the book would be detached and scientific, perhaps similar to the tone of the academic tomes that I tackle each week. I began to read. (shrink)

The Way of Siddhartha: a life of the Buddha. David J. and Indrani Kalupahana. Shambhala, Boulder [now Boston] 1982. Distributed by Routledge & Kegan Paul, London. xiii + 238pp. $9.00/£5.95.

Biswas's book is a panoramic treatment of contemporary world theatre. The book under review will help both the neophyte, as also a scholar to negotiate ancient dramaturgy and more recent theatre. Biswas's eye for details is also remarked in this review. The review shows how Biswas, as it were, has written a manifesto of protest in this book.

The chapter is divided into five sections. Firstly, I shall briefly describe the phenomenon of Kāpil Maṭh, a Sāṃkhya-Yoga āśrama founded in the early twentieth century by a charismatic Bengali scholar-monk Swāmi Hariharānanda Ᾱraṇya (1869–1947); while referring to Hariharānanda’s writings I will also consider the idea of the re-establishment of an extinct philosophical school. Secondly, I shall specify the method of analysis I apply while addressing the question raised in the title of my chapter and discuss some relevant Sanskrit and (...) Pāli sources. Thirdly, I intend to focus on Aśvaghoṣa’s record in reconstructing the Buddha’s argument against the self. Then I shall offer a possible defence of the self reinterpreted in Buddhist terms and formulated, so to say, ‘on behalf’ of the revived Sāṃkhya-Yoga school. Finally, I will conclude by explaining why and on what assumptions Sāṃkhya can benefit from Buddhist critiques. (shrink)

A comparison between Muḥammad and Siddhārtha’s psychological states is made to identify how they had their mystical experiences and how their presuppositions and personalities shaped their interpretation of these experiences. Muḥammad’s mystical experience appeared to be based on an altered state of consciousness. Siddhārtha’s teachings include that one must not have blind faith and remain open to various truths. These teachings may reflect that he was high in openness to experience, which may have fortified him from becoming delusional. While mystical (...) experiences may have pathological overlaps, they could be categorized in a similar way to psychological states. Yet, mindful presuppositions and personality traits, especially from within openness to experience spectrum, are what make perceptions of these experiences diverse. (shrink)

Résumé: L’image du “Dragon baignant le prince” est un thème important dans l’art bouddhique. L’image est née en Inde, et pendant le processus de propagation du bouddhisme vers l’est, elle est apparue dans le Xinjiang, le Gansu, le Qinghai, le Shanxi, le Shaanxi, le Henan, le Shandong, le Jiangsu, le Sichuan, le Tibet et d’autres endroits en Chine. Cependant, la forme et le contenu de ces images sont différents selon les régions et les périodes. L’étude de cette différence est non (...) seulement propice à la compréhension du processus de sinisation de l’art bouddhiste indien, mais approfondit également la compréhension du contenu spécifique de l’échange de l’art bouddhiste l’art entre la Chine et l’Inde. (shrink)

This paper argues that the central philosophical movement in the complex history of Buddhism that originated with Siddhartha Gautama, the Buddha and carried on by Nāgārjuna (among other later Buddhist philosophers) shares some common themes with the pragmatic philosophy of John Dewey. These themes are the rejection of traditional metaphysics as definitive of philosophy, a return to the correct understanding of the nature of experience, and a particular view about the conduct and nature of philosophy. Dewey is used to (...) illuminate such controversial problems in the Buddhist tradition as why the Buddha is silent about metaphysical questions, what it means to say that everything is anitya, and how we are to understand Nāgārjuna's key concepts of prattyasamutpāda and únyatá. (shrink)

Abstractabstract:Adopting a cross-cultural perspective on hierophanies, this article not only explores the fundamental patterns of prophet Muhammad and Buddhas as expositors of cosmic light as interpreted in the Islamic and Buddhist traditions, but it also engages in comparative theological reflection on how Islam and Buddhism use the symbol of light in describing the cosmological and practical dimension of Muhammad's prophetic nature and the revelatory role of the Buddha. Examples are Nūr Muḥammadī, Muhammadan light, and Shin Buddhism's understanding of Amitābha/Amida Buddha (...) as the Buddha of Infinite Light with Śākyamuni, Siddhārtha Gautama, as the narrator of the Pure Land Sutras. This essay considers the role and perception of the Muslim prophet in relation to the role of the Buddhas as a shared motif for building appreciation between Islam and Shin-Buddhism. (shrink)

This book, through extensive textual study, explores the Buddha's and Buddhism's uncompromising and unflinching emphasis on the centrality of ethics as against any pernicious dogmas and metaphysical beliefs, and their attempts to causally relate moral perfection to soteriological or eschatological goal. What is most admirable about Buddhism is that it integrates the vertical development of human consciousness, for which the other is the necessary condition, with the gradual development of morality. It was this emphasis which separated Siddhartha, before he (...) attained the Awakened Wisdom (bodhi), from his teachers - Alara Kalama and Uddaka Ramaputta - and it is for this reason that the Buddha calls himself and his Dhamma Patisotagami, i.e. going against the currents of the prevailing dogmas and pernicious beliefs. In brief, Buddhism is about overcoming of suffering, the greatest evil, through ethicization of human consciousness and conduct, which also takes care of the ethicization of the society and the universe. Besides, some of the essays of this book explore many other themes like Buddhist epistemology, nature of self, time, and intercultural. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Christ as the Truth, the Light, the Life, but a Way?Bokin KimA conservative Korean Presbyterian pastor asks me what I know about Christ. He asks again what a Buddhist can know about Christ. He claims that Christ cannot be understood from the other aspects of view, but only from the Christian view. Then do I know at all about Christ?My Buddhist understanding of Christ does not start with how (...) Christ has been understood in the Christian context. My understanding is based on the reading of the Christian scripture. My reading of the scripture is guided by Sot’aesan’s understanding of Christianity. 1According to my reading, the Bible presents two meanings of Christ: Christ in the transhistorical sense and Christ in the historical sense. The meaning of Christ as the Truth, the Light, and the Life represents a Christ in the transhistorical sense. The meaning of Christ as a way represents a Christ in the historical sense. Because Jesus did not make any distinction or clarification between these two meanings, it is obvious that even the Christian tradition has confusion on the meaning of Christ. As a result, most Christians hold to an exclusive view of Christ that claims his uniqueness.My attribution of two meanings of Christ is derived from a similar distinction in Buddhism. Buddha in the transhistorical sense represents the universal nature of Buddha, which is identical with Truth. Truth can be replaced by other terms, such as Light or Life. Buddha in the historical sense means the historical nature of Buddha. In this sense, Buddha is unique and should not be depicted as absolute nor as universal. Likewise, Christ can be construed in these two ways.Christ as the Truth, Light, and LifeWhen I read the description of Christ as the Truth, Light, and Life in the Gospel according to John, I feel a strong urge to replace Christ with the term Buddha—not Gautama Buddha but Dharmakaya Buddha. Here Christ refers to the source of the historical Christ just as Dharmakaya Buddha is the source of historical Buddha. In this sense, Christ cannot be compared with any beings in the world and thus is being described absolutely. Christ only is the Truth, Light, and Life. Similarly, there is a Zen koan saying, “Buddha alone exists.”Here the terms Christ and Buddha do not point to historical figures such as Jesus of Nazareth and Siddhartha Gautama. According to a story related to the compilation of Buddha’s teaching, Ananda, who heard Buddha talk the most, was excluded from the committee of compilation. The reason was that Ananda saw the corporal aspect of the Buddha only, but he could not meet the spiritual aspect of the Buddha. [End Page 76] The term awakening in the Buddhist tradition refers to understanding the absolute or universal nature within each transient being.It seems wrong if one claims that only Christ, not Buddha, is the Truth, Light, or Life. By the same token it is wrong to say that Buddha alone, not Christ, exists in eternity. It is wrong to identify historical figures such as Jesus or Gautama with the Truth, Light, or Life. It is more erroneous to exclusively describe only one historical figure as the Truth, Light, or Life. According to my understanding, the terms Christ and Buddha are not the starting point for arguing the uniqueness of the historical Jesus or Gautama but for awakening our absolute or universal nature. That is, Christ as Truth, Light, and Life is our true nature or true self. In this nature there is no distinction between Christ and Buddha, between Christ and me, or between Buddha and me.Regardless of how our foundation is named—Christ (or God), Buddha (Dharmakaya Buddha), Tao, or Wu-chi—our foundation is the basis from which religions are originated.Christ as a WayChrist is a way to our foundation—in other words, the Truth, Light, and Life. Christ’s way is faith/grace. Jesus taught that the faith in God and grace from God would bring forth salvation to the believers. Similarly, Buddha is a way to the Truth, Light, and Life. Buddha’s way is practice/enlightenment... (shrink)

William Irwin gives readers a deeply moving and insightful work into human relationships, our connection to others, the nature of reality, the pursuit of flourishing, and human nature in general. Little Siddhartha centers on three generations of family and explores how they respond to the pressures of life, their place in the world, and the fractured relationships that result. Starting with the younger Siddhartha’s mantra of “Eat, drink, and be merry,” and ending with a concerted chant of “Om,” (...) Irwin weaves a tale that explores the spiritual recesses of human existence, calling on readers to understand, forgive, and most importantly, to listen. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Buddhist Inclusivism: Attitudes Towards Religious OthersTerry C. MuckBuddhist Inclusivism: Attitudes Towards Religious Others. By Kristin Beise Kiblinger. Hants, England: Ashgate, 2005. 145 pp.Kristen Beise Kiblinger, who teaches in the religion department at Thiel College, has written a provocative and imaginative book. It is provocative in that [End Page 168] she appears to be doing buddhology even though she resists calling it that. She says she doesn't want to (...) take the voice of a buddhologian. She does not describe what is as a phenomenologist might or what was as an historian of religion might, or what should be as a buddhologian might. She describes what might be, as a—well, as a participant-philosopher might. She writes as an outsider taking the voice of an insider.Kiblinger chooses as her topic the relationship of Buddhists to people of other religions. She begins by noting that Buddhists themselves have not explicitly addressed this topic in their religious philosophizing, at least not to the extent Christians have. But, she suggests, implicitly they behave as if they do have a favored response to this issue. Citing a wide variety of Buddhist sources across the Buddhist spectrum, she concludes that inclusivism is the most natural position for Buddhists to take vis-à-vis the other religions. She describes that position in some detail, all the while persisting in her refusal to be considered a spokesperson in the insider sense.Kiblinger draws her examples from the way two historical figures related to people of non-Buddhist ideologies and from historical contacts Buddhism as a movement had with other religions or sects. The first historical figure is Siddhartha Gautama himself. The Buddha, Kiblinger notes, was not shy about identifying what made any religion (not just his dhamma) useful—the noble eightfold path. This path is the core of Gautama's dhamma, but it also appears in other religions in other forms. The Buddha put forth the presence of this content as the measure of a religion's usefulness (see the Mahaparinibbana Sutta). And of course the parable of the raft relativizes all religious teachings, making them true only to the extent that they enable humans to "cross the stream" of temporal existence, a common tenet of the inclusivist position in all its forms.Asoka represents a second example of Buddhist inclusivism for Kiblinger. In the seventh and twelfth of his Rock Edicts, Asoka makes clear that all members of all religious traditions are welcome to practice in his kingdom, even though he thinks Buddhism is the best position. He makes clear that both exclusivism and intolerance of other religious ideas are not acceptable positions in his way of looking at the spiritual dimension of the world. Existentially, Asoka's life story is a model of a reformed "exclusivist" finally embracing the all-truth-no-matter-where-you-find-it-is-still-truth position.Not just these giant figures model inclusivism. Buddhism as a movement has consistently, Kiblinger argues, behaved toward other movements as inclusivists would. She uses as a first example the Buddhist attitude toward Vedic sacrifice, the religious practice most liable to be cast aside by the new teaching of Gautama. We see in this example, Kiblinger says, "the technique of significant reinterpretation and new application rather than subordination" (p. 41). She also notes that a technique she calls "reinterpretation by ethicization" that does not throw out Vedic teaching altogether but claims at its root a teaching that was originally Buddhist.Evidence for the inclusivist position can also be found in the way Mahayanists treated Theravadins, or Hinayanists as Kiblinger refers to them. Scholars of Buddhism [End Page 169] have for the most part recognized that the term "hinayana," perhaps best translated as "lesser vehicle," is a pejorative term given to Theravadins by the Mahayanists, the "great vehicle" folks. Kiblinger argues that even though Mahayanists consider their tradition superior (a common trait of all inclusivists, Buddhist or not), they do so with an openness to the value of the way Theravadins approach the problem of enlightenment. Their way may not be the best, but it is a way, and in some contexts it may be an effective way. Mahayanists are able... (shrink)

From Fall 2016 to Fall 2019 Marcelo Gleiser conducted a series of nine public dialogues between eminent scientists and humanists on challenging topics and ideas whose very definitions and meanings are disputed. Sponsored by the Institute for Cross-Disciplinary Engagement at Dartmouth College, founded by Gleiser, these events were held in theaters and universities across the US and immediately followed by workshops, open to the public, at which attendees could converse directly with participants. Great Minds Don't Think Alike collects edited versions (...) of these discussions, which set an example, in a time when public discourse is seriously threatened, of how people can engage in a fruitful exchange of ideas even when they strongly disagree. The cast of characters is stellar: David Chalmers and Antonio Damasio on consciousness, Sean Carroll and Alan Wallace on reality, Patricia Churchland and Jill Tarter on the future of intelligence, Rebecca Goldstein and Alan Lightman on faith, Jimena Canales and Paul Davies on time, Ed Boyden and Mark O'Connell on transhumanism, Elizabeth Kolbert and Siddhartha Mukherjee on immortality, and Jeremy DeSilva, David Grinspoon, and Tasneem Zehra Husain on being human. (shrink)

From Fall 2016 to Fall 2019 Marcelo Gleiser conducted a series of nine public dialogues between eminent scientists and humanists on challenging topics and ideas whose very definitions and meanings are disputed. Sponsored by the Institute for Cross-Disciplinary Engagement at Dartmouth College, founded by Gleiser, these events were held in theaters and universities across the US and immediately followed by workshops, open to the public, at which attendees could converse directly with participants. Great Minds Don't Think Alike collects edited versions (...) of these discussions, which set an example, in a time when public discourse is seriously threatened, of how people can engage in a fruitful exchange of ideas even when they strongly disagree. The cast of characters is stellar: David Chalmers and Antonio Damasio on consciousness, Sean Carroll and Alan Wallace on reality, Patricia Churchland and Jill Tarter on the future of intelligence, Rebecca Goldstein and Alan Lightman on faith, Jimena Canales and Paul Davies on time, Ed Boyden and Mark O'Connell on transhumanism, Elizabeth Kolbert and Siddhartha Mukherjee on immortality, and Jeremy DeSilva, David Grinspoon, and Tasneem Zehra Husain on being human. (shrink)

There is nothing like a little controversy to generate publicity for your new book. In May of 2016, two weeks before the release of The Gene: An Intimate History, author and physician Siddhartha Mukherjee published a New Yorker article that generated a firestorm of criticism. His subject was epigenetics, a newly popular subdiscipline of genetics that seeks to explain how an organism’s traits can be affected by factors other than its genes. The conventional view within biology is that an (...) organism’s physical traits are specified by its genetic information. Genotype determines pheno-type, and different phenotypes imply different genotypes. But findings within epigenetics suggest... (shrink)

At its heart, Buddhism blossoms from one source: the words and life of Siddhartha Gautama, the Buddha. Chad Mercree, a lifetime student of Buddhist philosophy and meditation, reveals in simple language how Buddhism can yield personal growth in the modern world. Because every journey is unique, Mercree relates his own story, as well as the experiences of famous Buddhists throughout history, to help you apply Buddha's principles to your personal path.

In lieu of an abstract, here is a brief excerpt of the content:T. S. Eliot, Dharma Bum:Buddhist Lessons in The Waste LandThomas Michael LeCarnerMany critics have argued that T. S. Eliot's The Waste Land is a poem that attempts to deal with the physical destruction and human atrocities of the First World War, or that he had somehow expressed the disillusionment of a generation. For Eliot, such a characterization was too reductive. He replied, "Nonsense, I may have expressed for them (...) their own illusion of being disillusioned, but that did not form part of my intention." He did not want to be the poet of a "lost generation" of war survivors, but rather, he wanted, like most poets, to write for all ages. To that end, Eliot sought to transcend time and space by bringing to The Waste Land scores of literary, cultural, and artistic allusions from a variety of sources including the Upanishads, Greek mythology, the Bible, Chaucer, Dante, Spenser, Shakespeare, and Leonardo Da Vinci. Ironically, within this menagerie of literary homages, Eliot has created a vast emptiness, a world of pain, suffering, desolation and despair, as if to suggest that even in the presence of all the greatest artistic and cultural achievements of mankind, we must understand that life is transitory and material things ephemeral.The idea that life is fleeting and filled with suffering is at the core of Buddhist thought and one that Eliot surely learned from his graduate studies at Harvard. Several scholars have examined the influence of Eastern philosophy, and in particular Buddhist thought, on Eliot's work, largely in the past forty years.1 My argument departs from this scholarship in two significant ways. First, I will read The Waste Land through the lens of Eliot's graduate studies, and in doing so will show how the poem functions as a didactic, artistic representation of the Buddhist doctrine of samsāra, an idea that views the world as transitory, overcome [End Page 402] with lustful desires, and forever bound to a cycle of life, death, and rebirth. From this perspective, we can see how Eliot's understanding of the original Buddhist texts, which informed much of his writing of The Waste Land, allowed him to see through the all-too-common misconceptions about Buddhism during the early part of the twentieth century. Lastly, we will see that Eliot looked at these misconceptions as a psychological projection of Europeans' discontent with their own lives in an uncertain time.Over the past three decades an increasing number of scholars have studied Eliot's graduate work. In 1985, Jeffrey Perl and Andrew Tuck published a study that examines the impact that Eliot's coursework and professors had on during his studies at Harvard.2 Perl and Tuck point out that Eliot devoted nearly one third of his graduate program to the study of Asian philosophy and philology. Eliot studied Sanskrit and Pali under C. R. Lanman, the preeminent Sanskrit specialist of the age. In his third year, Eliot took a course entitled "Schools of Religious and Philosophical Thought in Japan" with Professor Masaharu Anesaki, a course that had a profound impact on him. Eliot was exposed to several schools of Buddhism in his studies including the Kegon, Shingon, and Tendai, which are characterized as "descendants of the Madhyamika School, which was founded in the second century A.D. by Nāgārjuna, the Indian Buddhist philosopher." Nāgārjuna is widely considered the most influential Buddhist philosopher after Siddhartha Gautama himself and is the leading proponent of the Mādhyamika ("Middle Way") philosophy.The central teaching of Nāgārjuna was the doctrine of śūnyatā, or as it is often translated, "emptiness." For Mahāyāha Buddhists, all things are totally empty of any defining essence. Thus, all things are void of any fixed identity or inherent existence and remain in a constant state of impermanence, change, and flux. This is the fundamental premise of Mahāyāha Buddhism. Only through the realization of this emptiness in material things can one achieve Buddhahood. According to one standard text, "the real knowledge of Buddha nature is empty of empirical content, and it is the discovery of that emptiness or void, śūnyatā, of the true Buddha... (shrink)